LOCUS       NM_001309391            5833 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus par-3 family cell polarity regulator (Pard3),
            transcript variant 5, mRNA.
ACCESSION   NM_001309391 XM_006531522
VERSION     NM_001309391.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5833)
  AUTHORS   Cho,S.H., Kim,J.H. and Kim,S.
  TITLE     Perturbed cell cycle phase-dependent positioning and nuclear
            migration of retinal progenitors along the apico-basal axis
            underlie global retinal disorganization in the LCA8-like mouse
            model
  JOURNAL   Dev Biol 517, 39-54 (2025)
   PUBMED   39284539
REFERENCE   2  (bases 1 to 5833)
  AUTHORS   Voglewede,M.M., Ozsen,E.N., Ivak,N., Bernabucci,M., Tang,R.,
            Sun,M., Pang,Z.P. and Zhang,H.
  TITLE     Loss of the polarity protein Par3 promotes dendritic spine neoteny
            and enhances learning and memory
  JOURNAL   iScience 27 (7), 110308 (2024)
   PUBMED   39045101
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5833)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5833)
  AUTHORS   Kim,K.M., Yoo,G.D., Heo,W., Oh,H.T., Park,J., Shin,S., Do,Y.,
            Jeong,M.G., Hwang,E.S. and Hong,J.H.
  TITLE     TAZ stimulates exercise-induced muscle satellite cell activation
            via Pard3-p38 MAPK-TAZ signalling axis
  JOURNAL   J Cachexia Sarcopenia Muscle 14 (6), 2733-2746 (2023)
   PUBMED   37923703
  REMARK    GeneRIF: TAZ stimulates exercise-induced muscle satellite cell
            activation via Pard3-p38 MAPK-TAZ signalling axis.
REFERENCE   5  (bases 1 to 5833)
  AUTHORS   Grego-Bessa,J., Gomez-Apinaniz,P., Prados,B., Gomez,M.J.,
            MacGrogan,D. and de la Pompa,J.L.
  TITLE     Nrg1 Regulates Cardiomyocyte Migration and Cell Cycle in
            Ventricular Development
  JOURNAL   Circ Res 133 (11), 927-943 (2023)
   PUBMED   37846569
REFERENCE   6  (bases 1 to 5833)
  AUTHORS   Johansson,A., Driessens,M. and Aspenstrom,P.
  TITLE     The mammalian homologue of the Caenorhabditis elegans polarity
            protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and
            Rac1
  JOURNAL   J Cell Sci 113 (Pt 18), 3267-3275 (2000)
   PUBMED   10954424
REFERENCE   7  (bases 1 to 5833)
  AUTHORS   Lin,D., Edwards,A.S., Fawcett,J.P., Mbamalu,G., Scott,J.D. and
            Pawson,T.
  TITLE     A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC
            signalling and cell polarity
  JOURNAL   Nat Cell Biol 2 (8), 540-547 (2000)
   PUBMED   10934475
REFERENCE   8  (bases 1 to 5833)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat Cell Biol 2 (8), 531-539 (2000)
   PUBMED   10934474
REFERENCE   9  (bases 1 to 5833)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 5833)
  AUTHORS   Lin,D., Gish,G.D., Songyang,Z. and Pawson,T.
  TITLE     The carboxyl terminus of B class ephrins constitutes a PDZ domain
            binding motif
  JOURNAL   J Biol Chem 274 (6), 3726-3733 (1999)
   PUBMED   9920925
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC090616.1.
            
            On May 28, 2015 this sequence version replaced XM_006531522.1.
