LOCUS       NM_001081050            8382 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus par-3 family cell polarity regulator beta (Pard3b),
            mRNA.
ACCESSION   NM_001081050 XM_110852
VERSION     NM_001081050.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8382)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8382)
  AUTHORS   Koehler,S., Odenthal,J., Ludwig,V., Unnersjo Jess,D., Hohne,M.,
            Jungst,C., Grawe,F., Helmstadter,M., Janku,J.L., Bergmann,C.,
            Hoyer,P.F., Hagmann,H.H., Walz,G., Bloch,W., Niessen,C.,
            Schermer,B., Wodarz,A., Denholm,B., Benzing,T., Iden,S. and
            Brinkkoetter,P.T.
  TITLE     Scaffold polarity proteins Par3A and Par3B share redundant
            functions while Par3B acts independent of atypical protein kinase
            C/Par6 in podocytes to maintain the kidney filtration barrier
  JOURNAL   Kidney Int 101 (4), 733-751 (2022)
   PUBMED   34929254
REFERENCE   3  (bases 1 to 8382)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8382)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 8382)
  AUTHORS   Huo,Y. and Macara,I.G.
  TITLE     The Par3-like polarity protein Par3L is essential for mammary stem
            cell maintenance
  JOURNAL   Nat Cell Biol 16 (6), 529-537 (2014)
   PUBMED   24859006
  REMARK    GeneRIF: Par3L is expressed by multipotent stem cells in the
            terminal end buds of murine mammary glands. Ablation of Par3L
            resulted in rapid and profound stem cell loss.
            Erratum:[Nat Cell Biol. 2014 Jul;16(7):716]
REFERENCE   6  (bases 1 to 8382)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 8382)
  AUTHORS   Kanda,A., Noda,K., Yuki,K., Ozawa,Y., Furukawa,T., Ichihara,A. and
            Ishida,S.
  TITLE     Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity
            determinant required for laminar formation during retinal
            development in mice
  JOURNAL   J Neurosci 33 (49), 19341-19351 (2013)
   PUBMED   24305829
  REMARK    GeneRIF: Atp6ap2/(P)RR interacted with partitioning defective 3
            homolog (PAR3) protein, which is known to function in the
            Par-atypical protein kinase C
REFERENCE   8  (bases 1 to 8382)
  AUTHORS   Brunskill,E.W., Georgas,K., Rumballe,B., Little,M.H. and
            Potter,S.S.
  TITLE     Defining the molecular character of the developing and adult kidney
            podocyte
  JOURNAL   PLoS One 6 (9), e24640 (2011)
   PUBMED   21931791
REFERENCE   9  (bases 1 to 8382)
  AUTHORS   Behnke,J.M., Iraqi,F.A., Mugambi,J.M., Clifford,S., Nagda,S.,
            Wakelin,D., Kemp,S.J., Baker,R.L. and Gibson,J.P.
  TITLE     High resolution mapping of chromosomal regions controlling
            resistance to gastrointestinal nematode infections in an advanced
            intercross line of mice
  JOURNAL   Mamm Genome 17 (6), 584-597 (2006)
   PUBMED   16783640
REFERENCE   10 (bases 1 to 8382)
  AUTHORS   Wicker,L.S., Chamberlain,G., Hunter,K., Rainbow,D., Howlett,S.,
            Tiffen,P., Clark,J., Gonzalez-Munoz,A., Cumiskey,A.M., Rosa,R.L.,
            Howson,J.M., Smink,L.J., Kingsnorth,A., Lyons,P.A., Gregory,S.,
            Rogers,J., Todd,J.A. and Peterson,L.B.
  TITLE     Fine mapping, gene content, comparative sequencing, and expression
            analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and
            Idd5.2 in the nonobese diabetic mouse
  JOURNAL   J Immunol 173 (1), 164-173 (2004)
   PUBMED   15210771
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645544.16, AL662815.13, AC101661.7, AL662920.14 and AL645727.16.
