LOCUS       NM_028748               3513 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus progestin and adipoQ receptor family member V (Paqr5),
            transcript variant 1, mRNA.
ACCESSION   NM_028748 XM_134937
VERSION     NM_028748.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3513)
  AUTHORS   Flock,G.B., Cao,X., Maziarz,M. and Drucker,D.J.
  TITLE     Activation of enteroendocrine membrane progesterone receptors
            promotes incretin secretion and improves glucose tolerance in mice
  JOURNAL   Diabetes 62 (1), 283-290 (2013)
   PUBMED   22933106
REFERENCE   2  (bases 1 to 3513)
  AUTHORS   Lemale,J., Bloch-Faure,M., Grimont,A., El Abida,B.,
            Imbert-Teboul,M. and Crambert,G.
  TITLE     Membrane progestin receptors alpha and gamma in renal epithelium
  JOURNAL   Biochim Biophys Acta 1783 (12), 2234-2240 (2008)
   PUBMED   18722485
REFERENCE   3  (bases 1 to 3513)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151969.3.
            
            On Mar 10, 2023 this sequence version replaced NM_028748.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085411.1, AK086679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC151969.3         185591-185707       c
            118-263             AC151969.3         147897-148042       c
            264-391             AC151969.3         134976-135103       c
            392-597             AC151969.3         131530-131735       c
            598-724             AC151969.3         127685-127811       c
            725-821             AC151969.3         122632-122728       c
            822-963             AC151969.3         120433-120574       c
            964-3513            AC151969.3         112642-115191       c
FEATURES             Location/Qualifiers
     source          1..3513
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 33.52 cM"
     gene            1..3513
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /note="progestin and adipoQ receptor family member V"
                     /db_xref="GeneID:74090"
                     /db_xref="MGI:MGI:1921340"
     exon            1..117
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /inference="alignment:Splign:2.1.0"
     exon            118..263
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1205
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane progestin receptor gamma; mPR gamma; membrane
                     progesterone receptor gamma; membrane progesterone P4
                     receptor gamma; progestin and adipoQ receptor family
                     member 5; progesterone and adipoQ receptor family member
                     5"
                     /codon_start=1
                     /product="membrane progestin receptor gamma isoform 1"
                     /protein_id="NP_083024.1"
                     /db_xref="CCDS:CCDS23261.1"
                     /db_xref="GeneID:74090"
                     /db_xref="MGI:MGI:1921340"
                     /translation="MLSLKLPRLFRIDQVPQVFHEQGILFGYRHPQSSATACILSLFQ
                     MTNETLNIWTHLLPFWFFVWRFMTALYVTDIQNDSYSWPMLVYMCTSCVYPLASSCAH
                     TFSSMSKNARHICYFLDYGAVNLFSLGSAIAYSAYTFPDALVCSTFHECYVALAVLNT
                     ILSTGLSCYSRFLELQKPRLCKLLRVLAFAYPYTWDSLPIFYRLFLFPGESSRNEAML
                     YHQKHMGMTLLASFFYSAHLPERLAPGRFDYIGHSHQLFHVCVILATHLQMEAILLDK
                     TLRREWLLATSRPFSFPQIAAAMLLCIIFSLSNIIYFSAALYRIPEPELHEKET"
     exon            264..391
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /inference="alignment:Splign:2.1.0"
     exon            392..597
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /inference="alignment:Splign:2.1.0"
     exon            598..724
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /inference="alignment:Splign:2.1.0"
     exon            725..821
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /inference="alignment:Splign:2.1.0"
     exon            822..963
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /inference="alignment:Splign:2.1.0"
     exon            964..3513
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1184..1189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /note="hexamer: ATTACA"
     polyA_site      1205
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /note="major polyA site"
     polyA_site      1285
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
     regulatory      1667..1672
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /note="hexamer: ATTAAA"
     polyA_site      1689
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
     regulatory      2586..2591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /note="hexamer: AATAAA"
     polyA_site      2611
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
