LOCUS       NM_028829               5404 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus progestin and adipoQ receptor family member VIII
            (Paqr8), transcript variant 1, mRNA.
ACCESSION   NM_028829
VERSION     NM_028829.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5404)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5404)
  AUTHORS   Chen,S., Paul,M.R., Sterner,C.J., Belka,G.K., Wang,D., Xu,P.,
            Sreekumar,A., Pan,T.C., Pant,D.K., Makhlin,I., DeMichele,A.,
            Mesaros,C. and Chodosh,L.A.
  TITLE     PAQR8 promotes breast cancer recurrence and confers resistance to
            multiple therapies
  JOURNAL   Breast Cancer Res 25 (1), 1 (2023)
   PUBMED   36597146
  REMARK    GeneRIF: PAQR8 promotes breast cancer recurrence and confers
            resistance to multiple therapies.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5404)
  AUTHORS   Zhao,L., Thomson,E., Ng,E.T., Longmuss,E., Svingen,T.,
            Bagheri-Fam,S., Quinn,A., Harley,V.R., Harrison,L.C., Pelosi,E. and
            Koopman,P.
  TITLE     Functional Analysis of Mmd2 and Related PAQR Genes During Sex
            Determination in Mice
  JOURNAL   Sex Dev 16 (4), 270-282 (2022)
   PUBMED   35306493
  REMARK    GeneRIF: Functional Analysis of Mmd2 and Related PAQR Genes During
            Sex Determination in Mice.
REFERENCE   4  (bases 1 to 5404)
  AUTHORS   Dong,Y., Li,H., Zhao,L., Koopman,P., Zhang,F. and Huang,J.X.
  TITLE     Genome-Wide Off-Target Analysis in CRISPR-Cas9 Modified Mice and
            Their Offspring
  JOURNAL   G3 (Bethesda) 9 (11), 3645-3651 (2019)
   PUBMED   31492696
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5404)
  AUTHORS   Heng,X., Guo,Q., Leung,A.W. and Li,J.Y.
  TITLE     Analogous mechanism regulating formation of neocortical basal
            radial glia and cerebellar Bergmann glia
  JOURNAL   Elife 6, e23253 (2017)
   PUBMED   28489004
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5404)
  AUTHORS   Frye,C.A., Walf,A.A., Kohtz,A.S. and Zhu,Y.
  TITLE     Progesterone-facilitated lordosis of estradiol-primed mice is
            attenuated by knocking down expression of membrane progestin
            receptors in the midbrain
  JOURNAL   Steroids 81, 17-25 (2014)
   PUBMED   24269738
  REMARK    GeneRIF: Paqr7 and Paqr8 are expressed in the midbrain ventral
            tegmental area of proestrous mice.
REFERENCE   7  (bases 1 to 5404)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
REFERENCE   8  (bases 1 to 5404)
  AUTHORS   Zhu,Y., Bond,J. and Thomas,P.
  TITLE     Identification, classification, and partial characterization of
            genes in humans and other vertebrates homologous to a fish membrane
            progestin receptor
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2237-2242 (2003)
   PUBMED   12601167
REFERENCE   9  (bases 1 to 5404)
  AUTHORS   Suzuki,T., Ganesh,S., Agarwala,K.L., Morita,R., Sugimoto,Y.,
            Inazawa,J., Delgado-Escueta,A.V. and Yamakawa,K.
  TITLE     A novel gene in the chromosomal region for juvenile myoclonic
            epilepsy on 6p12 encodes a brain-specific lysosomal membrane
            protein
  JOURNAL   Biochem Biophys Res Commun 288 (3), 626-636 (2001)
   PUBMED   11676489
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY151331.1, BC059813.1, AK147376.1 and AI847259.1.
            
            [WARNING] On Aug 5, 2024 this sequence was replaced by NM_028829.5.
