LOCUS       NM_001359910            2276 bp    mRNA    linear   ROD 08-FEB-2024
DEFINITION  Mus musculus progestin and adipoQ receptor family member III
            (Paqr3), transcript variant 1, mRNA.
ACCESSION   NM_001359910 XM_006534874
VERSION     NM_001359910.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2276)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2276)
  AUTHORS   Qiao,S., Yang,D., Li,X., Li,W., Zhang,Y. and Liu,W.
  TITLE     Silencing PAQR3 protects against oxygen-glucose
            deprivation/reperfusion-induced neuronal apoptosis via activation
            of PI3K/AKT signaling in PC12 cells
  JOURNAL   Life Sci 265, 118806 (2021)
   PUBMED   33249098
  REMARK    GeneRIF: Silencing PAQR3 protects against oxygen-glucose
            deprivation/reperfusion-induced neuronal apoptosis via activation
            of PI3K/AKT signaling in PC12 cells.
REFERENCE   3  (bases 1 to 2276)
  AUTHORS   Huang,M., Zhao,Z., Cao,Q., You,X., Wei,S., Zhao,J., Bai,M. and
            Chen,Y.
  TITLE     PAQR3 modulates blood cholesterol level by facilitating interaction
            between LDLR and PCSK9
  JOURNAL   Metabolism 94, 88-95 (2019)
   PUBMED   30831144
  REMARK    GeneRIF: PAQR3 plays a pivotal role in controlling hepatic LDLR
            degradation and blood LDL-C level via modulating LDLR-PCSK9
            interaction.
REFERENCE   4  (bases 1 to 2276)
  AUTHORS   Zhao,Z., Xu,D., Wang,Z., Wang,L., Han,R., Wang,Z., Liao,L. and
            Chen,Y.
  TITLE     Hepatic PPARalpha function is controlled by polyubiquitination and
            proteasome-mediated degradation through the coordinated actions of
            PAQR3 and HUWE1
  JOURNAL   Hepatology 68 (1), 289-303 (2018)
   PUBMED   29331071
REFERENCE   5  (bases 1 to 2276)
  AUTHORS   Xu,D.Q., Wang,Z., Wang,C.Y., Zhang,D.Y., Wan,H.D., Zhao,Z.L.,
            Gu,J., Zhang,Y.X., Li,Z.G., Man,K.Y., Pan,Y., Wang,Z.F., Ke,Z.J.,
            Liu,Z.X., Liao,L.J. and Chen,Y.
  TITLE     PAQR3 controls autophagy by integrating AMPK signaling to enhance
            ATG14L-associated PI3K activity
  JOURNAL   EMBO J 35 (5), 496-514 (2016)
   PUBMED   26834238
  REMARK    GeneRIF: PAQR3 controls autophagy by integrating AMPK signaling to
            enhance ATG14L-associated PI3K activity
REFERENCE   6  (bases 1 to 2276)
  AUTHORS   Wang,X., Li,X., Fan,F., Jiao,S., Wang,L., Zhu,L., Pan,Y., Wu,G.,
            Ling,Z.Q., Fang,J. and Chen,Y.
  TITLE     PAQR3 plays a suppressive role in the tumorigenesis of colorectal
            cancers
  JOURNAL   Carcinogenesis 33 (11), 2228-2235 (2012)
   PUBMED   22828136
  REMARK    GeneRIF: Loss of PAQR3 is associated with tumorigenesis of
            colorectal cancers.
REFERENCE   7  (bases 1 to 2276)
  AUTHORS   Jiang,Y., Xie,X., Li,Z., Wang,Z., Zhang,Y., Ling,Z.Q., Pan,Y.,
            Wang,Z. and Chen,Y.
  TITLE     Functional cooperation of RKTG with p53 in tumorigenesis and
            epithelial-mesenchymal transition
  JOURNAL   Cancer Res 71 (8), 2959-2968 (2011)
   PUBMED   21385899
  REMARK    Erratum:[Cancer Res. 2011 Apr 15;71(8).
            doi:10.1158/0008-5472.CAN-11-1303. Ling, Zhiqiang [corrected to
            Ling, Zhi-Qiang]]
REFERENCE   8  (bases 1 to 2276)
  AUTHORS   Xie,X., Zhang,Y., Jiang,Y., Liu,W., Ma,H., Wang,Z. and Chen,Y.
