LOCUS       NM_019695               1284 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus par-6 family cell polarity regulator alpha (Pard6a),
            transcript variant 1, mRNA.
ACCESSION   NM_019695
VERSION     NM_019695.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   He,Y., Wang,H., Hong,T., Hu,L., Gao,C., Gao,L., Cui,Y., Tan,R.,
            Pu,D. and Wu,J.
  TITLE     HFM1 is essential for the germ cell intercellular bridge transport
            in primordial follicle formation in mice
  JOURNAL   Cell Mol Life Sci 82 (1), 28 (2024)
   PUBMED   39725823
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Wang,J., Xiao,B., Kimura,E., Mongan,M., Hsu,W.W., Medvedovic,M.,
            Puga,A. and Xia,Y.
  TITLE     Crosstalk of MAP3K1 and EGFR signaling mediates gene-environment
            interactions that block developmental tissue closure
  JOURNAL   J Biol Chem 300 (7), 107486 (2024)
   PUBMED   38897570
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Feng,S., Wen,H., Liu,K., Xiong,M., Li,J., Gui,Y., Lv,C., Zhang,J.,
            Ma,X., Wang,X. and Yuan,S.
  TITLE     hnRNPH1 establishes Sertoli-germ cell crosstalk through cooperation
            with PTBP1 and AR, and is essential for male fertility in mice
  JOURNAL   Development 150 (3) (2023)
   PUBMED   36718792
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Royer,C., Sandham,E., Slee,E., Schneider,F., Lagerholm,C.B.,
            Godwin,J., Veits,N., Hathrell,H., Zhou,F., Leonavicius,K.,
            Garratt,J., Narendra,T., Vincent,A., Jones,C., Child,T., Coward,K.,
            Graham,C., Fritzsche,M., Lu,X. and Srinivas,S.
  TITLE     ASPP2 maintains the integrity of mechanically stressed
            pseudostratified epithelia during morphogenesis
  JOURNAL   Nat Commun 13 (1), 941 (2022)
   PUBMED   35177595
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Johansson,A., Driessens,M. and Aspenstrom,P.
  TITLE     The mammalian homologue of the Caenorhabditis elegans polarity
            protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and
            Rac1
  JOURNAL   J Cell Sci 113 (Pt 18), 3267-3275 (2000)
   PUBMED   10954424
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Lin,D., Edwards,A.S., Fawcett,J.P., Mbamalu,G., Scott,J.D. and
            Pawson,T.
  TITLE     A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC
            signalling and cell polarity
  JOURNAL   Nat Cell Biol 2 (8), 540-547 (2000)
   PUBMED   10934475
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat Cell Biol 2 (8), 531-539 (2000)
   PUBMED   10934474
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Hung,T.J. and Kemphues,K.J.
  TITLE     PAR-6 is a conserved PDZ domain-containing protein that colocalizes
            with PAR-3 in Caenorhabditis elegans embryos
  JOURNAL   Development 126 (1), 127-135 (1999)
   PUBMED   9834192
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152826.2, AK158848.1, CX206739.1 and BF466814.1.
            
            On Nov 2, 2013 this sequence version replaced NM_019695.2.
