LOCUS       NM_023824               2507 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Mus musculus progestin and adipoQ receptor family member IV
            (Paqr4), mRNA.
ACCESSION   NM_023824
VERSION     NM_023824.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2507)
  AUTHORS   Zhu,Q., Chen,S., Funcke,J.B., Straub,L.G., Lin,Q., Zhao,S.,
            Joung,C., Zhang,Z., Kim,D.S., Li,N., Gliniak,C.M., Lee,C.,
            Cebrian-Serrano,A., Pedersen,L., Halberg,N., Gordillo,R.,
            Kusminski,C.M. and Scherer,P.E.
  TITLE     PAQR4 regulates adipocyte function and systemic metabolic health by
            mediating ceramide levels
  JOURNAL   Nat Metab 6 (7), 1347-1366 (2024)
   PUBMED   38961186
REFERENCE   2  (bases 1 to 2507)
  AUTHORS   Pedersen,L., Panahandeh,P., Siraji,M.I., Knappskog,S.,
            Lonning,P.E., Gordillo,R., Scherer,P.E., Molven,A., Teigen,K. and
            Halberg,N.
  TITLE     Golgi-Localized PAQR4 Mediates Antiapoptotic Ceramidase Activity in
            Breast Cancer
  JOURNAL   Cancer Res 80 (11), 2163-2174 (2020)
   PUBMED   32291319
REFERENCE   3  (bases 1 to 2507)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC122821.4.
            
            On Nov 17, 2006 this sequence version replaced NM_023824.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011185.1, AY424293.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-471               AC122821.4         123182-123652
            472-693             AC122821.4         125151-125372
            694-2507            AC122821.4         125513-127326
FEATURES             Location/Qualifiers
     source          1..2507
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.02 cM"
     gene            1..2507
                     /gene="Paqr4"
                     /gene_synonym="1500004C10Rik"
                     /note="progestin and adipoQ receptor family member IV"
                     /db_xref="GeneID:76498"
                     /db_xref="MGI:MGI:1923748"
     exon            1..471
                     /gene="Paqr4"
                     /gene_synonym="1500004C10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..1127
                     /gene="Paqr4"
                     /gene_synonym="1500004C10Rik"
                     /codon_start=1
                     /product="progestin and adipoQ receptor family member 4"
                     /protein_id="NP_076313.1"
                     /db_xref="CCDS:CCDS28461.1"
                     /db_xref="GeneID:76498"
                     /db_xref="MGI:MGI:1923748"
                     /translation="MAFLTGPRLLDWASSPPHLQFNKFVLTGYRPASSGSGCLRSLFY
                     LHNELGNIYTHGLALLGFLVLVPMTMPWSQLGKDGWLGGTHCVACLVPPAASVLYHLF
                     MCHQGGSPVYTRLLALDMCGVCLVNTLGALPIIHCTLACRPWLRPAALMGYTALSGVA
                     GWRALTAPSTSARLRAFGWQAGARLLVFGARGVGLGSGAPGSLPCYLRMDALALLGGL
                     VNVARLPERWGPGRFDYWGNSHQIMHLLSVGSILQLHAGVVPDLLWAAHHACPPD"
     exon            472..693
                     /gene="Paqr4"
                     /gene_synonym="1500004C10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            694..2507
                     /gene="Paqr4"
                     /gene_synonym="1500004C10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1938..1943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr4"
                     /gene_synonym="1500004C10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1955
                     /gene="Paqr4"
                     /gene_synonym="1500004C10Rik"
