LOCUS       XM_006496824            9494 bp    mRNA    linear   ROD 07-FEB-2024
DEFINITION  PREDICTED: Mus musculus pappalysin 2 (Pappa2), transcript variant
            X1, mRNA.
ACCESSION   XM_006496824
VERSION     XM_006496824.5
DBLINK      BioProject: PRJNA169
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000067.7) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Sep 21, 2020 this sequence version replaced XM_006496824.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001635.27-RS_2024_02
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.2
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 02/01/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..9494
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6J"
                     /db_xref="taxon:10090"
                     /chromosome="1"
     gene            1..9494
                     /gene="Pappa2"
                     /gene_synonym="PAPP-A2; Pappe; PLAC3"
                     /note="pappalysin 2; Derived by automated computational
                     analysis using gene prediction method: Gnomon. Supporting
                     evidence includes similarity to: 3 mRNAs, 66 ESTs, 32 long
                     SRA reads, 6 Proteins, and 100% coverage of the annotated
                     genomic feature by RNAseq alignments, including 7 samples
                     with support for all annotated introns"
                     /db_xref="GeneID:23850"
                     /db_xref="MGI:MGI:3051647"
     CDS             906..6275
                     /gene="Pappa2"
                     /gene_synonym="PAPP-A2; Pappe; PLAC3"
                     /codon_start=1
                     /product="pappalysin-2 isoform X1"
                     /protein_id="XP_006496887.1"
                     /db_xref="GeneID:23850"
                     /db_xref="MGI:MGI:3051647"
                     /translation="MMCWKVLRISLVVLTGWALSTTNSEQGWTRKKFLAQKEHLNQVL
                     LEGERCWLGYKVRRPRTAPQHHLFGVYPSRLENYPRSYPVGTQQQTLYAEWSQRSPER
                     QAPSGIPRDLTENPAGARRESQQPAAPWVGDGPIGQSQLLRNDDTYLGEGGSKEALGE
                     PAIQGSSEIAVSTIATFAYQKGPTAETQRKGQSKSRLPRQVQKRQAEDMTGDPQNTPQ
                     GFQLWPKEPLKHGDSDSPLEGTIQNGGGASLRRVETFNSQGGLPVLYFTGKRERLLLR
                     PEVLAEIPREAFTVEAWVRPEGGQSNPAIIAGVFDNCSHTVNDKGWALGIRSGKDKGW
                     RDARFFFSLRTDRMKKATIVTGHSRYQPGMWTHVAATYDGQHTALYVDGTRVASSRDQ
                     FGPLNSPFMASCRSLILGGDSSEDGHYFRGYLGTLVIWSTALSQTHLQHSPLHPSAAD
                     ELTTLILTATFDPLMEQWAPFRDDLYPRLEVLQDSESQPEILSPLQPPPCGQTACDNV
                     ELISQYNKHGPLRREKVIRYQVVNIYDDEGLHPIVSDHQIRRQHEALNQAFSRYNISW
                     QLSVHRVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGFDGGDCRLQGRCYSWNR
