LOCUS       NM_001285849            3679 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus progestin and adipoQ receptor family member VII
            (Paqr7), transcript variant 5, mRNA.
ACCESSION   NM_001285849
VERSION     NM_001285849.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3679)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3679)
  AUTHORS   Li,J., Liu,Y., He,J., Wu,Z., Wang,F., Huang,J., Zheng,L. and Luo,T.
  TITLE     Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic
            effect of P4 on human granulosa cells and its deficiency reduces
            ovarian function in female mice
  JOURNAL   J Ovarian Res 17 (1), 35 (2024)
   PUBMED   38317224
  REMARK    GeneRIF: Progestin and adipoQ receptor 7 (PAQR7) mediate the
            anti-apoptotic effect of P4 on human granulosa cells and its
            deficiency reduces ovarian function in female mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3679)
  AUTHORS   Frye,C.A., Walf,A.A., Kohtz,A.S. and Zhu,Y.
  TITLE     Progesterone-facilitated lordosis of estradiol-primed mice is
            attenuated by knocking down expression of membrane progestin
            receptors in the midbrain
  JOURNAL   Steroids 81, 17-25 (2014)
   PUBMED   24269738
  REMARK    GeneRIF: Paqr7 and Paqr8 are expressed in the midbrain ventral
            tegmental area of proestrous mice.
REFERENCE   4  (bases 1 to 3679)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3679)
  AUTHORS   Flock,G.B., Cao,X., Maziarz,M. and Drucker,D.J.
  TITLE     Activation of enteroendocrine membrane progesterone receptors
            promotes incretin secretion and improves glucose tolerance in mice
  JOURNAL   Diabetes 62 (1), 283-290 (2013)
   PUBMED   22933106
REFERENCE   6  (bases 1 to 3679)
  AUTHORS   Lemale,J., Bloch-Faure,M., Grimont,A., El Abida,B.,
            Imbert-Teboul,M. and Crambert,G.
  TITLE     Membrane progestin receptors alpha and gamma in renal epithelium
  JOURNAL   Biochim Biophys Acta 1783 (12), 2234-2240 (2008)
   PUBMED   18722485
REFERENCE   7  (bases 1 to 3679)
  AUTHORS   Gonez,L.J., Naselli,G., Banakh,I., Niwa,H. and Harrison,L.C.
  TITLE     Pancreatic expression and mitochondrial localization of the
            progestin-adipoQ receptor PAQR10
  JOURNAL   Mol Med 14 (11-12), 697-704 (2008)
   PUBMED   18769639
REFERENCE   8  (bases 1 to 3679)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
REFERENCE   9  (bases 1 to 3679)
  AUTHORS   Yu,S., Viswakarma,N., Batra,S.K., Sambasiva Rao,M. and Reddy,J.K.
  TITLE     Identification of promethin and PGLP as two novel up-regulated
            genes in PPARgamma1-induced adipogenic mouse liver
  JOURNAL   Biochimie 86 (11), 743-761 (2004)
   PUBMED   15589683
REFERENCE   10 (bases 1 to 3679)
  AUTHORS   Zhu,Y., Bond,J. and Thomas,P.
  TITLE     Identification, classification, and partial characterization of
            genes in humans and other vertebrates homologous to a fish membrane
            progestin receptor
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2237-2242 (2003)
   PUBMED   12601167
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669982.10.