            
            Transcript Variant: This variant (1) encodes the longest protein
            (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF070970.1, SRR11927938.4446961.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC152826.2         132446-132447       c
            3-380               AK158848.1         1-378
            381-647             CX206739.1         344-610
            648-1266            AK158848.1         643-1261
            1267-1284           BF466814.1         1-18                c
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..1284
                     /gene="Pard6a"
                     /gene_synonym="0710008C04Rik; 2610010A15Rik; Par-6;
                     PAR-6A; Par6; PAR6alpha; Par6c; TAX40; Tip-40"
                     /note="par-6 family cell polarity regulator alpha"
                     /db_xref="GeneID:56513"
                     /db_xref="MGI:MGI:1927223"
     exon            1..157
                     /gene="Pard6a"
                     /gene_synonym="0710008C04Rik; 2610010A15Rik; Par-6;
                     PAR-6A; Par6; PAR6alpha; Par6c; TAX40; Tip-40"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1135
                     /gene="Pard6a"
                     /gene_synonym="0710008C04Rik; 2610010A15Rik; Par-6;
                     PAR-6A; Par6; PAR6alpha; Par6c; TAX40; Tip-40"
                     /note="isoform 1 is encoded by transcript variant 1; Tax
                     interaction protein 40; partitioning defective 6 homolog
                     alpha; PAR-6 alpha; par-6 (partitioning defective 6,)
                     homolog alpha"
                     /codon_start=1
                     /product="partitioning defective 6 homolog alpha isoform
                     1"
                     /protein_id="NP_062669.2"
                     /db_xref="CCDS:CCDS22609.1"
                     /db_xref="GeneID:56513"
                     /db_xref="MGI:MGI:1927223"
                     /translation="MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRTSVRGFQEFSR
                     LLCVVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEGDSSG
                     LAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRL
                     HKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEV
                     NGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPSSVGPGPTDP
                     DSDDDSSDLVIENRHPPCSNGLSQGPLCWDLQPGCLLPGAGSSLPSLDSREQANSGWG
                     NGMRGDVSGFSL"
     exon            158..380
                     /gene="Pard6a"
                     /gene_synonym="0710008C04Rik; 2610010A15Rik; Par-6;
                     PAR-6A; Par6; PAR6alpha; Par6c; TAX40; Tip-40"
                     /inference="alignment:Splign:2.1.0"
     exon            381..1267
                     /gene="Pard6a"
                     /gene_synonym="0710008C04Rik; 2610010A15Rik; Par-6;
                     PAR-6A; Par6; PAR6alpha; Par6c; TAX40; Tip-40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1245..1250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pard6a"
                     /gene_synonym="0710008C04Rik; 2610010A15Rik; Par-6;
                     PAR-6A; Par6; PAR6alpha; Par6c; TAX40; Tip-40"
                     /note="hexamer: ATTAAA"
     polyA_site      1267
                     /gene="Pard6a"
                     /gene_synonym="0710008C04Rik; 2610010A15Rik; Par-6;
                     PAR-6A; Par6; PAR6alpha; Par6c; TAX40; Tip-40"
                     /note="major polyA site"
ORIGIN      
        1 aggggcgggg cggctcgggc cagcgggccg ggctgtgcac ctgcgcctcg gcgggctgct
       61 gtggggcact gtcccccgcc cgccaggccc tgcaatggcc aggccgcaga ggactccggc
      121 gcgcagtccc gatagcatcg tcgaggtgaa gagcaaattt gacgccgagt tccgacgctt
      181 tgcactaccc cgcacttcgg tgagaggctt tcaggagttc tcgcgattgc tgtgtgtggt
      241 acaccagatc cctggcctgg acgtcctgct tggctatacg gatgctcacg gtgacttgct
      301 gcccctcacc aacgatgaca gtttgcaccg ggccctggcc agcgggcccc cacctctgcg
      361 cctcttggtt cagaaacggg cagaaggtga ctcgagtggc ctggcttttg cctccaactc
      421 tctacaaagg cgcaagaaag ggctcctgct acgaccagtg gcacctctgc gcaccaggcc
      481 acccttgtta atcagcttgc cccaagattt ccgccaggtg tcttcagtta tagatgtgga
      541 cctactacct gagacccacc gacgagtgag gctgcacaaa catggttcag accgtcccct
      601 gggcttctac attcgagatg gcatgagtgt tcgcgtggct ccccagggcc tggagcgggt
      661 tccaggtatc ttcatctccc gcctggtacg tgggggcctg gctgagagta cagggctgct
      721 ggcggtcagt gatgagatcc ttgaggtcaa cggcattgag gtggccggga agaccttgga
      781 ccaagtgacg gacatgatgg tcgccaacag ccacaacctc atcgtcactg tcaagcctgc
      841 caaccagcgt aataatgtgg tacggggggc atctgggcgt ctgacagggc cttcctctgt
      901 agggcctggg cctactgatc ctgacagtga cgatgacagc agtgacctgg tcattgagaa
      961 tcgccaccct ccctgttcta atgggctgtc tcaggggccc ctgtgctggg acctgcaacc
     1021 tggctgccta cttcctggtg ctggcagctc tctgccctcc ttggatagca gagagcaagc
     1081 caattctggc tgggggaatg gcatgcgagg tgatgttagc ggattcagcc tctgacaggc
     1141 aaagatgcag cccttgtcac tttaggctgc gggaacatgg cctggacttt ccagctgggt
     1201 agagaagatt agcttgctca cagagccctc tcagtctggt gaacattaaa ggttttctac
     1261 aaatgtaaaa aaaaaaaaaa aaaa
//