  TITLE     Suppressive function of RKTG on chemical carcinogen-induced skin
            carcinogenesis in mouse
  JOURNAL   Carcinogenesis 29 (8), 1632-1638 (2008)
   PUBMED   18550569
  REMARK    GeneRIF: RKTG has a suppressive activity in chemical
            carcinogen-induced mitogenesis and tumor formation in mouse skin.
REFERENCE   9  (bases 1 to 2276)
  AUTHORS   Feng,L., Xie,X., Ding,Q., Luo,X., He,J., Fan,F., Liu,W., Wang,Z.
            and Chen,Y.
  TITLE     Spatial regulation of Raf kinase signaling by RKTG
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14348-14353 (2007)
   PUBMED   17724343
  REMARK    GeneRIF: reveal a paradigm of spatial regulation of Raf kinase by
            RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby
            inhibiting the ERK signaling pathway.
REFERENCE   10 (bases 1 to 2276)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125229.3 and AK149213.1.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_001359910.2.
            
            On Jan 18, 2018 this sequence version replaced XM_006534874.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1 and 2
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172689.1, AK149213.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                AC125229.3         70925-70947
            24-1064             AK149213.1         3-1043
            1065-1065           AC125229.3         86579-86579
            1066-2274           AK149213.1         1045-2253
            2275-2276           AC125229.3         95536-95537
FEATURES             Location/Qualifiers
     source          1..2276
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.29 cM"
     gene            1..2276
                     /gene="Paqr3"
                     /gene_synonym="6330415A20Rik; RKTG"
                     /note="progestin and adipoQ receptor family member III"
                     /db_xref="GeneID:231474"
                     /db_xref="MGI:MGI:2679683"
     exon            1..338
                     /gene="Paqr3"
                     /gene_synonym="6330415A20Rik; RKTG"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1089
                     /gene="Paqr3"
                     /gene_synonym="6330415A20Rik; RKTG"
                     /note="isoform a is encoded by transcript variant 1;
                     progestin and adipoQ receptor family member 3; Raf kinase
                     trapping to Golgi"
                     /codon_start=1
                     /product="progestin and adipoQ receptor family member 3
                     isoform a"
                     /protein_id="NP_001346839.1"
                     /db_xref="CCDS:CCDS19451.1"
                     /db_xref="GeneID:231474"
                     /db_xref="MGI:MGI:2679683"
                     /translation="MHQKLLKSAHYIELGSYQYWPVLVPRGIRLYTYEQIPVSLKDNP
                     YITDGYRAYLPSRLCIKSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLPSASASR
                     EDFVICSICLFCFQVCMLCSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGV
                     FYAFYCNNYWRQVYLITVLAMILAVFFAQIHPSYLTQQWQRLRPIIFCSVSGYGVIPT
                     LHWVWLNGGVSAPIVQDFAPRVIVMYVIALLAFLFYISKVPERYFPGQLNYLGSSHQI
                     WHVLAVVMLYWWHQSTVYVMQYRHSKPCPDYVSHL"
     exon            339..501
                     /gene="Paqr3"
                     /gene_synonym="6330415A20Rik; RKTG"
                     /inference="alignment:Splign:2.1.0"
     exon            502..657
                     /gene="Paqr3"
                     /gene_synonym="6330415A20Rik; RKTG"