            
            On Sep 20, 2017 this sequence version replaced NM_028829.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY151331.1, AK147376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                BY151331.1         1-74
            75-4494             BC059813.1         1-4420
            4495-5289           AK147376.1         4426-5220
            5290-5404           AI847259.1         1-115               c
FEATURES             Location/Qualifiers
     source          1..5404
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 6.5 cM"
     gene            1..5404
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
                     /note="progestin and adipoQ receptor family member VIII"
                     /db_xref="GeneID:74229"
                     /db_xref="MGI:MGI:1921479"
     exon            1..139
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            140..319
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            320..5388
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..1426
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
                     /note="mPR beta; membrane progesterone receptor beta;
                     lysosomal membrane protein in brain 1; membrane
                     progesterone P4 receptor beta; progestin and adipoQ
                     receptor family member 8; progesterone and adipoQ receptor
                     family member 8"
                     /codon_start=1
                     /product="membrane progestin receptor beta"
                     /protein_id="NP_083105.3"
                     /db_xref="CCDS:CCDS14844.1"
                     /db_xref="GeneID:74229"
                     /db_xref="MGI:MGI:1921479"
                     /translation="MTTAILERLSTLSMSGQQLRRLPKILEEGLPKMPCTVPETDVPQ
                     LFREPYIHAGYRPTGHEWRYYFFSLFQKHNEVVNVWTHLLAALAVLLRFWAFVEAGAL
                     QWASPHTLPLLLFILSSITYLTCSLLAHLLQSKSELSHYTFYFVDYVGVSVYQYGSAL
                     AHFFYSSDQAWYELFWIFFLPAAAFCGWLSCAGCCYAKYRYRRPYPVMRKICQVVPAG
                     LAFVLDISPVAHRVALCHLAGCQEQAAWYHTLQILFFLVSAYFFSCPVPEKYFPGSCD
                     IVGHGHQIFHAFLSVCTLSQLEAILLDYQGRHEIFLQRHGPLSVYSACLSFFVLAACS
                     AATATLLRHKVKDRLIKKDS"
     regulatory      3139..3144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
                     /note="hexamer: AATATA"
     polyA_site      3157
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
                     /note="major polyA site"
     regulatory      4774..4779
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      4800
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
     regulatory      5363..5368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      5388
                     /gene="Paqr8"
                     /gene_synonym="1700019B16Rik; 3110001D06Rik"
                     /note="major polyA site"
ORIGIN      
        1 gggttgtccc ctcctcccgg ccgctctcgg gtgcagagcc ctcggcggtc ggggaggctc
       61 agaaagagct ctcccggagc tggagtcggg agtgcggctg gcggagctgg gctgcaggag
      121 ctcggccgcg ctggtgttcg agttcctcag gtcctgattg aagcacttga agtagcttat
      181 ctgccagctc tacctccctg cttgtttgca gaaaccccat ggttcatctc acacctcagc
