LOCUS       NM_011960               5574 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus poly (ADP-ribose) glycohydrolase (Parg), transcript
            variant 1, mRNA.
ACCESSION   NM_011960
VERSION     NM_011960.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5574)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5574)
  AUTHORS   Sasaki,Y., Nakatsuka,R., Inoue,A., Inouchi,T., Masutani,M. and
            Nozaki,T.
  TITLE     Dysfunction of poly (ADP-ribose) glycohydrolase suppresses
            osteoclast differentiation in RANKL-stimulated RAW264 cells
  JOURNAL   Biochem Biophys Res Commun 692, 149309 (2024)
   PUBMED   38048727
  REMARK    GeneRIF: Dysfunction of poly (ADP-ribose) glycohydrolase suppresses
            osteoclast differentiation in RANKL-stimulated RAW264 cells.
REFERENCE   3  (bases 1 to 5574)
  AUTHORS   Karpova,Y., Orlicky,D.J., Schmidt,E.E. and Tulin,A.V.
  TITLE     Disrupting Poly(ADP-ribosyl)ating Pathway Creates Premalignant
            Conditions in Mammalian Liver
  JOURNAL   Int J Mol Sci 24 (24), 17205 (2023)
   PUBMED   38139034
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5574)
  AUTHORS   Li,J., Liu,X., Peng,B., Feng,T., Zhou,W., Meng,L., Zhao,S.,
            Zheng,X., Wu,C., Wu,S., Chen,X., Xu,X., Sun,J. and Li,J.
  TITLE     O-GlcNAc has crosstalk with ADP-ribosylation via PARG
  JOURNAL   J Biol Chem 299 (11), 105354 (2023)
   PUBMED   37858678
  REMARK    GeneRIF: O-GlcNAc has crosstalk with ADP-ribosylation via PARG.
REFERENCE   5  (bases 1 to 5574)
  AUTHORS   Farhana,F., Sakai,E., Koyanagi,Y., Yamaguchi,Y., Alam,M.I.,
            Okamoto,K. and Tsukuba,T.
  TITLE     Abr, a Rho-regulating protein, modulates osteoclastogenesis by
            enhancing lamellipodia formation by interacting with
            poly(ADP-ribose) glycohydrolase
  JOURNAL   Mol Biol Rep 50 (9), 7557-7569 (2023)
   PUBMED   37507586
  REMARK    GeneRIF: Abr, a Rho-regulating protein, modulates
            osteoclastogenesis by enhancing lamellipodia formation by
            interacting with poly(ADP-ribose) glycohydrolase.
REFERENCE   6  (bases 1 to 5574)
  AUTHORS   Cortes,U., Tong,W.M., Coyle,D.L., Meyer-Ficca,M.L., Meyer,R.G.,
            Petrilli,V., Herceg,Z., Jacobson,E.L., Jacobson,M.K. and Wang,Z.Q.
  TITLE     Depletion of the 110-kilodalton isoform of poly(ADP-ribose)
            glycohydrolase increases sensitivity to genotoxic and endotoxic
            stress in mice
  JOURNAL   Mol Cell Biol 24 (16), 7163-7178 (2004)
   PUBMED   15282315
  REMARK    GeneRIF: These data indicate that the poly(ADP-ribose)
            glycohydrolase 110 kDa isoform plays an important role in DNA
            damage responses and in pathological processes.
REFERENCE   7  (bases 1 to 5574)
  AUTHORS   Dumitriu,I.E., Voll,R.E., Kolowos,W., Gaipl,U.S., Heyder,P.,
            Kalden,J.R. and Herrmann,M.
  TITLE     UV irradiation inhibits ABC transporters via generation of
            ADP-ribose by concerted action of poly(ADP-ribose) polymerase-1 and
            glycohydrolase
  JOURNAL   Cell Death Differ 11 (3), 314-320 (2004)
   PUBMED   14685157
  REMARK    GeneRIF: Hydrolysis of PARP requires PARG.