                     /note="major polyA site"
     regulatory      2482..2487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paqr4"
                     /gene_synonym="1500004C10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2506
                     /gene="Paqr4"
                     /gene_synonym="1500004C10Rik"
ORIGIN      
        1 ccgggctgcg gcgagacgcc tggctgccgt tgcggccaac cggagctctc cctccgccgc
       61 tctgctacgg tggagctgaa tgcactgagc tccgacctgg ggttgccagc tttctctccc
      121 ttgcgggggc gtcgaactcg cgcgtgcgca gcgcgtgagg gaagggggcc gggacctcct
      181 tgctgacccg ggcagggcca ccggatagcc ggaggtgaat cgggatgagc ttcccagcgc
      241 tgcagctcca ctgagaagga agcccaggcg cagagggtcg ccggtcggcc gcagtgcgtg
      301 aggccatggc attcctgacc gggcctcgtc tcctggactg ggctagctcg ccgccgcacc
      361 tgcagttcaa taagttcgta ttaaccggct accggccggc cagcagcggc tcgggctgtc
      421 tgcgcagcct tttctaccta cacaacgagc tgggcaacat ctacacacac gggctagccc
      481 tgctgggctt cctggtgttg gtgccaatga ccatgccctg gagtcagctg ggcaaggatg
      541 gctggctagg aggtacacac tgtgtggctt gcctggtgcc ccctgcagcc tctgtgctgt
      601 atcacctctt catgtgccac caaggaggca gtcctgtgta cacccggctc cttgccttgg
      661 atatgtgtgg agtctgcctt gtcaacaccc ttggagccct gcccatcatc cactgcactc
      721 tggcctgcag accgtggctt cgcccagctg ccctgatggg ttacactgca ctgtcaggtg
      781 tagccggctg gagagctctc actgccccct ccaccagtgc ccggcttcga gcctttggtt
      841 ggcaagctgg ggcccgcctg ctggtgtttg gggcccgtgg agtggggctg ggctcagggg
      901 ctccaggctc tctgccctgc tacctgcgca tggacgcact ggctctgctt ggagggctgg
      961 tgaatgtggc acgcctgcca gagcggtggg ggcctggtcg cttcgactac tggggcaact
     1021 cccaccagat catgcacttg ctgagtgtgg gctccatcct ccagctccat gctggggttg
     1081 tgcctgacct gctctgggct gcacaccatg cctgtccccc agactgagct gcctcctagc
     1141 tgccaaactg gcttgcccac agcttcctgg acaaattcca ccacctttcc tcctactggt
     1201 ctgcaagggg ctggttccct ggaagaacca gcacatggga cttcctagct gggagaccat
     1261 tcttcattct tccccatgga ttcacttctt gcatccaggc cttcaaaccc cagcttccac
     1321 tttccttgcc atcttccctc ctgggcattg ttttgctgtc attagaagga aaccattttt
     1381 ttttttccca atttaccctg tttaacctgt gagagtctct gacagttgag tcctgccaac
     1441 ttaccaagcc tccagcccag aaccactacc cctatgttgc tgctcccata cataactaca
     1501 cctcctgctc ctggattctt gagctagcca ctctgaccct gcttcctgac ctccatctcc
     1561 ctgctctgca tgtcaaacct ctcagcagcc agaattttgc tgttcctgtc attcctgcag
     1621 tgaggatgca gaggagtggg accaggcttc tctcagagcc aagtggacat tggtcctgct
     1681 tgtatcatct ggccaggaga caggagggga actgctgctt ttcctaggca acaggcacag
     1741 ctgtggaatg gaggtgttgg attcgggctt cactggacca aggactcagc tcttcagtgc
     1801 catggtctga ctgacctgcc taccagagac ttgtctgctc aggaaatctc tatacagtgg
     1861 gtggctccag cctgctggcc caagggtact gactcgcagc cagatcatcc caaaggccca
     1921 agaccctagg caacatcaat aaagggacaa gaagagctat gctgccacat gagcaacctt
     1981 gggtgttccc aagacgcatt actttttatt agacacggaa gtttcagggg agaggtgggc
     2041 aagacggtca gaggtttaaa agcaccaagg ctggctgggc ctgtgctcag gctgggtcta
     2101 gggagtcctc aaacaggctg aggaggttcc ttggctcaaa ggtggggcag ggacctcttg
     2161 gaggctctga gtccacatca gttaggtcca gggcatccct tgggggagga agaagaagaa
     2221 gaagaaaaaa agaataagac actggatcct aaagaaaacc gtgcccaagc ctagaccccg
     2281 ggcttgctca cctaggtatg tacctgcccc gaggggtaga ggttcttcta gtgatccggg
     2341 acaggacggt ctctggggag agtgagggac tacaagaaag aggacaagca gggtggtgac
     2401 ggttgggcaa agtaggatat aaacagccct gctcctcctt gtttcaggcc tctgcttggt
     2461 gaagggacaa ggcacacttg aaataaacac tggcagctga caagttc
//