            
            Transcript Variant: This variant (5) encodes isoform 5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090616.1, SRR10223970.10898.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5833              BC090616.1         1-5833
FEATURES             Location/Qualifiers
     source          1..5833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 74.66 cM"
     gene            1..5833
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /note="par-3 family cell polarity regulator"
                     /db_xref="GeneID:93742"
                     /db_xref="MGI:MGI:2135608"
     exon            1..418
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..4303
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /note="isoform 5 is encoded by transcript variant 5;
                     partitioning defective 3 homolog; par-3 (partitioning
                     defective 3) homolog; ephrin-interacting protein; atypical
                     PKC isotype-specific-interacting protein"
                     /codon_start=1
                     /product="partitioning defective 3 homolog isoform 5"
                     /protein_id="NP_001296320.1"
                     /db_xref="CCDS:CCDS80945.1"
                     /db_xref="GeneID:93742"
                     /db_xref="MGI:MGI:2135608"
                     /translation="MKVTVCFGRTRVVVPCGDGRMKVFSLIQQAVTRYRKAVAKDPNY
                     WIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPE
                     IFGSELGTNNVSAFQPYQATSEIEVTPSVLRANMPLHVRRSSDPALTGLSTSVSDNNF
                     SSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDPSSWSNQFQRDNA
                     RSSLSASHPMVDRWLEKQEQDEEGTEEDSSRVEPVGHADTGLENMPNFSLDDMVKLVQ
                     VPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRN
                     RRFEQAQHMFRQAMRARVIWFHVVPAANKEQYEQLSQREKNNYSPGRFSPDSHCVANR
                     SVANNAPQALPRAPRLSQPPEQLDAHPRLPHSAHASTKPPAAPALAPPSVLSTNVGSV
                     YNTKKVGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAG
                     DRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEEAFHPREMNAEPSQMQTP
                     KETKAEDEDVVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSI
                     INGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRSMSTEGNKRGMIQLIVAR
                     RISRCNELRSPGSPAAPELPIETELDDRERRISHSLYSGIEGLDESPTRNAALSRIMG
                     KCQLSPTVNMPHDDTVMIEDDRLPVLPPHLSDQSSSSSHDDVGFIMTEAGTWAKATIS
                     DSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIAD
                     ETKLNTVDDQRAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIR
                     GRGCNESFRAAIDKSYDKPMVDDDDEGMETLEEDTEESSRSGRESVSTSSDQPSYSLE
                     RQMNGDPEKRDKTERKKDKAGKDKKKDREKEKDKLKAKKGMLKGLGDMFRFGKHRKDD
                     KMEKMGRIKIQDSFTSEEDRVRMKEEQERIQAKTREFRERQARERDYAEIQDFHRTFG
                     CDDELLYGGMSSYEGCLALNARPQSPREGHLMDTLYAQVKKPRSSKPGDSNRSTPSNH
                     DRIQRLRQEFQQAKQDEDVEDRRRTYSFEQSWSSSRPASQSGRHSVSVEVQVQRQRQE
                     ERESFQQAQRQYSSLPRQSRKNASSISQDSWEQNYAPGEGFQSAKENPRYSSYQGSRN
                     GYLGGHGFNARVMLETQELLRQEQRRKEQQLKKQPPADGVRGPFRQDVPPSPSQVARL
                     NRLQTPEKGRPFYS"
     exon            419..520
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            521..701
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            702..880
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1012
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1104
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1188
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1314
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1697
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..1837
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1966
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2005
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2194
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2365
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2516
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            2517..2706