REFERENCE   8  (bases 1 to 5574)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 5574)
  AUTHORS   Olski,T.M., Noegel,A.A. and Korenbaum,E.
  TITLE     Parvin, a 42 kDa focal adhesion protein, related to the
            alpha-actinin superfamily
  JOURNAL   J Cell Sci 114 (Pt 3), 525-538 (2001)
   PUBMED   11171322
REFERENCE   10 (bases 1 to 5574)
  AUTHORS   Ame,J.C., Apiou,F., Jacobson,E.L. and Jacobson,M.K.
  TITLE     Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to
            human chromosome 10q11.23 and mouse chromosome 14B by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 85 (3-4), 269-270 (1999)
   PUBMED   10449915
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059827.1, BC053037.1, AC167565.1 and AI450246.1.
            
            On Jan 19, 2018 this sequence version replaced NM_011960.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059827.1, AK164013.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1383              BC059827.1         10-1392
            1384-2324           BC053037.1         1367-2307
            2325-4391           BC059827.1         2334-4400
            4392-5485           AC167565.1         28450-29543
            5486-5574           AI450246.1         1-89                c
FEATURES             Location/Qualifiers
     source          1..5574
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.4 cM"
     gene            1..5574
                     /gene="Parg"
                     /note="poly (ADP-ribose) glycohydrolase"
                     /db_xref="GeneID:26430"
                     /db_xref="MGI:MGI:1347094"
     exon            1..495
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..3161
                     /gene="Parg"
                     /EC_number="3.2.1.143"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cytosolic poly(ADP-ribose) glycohydrolase"
                     /codon_start=1
                     /product="poly(ADP-ribose) glycohydrolase isoform 1"
                     /protein_id="NP_036090.2"
                     /db_xref="CCDS:CCDS36865.1"
                     /db_xref="GeneID:26430"
                     /db_xref="MGI:MGI:1347094"
                     /translation="MSAGPGWEPCTKRPRWGAAGTSAPTASDSRSFPGRQRRVLDPKD
                     APVQFRVPPSSPACVSGRAGPHRGNATSFVFKQKTITTWMDTKGPKTAESESKENNNT
                     RIDSMMSSVQKDNFYPHKVEKLENVPQLNLDKSPTEKSSQYLNQQQTASVCKWQNEGK
                     HAEQLLASEPPAGTPLPKQLSNANIGQSPHTDDHSDTDHEEDRDNQQFLTPIKLANTK
                     PTVGDGQARSNCKCSGSRQSVKDCTGCQQEEVDVLPESPLSDVGAEDIGTGPKNDNKL
                     TGQESSLGDSPPFEKESEPESPMDVDNSKNSCQDSEADEETSPVFDEQDDRSSQTANK
                     LSSCQAREADGDLRKRYLTKGSEVRLHFQFEGENNAGTSDLNAKPSGNSSSLNVECRS
                     SKQHGKRDSKITDHFMRISKSEDRRKEQCEVRHQRTERKIPKYIPPNLPPEKKWLGTP
                     IEEMRKMPRCGIHLPSLRPSASHTVTVRVDLLRAGEVPKPFPTHYKDLWDNKHVKMPC
                     SEQNLYPVEDENGERTAGSRWELIQTALLNKFTRPQNLKDAILKYNVAYSKKWDFTAL
                     VDFWDKVLEEAEAQHLYQSILPDMVKIALCLPNICTQPIPLLKQKMNHSVTMSQEQIA