            
            On Jan 5, 2023 this sequence version replaced NM_001285849.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. All variants (1 through 5) encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY286520.1, BY288540.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               AL669982.10        156345-156551
            208-244             AL669982.10        165985-166021
            245-3679            AL669982.10        166107-169541
FEATURES             Location/Qualifiers
     source          1..3679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.8 cM"
     gene            1..3679
                     /gene="Paqr7"
                     /gene_synonym="2310021M12Rik; mPR; mPR alpha; Mpra; PGLP"
                     /note="progestin and adipoQ receptor family member VII"
                     /db_xref="GeneID:71904"
                     /db_xref="MGI:MGI:1919154"
     exon            1..207
                     /gene="Paqr7"
                     /gene_synonym="2310021M12Rik; mPR; mPR alpha; Mpra; PGLP"
                     /inference="alignment:Splign:2.1.0"
     exon            208..244
                     /gene="Paqr7"
                     /gene_synonym="2310021M12Rik; mPR; mPR alpha; Mpra; PGLP"
                     /inference="alignment:Splign:2.1.0"
     exon            245..3679
                     /gene="Paqr7"
                     /gene_synonym="2310021M12Rik; mPR; mPR alpha; Mpra; PGLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1313
                     /gene="Paqr7"
                     /gene_synonym="2310021M12Rik; mPR; mPR alpha; Mpra; PGLP"
                     /note="PPAR-gamma-induced liver protein; membrane
                     progesterone receptor alpha; membrane progesterone P4
                     receptor alpha; progestin and adipoQ receptor family
                     member 7; progesterone and adipoQ receptor family member
                     7"
                     /codon_start=1
                     /product="membrane progestin receptor alpha"
                     /protein_id="NP_001272778.1"
                     /db_xref="CCDS:CCDS18773.1"
                     /db_xref="GeneID:71904"
                     /db_xref="MGI:MGI:1919154"
                     /translation="MAMAVAQKFNHLLSSLWHVGQKPPQPEPVFTVDRAQVPPLFWKP
                     YIYAGYRPLHQNWCFYFRTLFQRHNEAVNVWTHLLAALALLLRLIGLAASVDFREDPH
                     ALPLFFIVLASFTYLSFSAVAHLLQAKSEFWHYSFFFLDYVGVAVYQFGSALAHFYYA
                     IEPSWHDKVQAIFLPTAAFLAWLSCAGSCYNKYSQKPGLLGRIFQEAPSALAYVLDIS
                     PVLHRIIVSPLPAEEDPALLYHKCQVVFFLLAAAFFSTVMPESWFPGSCHIFGQGHQV
                     FHVFLVLCTLAQLEAVTLDYQARRGIYEPLHARWPHNFSGLFLLTVASSSLTALLLSQ
                     LVRRKLHQKTK"
     regulatory      2231..2236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr7"
                     /gene_synonym="2310021M12Rik; mPR; mPR alpha; Mpra; PGLP"
                     /note="hexamer: AATAAA"
     polyA_site      2253
                     /gene="Paqr7"
                     /gene_synonym="2310021M12Rik; mPR; mPR alpha; Mpra; PGLP"
                     /note="major polyA site"
     regulatory      3652..3657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr7"
                     /gene_synonym="2310021M12Rik; mPR; mPR alpha; Mpra; PGLP"
                     /note="hexamer: ATTAAA"
     polyA_site      3679
                     /gene="Paqr7"
                     /gene_synonym="2310021M12Rik; mPR; mPR alpha; Mpra; PGLP"
                     /note="major polyA site"
ORIGIN      
        1 gactgctcct ggagatcccg gggccgggcc gggctgggct gggctgggag tagagaagtg
       61 ctcccccggc acgcgggttg ggggtgtgct cctagctgca tgcgtgcggt gcccagtggc
      121 ggaagtgggc aggtggcaga agatggggcg aggccgaaga cagcaggacc ctgacagccg
      181 gacagttatg taggggagca cctcccgcgt gactccttga tcttcaaact cagcccatca
      241 gaagttttcc tgacttctct tccgggccct ccggcatggc gatggcagta gcccagaagt
      301 tcaaccacct tctgtccagc ctgtggcacg tgggccagaa gcctccgcaa ccagaacctg
      361 tgtttacagt ggaccgggcc caggtgccgc cacttttctg gaagccgtac atctatgctg
