LOCUS       NM_053117               3143 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus par-6 family cell polarity regulator gamma (Pard6g),
            mRNA.
ACCESSION   NM_053117
VERSION     NM_053117.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3143)
  AUTHORS   Passer,D., van de Vrugt,A., Atmanli,A. and Domian,I.J.
  TITLE     Atypical Protein Kinase C-Dependent Polarized Cell Division Is
            Required for Myocardial Trabeculation
  JOURNAL   Cell Rep 14 (7), 1662-1672 (2016)
   PUBMED   26876178
  REMARK    GeneRIF: Prkci and its downstream partners, such a Pard6g, direct
            polarized cell division of luminal myocardial cells to drive
            trabeculation in the nascent heart.
REFERENCE   2  (bases 1 to 3143)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   3  (bases 1 to 3143)
  AUTHORS   Hartleben,B., Schweizer,H., Lubben,P., Bartram,M.P., Moller,C.C.,
            Herr,R., Wei,C., Neumann-Haefelin,E., Schermer,B., Zentgraf,H.,
            Kerjaschki,D., Reiser,J., Walz,G., Benzing,T. and Huber,T.B.
  TITLE     Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C
            (aPKC) complex to regulate podocyte cell polarity
  JOURNAL   J Biol Chem 283 (34), 23033-23038 (2008)
   PUBMED   18562307
REFERENCE   4  (bases 1 to 3143)
  AUTHORS   Cui,X.S., Li,X.Y., Shen,X.H., Bae,Y.J., Kang,J.J. and Kim,N.H.
  TITLE     Transcription profile in mouse four-cell, morula, and blastocyst:
            Genes implicated in compaction and blastocoel formation
  JOURNAL   Mol Reprod Dev 74 (2), 133-143 (2007)
   PUBMED   16998848
  REMARK    Review article
REFERENCE   5  (bases 1 to 3143)
  AUTHORS   Wu,X., Quondamatteo,F., Lefever,T., Czuchra,A., Meyer,H.,
            Chrostek,A., Paus,R., Langbein,L. and Brakebusch,C.
  TITLE     Cdc42 controls progenitor cell differentiation and beta-catenin
            turnover in skin
  JOURNAL   Genes Dev 20 (5), 571-585 (2006)
   PUBMED   16510873
REFERENCE   6  (bases 1 to 3143)
  AUTHORS   Koike,C., Nishida,A., Akimoto,K., Nakaya,M.A., Noda,T., Ohno,S. and
            Furukawa,T.
  TITLE     Function of atypical protein kinase C lambda in differentiating
            photoreceptors is required for proper lamination of mouse retina
  JOURNAL   J Neurosci 25 (44), 10290-10298 (2005)
   PUBMED   16267237
REFERENCE   7  (bases 1 to 3143)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3143)
  AUTHORS   Manabe,N., Hirai,S., Imai,F., Nakanishi,H., Takai,Y. and Ohno,S.
  TITLE     Association of ASIP/mPAR-3 with adherens junctions of mouse
            neuroepithelial cells
  JOURNAL   Dev Dyn 225 (1), 61-69 (2002)
   PUBMED   12203721
REFERENCE   9  (bases 1 to 3143)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat Cell Biol 2 (8), 531-539 (2000)
   PUBMED   10934474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY732180.1, BB663070.1, AK035811.1 and AC131065.16.