            
            On Oct 17, 2022 this sequence version replaced NM_001081050.2.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2487674.1,
                                           SRR7652917.1281121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-529               AL645544.16        4114-4642
            530-631             AL645544.16        133228-133329
            632-803             AL662815.13        24690-24861
            804-913             AL662815.13        90768-90877
            914-1002            AC101661.7         6026-6114
            1003-1089           AC101661.7         15112-15198
            1090-1215           AC101661.7         20614-20739
            1216-1574           AC101661.7         22289-22647
            1575-1714           AC101661.7         25259-25398
            1715-1843           AC101661.7         27533-27661
            1844-2029           AC101661.7         59756-59941
            2030-2200           AC101661.7         72713-72883
            2201-2333           AC101661.7         77602-77734
            2334-2433           AC101661.7         91358-91457
            2434-2549           AC101661.7         100016-100131
            2550-2594           AC101661.7         137062-137106
            2595-2801           AC101661.7         205113-205319
            2802-3039           AC101661.7         206049-206286
            3040-3150           AL662920.14        74257-74367
            3151-3447           AL662920.14        113745-114041
            3448-3583           AL645727.16        22309-22444
            3584-3663           AL645727.16        77401-77480
            3664-8382           AL645727.16        127230-131948
FEATURES             Location/Qualifiers
     source          1..8382
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 30.92 cM"
     gene            1..8382
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /note="par-3 family cell polarity regulator beta"
                     /db_xref="GeneID:72823"
                     /db_xref="MGI:MGI:1919301"
     exon            1..529
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             410..4021
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /note="PAR3-L protein; partitioning defective 3-like
                     protein; amyotrophic lateral sclerosis 2 chromosomal
                     region candidate gene 19 protein homolog; par-3
                     partitioning defective 3 homolog B"
                     /codon_start=1
                     /product="partitioning defective 3 homolog B"
                     /protein_id="NP_001074519.2"
                     /db_xref="CCDS:CCDS48276.1"
                     /db_xref="GeneID:72823"
                     /db_xref="MGI:MGI:1919301"
                     /translation="MKVTVCFGRTGIVVPCKDGQLRVRELTQQALQRYLKTRDQDPGY
                     WVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFDEQEPLQKTESPGGNPADRQSPD
                     AFETEVAAQLAAFKPVGGEIVVTPSALKLGTPLLVRRSSDPAPGPHADAQPSTASLSG
                     QSLKPVVLDSTQNVENKEAMNGEQAGLLSLHRPKDELSDMTRAVEISGEGDPLGIHVV
                     PFFSSLSGRILGLFIRGIEENSRCKQEGLFQENECIVKINNVELLDKTFAQAQDVFRQ
                     AMKSPSVILHVLLPQNREQYEKSVIGPLNIFGNNDGASRTKAAPPARGKPGLKAVHLT
                     RASSPEGEEPASPQQSKSPRVPRLGRKPSSPSLSPLMGFGSKKNAKKIKIDLKKGPEG