                     SLLANAFFCTFPRRNAKMKSEYSSYPDINFNRLFEGRSSRKPEKLKTLFCYFRRVTEK
                     KPTGLVTFTRQSLEDFPEWERCEKPLTRLHVTYEGTIEGNGRGMLQVDFANRFVGGGV
                     TGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIITGTEQYSEYTGYAETYRWARSH
                     EDGSEKDDWQRRCTEIVAIDALHFRRYLDQFVPEKVRRELNKAYCGFLRPGVPSENLS
                     AVATGNWGCGAFGGDARLKALIQILAAAAAERDVVYFTFGDSELMRDIYSMHTFLTER
                     KLDVGKVYKLLLRYYNEECRNCSTPGPDIKLYPFIYHAVESSAETTD"
     exon            496..562
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            563..1525
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1709
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1710..1832
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1916
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1991
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2084
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2242
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2322
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2383
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2459
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2607
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2608..2686
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2687..2795
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..2901
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3030
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..5555
                     /gene="Parg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4042..4047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parg"
                     /note="hexamer: AATAAA"
     polyA_site      4061
                     /gene="Parg"
                     /note="major polyA site"
     regulatory      4364..4369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parg"
                     /note="hexamer: AATAAA"
     polyA_site      4391
                     /gene="Parg"
     regulatory      5531..5536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Parg"
                     /note="hexamer: AATAAA"
     polyA_site      5555
                     /gene="Parg"
ORIGIN      
        1 gggaaagtga gcctggagcc ggagcccgat ctcgagccga gtggaagcgg cgcgtcccgg
       61 ggctggtggg ctccctgctg ccgagcggag gcaagcggct gcgcagcgag ggtctcgctc
      121 gaaggcccga ggagtggcag cctccaggcg ggccgctgcg gagagggaat ggtgcgcggc
      181 gcgccgagaa ggaggcgcag tccgtccctg tccgggttag tgaatgaggc tctccgcccg
      241 ggccggcccg gggactgtgt gctgcgggtc ccagcatgag tgcgggcccc ggctgggagc
      301 cctgcacgaa gcggccccgc tggggcgccg ctggaacttc tgcgccgact gcctcggact
      361 cccggagctt ccctggcagg cagaggcgtg ttctcgaccc caaggacgct cccgtccagt
      421 tcagggtccc tccgtcctcg ccagcctgcg tctcggggcg ggcgggaccg cacagaggca
      481 acgccacctc gtttgttttc aaacaaaaga ctattactac ttggatggat actaaaggac
      541 ccaagacagc tgaatcagaa agtaaagaaa acaacaatac aagaattgac tccatgatga
      601 gttctgtgca gaaagataac ttttacccac ataaggtgga aaaattggaa aatgttcctc
      661 agctaaatct tgataaatca cccacagaaa agagttcaca gtatttgaac caacagcaga