                     RDGLCHVECNNMLNDFDDGDCCDPEVTDVRKTCFDPDSPKRAYMSVKELKEALQLNST
                     HFLNVYFASSVREDLAGSATWPWDKEALSHLGGVVLNPTYYGMLGHTNIMIHEVGHVL
                     GLYHVFKGVSERESCDDPCRETVPSMETGDLCADTAPTPKSKLCRDPEPANDTCGFTL
                     FPGAPFNNYMSYTDDECTDNFTPNQVARMHCYLDLVYQQWSESQKPTPIPIPPMVIGQ
                     THKSLTIHWLPPISGVVYDRAPDSMCSACTEDGTFRQYVYKASSGRVCDSSGYWTPEE
                     AVGPPDVDQPCEPSLQAWSPELHLNHMNMTVPCPAEGCSLELLFQYPVQADTLTLWVT
                     YLSMNSSKAFFDIEILLEHKKSMHLGPLNTFCDIPLTIKLHMDEKVMGAKVYTFDERM
                     EIDAALLTSRPNSSLCSGCKPMSYQVLREPPFSSGLPMVVTHPHRKFTDTEVIPGQMY
                     QYQVQAEAVGELGEASPPLSHIHGGPYCGDGKVERSIGEMCDDGDLLNGDGCSRACEL
                     EEGFNCAGEPSLCYRYEGDGVCEDFEKESIITDCGLHTPEGYLDQWASQAYSYHEDKE
                     KCPVSLVTGEPHSMICTSWHPDSSPYHSFPGWFPCVFSLKKDQDAGSEQAKDSLQKDN
                     EIWLEVCFNRPGVAVAIYIFLASDGVTPGEHQQATVTLYLIDVSGSNHSLGTYGLSCQ
                     QNPLVINVSHHVNVYPQHTSSMLLNFSSPLVGISAVALRTSSQTSSSAPSNCIPEQNY
                     EGKSCAQRPCGEQGRCAPLLLDHTDMVNCTSSSPGHMECAITCQRGYVLQTSSGQYLR
                     NMQKEILLTCSSGHWDKDVICKRLDCGVPDSSLVNYANFSCLEGTDFLKQCSISCVPP
                     AKLQGLNPWLTCLEDGLWSLPEVYCKLECEAPPVIPNANLLLPHFLEGNHDVGTICKY
                     ECKPGYYVKETSGSQGKNKFLKIQCLDDGSWEQGSCVPVVCEPPPPVFEGMYECTDGF
                     KLDSQCVLNCNQETEGIPILCTKEGLWTQEFKLCENLQGECPPPTSELNSVEYKCGQG
                     YGIGAVCSPSCVIPPSDPVILPENVTTDTLEHWMEPVKVQSIVCTGRRQWHPDPSLVH
                     CIQSCEPFQADGWCDTINNRAYCNYDGGDCCSSTLSSKKVIPFAADCDLDECTCRDPK
                     AEENQ"
ORIGIN      
        1 gaggaaaaca cagaaatggt tcaacatttt ttttttaaac tttggactgc caagagctga
       61 agagtggtgt gcaaaggaat gaaggagaga gagagagaga gagagagaga gagagagaga
      121 gagagagaga gagagagaga gagagagaaa ctaaactgga agcctgagtt tggtgttgcc
      181 tcttgaaatc ttatgaatgg attactagca gctgagagcc aggagagtcc tataggggat
      241 gcaagatcac ccacacactc agggggagaa aagcaggagg aacccttttc tgatgtccta
      301 tcccccttcc tgaaatgaat gggacccacc agcctctcca aaggtgaaac caagggctcc
      361 cagactcatt tgatcaggag agcagcagac tggcagccag agaactttac agagacttgc
      421 agcataccaa caagttggac aggaattaaa acactctctt caatagtcaa caaccccgag
      481 tgccacgctg caggagtgct cacctatcct ggcagactgg aagctgaatg gacacctagc
      541 tgaggacctc tgaggaaaga agtgaggaga ggagttactg aaggaagaaa aggaaacctg
      601 aggtctctgg gtggagattc aaagtaagaa cacttaactt cactctgaag gactgaaatc
      661 aagaagagag gtcacagaag aaggcaagag aagccaaaag ttacagaagc cactggggtt
      721 ggctgaatcc ccaggacagg tagccagtag aggcatcctt ctggggccac ttgagaaagt
      781 ttggcttggg aatcgatttc cccggtgact tcaattccat tgctggttgt ctttccttct