                     LGFTVVTRDSSIHGPGPIFVKNILPKGAAVKDGRLQSGDRILEVNGRDVTGRTQEELV
                     AMLRSTKQGETVSLVIARQEGSFLPRELKGEPDCYALSLESSEQLTLEIPLNDSGSAG
                     LGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGETLLGKSNHEA
                     METLRRSMSMEGNIRGMIQLVILRRPERPLEELSECGALSRPGFENCQEALSTSRRND
                     SSILYPFGTYSPQDKRKDLLLPSDGWAENEVPPSPPPHPALEWGLEDFSHSSGVDSTG
                     YFPDQHVNFRTVTPVRQPELINLKASKSMDLVPDEGKVQSLADRRSDSPGKDFGPTLG
                     LKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEADAD
                     GLSDKSSRSGHTALNCESAPQGNPELDNVENKAKNIKKTKEKEKKKGKGKLKVKEKKL
                     KEEHEDAERKMKRKGFGAMLRFGKKKDDKVGKAEQKGAQKSGHPEEEELERMKEERER
                     IGAKHQELREKQARGLVDYATAVTGPVHDMDDDEMDPNYARVNHFREPCASANVFRSP
                     SPLRAGPLAYPRDGRPLSPDHLEGLYAKVNKPYHPPALADSGRPMAGTTDRIQKLRKE
                     YYQARREGFLLYEDENTRARPSDHDLRWVSGKGPDGSTHNLRFEGMERQYASLPRGGS
                     ADPVDYLTASPRGRYNDRELPYYPGPHPVHAPRGSYPRPPDLRATDLRYPQYYPPPPA
                     HQHKGPFRQDVPPSPPQHQRVPVYQEMGRAGPRGSSPDQYPYRNQDPRQKNPMTAAV"
     exon            530..631
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            632..803
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            804..913
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1002
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1089
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1215
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1574
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1714
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1843
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..2029
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2030..2200
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2333
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2433
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2549
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2594
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2801
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2802..3039
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            3040..3150
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3447
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            3448..3583
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            3584..3663
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            3664..8382
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8359..8364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /note="hexamer: AATAAA"
     polyA_site      8382
                     /gene="Pard3b"
                     /gene_synonym="1810008K04Rik; 2010002N16Rik;
                     2810455B10Rik; Als2cr19; PAR3B; PAR3beta; PAR3L"
                     /note="major polyA site"
ORIGIN      
        1 agagcgccgc gcgcgtcgga ggagttggga gccggcgcaa aagtttcctc ccaactctgg
       61 ccccgcgcgc cgccgccgcc gcccactcca gcccggggcc tggggccggc cctgccacgg
      121 tcgctagggc caccgccaga ggcagggccg ggccgggccg cacccgcagt ttcactttgg
      181 cgcgtggagc ctccgcttgc gcccggccga ccctccgcgt ccccgcgtct ccgagcccgc
      241 gttcccgccc tcggcctccc gtggggctgc aggggagcag ctgtgggtcc cggtcccgga
      301 ggcacgcgtg ggacagcgtc gtgtccgccc cacgtccccc gacggagggg ctgtgcctgg
      361 gggccaggca cctgttcggc ccagccccgc gcgggagccc agggccagga tgaaagtgac