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            2707..2858
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            2859..2903
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3131
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3363
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3474
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3711
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            3712..3832
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            3833..3960
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     exon            3961..5815
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5790..5795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /note="hexamer: AATAAA"
     polyA_site      5814
                     /gene="Pard3"
                     /gene_synonym="Asip; D8Ertd580e; Par-3; Par3; Pard-3;
                     Pard3a; Phip"
                     /note="major polyA site"
ORIGIN      
        1 ctcgccgtcc cctcctcgga gtcccgactg agcgcgagcg ccacacggcc ccgggccgcc
       61 gccgagcgcg ccaagacgcc gagacgccga acaggtggcc ggaggctgca ggcgcccggg
      121 cggggacagg caaggccagg cgaaggcggc cgggctggac atggtagccg ggcagctctg
      181 tgcggccgcc tgctcgcgcc tctagccgcc ggcgcgccgg cgcagcggcc ccaccgcgcc
      241 ctgcgtacag tctcccggcc cagcgccgct ccggccacgg acagcgaggg acggcggcat
      301 gaaagtgacc gtgtgcttcg ggaggacccg ggtggtcgtg ccgtgcggag atggccgcat
      361 gaaagttttc agcctcatcc agcaggcggt gacccgctac cggaaggccg tggccaagga
      421 tccaaactac tggatacagg tgcatcgctt ggagcatgga gatggaggga ttctagacct
      481 ggatgacatc ctctgtgacg ttgctgatga caaagacaga ctggtagcag tatttgatga
      541 acaggatccc caccatggag gagatggtac cagcgccagc tccacgggaa cccagagtcc
      601 agagatattc ggcagtgagc tgggcaccaa caatgtttct gcttttcagc cttatcaagc
      661 cacaagtgaa attgaggtca cgccttcagt tcttcgggca aatatgcctc ttcatgtccg
      721 ccggagcagc gacccagctt taactggcct ttccacttct gtcagtgata acaacttttc
      781 ctcagaggag ccctccagga aaaaccccac ccgctggtcc acgacagctg gctttctcaa
      841 gcagaacacc gctggaagtc ccaaaacctg cgacaggaag aaagatgaaa actacagaag
      901 ccttccacgg gatcccagta gctggtccaa ccagttccag cgagacaacg cccgctcctc
      961 cctgagcgcc agccacccaa tggtagaccg gtggctggag aagcaagaac aggatgagga
     1021 aggcacagaa gaagacagca gccgagtgga gccggttgga catgctgata ccggattgga
     1081 gaacatgccc aacttttccc tcgatgatat ggtaaagctc gtacaagtcc ccaacgatgg
     1141 agggcccctg ggaatccatg tagtgccttt cagtgctcga ggcggcagaa cattggggtt
     1201 gttagtgaag cggttggaga aaggcggtaa ggctgagcaa gaaaaccttt tccatgagaa
     1261 tgactgcatt gtgaggatta acgatggaga tcttcgaaac agaagatttg agcaagcaca
     1321 acatatgttc cgccaagcta tgcgtgcgcg tgtcatttgg ttccatgtgg tccctgcagc
     1381 aaacaaggag caatatgaac aactgtccca acgcgagaag aacaactact ccccaggccg
     1441 cttcagccct gacagccact gtgtggccaa caggagtgtg gccaacaatg cccctcaagc
     1501 attgcccaga gcacccagac tgagtcagcc acccgagcag ctggatgctc acccccgact
     1561 acctcatagt gctcacgcct caaccaaacc acccgcagcc ccggccttgg ctccacccag
     1621 tgtgcttagt accaacgtag gcagtgtgta caacacgaag aaagtaggca agaggctcaa
     1681 catccagctt aagaaaggta cagaaggact gggattcagc atcacctccc gggacgtcac
     1741 cataggtggc tcagctccca tttatgtcaa gaatatcctt cctcgagggg ctgccattca
     1801 ggatggcaga ctcaaggcag gagaccggct aatagaggtc aatggagtag atttagcagg
     1861 caaatcccag gaggaagttg tttccctgtt gagaagcacc aagatggagg ggactgtgag
     1921 ccttctggtc tttcgtcagg aagaggcttt ccacccaagg gaaatgaatg ctgaaccaag
     1981 ccagatgcag actccaaaag aaacgaaagc tgaagatgag gacgttgttc tcacacccga
     2041 tggtaccagg gagtttctga cttttgaagt tccactgaat gactcaggat ctgcagggct
     2101 tggtgtcagt gtcaagggga accgttccaa agagaaccac gcagatttgg ggatcttcgt
     2161 taaatccatt atcaatggtg gagctgcatc taaagatgga aggctgaggg taaatgacca
     2221 gctgatagct gtgaatggag aatctctact gggcaaagcc aaccaggaag ccatggagac
     2281 tctacggagg tccatgtcca ccgagggcaa caagcgtggc atgatccagc tcattgtggc
     2341 gaggcggatc agcagatgta acgagctgcg gtctcctggg agccctgctg cacctgagct
     2401 gcccatcgag acagaactgg atgaccgaga acgcaggatc tcacactccc tctacagtgg
     2461 gatcgagggg ctggatgagt cgcccaccag gaacgcagca ctgagcagga taatgggtaa
