LOCUS       NM_011864               3635 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus 3'-phosphoadenosine 5'-phosphosulfate synthase 2
            (Papss2), transcript variant 1, mRNA.
ACCESSION   NM_011864 XM_993984
VERSION     NM_011864.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3635)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3635)
  AUTHORS   Wishart,T.F.L. and Lovicu,F.J.
  TITLE     Spatiotemporal Localisation of Heparan Sulphate Proteoglycans
            throughout Mouse Lens Morphogenesis
  JOURNAL   Cells 12 (10), 1364 (2023)
   PUBMED   37408198
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3635)
  AUTHORS   Feng,S., Bai,M., Rivas-Gonzalez,I., Li,C., Liu,S., Tong,Y.,
            Yang,H., Chen,G., Xie,D., Sears,K.E., Franco,L.M.,
            Gaitan-Espitia,J.D., Nespolo,R.F., Johnson,W.E., Yang,H.,
            Brandies,P.A., Hogg,C.J., Belov,K., Renfree,M.B., Helgen,K.M.,
            Boomsma,J.J., Schierup,M.H. and Zhang,G.
  TITLE     Incomplete lineage sorting and phenotypic evolution in marsupials
  JOURNAL   Cell 185 (10), 1646-1660 (2022)
   PUBMED   35447073
REFERENCE   4  (bases 1 to 3635)
  AUTHORS   Xu,P., Xi,Y., Wang,P., Luka,Z., Xu,M., Tung,H.C., Wang,J., Ren,S.,
            Feng,D., Gao,B., Singhi,A.D., Monga,S.P., York,J.D., Ma,X.,
            Huang,Z. and Xie,W.
  TITLE     Inhibition of p53 Sulfoconjugation Prevents Oxidative
            Hepatotoxicity and Acute Liver Failure
  JOURNAL   Gastroenterology 162 (4), 1226-1241 (2022)
   PUBMED   34954226
REFERENCE   5  (bases 1 to 3635)
  AUTHORS   Xu,P., Xi,Y., Zhu,J., Zhang,M., Luka,Z., Stolz,D.B., Cai,X.,
            Xie,Y., Xu,M., Ren,S., Huang,Z., Yang,D., York,J.D., Ma,X. and
            Xie,W.
  TITLE     Intestinal Sulfation Is Essential to Protect Against Colitis and
            Colonic Carcinogenesis
  JOURNAL   Gastroenterology 161 (1), 271-286 (2021)
   PUBMED   33819483
  REMARK    GeneRIF: Intestinal Sulfation Is Essential to Protect Against
            Colitis and Colonic Carcinogenesis.
REFERENCE   6  (bases 1 to 3635)
  AUTHORS   Sugahara,K. and Schwartz,N.B.
  TITLE     Defect in 3'-phosphoadenosine 5'-phosphosulfate formation in
            brachymorphic mice
  JOURNAL   Proc Natl Acad Sci U S A 76 (12), 6615-6618 (1979)
   PUBMED   230515
REFERENCE   7  (bases 1 to 3635)
  AUTHORS   Johnson,D.R.
  TITLE     The growth of femur and tibia in three genetically distinct
            chondrodystrophic mutants of the house mouse
  JOURNAL   J Anat 125 (Pt 2), 267-275 (1978)
   PUBMED   624676
REFERENCE   8  (bases 1 to 3635)
  AUTHORS   Eicher,E.M. and Washburn,L.L.
  TITLE     Assignment of genes to regions of mouse chromosomes
  JOURNAL   Proc Natl Acad Sci U S A 75 (2), 946-950 (1978)
   PUBMED   273256
REFERENCE   9  (bases 1 to 3635)
  AUTHORS   Orkin,R.W., Williams,B.R., Cranley,R.E., Poppke,D.C. and Brown,K.S.
  TITLE     Defects in the cartilaginous growth plates of brachymorphic mice
  JOURNAL   J Cell Biol 73 (2), 287-299 (1977)
   PUBMED   67117
REFERENCE   10 (bases 1 to 3635)
  AUTHORS   Silberberg,R. and Lesker,P.
  TITLE     Defective endochondral ossification in brachymorphic mice
  JOURNAL   J Comp Pathol 87 (2), 319-323 (1977)
   PUBMED   858816
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162887.5.
