LOCUS       NM_021409               3409 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus par-6 family cell polarity regulator beta (Pard6b),
            mRNA.
ACCESSION   NM_021409
VERSION     NM_021409.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3409)
  AUTHORS   Wu,X., Shi,Y., Hu,B., Zhao,P., Li,S., Xiao,L., Wang,S. and Zhang,K.
  TITLE     TEAD4 regulates KRT8 and YAP in preimplantation embryos in mice but
            not in cattle
  JOURNAL   Reproduction 167 (3), e230322 (2024)
   PUBMED   38206180
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3409)
  AUTHORS   Hiremath,C., Gao,L., Geshow,K., Patterson,Q., Barlow,H., Cleaver,O.
            and Marciano,D.K.
  TITLE     Rap1 regulates lumen continuity via Afadin in renal epithelia
  JOURNAL   Dev Biol 501, 20-27 (2023)
   PUBMED   37276970
REFERENCE   3  (bases 1 to 3409)
  AUTHORS   Barlow,H.R., Ahuja,N., Bierschenk,T., Htike,Y., Fassetta,L.,
            Azizoglu,D.B., Flores,J., Gao,N., De la,O. S, Sneddon,J.B.,
            Marciano,D.K. and Cleaver,O.
  TITLE     Rab11 is essential to pancreas morphogenesis, lumen formation and
            endocrine mass
  JOURNAL   Dev Biol 499, 59-74 (2023)
   PUBMED   37172642
REFERENCE   4  (bases 1 to 3409)
  AUTHORS   Ozguldez,H.O., Govindasamy,N., Fan,R., Long,H., Mildner,K.,
            Zeuschner,D., Trappmann,B., Ranga,A. and Bedzhov,I.
  TITLE     Polarity inversion reorganizes the stem cell compartment of the
            trophoblast lineage
  JOURNAL   Cell Rep 42 (4), 112313 (2023)
   PUBMED   36989113
REFERENCE   5  (bases 1 to 3409)
  AUTHORS   Abou Nader,N., Menard,A., Levasseur,A., St-Jean,G., Boerboom,D.,
            Zamberlam,G. and Boyer,A.
  TITLE     Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis
            Development and Alters Somatic Cell Fate
  JOURNAL   Int J Mol Sci 23 (21), 13585 (2022)
   PUBMED   36362374
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3409)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3409)
  AUTHORS   Manabe,N., Hirai,S., Imai,F., Nakanishi,H., Takai,Y. and Ohno,S.
  TITLE     Association of ASIP/mPAR-3 with adherens junctions of mouse
            neuroepithelial cells
  JOURNAL   Dev Dyn 225 (1), 61-69 (2002)
   PUBMED   12203721
REFERENCE   8  (bases 1 to 3409)
  AUTHORS   Gao,L., Joberty,G. and Macara,I.G.
  TITLE     Assembly of epithelial tight junctions is negatively regulated by
            Par6
  JOURNAL   Curr Biol 12 (3), 221-225 (2002)
   PUBMED   11839275
REFERENCE   9  (bases 1 to 3409)
  AUTHORS   Lin,D., Edwards,A.S., Fawcett,J.P., Mbamalu,G., Scott,J.D. and
            Pawson,T.
  TITLE     A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC
            signalling and cell polarity
  JOURNAL   Nat Cell Biol 2 (8), 540-547 (2000)
   PUBMED   10934475
REFERENCE   10 (bases 1 to 3409)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat Cell Biol 2 (8), 531-539 (2000)
   PUBMED   10934474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ062867.1, CJ050007.1, CX568497.1, AL831766.3 and AI837082.1.