            
            On May 28, 2009 this sequence version replaced NM_053117.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037678.1, AK035811.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                BY732180.1         7-28
            23-194              BB663070.1         1-172
            195-2881            AK035811.1         2-2688
            2882-3143           AC131065.16        80913-81174
FEATURES             Location/Qualifiers
     source          1..3143
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 53.22 cM"
     gene            1..3143
                     /gene="Pard6g"
                     /gene_synonym="2410049N21Rik; Par6a"
                     /note="par-6 family cell polarity regulator gamma"
                     /db_xref="GeneID:93737"
                     /db_xref="MGI:MGI:2135606"
     exon            1..248
                     /gene="Pard6g"
                     /gene_synonym="2410049N21Rik; Par6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1325
                     /gene="Pard6g"
                     /gene_synonym="2410049N21Rik; Par6a"
                     /note="partitioning-defective protein 6, alpha; par-6
                     partitioning defective 6 homolog gamma; PAR-6 gamma"
                     /codon_start=1
                     /product="partitioning defective 6 homolog gamma"
                     /protein_id="NP_444347.3"
                     /db_xref="CCDS:CCDS29363.1"
                     /db_xref="GeneID:93737"
                     /db_xref="MGI:MGI:2135606"
                     /translation="MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFED
                     FYQLVVHTHHISNTEVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAD
                     HYSFGAGTLSRKKKVLVTLRDDGLRRRPHLNISMPHDFRPVSSIIDVDILPETHRRVR
                     LYRHGYEKPLGFYIRDGTSVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLE
                     VNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRSSRTSGSSVHSTDSTTSH
                     HSLPGAHVLQNSEDVESDEEADIVIEGALEPQHIPKTQAVPPGSLSRANGTSLAHGLH
                     RRDMSLHSSGRESNGSIHRFLSSLKPDPRHSLVLPQGGVEEHGPAITL"
     exon            249..471
                     /gene="Pard6g"
                     /gene_synonym="2410049N21Rik; Par6a"
                     /inference="alignment:Splign:2.1.0"
     exon            472..3143
                     /gene="Pard6g"
                     /gene_synonym="2410049N21Rik; Par6a"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1437
                     /gene="Pard6g"
                     /gene_synonym="2410049N21Rik; Par6a"
ORIGIN      
        1 ccccgcggcg cgccgccagc cccgctccgg cccgcctcac gccgtgcagc cgggcgccct
       61 agcgagcgcg ggcccggcgc cgggcccggg cagacgttgg ggggcgtctc cgcggagact
      121 ctctctgagg cccctgagcg gcgagggcga aggcgaggct gagtggggcc gaaatcatga
      181 accggagttt tcataagtct cagaccctac gcttctacga ctgcagcgct gtggaagtca
      241 agagcaagtt tggcgccgag ttccgaaggt tctccttgga ccgccacaag cctgggaagt
      301 ttgaagattt ctaccagctg gtggtgcaca cccaccacat ctctaacacc gaggtgacca
      361 tcggctatgc tgatgtgcac ggggacctgc tgcccatcaa caatgacgac aacttctgca
      421 aggcagtctc aagtgcaaac cccttgcttc gagtcttcat ccagaaacga gaagaagcag
      481 accattacag cttcggagca ggcactctgt cacggaagaa aaaggtgctg gtgaccctga