      841 tctccttatt cttgtgtggt accaagaagc tgactttggg ttctaaggaa caagctgagg
      901 gagatatgat gtgttggaag gtcctgagaa taagcctggt ggtcctgact gggtgggcac
      961 tcagtaccac caactcagag cagggctgga cacgcaagaa attcctggcc cagaaggaac
     1021 acctgaacca agtgctgttg gaaggggaac gctgttggct ggggtataag gttcgaagac
     1081 ccaggactgc tccacagcac catctctttg gggtctaccc aagccgcctc gaaaactacc
     1141 caaggtccta tcctgtgggg acacagcagc aaaccctgta tgcagaatgg agtcagcgaa
     1201 gcccagagag acaggctccg agtggtattc cccgagacct gactgaaaac ccagcaggag
     1261 caaggagaga gtctcagcag ccagctgccc cgtgggtagg ggatggtcct attgggcaat
     1321 cgcagctgct gagaaatgat gacacttatc ttggcgaggg aggatctaag gaggctctag
     1381 gtgagcctgc gattcaggga agctcagaaa ttgctgtctc caccattgct accttcgcat
     1441 atcagaaggg acccacagca gagacccaga ggaagggcca gtccaagtct aggcttcctc
     1501 gccaagtgca gaagaggcag gcagaagaca tgactggaga cccccagaat acccctcaag
     1561 gtttccagct ttggcctaaa gagccactta agcatggaga tagtgacagt ccattggagg
     1621 gcaccatcca aaatggtgga ggggcctctc tccggagagt agagaccttt aactcccaag
     1681 gaggattgcc tgtactgtat ttcactggga agagggagcg gctgttgctg cgtccagaag
     1741 tgctggctga gattccccgg gaggcgttca cagtggaagc ctgggtgaga ccagagggag
     1801 gacagagcaa cccagccatc attgcaggtg tgtttgataa ctgctcccac acagtcaatg
     1861 acaagggctg ggccctgggg atccgctcag ggaaggacaa ggggtggaga gatgctcgct
     1921 tcttcttttc cctccgcact gaccggatga agaaagccac tattgtgact ggccacagcc
     1981 gttaccagcc aggcatgtgg actcatgtag cagccactta cgatggacag catacagctc
     2041 tgtatgtgga tggcactcga gtggctagta gtcgtgacca gtttggaccg ctaaatagcc
     2101 ctttcatggc gtcttgccgc tctttaatcc tgggagggga cagctccgag gatggacatt
     2161 atttccgtgg ttacctgggc acactggtaa tctggtcgac cgccctttca caaacccacc
     2221 tccagcacag tcccctgcat ccaagtgcag cagatgagtt gaccaccctg atcctgacag
     2281 ccactttcga tcctctgatg gaacagtggg ctccatttag agatgactta tatccccggc
     2341 tggaggttct ccaggactct gagtcacagc ctgagattct gtcaccttta caacccccac
     2401 cttgtgggca aacagcttgt gacaatgtgg aactcatctc ccagtacaat aagcatgggc
     2461 cccttcgtag agagaaagtg atccgctacc aggtggtaaa catctatgat gatgagggtc
     2521 tgcatcccat tgtgagtgat catcagatcc gccgtcagca tgaggccctc aaccaggcct
     2581 tcagccgcta caatatcagc tggcagctga gtgtccaccg agtccacaac tccaccctgc
     2641 gccaccgggt tgtgcttgtt aattgtgagc ccagcaagat tggcaatgac cactgtgacc
     2701 ctgaatgtga gcatccactc accggcttcg atgggggcga ttgccgcctg cagggacgct
     2761 gctactcctg gaatcgcagg gatggcctct gtcacgtgga gtgcaacaac atgctgaatg
     2821 acttcgatga tggagactgc tgcgatccgg aagtgactga tgtccgaaag acttgctttg
     2881 atcctgactc acccaagagg gcatacatga gtgtgaagga actaaaggag gccttgcagc
     2941 tcaacagcac tcacttcctt aatgtctact tcgccagctc agtccgggaa gaccttgcag
     3001 gttctgccac atggccctgg gacaaggaag ctctcagtca cctgggtggt gttgtcctca