            
            On Nov 17, 2006 this sequence version replaced NM_011864.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090997.1, AF052453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC162887.5         141859-142040       c
            183-297             AC162887.5         128045-128159       c
            298-533             AC162887.5         124776-125011       c
            534-672             AC162887.5         123653-123791       c
            673-791             AC162887.5         123008-123126       c
            792-905             AC162887.5         122714-122827       c
            906-1017            AC162887.5         120634-120745       c
            1018-1032           AC162887.5         115702-115716       c
            1033-1238           AC162887.5         109944-110149       c
            1239-1374           AC162887.5         101331-101466       c
            1375-1643           AC162887.5         98722-98990         c
            1644-1873           AC162887.5         97395-97624         c
            1874-3635           AC162887.5         94858-96619         c
FEATURES             Location/Qualifiers
     source          1..3635
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 27.46 cM"
     gene            1..3635
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /note="3'-phosphoadenosine 5'-phosphosulfate synthase 2"
                     /db_xref="GeneID:23972"
                     /db_xref="MGI:MGI:1330223"
     exon            1..182
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2015
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /EC_number="2.7.1.25"
                     /EC_number="2.7.7.4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     bifunctional 3'-phosphoadenosine 5'-phosphosulfate
                     synthase 2; PAPS synthase 2; sulfurylase kinase 2;
                     brachymorphic"
                     /codon_start=1
                     /product="bifunctional 3'-phosphoadenosine
                     5'-phosphosulfate synthase 2 isoform 1"
                     /protein_id="NP_035994.2"
                     /db_xref="CCDS:CCDS37960.1"
                     /db_xref="GeneID:23972"
                     /db_xref="MGI:MGI:1330223"
                     /translation="MSANFKMNHKRDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGC
                     TVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIR
                     RIAEVARLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRD
                     VKGLYKRARAGEIKGFTGIDSDYEKPETPECVLKTNLSSVSDCVQQVVELLQEQNIVP
                     HTTIKGIHELFVPENKVDQIRAEAETLPSLPITKLDLQWVQILSEGWATPLKGFMREK
                     EYLQTLHFDTLLDGVVPRDGVINMSIPIVLPVSADDKARLEGCSKFALMYEGRRVALL
                     QDPEFYEHRKEERCSRVWGTATAKHPHIKMVMESGDWLVGGDLQVLERIRWDDGLDQY
                     RLTPLELKQKCKDMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPL
                     GGWTKDDDVPLEWRMKQHAAVLEERVLDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMI
                     AGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKK
                     AMDFYDPARHEEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKTN"
     exon            183..297
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            298..533
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            534..672
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..791
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            792..905
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1017
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1032
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1238
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1374
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1643
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1873
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..3635
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3615..3620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /note="hexamer: AATAAA"
     polyA_site      3633
                     /gene="Papss2"
                     /gene_synonym="1810018P12Rik; Atpsk2; AtpsU2; bm; Sk2"
                     /note="major polyA site"
ORIGIN      
        1 attcccattc acacccacct cacagacctt cacagactct gcagctcatt cattcacccc
       61 aatggccagc aaagccagtt tgtaaccgag tattctcaac atcagatatc atgtcttgga