     2521 atgccagctg tcccccacgg tgaacatgcc tcacgatgac actgtcatga ttgaagatga
     2581 caggctgcct gtgctccctc ctcacctctc tgaccagtcc tcctccagct cccatgatga
     2641 cgttggattc ataatgacag aagcaggcac gtgggccaaa gctaccatca gtgactcagc
     2701 cgactgctca ttgagtccag atgttgatcc ggttctcgct tttcaacggg aaggatttgg
     2761 acgccagagt atgtcagaaa aacgcacaaa gcaattttca gatgccagtc aattggattt
     2821 cgttaaaaca cgaaaatcaa aaagcatgga tttaggtata gctgacgaga ctaaactcaa
     2881 tacagtggat gaccagagag caggctctcc cagtagagat gtgggaccct ccttaggtct
     2941 gaagaaatct agctccttag aaagtctgca gaccgctgtc gccgaggtga cgctgaacgg
     3001 gaacattcct ttccaccgcc ctcggccacg aatcatccgg ggaaggggct gcaacgaaag
     3061 cttcagagcc gccattgaca agtcctacga caagcccatg gttgatgatg acgacgaagg
     3121 catggagacc ttggaagaag acacagagga aagctcgagg tcagggaggg agtccgtgtc
     3181 cacgtccagc gatcagcctt cctattctct ggagaggcaa atgaatggag acccagagaa
     3241 aagggacaag acagagagga aaaaggacaa agccggaaag gataagaaga aagaccgaga
     3301 gaaggagaag gataaactga aagccaagaa ggggatgctg aaaggcttgg gggacatgtt
     3361 caggtttggc aaacatcgaa aagatgacaa gatggaaaaa atgggtcgaa taaaaatcca
     3421 ggattctttc acctcagaag aggacagggt gcggatgaag gaagaacagg agaggattca
     3481 agccaaaact cgagagttta gggagcggca agcccgagag cgtgactatg cagagatcca
     3541 agatttccat cggacgtttg gctgtgatga cgagttgctg tatgggggca tgtcatccta
     3601 tgaaggctgc ttggctctca atgccagacc ccagagccca agagaagggc acctgatgga
     3661 cactttgtat gcccaagtaa agaaacctcg gagctccaaa cctggagaca gcaatcgatc
     3721 cactcctagc aaccatgacc ggatacagcg tctacggcaa gagttccagc aagccaaaca
     3781 ggatgaggat gtggaagacc ggcgccgtac ctacagcttt gagcaatctt ggtccagctc
     3841 gcggccggca tcgcagagtg gtcggcactc ggtgtccgtg gaggttcaag tacaacggca
     3901 gcgccaggag gagcgagaga gcttccagca ggcccagcgc cagtacagct cactgccaag
     3961 acaaagcagg aagaatgcca gctccatatc acaggattcc tgggaacaga actacgcccc
     4021 tggtgaaggc ttccagagtg ccaaggagaa ccccaggtat tccagttacc agggctcaag
     4081 gaacggctat ctaggcgggc acggctttaa tgccagggtc atgctggaga cccaggagct
     4141 tctccgacag gaacagaggc ggaaagagca gcagctgaag aagcagcctc cagctgatgg
     4201 agtcagaggg cccttccggc aagatgtgcc cccttctcca tctcaggtgg ctaggctgaa
     4261 cagactgcag acaccggaga aagggcggcc cttctactcc tgagctcaaa gaaggatggc
     4321 agcattttgt gtcatgcaat aaaggacatt tacccatgaa gacttgtgct gttggagttt
     4381 tttaaaaaaa aaaaaaacct tcggtggtac tccagaacac ttctgttgct ggtatcagtg
     4441 cctttaagca gcatgagcaa agaaatggaa ggccttaatg tctttgccac tgcgtctatc
     4501 tcgtggaagg acccccacca ccccctgacc ccaatatcaa gttcaaggca tcaactacct
     4561 gcttctctgc agtaccggaa acttcagctc catgcctaag atgcctacgg acttcacagc
     4621 ttcatcttag agagtgaacc cccccacccg aggctgcaga tgttgctgac gcccgctccc
     4681 cccggaagtg actgcggtgt gcaccagaac tttgcagcag ggttacccct gttctcccac
     4741 tcgatctggg gttcccttta tttcctcaga tcctcggagc atgaaggctc tagagtggta
     4801 gtgaagaaac taagccatac gccagtgccg tttggttgtg agggggtggg gggtactttc
     4861 caactgcctt ataactccac tacccatatc acaatgattc tagtctgcgt ttataaatac
     4921 acgtgttcag tcccgttcat gatacctggg aacaaggaac atgggagtgg cccatttgca
     4981 ttgcaccccg aggaaggata taggaactga gggaagattc tctggaggag tttaggccag
     5041 tctaccctgt ccttgtttta cttcatttgt gtcgcagtag gttggcaagg aaggcacaga
     5101 gtggggcaag gaaaaaagtc agtcactttg gattctgaga atcaatctca atacatcttt
     5161 tgaggttgga gtcagtattt gtctcctatt ccctctactg tgtcccttcc tgacaaggcc
     5221 gcattactaa gttattctgc cgtttatcat aaagacaaat caaagaagag ccatcccact
     5281 tgagaacatt ttgatgcccc tctgagcaac aggagtcaca ttttcgtgca tgcctgtgtc
     5341 acgaggccct cctcatgttc ccgctgttca tctgtaggtc tgaacatcct gtattgtaag
     5401 ccaaggctgg gttgctaaag tgcctgcgaa tcttgatatg aaataaaaga aaaaaaaaaa
     5461 aaacaaacct tgagcaaaaa gctcagagta ccatgtatta acaaaaaaga aagaaaaaaa
     5521 aaaagacatg tattgatatg cctatttttt ttttttactg gcacactgta ttttttgtgt
     5581 agacttgttt ttagaaaata atgcgcagtg tccacaggcg ccgtgtctct ctgcatctgt
     5641 gtgtaatggc tttatctgtt aatgactttc agtggtgttt aagtggtgtt tccagtgtaa
     5701 gtaagcgtgg tgaccttgga cagcggtggc ttcctcgcag cctcccctaa gctgtgaggg
     5761 acagctgtcc ctgtacatat aagacttcta ataaaagaca tatttcttcc tgttcaaaaa
     5821 aaaaaaaaaa aaa
//