      421 agtgtgcttc gggaggacgg gcatcgtggt gccctgcaag gacggccagc tccgggtccg
      481 cgagctcacc cagcaggcgc tgcagcggta cctgaagacc cgggaccagg atcctggata
      541 ctgggtgaag attcatcact tagaatacac agatggagga atcctggatc cggatgatgt
      601 cttagcagat gttgttgaag acaaagataa gctgattgct gtgtttgacg aacaagagcc
      661 actccaaaag actgagagcc ccggtggaaa ccctgcggat cggcagagcc cagatgcttt
      721 cgagacagaa gtggctgccc aactggctgc atttaaacct gtcggtgggg aaatcgtagt
      781 aaccccttct gctctgaagt taggcactcc actgctggtt aggagaagca gtgacccagc
      841 accagggccc catgctgatg cccagccaag cactgcaagc ctgagtggcc agagtttgaa
      901 acctgttgtt ctggattcca cccagaacgt ggaaaacaaa gaagctatga atggtgaaca
      961 ggcagggctg ctttcactgc acagaccgaa ggatgagctg agtgatatga cgagagctgt
     1021 ggagatttct ggggaaggag accccctggg gatccacgtg gtgcccttct tttcatccct
     1081 gagtggccgg atcctaggac tcttcatccg aggcattgaa gaaaacagca ggtgcaagca
     1141 ggagggacta tttcaggaga atgagtgcat tgtaaaaatc aacaatgtgg aactcctgga
     1201 caaaactttt gctcaggccc aagatgtctt ccgccaggca atgaaatctc ccagtgtgat
     1261 tctccatgtg cttctgcctc aaaaccgtga acaatatgaa aaatcagtca ttggaccact
     1321 caacattttt ggcaacaatg atggggcttc gagaacaaag gcagcacctc ctgcccgtgg
     1381 gaaaccaggt ctgaaggcag tacatctaac aagagcgagc agccctgaag gagaagagcc
     1441 agcctccccg cagcaaagca agagtccccg ggttccaaga ctaggaagaa aaccttcctc
     1501 tccctcactc tctcctctca tggggtttgg cagcaagaaa aatgcaaaaa aaattaagat
     1561 tgacctaaag aaaggccctg agggacttgg tttcactgtg gtaaccagag attcttctat
     1621 acatggtcct ggtcccattt ttgtaaaaaa catcttacca aaaggagcag cagtaaagga
     1681 tggccgccta caatcagggg acagaatttt ggaggtaaat ggcagagatg ttacaggaag
     1741 aacccaagaa gaactcgtgg ccatgttaag gagcaccaag cagggagaga cagtgtcatt
     1801 ggtcattgcc cgccaggaag ggagcttcct gccccgagag ctgaaaggag aacctgattg
     1861 ttatgctctc tccctggagt caagcgagca gctcaccttg gagatccccc tgaatgattc
     1921 tggctccgct ggcctggggg ttagcctgaa agggaataag tctcgagaaa ctggaactga
     1981 cttggggatt tttatcaaat ccatcatcca tggaggtgct gctttcaagg atggccgtct
     2041 ccgaatgaat gaccaactga ttgctgttaa cggggaaact cttctgggaa agtccaacca
     2101 cgaagccatg gaaacactca ggcgatccat gtccatggag ggaaacatcc ggggcatgat
     2161 ccagttggtg attctgagga gacctgagag accactggag gagctttcag aatgtggagc
     2221 actttccaga ccaggctttg agaactgtca agaagctctg agcacctcca ggcgaaatga
     2281 tagtagtata ttatatccgt ttggcaccta tagtccacaa gataaaagga aagacctatt
     2341 gcttcccagt gatgggtggg ctgagaatga agtaccaccg tccccgccac cacatcctgc
     2401 tctggaatgg ggccttgaag atttcagtca cagctctgga gtggattcca caggatattt
     2461 tccagatcaa catgtcaact tcagaacggt gacaccagtc aggcagcccg aattgattaa
     2521 ccttaaagcc tccaagagca tggaccttgt gccagatgaa ggcaaagttc agtcgctggc
     2581 ggatcgcaga tcagactctc caggcaaaga ttttggtcca actttgggtc tgaaaaagtc
     2641 cagttccttg gagagcctac agacggctgt ggctgaagtc aggaagaatg atctgccctt
     2701 ccacaggccc agaccacaca tggtgcgggg ccgaggctgc aacgagagct tccgagcagc
     2761 catcgacaaa tcgtacgatg ggccagaaga ggcagacgcg gatggtctgt ctgataagag
     2821 ctctcgctca ggccacacag ctctgaattg tgagtctgcc cctcagggaa accccgagct
     2881 agacaatgtg gaaaataaag ccaaaaacat caaaaaaaca aaagagaagg agaagaaaaa
     2941 aggaaagggc aagctgaaag tcaaggaaaa aaagctgaag gaggaacatg aggacgcaga
     3001 gaggaaaatg aagaggaagg gcttcggtgc catgctgaga tttggaaaga agaaagatga