      121 ggaagttacc taaactctga agaattatca tgtctgcaaa tttcaaaatg aaccataaaa
      181 gagaccagca aaaatccacc aatgtggtct accaggccca tcatgtgagc aggaacaaga
      241 gaggacaagt ggttggaacc aggggaggat tccgaggatg taccgtgtgg ctaacaggtc
      301 tctctggtgc tgggaaaaca accataagct ttgctttgga agagtacctt gtatctcacg
      361 ccatcccatg ttactctctg gatggggaca atgtccgtca tggccttaat aagaacctgg
      421 gattctctgc gggggaccga gaagagaata tccgccggat cgcggaggtg gccaggctct
      481 ttgccgacgc cggcctggtt tgcatcacca gctttatctc tccttttgca aaggatcgtg
      541 agaatgcccg aaaaatccac gaatcagcag gactcccgtt ctttgagatc tttgtagatg
      601 cgcctttaaa tatctgtgaa agccgagacg taaaaggact ctacaaacga gcccgagcag
      661 gagagattaa agggtttaca ggcatcgatt ctgactatga gaaacctgaa actccagagt
      721 gtgtgctgaa gaccaacctg tcttcagtaa gcgactgtgt gcaacaggtg gtggaacttt
      781 tgcaggagca gaacattgta ccccacacca ccatcaaagg catccacgaa ctctttgtgc
      841 cagaaaacaa agtcgatcaa atccgagctg aggcagagac tctcccatca ctaccaatta
      901 ccaagctgga tctgcagtgg gtgcagattc tgagtgaagg ctgggccact cccctcaaag
      961 gctttatgcg ggagaaggag tacttgcaaa ctctacactt cgacactcta ctggacggcg
     1021 tggttccccg tgatggagtc atcaacatga gtattcccat tgtattgccc gtttctgcgg
     1081 atgacaaggc acggctcgaa gggtgcagca aatttgcctt gatgtacgaa ggtcggaggg
     1141 tcgctctatt acaggaccct gaattctatg agcataggaa agaggagcgc tgttctcgtg
     1201 tgtggggaac agccactgca aagcaccccc atatcaaaat ggtgatggaa agtggggact
     1261 ggcttgttgg tggagaccta caggtgctag agagaataag gtgggacgat gggctggacc
     1321 aataccgcct tacgcctctg gagctcaaac agaagtgtaa agacatgaat gctgatgccg
     1381 tgtttgcatt ccagttgcgc aatcctgtcc acaatggtca tgccctcctg atgcaggaca
     1441 cccgccgcag gctcctggag aggggttaca agcacccagt cctcctgctc caccctcttg
     1501 ggggctggac caaggacgat gacgtacctc tggaatggag gatgaaacag catgcagctg
     1561 tactggagga aagggtcctg gatcccaagt caactattgt tgccatcttt ccatctccta
     1621 tgttatatgc tggtcccaca gaggtccagt ggcattgcag atgccggatg attgcaggag
     1681 ccaatttcta cattgtgggt agggatcccg caggaatgcc ccatcctgag acaaagaaag
     1741 acctatatga acccacccac gggggcaagg tcttgagtat ggcccctggc cttacctctg
     1801 tggaaataat tccgttccga gtggctgcct acaataaaat taaaaaggcc atggactttt
     1861 atgatccagc aaggcacgag gagtttgact tcatctcagg aactcgcatg aggaagctcg
     1921 cccgggaagg agaagatccc ccagatggct tcatggcccc gaaagcgtgg aaagtgttga
     1981 cagattacta caggtctctg gagaagacca actaggtgct cctggctctg gcttcttcct
     2041 caagtgctct ctgacgattt tttttttcta tttttgtgat ttagctgctc tgtatccaat
     2101 tgcttctcgg tgacttttta aagctagtat ttttgcaatg aagtaaaaag ctgtaaccat
     2161 aatttaaaac caagttcatt atgtctatga agctcacact ggagactgag tcttaggtga
     2221 aagcaatatc gttgtacgtt ccagaatgaa agcatttgca ctgtacactt catctcagcc
     2281 actatgtctc agatttctta aaaatgtaac tgtgtggcta gctgactagc ccagaacaga
     2341 atcatacttt ccagcttact tgtgccagcc tggaatctca atgtcactta ccaaaagaaa
     2401 acacacacac acacacacac acacacatac atacacacac acacacacac atatacatac
     2461 acacacactg tcgctttgaa ggaaatgtgt tatatcagga ctcttacttc ataactacac
     2521 ataccatcac tgcccaatgt acgagctgaa gatgcaactg gaagaaaaat tcatgtgaag
     2581 atgtaaatta agtcttaaag aacaatgtaa tttatgtctg ccatgaaaat gtcatcatcc
     2641 aatagagaga gacgctctaa tggccttcta tgaatagtta ctctagtttg gctggcactt
     2701 ttcaaaagca tggtatgctt ggatcaaaac aacccccccc ccagactaaa ccaccagggt
     2761 atattgtaga ctactttccc cacactttgc tgtggccata gttattatag aagcacctaa
     2821 gtgatcgctg taatcaaaac caacccacat tattaatgag aagctaaaac ttgatttctg
     2881 tagcaaagat aaaatccaaa catcatccta gtgaagatat atacacataa gctttgagag
     2941 ctgctgagca ctgtaatata caaagttgac attagtgaat actgccgaca ctgaaagact
     3001 gaccatcctc ctaagctagg gccctgccta ccctagacaa cacaggaaga ggttccgatt
     3061 tcctgaagct acttagtgaa gctctccttg aggatgctaa gaagcaacca ccttggagac
     3121 cgaaggttta gggtatccca aactcttgat gttataagtt tccagaatga acctgttgtg
     3181 agatgtcctt tgatggttta tttgctaaga gggaattttg gtattttatg catggttcat
     3241 tgttgccaag aaatacataa gagaaaaggc atctttacat acaggtttct ttggaagaga
     3301 ccacagactg aaaagagaaa ctgatttttt tcatactgcc acgtttttta aaaatgctag
     3361 gaaaagctct actgagagta agttatatac tgtgaccaca gcaaagtgag tcttcgactg
     3421 tatggcgcct gtgctcactt acatcagagc tatttattca ctgctgcctt taaaactatg
     3481 tcttcactga aaacgtgaca gggttgtagt gccttcttag catatgaagt tgtgatttta
     3541 agacagtaga gtgcctttct gctgtagcac acagcataac tgtttcagtg tcccgctggt
     3601 acctgttctt attcaataaa tctctcaaaa gacca
//