      241 tggagcgtgg attgcacatc tgtcataatc ccactacacg tctctctatg gaacactaca
      301 gacgctaatc tctacaaagg ttgtctaact gagccccgag gagcccaggg ccaccgctgt
      361 catgacgact gccatcctag agcgcctgag caccctgtca atgagtgggc agcagctgcg
      421 ccgtctgccc aagattctgg aagaaggact tcccaagatg ccatgcaccg tcccagaaac
      481 cgacgtgccc cagctcttta gggagccgta catccacgcg ggctaccgcc ccacggggca
      541 cgagtggcgt tactacttct tcagcctctt tcagaagcac aacgaggtgg tcaacgtctg
      601 gacccacttg ctggctgctc tagcggtcct tttgcgattc tgggcctttg tggaggcagg
      661 ggcattgcag tgggcctctc cccacaccct ccccctgctc ctctttatct tgtcgtccat
      721 cacttacctc acctgcagcc tcttggccca cctgctccag tccaaatcag agctgtccca
      781 ctacacgttc tactttgtgg actacgtcgg ggtcagcgtc taccagtatg gcagcgccct
      841 ggctcacttc ttctatagct ccgaccaggc ctggtatgag ctgttttgga ttttcttcct
      901 gccggcggct gctttctgtg gctggctctc ctgcgctggc tgttgttatg ccaagtatcg
      961 ctaccgacgg ccttatccag ttatgaggaa gatctgtcaa gtagtaccag cagggctggc
     1021 cttcgtccta gacatcagcc cggtggcaca ccgcgtggct ctctgccacc tggccggttg
     1081 ccaggagcag gcggcctggt accacaccct tcagatcctc ttcttcctcg tcagcgcata
     1141 cttcttctcg tgccctgtcc ccgagaagta cttccccggt tcctgtgaca ttgtgggcca
     1201 cggacatcaa atcttccacg ccttcctgtc cgtctgcacg ctctcccagc tggaggccat
     1261 tcttctggac taccagggac gccatgagat cttcctccag cgccacggtc ccctgtctgt
     1321 gtacagcgcc tgtctctcct ttttcgtttt agctgcctgc agtgcggcca ccgccaccct
     1381 cctgaggcac aaggtcaagg acagactgat taagaaagat tcctgaggtc cttcaaatga
     1441 ggaaaggtgt ggaggtgggc tactgtgact tggagaaaac ttgacccaat aatagaagtt
     1501 gactttttat ttttcaggct tgattttttt tctaaattaa tatgtattac gggctgagga
     1561 tgaaactcac attggtagag agtgcttata cagcatgcag aaagcccagg gtttgatttc
     1621 ccagggccac agaagccagg gggaggcaca ggcaggaaga tcagaaattc taggtcaccc
     1681 tctgacatat agtgagttca aggctagcct ttgatacatg atagatacca tatctcaaac
     1741 aaaattatta tgtattttca aaggcatggt atgactatgg aatttcaaat gcaggccatt
     1801 tgagagtttt aaaacagtgc gttcattttt ctgtctgggt gatagccttg tttgggaaga
     1861 gatcttggct aagattcatg agaccccaaa ctaaggagag ccatcttcac ccatgagcaa
     1921 tgagcagaat tctggttgta gcttccaaag agtagtcctg aaactagaca gatatttaaa
     1981 ctggactgcc aagtataacc ttgccctaac agaacagcca ccctccgcgc tgctgggctt
     2041 ggtgtctgtg taaactgacc aacgaactct gtcttatcag gatttcagat tgctttgggt
     2101 ggaaaaaaac agaatcttca agaagtttcc ttgaaactct tagacaaaat ggactattca
     2161 atttatcatt cctggtctcg accactggtt cttctctcag gataaccaac taagctggcc
     2221 aatttgcctg aagtactact gttctcatcc ctagtctgca tggtaacaaa gaatcccgaa
     2281 gctattaccc ttccaggaaa tgcttggagc catatgaaca ttcaggaagc tgattcccgc
     2341 gtaatacaga ggtatcgaca gatttaacag tgccaagagc tgccaagaga cccagccagc
     2401 aagcacggct acccttgcct gcctgctgcc catgggaccc ttgtagttta tatctgagga
     2461 cagcagtatt aactgccagc cacttagggt tgtcttgcag gtcaggagat tggttgtctg
     2521 aaggtttgaa gagactcctt tacaagcatg gttctaaagt tctccgagaa agcagactat
     2581 gtcaagcgga tcctaagatc caaggttcaa gctgctgtta gatgctgccc cgtgaaggac
     2641 caacgcagct accccagttc agagtcctca tgaggcagtt ccacctccga cttgagaaga
     2701 aaccttaaaa tgggtcctag gaggggtgaa tgtgtgctca ccgtcgttgg cccctgaagg
     2761 tcccttgagt aagaacgagg cacctgatgg ccgaaggcac tgtccgtgat atggctgcca