                     /inference="alignment:Splign:2.1.0"
     exon            658..855
                     /gene="Paqr3"
                     /gene_synonym="6330415A20Rik; RKTG"
                     /inference="alignment:Splign:2.1.0"
     exon            856..946
                     /gene="Paqr3"
                     /gene_synonym="6330415A20Rik; RKTG"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1095
                     /gene="Paqr3"
                     /gene_synonym="6330415A20Rik; RKTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..2276
                     /gene="Paqr3"
                     /gene_synonym="6330415A20Rik; RKTG"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagagctgaa gcggcggagg tgtgtgtagc ggagccgggc ctgagcagac gcgggccgaa
       61 gctcctggct cagcggcggc ggctccgggg cgggggcgcc agcggcaaag ccccctcccc
      121 ggggaggcgg ggccgggccg gcgcctggga accatgcatc agaagctgct gaagagtgcg
      181 cactacatcg agctgggcag ctaccaatac tggccggtcc tggtaccccg cggcatccgc
      241 ctctacacct atgaacagat cccggtatcc ctcaaagaca acccctacat caccgacggc
      301 taccgggcct accttccttc cagactgtgt atcaaaagtt tgtttatcct gtctaatgag
      361 acggtaaaca tctggagtca tttgctgggt ttctttctct tcttcaccct ggggatatat
      421 gacatgacat ccgtgctgcc ttccgccagc gcatccagag aagactttgt gatttgctcc
      481 atttgtcttt tctgcttcca ggtctgcatg ctttgctcgg tgggctatca tcttttttcc
      541 tgtcatcggt cagaaaaaac ttgtcggaga tggatggcat tggattatgc aggaatttct
      601 attggaatac tgggctgcta tgtctcagga gtattttatg cattttattg caataattac
      661 tggcgtcaag tgtacctgat caccgtgctt gccatgatcc tggcagtctt cttcgcacag
      721 atccacccca gctacctcac acagcagtgg cagaggctcc gccccatcat cttctgctct
      781 gtttcgggat atggagtgat ccctactctt cactgggttt ggctcaatgg aggagtcagt
      841 gctcctattg tacaggactt cgcaccccga gtaattgtga tgtacgtgat tgctcttctt
      901 gctttcctgt tctacatttc caaggtcccg gaacggtact ttccaggaca actgaactac
      961 ctcggatcaa gccaccagat ctggcatgtc cttgcagtag tgatgctgta ttggtggcat
     1021 cagtccacgg tgtatgtcat gcagtacaga cacagcaagc cttgccctga ctatgtttcc
     1081 cacctgtgac tccaggagtt attgctgagt ccacctgaag tatctactgt ttagaaggaa
     1141 atggagcagc accaaagggg tctagttcga ccggttggga ctgttgtgga gtgacacttt
     1201 gcaccacgag ttctgtaaag ggcacggcac caaagtcatc cattctcaat gtctctgcgc
     1261 tgtggaagga cccgtgtact gaattctgtc gcggcctccc aggcaaaatg gtggtgtgat
     1321 caacgcagat gtcgcttagg ccctgatggg gctggtgcca caagtctgga ggatgaaagg
     1381 gcttggcacc gaatgggtcc agcagactct cgtcagatgg caggacactg gccctgtctt
     1441 tgccatcagt cagcgcgacg ctgatgttct ccttggaatc ggaaatggtt aaaaactcat
     1501 tgctgctctg ggagtctctg cggcccacct tcttgtgtct gcgggccctc tcgggcgtgc
     1561 ggtagggggg cttcagcgtc ttctttgcgc tggtaggggt gccgtgatgg cgcttcccat
     1621 tgcttttgga cacatcctgc tttgtgcgtc tctggcgaga ggagagtttc tgcaagctgc
     1681 gctgcttgac tttctgctgc tgctgactcc cagttatttc ctcaaagggc acgagcccaa
     1741 aaacatcctc cttgctttca cttttactgg ctgacacgga gaagggctgg aagggagtgg
     1801 agccaaatat atctacactt ctgggccgtg caggcagagg ccgggcatct ggccccaccg
     1861 cgggccagtc ctgtacgctg accttcttgt tgaagggtgc ctttgtgaac acgtcgaagt
     1921 cctcctgctc tggaaaagca tgctgggaca ggttcttccc atcccctctg tgctgcaggc
     1981 tctgcggagc aggcgctgca aagaagggaa cagcgccaaa cacatcgaac tcctgactgg
     2041 gagtcagcgc atcagcaggc gagcgggccg gggtcaggag ggctgtgtct ggggccacgc
     2101 caggtttgtc cctgcgcagg gagctcgtgt ctcctctctt ggtctttgcc tgttcacact
     2161 ctgaatcaga gctgtgtttg tcgtcctctt cctcatcttc agagtccatc agcagaggcc
     2221 tgtgacccag gttctccggc tcagtgtcgt catcattaaa gtccccgtgt tctccc
//