            
            On Jul 9, 2009 this sequence version replaced NM_021409.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3163256.1,
                                           SRR7974084.225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-240               CJ062867.1         2-241
            241-584             CJ050007.1         2-345
            585-1111            CX568497.1         183-709
            1112-3097           AL831766.3         107389-109374
            3098-3409           AI837082.1         7-318               c
FEATURES             Location/Qualifiers
     source          1..3409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 88.24 cM"
     gene            1..3409
                     /gene="Pard6b"
                     /gene_synonym="Par6b"
                     /note="par-6 family cell polarity regulator beta"
                     /db_xref="GeneID:58220"
                     /db_xref="MGI:MGI:2135605"
     exon            1..356
                     /gene="Pard6b"
                     /gene_synonym="Par6b"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1406
                     /gene="Pard6b"
                     /gene_synonym="Par6b"
                     /note="partitioning-defective protein 6, beta; PAR-6B;
                     PAR-6 beta; par-6 (partitioning defective 6) homolog beta"
                     /codon_start=1
                     /product="partitioning defective 6 homolog beta"
                     /protein_id="NP_067384.2"
                     /db_xref="CCDS:CCDS17108.1"
                     /db_xref="GeneID:58220"
                     /db_xref="MGI:MGI:2135605"
                     /translation="MNRGHRHGASSGCLGTMEVKSKFGAEFRRFSLERSKPGKFEEFY
                     GLLQHVHKIPNVDVLVGYADIHGDLLPINNDDNYHKAVSTANPLLRIFIQKKEEADYS
                     AFGTDTLIRKKNMLSNVLRPDNHRKKPHIVISMPQDFRPVSSIIDVDILPETHRRVRL
                     YKYGTEKPLGFYIRDGSSVRVTPHGLEKVPGIFISRLVPGGLAQSTGLLAVNDEVLEV
                     NGIEVSGKSLDQVTDMMIANSRNLIITVRPANQRNNVVRNSRTSGSSSQSTDNSLLGF
                     PQQVEASFEPEDQDSDEDDIIIEDSGEPQQIPKATPAQSLESLTQIELSFESGQNGFS
                     PPQDTSLVPVPGSLDTELESRAPDQKLLEEDGTIITL"
     exon            357..579
                     /gene="Pard6b"
                     /gene_synonym="Par6b"
                     /inference="alignment:Splign:2.1.0"
     exon            580..3399
                     /gene="Pard6b"
                     /gene_synonym="Par6b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3195..3200
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pard6b"
                     /gene_synonym="Par6b"
                     /note="hexamer: ATTAAA"
     polyA_site      3219
                     /gene="Pard6b"
                     /gene_synonym="Par6b"
                     /note="major polyA site"
     regulatory      3373..3378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pard6b"
                     /gene_synonym="Par6b"
                     /note="hexamer: AATAAA"
     polyA_site      3399
                     /gene="Pard6b"
                     /gene_synonym="Par6b"
                     /note="major polyA site"
ORIGIN      
        1 agggaggctg cggcggctgt agggctgtgc tccgccctct cctcaccgcc gcggccgccg
       61 ccgcccccga gcctcgctgg gagggaccgg tgtccccgcc tgctgcactg gcagtccgac
      121 cctcaggccg ccgcggagca gccggcactg cgctgcgggg aggacctcag caggtgccgt
      181 gacgaggcgc cgtgcggcgc ttcgagtccc gagcccgcgc tccgcggccc cgccgcccgc
      241 gctcccgagg gccggccccc gacgaggccg ccggcggccg ggcactcagc atgaaccgcg
      301 gccaccggca cggggcgagc agcggctgcc tgggcaccat ggaggtgaag agcaagtttg
      361 gagctgagtt tcgtcggttt tcactggaaa gatctaagcc tggaaaattt gaggagtttt
      421 acggactgct gcaacatgtt cacaagatcc ccaatgtcga cgtgttggtg ggctacgcag