     2821 gcccctgatg tgaggggagt ggtgcttgca gctgagatgt tctggccaca cagctctccc
     2881 cgaggactgt cttctgcatg aacccagtgg aggaggctgt gtttgaggaa gggctgaggt
     2941 gccctctact cgcaggctgc acttcctatc attataaggt ccctgtgtac taaaaaagga
     3001 agctaaagtt tccaactcca gttaatgaac ctcctcttgc tagtcttaaa acctttgttt
     3061 tctatatata tattttttgt gcgagtgact tgtgaatttt gtgccttata catgggaatg
     3121 tctaaactct tttattttaa tatatgcaca catggaattt ttctgttttg tgttcttggg
     3181 acaagaaaaa aaaaggaacc cccaaaagct agagtgacct gtcaatcaac tattaatctg
     3241 tatgtgagag gggtcagcag cagtatccct gctgctttta aatcaagaga gcatgtgtct
     3301 cctgcactgt tttattagat ggggttcttg ttcattcatg gtcaagaaga tgaacgccta
     3361 tgctagccaa atgacccaag gttctgattg tctaggtcaa gttcatgcca aggaatgtta
     3421 gcaaaactga acgggtttgg actgagcaaa gacttcttag ggtgtgtatg tgtaaacgct
     3481 ccaagtagag ggtctgttta aaatgggaac cagaaagtgt tagaagttct gctgttgtgg
     3541 attcaaagac tgtattcttt taaaagttgg tgggaaacgt gagagaggaa agggatgagg
     3601 aaggcggtct tctggtggta tctgtgaaca aagatttttt tttttccttt ttcctgagat
     3661 cagatctcac tgtataaccc aggctgtcct ggaaatcctt atgtagacca tgcaaacctt
     3721 gacctctaga actctataga aatcaagctg tctctgcctc ccacatggca gggctaaagg
     3781 tgtggcattc tgagtcttgt ggacagggat ctgtggtatt caatggtcct gcagcctagg
     3841 gtcgagctga actctgttcc tcacaagtct gtgacacccg tgacacccgt gacacccgtg
     3901 acgcccgtga gaaacgtgag atactggcgt tcagttccta gtttaattat acaactattg
     3961 ctaactatgg acttgggaac tgatgaaaaa gaaaaagaaa gtgatttcta tggagttggg
     4021 acttgaacct aagacctgca acatgttaac aaagagttct cccattgatg tgcaccccag
     4081 gccaagcaac cgtgtattta taatagatat ttggggaggg cactgaggtg gggggaaaac
     4141 accagtatct aattggaata atgcaaatgc ctttacaaat gcatacacaa atgggtgatt
     4201 tttaactctt cagagtcctc aaacagtgtc attaaaatgg gcctatcagg atggtaaaga
     4261 ctaggctagt ttaaaagtaa caaccaaaaa ttgtaaagag gagtatgcat gcctcttgat
     4321 tttacaatgg agtttgtcac cctgcaaaat cagcataatg tttaaaaagg tataagggag
     4381 atagtttatc ttgctctcca aaactagaaa ttttggttgt tgcctctctt agttaagact
     4441 ttcaacccat taatatgtaa acgcctctga taagattaaa ccatcagtca tctatacttt
     4501 ctcatgaata agattcttgt gggttgatat aaggccccac ttagttcaag aagaggatac
     4561 actggacatg gggggcttgt ttctcatttc agaatcctga cttttgtttg acggtgaagg
     4621 ctgtttttgt tgtttcttgt tcaaggtgtt tgttttgttc gagatggacc tcactgtgta
     4681 tcccaggctg gcctggaact ccagatggat tctcctgtcg cagtcggcca aggagctggg
     4741 attccaggct gcaccaacac catatccaat tctaataaaa ctaattttaa agttcttaaa
     4801 gatgtcaggg ttacaatttc agctcttaag tctctcaata acaatagtgt aagccataga
     4861 ctggaagctt gaaatagaat tcagagccct gacaggaggg tagtttagcc ctgtttcggt
     4921 cgccctccat ttgtttggtt actattctgt agttccacct gcatcctcca gagggtgatg
     4981 ttgtcactct cagtacactc agagcttgtt gccaaggctt catggctaga tctgtgtttt
     5041 gcttggttaa agaaaaagtg tgggattttt tttctgtctc tataaaccta cttacgtgaa
     5101 taatcattaa tcagattttg cacatggatt tttgtcctgt tggtaatgga cccagagctc
     5161 attctaaagc tgggttttat ttagcctgcc aactgccaac tgaaagaggt tgaacactac
     5221 acctatctaa aactaggaag atataaaaac tttgaaaaat aagtctactg cagaataaac
     5281 tacccttcga agaaatgtgg agttgatttc tctgcagatt tcagtataat tgcgtagata
     5341 ttcctagcta catcacaatc ttattaaaga tcttggattt tgaattgaaa aaaaaaaaaa
     5401 aaaa
//