      421 gctaccggcc gctgcatcag aactggtgtt tctacttccg cacactgttt cagcggcaca
      481 acgaggctgt gaacgtgtgg acccacctcc tggcggccct ggctctgctg ctgcggctga
      541 tcggcttggc ggcaagtgtg gacttccggg aagaccctca cgcgctgccc ctcttcttca
      601 tcgtcttggc ctccttcacc tacctctcgt tcagtgctgt ggctcacctc ctgcaggcca
      661 agtcggagtt ctggcattac agcttcttct tcttggacta tgtgggtgtg gccgtgtacc
      721 agtttggcag tgccctggca cacttctact atgccataga gccgtcctgg catgacaagg
      781 tgcaggctat tttcctgccc acggccgcct tcctggcctg gctttcctgc gctggctcct
      841 gctacaacaa gtacagccag aagccgggtc tgctggggcg cattttccag gaggcgccat
      901 cggcgctggc ctatgtgctg gacatcagtc ccgtgttgca ccgcatcata gtgtctcccc
      961 tccctgccga ggaggatccc gctcttctct atcacaaatg ccaagtggtt ttcttccttc
     1021 tagctgctgc ctttttctcc acggttatgc ctgagagttg gttccccggc agctgtcaca
     1081 tctttgggca gggacaccaa gttttccatg tctttttggt gctgtgcact ctggcccagc
     1141 tagaggcggt gacactggat tatcaggccc ggaggggcat atacgagcct ctgcacgccc
     1201 gttggcccca caacttctct ggcctcttcc tgctcaccgt ggccagcagc agcctcactg
     1261 cgctcctcct cagccagctg gtgcggcgca aactccatca gaagaccaag tgaaagcggg
     1321 tgggtgggag ctggcagggt gagagaaggt gctagggaca aaagcctgga cttggctcca
     1381 gatcggaaca aggcctggta aagctggttc tatctggcag gccatgactc cctgcataca
     1441 agctcaatgg ccaaagtgat gctgctagcc aatccttggg cctgcagatt ggctgggagc
     1501 tgtagagcct tgctcagttc cctgggaggg gcagagatga aggactcctg actgcccctc
     1561 ccttgccgcc tatcagggct aagggttgga gttcagcttt ggtcaccaca ctggtttggg
     1621 gttttcaggt tgctgggcga gaagactcag gccagtgtca aatttgagca gagagggagt
     1681 ggaagtctta gcagccacca cctaccagag ctcactggtg gagggaaaag aaacaggccc
     1741 aacgatgggt agtgttttaa cttcactgtc ccctgcacca cagcctggat cgctgggttc
     1801 cagagagtct ccaaagataa gagatcccct ctcctgccca catccctgca tcacagccca
     1861 gccagaaagc ctcacagcta gcattggcct gtatctcttg cacactgttt ccagcttctc
     1921 cccacaactc atttatgatt ttgagatatg actccttagc tcactgtttc ctggggctcc
     1981 aggctttaga accgttagga attgtcaagg aaaactcaaa gtgctgacta gtcagcactg
     2041 cagggcacgc agagccttgg cttaggaagg gtgaggagtt tgcaggctga gcttagaagg
     2101 gcgttgcagg caaaagggaa gcctgtaccg agattcgaga tgcagagatg cagggagttc
     2161 aggggggcta aaggcaagtt tggtccctgg ggctgagagc caaggctggt ccctgatatg
     2221 ccctagattc aataaaatga ctatgatatt gcttcctctt tgttttgact cctgttccag
     2281 ggaggggccc tgttcacagg aggtgggatt tttgtgtttt tttgggtttt tcttgtttgc
     2341 ttttttgcat gaagctgcag gtgctgaagg ggtgcatgtg gagccgtagg ggttcatggt
     2401 acatttttac caaagggtag aactgtaaga cccccggagc tgggcctctg ctcaagtccc
     2461 gggatgagct ggccaacacc ccaacgtccc aagagataac ccacctgatg caaattgcaa
     2521 gaggttttat tatcagctag ctgaggacga acccctggca cctagaaggg caggggagtt
     2581 ccacccagag cagtgacagt agagggcttt taacagctag ctgaggagtt gggaggagtt
     2641 gggaagagtt gggaggagtt gggaagagag ttctcttcca ggtgtccttg gtgaaattta
     2701 caaggcagga gtggggagtg agttctttct gaatttttat ctcccgagtc ctccgcacag
     2761 gaaggcaggc atctctggtt gtaaagtata gaaacaaaaa ggctttttgc tggctataga
     2821 gaacaaagag cttctttctg gctgtgtttt tagagatcag ggaaaacaag cttggggaac
     2881 atttaggggc tttaccttcc agggagaaac actttaagtt ggggtctcac agaactgttg
     2941 ttgggaatgc agtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgcgcatg tgtgtaatta
     3001 tattcctatc tggcattttg agggattaaa gatcggccag attgccagcc tgggaaacag
     3061 agagattctg tctggaagta aagaaaggac tgggaactgc tcatgaagag ccttgcatga
     3121 gacacttcat tcagtcccca gaactgcaga tgaataagga aacagatagg acatgtcccg
     3181 ccacttataa tatattctaa gggttttcgt gtaatacata tgaaattcat atataaaatt
     3241 tatataaaac cagacatacg aaaagttaca agaaatattc acccagggct ggagagaggg
     3301 ctcactggtt aagagtgtgt cctgcccttc caggagatct gagtttgatt tccagcacac
     3361 atattgggtg gctcacaatc tcctgtaact ctaaataata attacaaact ttcttttagt
     3421 tctgctttga actgacagag atctgcctgc ctctgtctct caagtgtttg catttaagcc
     3481 tcccatgcct gctagacaag cactctaaca aatgaagtta cagcctcatc cctggattcc
     3541 aattttgttt cttttgtttt tttttttgaa acagtgtttc tctgtcctgg aacttgctct
     3601 gtacaccagg tttgttttgt aactcacaga aatccacctg cctctgctgg gattaaaggc
     3661 ctgtggttcc accacccaa
//