     3061 taaggtcgga aaggctgagc agaaaggtgc gcagaagtcc ggccacccgg aggaagagga
     3121 gctggaaaga atgaaagaag agagagagag gattggagca aaacatcagg agctgagaga
     3181 aaagcaggca agaggccttg ttgattatgc cacggcagtg actggaccag tgcacgatat
     3241 ggacgatgac gaaatggacc ccaattatgc cagagtgaac cactttcggg aaccatgtgc
     3301 atcagcaaat gtctttagat ctccatctcc ccttcgagct ggaccacttg cttaccctcg
     3361 ggatgggcgt ccactgtctc cagaccactt agagggtctc tatgccaagg tcaacaagcc
     3421 atatcatcca ccagccctag ctgacagtgg ccgacccatg gctggaacca cggaccgcat
     3481 ccagaagctt cggaaggagt attaccaggc tcggagagaa gggttccttt tgtatgaaga
     3541 tgaaaacaca agagcacggc catctgacca tgacctccgc tgggtgtctg gaaagggtcc
     3601 agatgggagc acacacaacc tccgctttga ggggatggag cggcagtacg catccttacc
     3661 caggggaggc tcagcagatc ccgtggacta cctgacagct tcaccccgag ggcgctacaa
     3721 tgacagagag cttccatact acccagggcc tcatcctgta catgccccaa gggggagcta
     3781 tccccgcccc ccagatctga gggcaacaga tctacgatac ccacagtact acccaccccc
     3841 accagcccat cagcacaaag ggcccttcag acaagatgtt cctccttcac cacctcagca
     3901 ccagcgagta ccggtctacc aggagatggg cagagcaggg ccccgaggga gcagccctga
     3961 ccaatacccc tatcgtaacc aggatcccag gcagaagaat cccatgactg cagcggtata
     4021 gctgaacatc acagagatct gccaagcaaa gaggacatcc aacaataatc tttgccgttg
     4081 ctagaaccta aggccttctc tgggctaagg tgttccgtgg tacagagtgg ctcttgcttc
     4141 ctgaggatgc gtggcctaac tgctaatcag aagagaaaag agggacgggg gtttgaggat
     4201 gtagattcaa aatggaagaa ggatgcagtc atgaaaacag tacttcctga tacttgaaag
     4261 gcttgcagga ttggttgatt cggtgagaat gacaactgat taacaatcaa tggagctata
     4321 ctatagtagc ccctggctgg aaagccagcg ctacatacaa cccccacccc accacacaca
     4381 cacacacaca cacacacaca cacacacaca cacacacaca tatagtacaa gcaatagcac
     4441 agaggtaaaa gtctctcttt gtcaggccca gtcacccatt tagagactca gccctatact
     4501 ttgaggtgtg agacctatag agtggcagag cagagaggct gcagatattc actgagaaca
     4561 aagcaaccgc gtacatgact agtgacctct tggaaacgtt cgacccaaag gaagactgta
     4621 tttccttatt tgtagtctag cctgggttcc tggtactact tgttaccagc cttttgcact
     4681 tccttgcttt tgatataaaa agacagtaat ttgaatttga atgcagtatt agtgtcctgg
     4741 gaggatgtga gctgctcaga gcttccagaa gggcgttcat tccaagaacc acagtgaaca
     4801 gatgaagaag gttgattgtc ccatggtcct tgctttcccc ctcctggtcc ctggcatgct
     4861 tgcttggaga tagctccttt cagagtcctc ctcaaatgcc tataattatt ttagacttcc
     4921 actaaagggc taaaggatac ctatgagtgg ggtgggtaaa caaaacagag cctgctggtc
     4981 aggacacacc gagagcaatg tcctagggat gtcagttcca gaccaagtgc caaacagtac
     5041 ccatctgccc ctggaacagc aagtagatga aagtgtgtgt gtgtgtgtgt gtgtgtgtgt
     5101 gtgtgtgtgt gtgtgtgtgc acgcatgagt gcactcgtgc gcacgcacaa gcatgtgatt
     5161 accagcatgg agaagagaag ataaaatcgc cttctggatg tttaatgcgg gaggagtcag
     5221 gcagggaagt aaagggagat gatggtaaga ttaaatcagt ctgcatctgc tctatctcat
     5281 taccaaatgt cagggcacag ctaaggtctc cacctgattt aaaggaaaag cattctgacg
     5341 taagaagctg aaaagccacc cttgcttcct ttgaactttc ttatacagca cagcatctga
     5401 agcttcctgt gtgaccaaga caagaacacg tgcacaagac tgagaaacag caagaaacgg
     5461 cccggcattc tggctttctc agcgactgat acatacttta aacctttcac gttccttctt
     5521 cacccctcca aaaaagtctt tagttcaata tagacatatt ttggctgaga gtagaatacc
     5581 attgaccaat aggttttact gaattgtagt gttctagaag ccatagagta gccatttggc
     5641 ccaattcttt tttccttttt taatttgaaa tacttttgtg gccagcaatg atgcaattgc