      541 gggatgacgg tctgcgtcgg cgtccccacc tcaacatcag catgccgcat gacttccgcc
      601 cagtgtcatc catcattgac gtggacatcc tcccggagac gcaccgccga gtgaggctct
      661 acagacacgg ttatgagaag ccactgggct tctacattcg agatggcacc agcgtgcggg
      721 tgacgcccca tgggctagaa aaggtaccag gtatcttcat ttctcgaatg gtacccgggg
      781 gccttgcgga gagcactggg ctactggctg tgaatgatga agtcctggag gtgaatggga
      841 ttgaggtagc tggaaagacc ttggatcaag tcacagacat gatgatagcc aacagccaca
      901 acctcattgt cactgtcaag ccggccaacc aaaggaacaa tgtggtccgc agcagccgca
      961 cgtccggcag ctctgtgcat tccacagaca gcaccaccag tcaccacagc ctgccaggtg
     1021 cccatgtcct gcagaattct gaggacgtgg agagtgacga ggaagccgac attgtcattg
     1081 aaggggctct agaacctcaa cacattccca agacgcaggc tgtacctcca ggcagcctct
     1141 ccagggccaa tggcaccagc cttgctcacg ggctgcacag aagggacatg agcctgcata
     1201 gctctgggag ggagagcaac ggcagcatcc acagatttct cagctctctg aagccagacc
     1261 cccgacacag cctggtcctc ccccaaggag gggtggagga acatgggcca gccattacac
     1321 tctagggctc gagccacttg ggcaggctag agtcccagac agactgtgtg ttaccaagac
     1381 ccatgagtgg caaatattaa tagcatgtag tactgttaga tatatagtga ctccaaagag
     1441 aagcgctttc catttttatg tcaattttaa aataagaaaa ataattgtgt acttcatctt
     1501 ttctttttca tcatcattcc tacaacctta ttctttattt aaacttttaa acaagaatac
     1561 tatttttata gggtttttcc acaaacttaa aatatgcaca actgcaaatt atctgggcca
     1621 ggcctcagtg cctgtccaga acctttgtgg agtgaaacac aacacaaaag tgcagagagt
     1681 atttttaaca tttttttaaa tacttgtttt taaaatgaag ctttatagat aactttttaa
     1741 aaacagtaaa attcatgttt ttaaccagtt catgtaaaac tatcttgtga tgcccgagtg
     1801 ttccactgac cccgtgtggc tgtgacagag caatggctgg gctccatcac agagagtctg
     1861 tttccacact gtttacaacc agctcagaaa gccctctgaa ctatactcaa gacccgctgg
     1921 gattacaacg ccctgcatct gcggagctgc cccagccgtg acagtcaggc ggtcactgct
     1981 gtcggcggct ccagtggatt taggagccca gcaactctgc tggctagaag gtgaggccag
     2041 tggtagcacg tgggattaaa agccaactgt tccatccgtg tttcctctgg gttggctgac
     2101 tagggcggtt ttaaggcatc ttcagtagaa atgagtctcg tacctctgaa ggcccgcagc
     2161 cgtgggtgaa tgtgcatgtt agctagttat ttttataaga ggagattcga gcatgtcagt
     2221 gcctgttcct agaatagcga tccgtggcag gaatcatctt aactacaagt caccgtggaa
     2281 cttaaatagt tttgacagat cacttttctt tctccttaga ggtggtgtat caatgtctga
     2341 cccagttaaa ttttatatga attgcgcctt ctgtttggat acagtgttgg gagagaatat
     2401 ccaattgatt aactgaggac aaactgacca agtgactcct tcatgtaaat aaaggtttta
     2461 aagcatcttc gtcttccagg tcgagtgccc cagctgctgc ccttatggtc tagtgccacc
     2521 tgctggtaag acgcagaact gtcctgactt catgaatgcc agatggagaa tgcatctcag
     2581 cattggcctt tgtccagaac tcatactgtc aaatagtgtt gttccttcct ttggggaact
     2641 gtttcctggg cagaggtggc cttggttaag gatcgtttcc ttgccctgtg cctgtttctc
     2701 cgttatgtgc ggagtgtcca cacaaggaga gcaagatact ccccgggcct cggtgaggat
     2761 ccaggcaccc agactcatgg cttctaaact gctaaaagca actgttttgt ttccatgttg
     2821 ctgcagtgat ctggaatgtg ctttactaag acaaatatta cagaaccaaa aaaaaaaaaa
     2881 aaaggatgct aagttcctat aagacttgtt ctcggctata ctgtcacttg gtgtatcagt
     2941 ttattcaaaa gaaaaaaaat ttaagtgaag aggtcagacc tttgtgagct attgcctgtg
     3001 aggaattaca tgtgtttagc agatgcctga gagtattttt ctaaacagaa ctcctaccat
     3061 tttatttctt ctttcaaaaa aaaatctgtc attatatatt aaattttttg ttttatatat
     3121 cagaataaaa cctttttctt ttg
//