      721 ctgcgagtgt gtgcaagtgg cagaatgaag ggaagcatgc agaacagctt ttggcaagtg
      781 agcctcccgc ggggactccg ctaccaaagc agcttagtaa tgctaacatt ggtcagtcac
      841 cccacactga tgaccacagt gacacagatc atgaagaaga cagagacaat cagcagtttc
      901 ttacacctat aaaacttgca aatacaaagc caacagtagg agatgggcag gccagaagca
      961 actgtaagtg cagtggatct cgccagtctg tgaaagactg tacaggctgt caacaggagg
     1021 aggtggatgt gctaccagag agtcctttgt cagatgttgg tgccgaggac attggaactg
     1081 gaccaaaaaa tgacaacaaa ttgactggac aagaaagcag cctaggtgat tcgcctccat
     1141 ttgagaaaga aagtgagcct gagtcaccaa tggatgtaga caactcgaaa aacagttgtc
     1201 aagattcaga agcagatgaa gaaacaagtc cagtctttga tgagcaagat gatcgttcct
     1261 cccaaacagc aaataaactt tcaagttgcc aagcaagaga agctgatggc gatcttagga
     1321 aacggtattt gactaaggga agtgaagtta gattgcattt ccaatttgaa ggagaaaata
     1381 atgctgggac cagtgactta aatgccaagc catctggaaa ctcttctagc cttaatgtag
     1441 agtgtagaag ttccaagcag catggaaaaa gggattctaa aattacagat catttcatga
     1501 gaatttccaa gtcagaggac agaagaaaag aacaatgtga agtcagacat caaagaacag
     1561 aaaggaagat tccaaaatac atcccaccta acctccctcc agagaagaag tggctgggaa
     1621 ctcctattga ggaaatgaga aaaatgcctc ggtgtgggat ccatttgcct tccttaagac
     1681 catctgcaag tcacacagtg actgttcggg tagaccttct gagagcagga gaggttccga
     1741 aaccttttcc aacacattac aaagatttgt gggataacaa acatgtgaaa atgccttgtt
     1801 cggaacaaaa cttgtaccct gtggaagatg agaatggtga gcgaactgca gggagtaggt
     1861 gggagctcat tcagactgca cttctcaaca aattcacacg accccagaac ttgaaggatg
     1921 cgattctgaa atacaatgtg gcatattcta agaaatggga ctttacagct ttggttgatt
     1981 tctgggataa ggtacttgaa gaagcagagg cccaacattt atatcagtcc attttacctg
     2041 acatggtgaa aattgcactc tgtctgccaa atatttgcac ccagccaata ccactcctga
     2101 aacagaagat gaatcattct gtcacgatgt cacaggaaca gatcgccagt cttttagcta
     2161 atgctttctt ctgcacattt ccccgacgga atgccaagat gaaatcggag tattctagtt
     2221 acccagacat taacttcaat cggttgtttg aaggacgttc atcaaggaaa ccagaaaaac
     2281 tgaaaacact cttctgctac tttcgaagag tcacagagaa aaaacctaca ggattggtga
     2341 catttacaag acagagtctt gaagattttc cagaatggga aaggtgtgaa aagcctctga
     2401 cacgcttaca cgtcacttac gagggtacca tagaaggcaa cggccgaggc atgctacagg
     2461 tggattttgc aaatcgtttt gttggaggtg gtgtgactgg tgcgggactt gtacaagaag
     2521 aaatcagatt tttaatcaat cctgaattga ttgtttcacg gctgttcact gaggtgctgg
     2581 atcacaatga gtgtcttatt atcacaggta ctgaacagta cagtgaatac acaggctatg
     2641 ctgaaactta tcgttgggcc cgaagccatg aagatgggag tgaaaaggac gattggcagc
     2701 ggcgctgcac ggagatcgtt gccattgacg cacttcactt cagacgctac ctcgatcagt
     2761 ttgtgcctga gaaagtgaga cgtgagctta acaaggctta ctgcggattc ctccgtcctg
     2821 gagttccttc tgaaaatctt tctgcagtgg ccacgggaaa ctggggctgt ggtgcctttg
     2881 ggggtgacgc tagattaaaa gccttaatac agatcctggc agctgctgcg gctgaacgtg
     2941 acgtggttta tttcaccttt ggggactcag agttgatgag agacatttac agcatgcaca
     3001 ctttccttac cgagaggaag ctggatgttg gaaaagtgta caagttattg cttagatact
     3061 acaatgaaga atgcagaaac tgttccaccc ctggaccaga catcaagctt tatccattca