     5701 tggttttcga cgtaaatagc gtcatttgct ggacttagga gagatcatta tctaaaccac
     5761 aattactgtg gccctctgaa ttatagactg tcaagttgct ttctgtcctc ttccatctct
     5821 cttcagccag caaccttaca tcatacgtaa tttgttccat ggagtggagg gtcccaggct
     5881 ctgatcaaca aggtcttgtg gctgccctga aggttccctg gccaccatgc tggaaatggc
     5941 ctttcctttg agacaaatgt tacaatgagg gaaaaatgca gtgcaggagg ccagagcatt
     6001 aaatcaactc ataaaccagg aaggtactat gagcctagaa gccacatagt accacatagt
     6061 atcaggaagc caaagcagga aggcttcaag gtgcgggcta gcctggacta tcgggtgagt
     6121 ttgagatcat ataatgagac cctgcattta aaaaagaaaa ttactcttca gtgtgttcta
     6181 tattttactc aaatttctgt gaagcactga ttttatccaa ggcacaagtt tccccttgca
     6241 aggaggctgg gccacttgca ggctggcaag gggtaggtga cagtgctgtg ctgcagaggg
     6301 gttggccctt gaggatggct gcttggctca cgtttccagc tccagcatgt tcgccctagg
     6361 tgcacagcac ccctacacaa aggctacaga aaagcttctc cagaccttgg ctttgtgttg
     6421 tacacagtca acacaatcgt tgctaatcct gagaagcaca caaaagtcca aaggtattat
     6481 taaagagaac aaaaaaaaat agacaacagc tttctgttct tgcttaaagt atagcactca
     6541 ctgcatctga ttctgcccta aagaactaac attatatctg tgacagaggc tacagcaagc
     6601 caagcaatgg ttaagaaaag ctggggcagt aagctttatc aatgcctgtg taacatccct
     6661 ccaactgtct cccctccaag gctacgagac cattttccag ggctccggga gagcatatgg
     6721 ttatctggaa gtccaggcta tgatcagcag gtccccagga gaagggaata gctaccagta
     6781 tatttacagc cttgggaaaa ctcactaggg tatctctctg tagctgggag ctctataaca
     6841 gagaaagggt ttttaacagg agctacaaac gtgctgccgg gccatccagc ctcgtgggcc
     6901 ctctcctcgc cacctcctcc accccctttt tgtatagcta gaaaggtatg agagaggaaa
     6961 ctcactgaaa accctttact ctaaagaatt cagccttcct cacgagagag aacgctgcct
     7021 cactggtcca ccacgcacct ggactgaggc atgatcccag tgggcttaac actgtttccc
     7081 cacagggcca agtcagcaga caaacaaagg aacctttcct tcaatcatta tttcatagca
     7141 aacaaagctg agaggaaaaa aataaacccg aaactcatta ttcttcaact ttcagaacat
     7201 ctatgtggaa cccacagggc cacatggagc aaaaggctga tgaattcaat agcattgtag
     7261 agaagcggag ccttggaggc tttgtggagc ctcatttctg ctaccaacag aataaaatta
     7321 aaataagacc cactgccttg attttttttt tccttttaaa gctaaaccta ccttgtgaag
     7381 gaaatcctcc tgcaacttca ggaagatcag agagctgatt tctctgttcc ctggtccaca
     7441 gagagaccaa acctaaaaag agtgattact tttcccctca ctggaaatca cctgcatttg
     7501 ttttcgtttg ttttctgttt agtgtttgag caatgttata gaatttcagg cccgtggaag
     7561 gaattggaaa gtggttgata caggaatgtg tgtctgagaa ttcccatcag cactgaacac
     7621 tgagatccac tgtgagcagc tttcaaactg gcgttaaatt gggtagacgt cccagtgctt
     7681 cctgggtcca tgtgaacaga aagtccaagt ttaatgcaat taggcaggag ggtgttccat
     7741 tcagaaaagt ccataatagt gttcctctgc tgcctcagtt catgccaact tagggtggaa
     7801 acaaggctac agtgagacag aaaattcttc ataagatatc cctacagagt cacctttccg
     7861 atagaaagga ggaaaaatag agatctaaaa taagccagga ctctcacatg caactgtggc
     7921 ttccaggtgc aactctttct tcctcctttc cttaaatagc catgcagtcg cccacagcct
     7981 ggcttttaaa agttggggtt ggctactaag ctcagattga gaagtgaacc attcccacag
     8041 actctttgag cccatctctt gatctgctct tcagaaagtg ttccgttcca tctgcaaagc
     8101 tatttactac tggaacataa aacaaaacct gttgtttata ccctcgcttt ctctcgtctt
     8161 tcctgttctt ttatgattac caagtcatct gttcatatgt tctaaagata aattatgtga
     8221 aatcatactt tggcatatgg ggacggagag tgaattcttt acaaactttt taaagataat
     8281 cccgtttata tcaccgaaga cattttggat gttattgtat atgagtatat aaatttttca
     8341 tgttttattt tgcattaaaa taaagcttta ttcagtcagt ga
//