      481 atatccacgg ggacctgctg cctataaata atgatgacaa ctaccacaag gcggtttcca
      541 ccgccaatcc actgctcagg atttttatac agaagaagga agaagctgac tacagtgcct
      601 ttggcaccga caccctgatc aggaagaaga acatgctgag caacgtgctg cgtcccgaca
      661 accaccggaa gaagcctcac atcgtcatca gcatgccgca ggacttccgg cccgtgtcat
      721 ccatcatcga cgtggacatc ctcccagaga cgcaccggag ggtccgtctg tacaagtacg
      781 gcacagagaa gccgctgggc ttctacatcc gggatggctc cagcgtccga gtgacaccgc
      841 acggcttgga gaaagtcccc ggcatcttca tatctcggct cgtccctggg ggtctggccc
      901 agagcacggg cctgctagct gtcaacgatg aggtgttaga agtcaacggt atagaagtgt
      961 ccgggaagag cctggaccag gtgactgaca tgatgatagc caacagccgc aacctcatca
     1021 tcaccgtgcg cccggccaac cagaggaaca acgtggtgcg caacagtcgg acttctggca
     1081 gctccagcca gtccactgac aacagcctcc tgggcttccc acagcaggtg gaggccagct
     1141 tcgagcccga ggaccaggac agcgacgagg acgacatcat cattgaagac agtggcgagc
     1201 cgcagcagat cccgaaggcc acccccgccc agagcctgga gtccctgacg cagatcgagc
     1261 tcagctttga gtccggacag aacgggttct cccctcctca ggacacgagc ctggtgcctg
     1321 tgcccggcag cctggacaca gagctggaaa gccgggctcc ggaccagaaa ctcttagagg
     1381 aagatgggac aatcataaca ttgtgaacca ccaggttgtt ttctgtttga gggtgtaagg
     1441 aacaatgttg gtgtgcacac atgactgaca ctgtggacct gcaggccctg atgttccaca
     1501 acaagtgtgg ccgggctggg ctgggagtct gccgaggcag gctgccgtga cacggagcag
     1561 gtgctgctgc tctgaaactg agacctgcct gagccgagct gcggtggccg gtgtccacct
     1621 gcctgcagag cccgctcctt gccctctgtg aagtctgatc atctgctagc cactggggac
     1681 ctcggttctt cgattcccag accctgtttt ctgactttta aagtgttcct ctgttaactg
     1741 tgacaaatta ttttttcatg tgcagttttt gttctgtctt cccattttct aaaactttag
     1801 ctggccatgt ctaggggcct ttcccctggc cctggagcga cacctgttgt cgtcaccctg
     1861 gaactttaca gtttcggggt gccatagtcc ttcattccag tccagtggag attatttcag
     1921 tgtgtgctgt gcacgtgtgc gcatgtgtgt gtgtgtgtgt gtatgtgtgg tgtatgtgtg
     1981 tgtgtgtgtg tgtgtttgtg ggtaggtgat agcatagtta gttgactccc acactcttca
     2041 gtgtaccaga cagtgtggat catgggataa aaatgccccc aggttaagag acttacacac
     2101 gatatagatg tgcacttttt attcaaaaga cggagttttc ttcctgggga ttctagggtg
     2161 ctgcccacat ttggggaaac ccgtgtcaag tacaccactc gcagggctgg tgattatttg
     2221 agtctattta ttctcttctg tgcgtccatt tgggatgagg ggaccgcagt tgtcttccct
     2281 tacctggctc cctcctgttg catgcacagt cagcgagacc cacgtgtgtg gctcagactt
     2341 ccctgaggcc caaggctctg agggggacag ttatttattt cttaaccttg tggtggccga
     2401 gtgtgggtgc ctcataggtg tgtactgact ccgagttgaa ggactttttc ctcgtagtaa
     2461 gagccggcag aaatgaagtc ttgatccaat gaagggcact gactgagcga gttatctgca
     2521 ggcgcctggc ggaggctggg tgcagtgagc ctgtgactgt tgaattcact gagtttctcc
     2581 tctcacacgg cacccaccgc ttgctagcag tgctccccct cgctccccct ctgacactgc
     2641 gctccctgca gtggaaggca gccataggca cagaaggctc agttgcatat gtaacttagg
     2701 ggtgcatggg ctcagcattg taagtaaaga tatttcacat actacctctc tcttctctct
     2761 ttctctctct ttttttaaca gagttttaac atagaacctt tctcttgggg gaagaaatac
     2821 ttcagggctt gacttttgta caaattttaa ctgaaaaaca gatttctctt ctgtctgaaa
     2881 acggagatca gagctgctga cgctgatttt aatttcaagg acaatagtgt ttgttagtga
     2941 tgaggtcgta ccaatgaagt caatgtcagt agaccttctg tgaggccagt gagtcttggc
     3001 tgtggaggtc ccgtcccgtc ccgtcccgtc ccgtcggctc agttcttgag acacctcgga
     3061 acaggagcgt aagcgtcggc agcttagcgt gcagttctgt tgtcccgaac gtcgagcctc
     3121 actgtgaatt ctgttctgtc ctaagtccgc catgtcaacc agatgctgtg ctgttgtgaa
     3181 ccatgaattt tctaattaaa ttttacatgc tataacatac atgctataac atgattttta
     3241 catgaatgat actttgttta aactattaaa tgtcagtatt ttactacaat tttattataa
     3301 aatgtacatt atcactaaat gaactttgat tttaagaatc aagttagctt tagttacata
     3361 ttatttttta caaataaaaa cggacttgta taaaggctaa aaaaaaaaa
//