     3121 tataccatgc tgttgagtca agtgcagaga ccactgacta gccaggacag aaggcaggca
     3181 cctgaggaac aagtgactag gacctcctct caaagagaca tcctatttga aatgtggggt
     3241 gtgatgtctg aattgactga atctgatcta agtgtgtata taatccacat ttgtaatcaa
     3301 ggatgcagtc tcttctgcat atgcagttgt ttcttgttca tcctggtgga catgccttta
     3361 gacatggctt cttcaatttt tcttctcctt cagtctttat tctttgattt tttttttcca
     3421 acttgatttc ttgggaaaac tcaagaaagg ttgcactcag cttctagatc tttctcttcc
     3481 tgtctgtgtg ttgtccagac tgctttggtg gctagcagat accatcacac ttggaggaag
     3541 ttacaaatcc agaaatctga gtttgctgca gatttacctg tgagcttctc actcccaacc
     3601 cttgttaggc ttgtgttgtc tacattttca attttggaag ttgaagtttt tcttatgtta
     3661 cttaatgcta gtatctttta ggctaaaact attttctatt taaggcagac taatttccag
     3721 tttctctttt gaaacatcat ccctataagt aacggttttt ttcgtccttt tttccccagc
     3781 gctattttag aagctggcca agaggaaaga aaatgtagaa taaaaggatt ttcctcggat
     3841 gctataaaga agccaggttc aagagcgttg gggtttttgt ttttttcaag acttgttttt
     3901 cctttgcagc tagggtgagt gcttgttctg tggtgctgag ggcatagtcc tgtaaccaaa
     3961 ggtctttgct ggagacttga tgctgatttg tacatatgga agtttctctg gcaggaaata
     4021 ttagagttaa taaatttcat taataaatca tttgtcagaa actcccatgc cacttatatt
     4081 ttattcatac atataagcat ttgtgttgtg tctgcaggag tacataaaac ccaccaacca
     4141 aggacagagg acaatgaggt ctgagctttt gaaaagccct gtttcaaatc ttttactcac
     4201 aattgtattt ttaaaaccat caacaagata acctataatc gatgtctgtg aggctaatct
     4261 ggaaaccaaa gccagtctta cattaactga ttaaaatgaa atcatgaaaa ccctttttca
     4321 gacttccaaa gttctggttc cagtctagct gtcagcaaaa gccaataaaa gtcaagtcct
     4381 gataccacaa agcttttgtt agatgctctg agctcctttg ccagcactgg cagaaaaaaa
     4441 aatgggtcct ggtccagagc cttagctctt cccttttgta caaaaatcgg gaggataatg
     4501 ggctttggcc cgaaggctac cagttgtcat tgatgaagct ctttactgca acaactaaga
     4561 cttttttgat caaatcacaa atctagagga gtctggcctt atccccactg atgctaaaat
     4621 ctctttccct tccagctatt ctatgctttg ctaacagatt tatggatata ttttatttcc
     4681 ttctctttct attcccacac ctctttctct tagtcagtca aatgatgacg caagtaattg
     4741 taacaaaaat tatagagcca ggctagagga ccgctgataa tccagaggac agaagcttcc
     4801 gcccagctcc cagtttgtgc aggggttgtg acatggccat ctactagctg cctcatatag
     4861 ggttgccagg agtgaagcct gatgaggtga ctgtcagtgt atcttggtat cagtatgtcc
     4921 tgctgggctc agattaatga agcagaaccg actgatgagg gacagttaca cagagaacac
     4981 aacagagcta gtccgtgttt ccttctatcc cacccgcatg tccgaggctc actttaggaa
     5041 ggagtttcag tgtgcctctg tacaggcaaa aatgagtgac gtctcccctg tactcagagt
     5101 gaggttgaat gacctagaac ccaaaatggc attttctttt tactgccttg ttccagttta
     5161 acccagagaa accagttgca tcgttttgct gtcagttgga aaaccagtaa gaacccacat
     5221 tatgtccgtt caccagaact gaactttata gacacttgac tttgaagagt tgcataacaa
     5281 gtgacttaac acatagtgtg ggtgagctgt ctagactcct taacagtgct cacgtcagta
     5341 ggccctgaac tcggaggaag cagctctgaa gggtaaagag gacaatagaa cacacgtgac
     5401 atggaggtgc aaaggtgtcc actaggagca gagggttcaa ggggtgcagg gtatgcccaa
     5461 gaattgggaa gaaaaggaac aaacaaacaa aaaaaaaatg ccataatgaa gcctagtact
     5521 ttgtatgtca aataaataac tagtttttaa aagtgaaaaa aaaaaaaaaa aaaa
//