     regulatory      3488..3493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
                     /note="hexamer: ATTAAA"
     polyA_site      3513
                     /gene="Paqr5"
                     /gene_synonym="0610010I15Rik; mPRg"
ORIGIN      
        1 gcagttccca ggcgcttggg ggcccgcgct ggcctgggag gagtagcccg tctcggatct
       61 gctcttgctg cgtctctacg ccctatccac tggacgccag tgagcctcag aattcaggga
      121 agctaccttg atgtccctgg tatgtcagaa ctgagtggga cctgctgagg ggccagagtg
      181 acctcaactg cctttcccag cctggtgtca agatgctgag cctaaagctc cctaggctat
      241 tccgcataga ccaggtgccc caggtgttcc atgagcaggg catcctcttt ggttaccgac
      301 acccacagag ttccgccact gcctgcatcc tcagcctctt ccaaatgacc aatgagaccc
      361 tcaacatctg gacgcacttg ctacccttct ggttctttgt gtggaggttc atgactgcac
      421 tctatgtgac agacatccag aatgacagct actcgtggcc gatgcttgtg tacatgtgta
      481 ccagctgcgt gtaccccctc gcctccagct gtgcacacac attcagctct atgtccaaga
      541 acgcccggca tatctgctat tttctggact atggtgccgt caatctcttc agcctgggct
      601 cagccatcgc ctactctgca tacacgttcc ctgatgcact ggtctgcagt accttccatg
      661 agtgctacgt agcactggcc gtgctaaaca ccattctcag cactggcctc tcctgctact
      721 ccaggtttct tgaactccag aagccccggc tctgcaagct actccgggtc ctggccttcg
      781 cctaccccta cacttgggac tcactcccca tcttctacag gctcttcctg ttcccagggg
      841 agagttcaag aaatgaagcc atgttgtacc accagaagca catgggcatg actctcctgg
      901 cctctttctt ctactctgct cacctgccag agcgactagc ccctggacgc tttgactaca
      961 ttggccacag tcaccagctg tttcatgtgt gcgtcatcct ggccacacac ttgcagatgg
     1021 aagccatcct tctggacaag accctgagga gggagtggct cctggccacc tccagaccct
     1081 tctctttccc tcagatagca gcggccatgc ttctgtgcat catcttcagc ctcagcaaca
     1141 ttatttattt ctcagctgct ctgtatcgga tccctgagcc tgaattacat gaaaaggaaa
     1201 catgacttca gaatgtgcca ggctttggtg ttagcagttg gtgtggtgct ggcttacagt
     1261 ggccaaaagc attcgtagca actgatgtct tgacattttt ttaatgggtt catatcggaa
     1321 aaaacaaaac aaaaaggatt taattgggca gagttctctg cacacacaca gattctgtat
     1381 gtgttctgta aaaggtagaa tttgagcata agtcctggat aaggataaat attaagttta
     1441 aaacttattt aaaatggggt gtttagggcc tggaggtgta gctcagttgg taagtagttg
     1501 cctagaatat tcagagccct gtttttgttt tgttctttat tttgggttgt tgtttgtttg
     1561 aggcagggtc ccactatgta gctcaggatg tcctgaaatt tactatgtag accaggctgg
     1621 ctttgaactc acagagctct gcctgcctct gactcctgag cgctggatta aaggtgtgtt
     1681 gccaagacac tgaagctctg gttttgatcc tcagcacagc agaacttggt cctgtggctc
     1741 atgtctataa ttccagcacc agggaagcag aatcagaggg tcagaagttt aaaccatcct
     1801 cggatgcatg agattgtatc tctaaaaaca tagttctcaa ttctattcca acagttatat
     1861 taagcatact gccctgcctc tctagttttt gtattgatgt ttaaaaacag cagaggctac
     1921 atttgatgaa ctttgtatag ctaagctttt tcccccagat gagtgagatg gttcaatgag
     1981 ttaagaagct tgctgccaag gctgacaaca ggagttcgat ccccaggacc tgctacaaag
     2041 tattctacag tatcgataag gtgtgatggc ctctggagct cattgatgcc atcccagctg
     2101 ttagggctcc ctgtcccttt ttcaagcaat ggaagagctg tctttggaga catcccatgc
     2161 ctgacattgg gttggcatgc caagatgctg ccagacttag tatttatgca gagggtgttg
     2221 acctcaccag tgggacagtc aaatgtcctg tcttcaacct ttcctgtgac acagaaacac
     2281 acaggtgggt aagcttgtga catgcatttc ctggggtaaa ctagggcttc tgctttccta
     2341 caccaaatgt aggaagtgtg ggaaatgtag acagcagcac ttccccagaa gcccagcaca
     2401 ggagggagga ggcagatgct gaagacattt gtgctgtctt tcatttacaa cttgatcaaa
     2461 gctccagcaa cttgccatct acatgtgtgt ccctgttttc tctccaggat cttctactat
     2521 tgatattttt ttaactggtt aaatgaaaat gaagtcccat gggttagacc ctagactaaa
     2581 aagtaaataa agccaggaag cttgaaggca aggctctcgg acgtgcacac tgattttaaa
     2641 atgccagcgt cctgtgcgca gacgaagcgt ggtcagccgg cctcctgcct gccggcctcc
     2701 tgactgctgg gccagcctca gactcggaat ctgtgccttc cctaccatgc atggtggatg
     2761 ccaatttgcc ttctgaatga taagcccaac taaatccctg cttaaaaaaa ttaaacaata
     2821 aaaagaaatc acaaaacaga acatcaagaa cagcaaaaac ccaaaagcca actctgctaa
     2881 ggccatagcc ttgtgcgaca atcccttcag tcttccacag ataatacttg tgcaggactt
     2941 ctatccagag ctgcctgtcc acccttggac caacgttacc ttgttattga tgcttataac
     3001 caaatactgc tgtgttctta tacaacatgg catcttcctc attttgcctt aaaaatatca
     3061 ccttatagag tggagatggc aagatgtgca agcatcaagg tgagtttagc ccccacgtac
     3121 aacacggaaa cctaggtgtg gctgcatata cctgtaacca cagcattggg aacaaagata
     3181 ggcaggtgct ggtagctcac tggccaggca tccatacaga gcagcttagt gagaggtcct
     3241 gtttcagcaa ggtggggaag caatggagta gacattctga catcagcctc tagtcctaag
     3301 cgcataagca cgggtaagtg tgtccaggca cactcaccct tgcctagact ctgtatgtgc
     3361 acttcactta ccagcacgag tgcagctatc acagatctgt tctggattaa tttgttgtct
     3421 ttggagaaac tctgttattt aggttcatga taccaaacac gccaatccct tgtttgttgc
     3481 atttgtaatt aaagttcagc gttttatagt gtt
//