     3061 acccaaccta ttatggcatg cttggccaca ccaacatcat gatccatgag gtgggacatg
     3121 tcctgggact ctaccatgta ttcaaaggag tcagtgaaag agaatcctgt gatgatccct
     3181 gtagagagac agtgccatcc atggagacag gagacctgtg tgctgacact gctcccacac
     3241 ccaagagcaa gctgtgtcgg gacccagagc cagctaatga cacctgtggc ttcaccctct
     3301 tcccaggggc tccgttcaat aactacatga gctacacaga tgatgagtgc actgacaact
     3361 tcacccctaa ccaagtggcc cggatgcatt gctacttgga cctcgtatac cagcaatgga
     3421 gtgaaagcca aaaacctacc cccataccca taccacccat ggttattggg caaacccaca
     3481 agtcccttac tatccattgg ctgcctccaa tcagtggagt tgtgtatgat agggcccctg
     3541 acagcatgtg tagtgcctgc actgaagatg ggacattccg tcagtatgta tacaaggcat
     3601 cctctgggcg ggtgtgtgac tcttcaggtt actggactcc agaggaggct gtggggcctc
     3661 ctgatgtcga tcaaccctgt gagcctagct tgcaggcctg gagtcctgag ctccacctaa
     3721 accacatgaa tatgaccgtg ccctgcccag cagaaggctg tagcttggag ttgctttttc
     3781 aatacccggt ccaggcggat accctcaccc tctgggtcac ttacctctcc atgaactctt
     3841 ccaaggcatt ctttgacata gagatcttgc tagaacacaa aaaatctatg caccttggac
     3901 ctttaaacac tttttgtgac ataccgctca ccatcaaact ccacatggat gagaaggtca
     3961 tgggagcgaa agtctacacc tttgatgaac gaatggaaat tgatgctgct ctcctgacct
     4021 ctcggcccaa tagttccttg tgttctggat gcaagcctat gagttaccag gttcttcgag
     4081 agcctccttt ttccagtggc ttgcccatgg tggtgacaca tccacacaga aagttcacag
     4141 atacggaggt catccctggg cagatgtatc agtaccaagt tcaagctgaa gctgtagggg
     4201 aactcggaga agcttcacct cctctgagcc acattcacgg aggcccttac tgtggagatg
     4261 ggaaggtaga aaggagtatc ggagagatgt gtgatgatgg agacctgttg aatggagatg
     4321 ggtgctcaag agcatgtgaa ctggaggaag gcttcaattg tgcaggggag ccaagccttt
     4381 gctacaggta tgagggagat ggggtttgtg aagattttga gaaggaaagc atcatcacag
     4441 actgtggcct ccacactcct gaaggatatt tggatcagtg ggctagccag gcttattcct
     4501 accatgaaga caaggagaaa tgtcctgttt ccctggtaac aggagaacct cattcaatga
     4561 tctgtacttc atggcacccg gattcatccc catatcattc ctttcctggc tggtttccct
     4621 gtgtcttcag tctgaagaaa gaccaggatg caggcagtga gcaggctaaa gatagcctgc
     4681 agaaggacaa tgaaatttgg cttgaagtgt gtttcaatag gccaggggtt gcagtggcaa
     4741 tttacatttt cttggcatcg gatggcgtga cccctgggga gcatcagcag gcaacagtga
     4801 ccctttacct gattgatgtc agtggaagca accactctct tggaacctat ggactgtcgt
     4861 gtcaacaaaa tccactggtt atcaatgtga gccatcatgt gaatgtctac ccccaacata
     4921 cctcctccat gctgctgaat ttttcatccc cactggtggg catctcagca gtggctctaa
     4981 ggacatcctc ccagaccagt tcttcagctc ccagtaactg catcccagag caaaattatg
     5041 agggaaagag ctgtgctcaa cgaccttgtg gagaacaggg aagatgtgcg ccattgctac
     5101 tcgatcatac ggacatggtg aattgtacct ccagtagccc aggtcacatg gagtgcgcta
     5161 tcacttgtca aagggggtat gtccttcaga ccagcagtgg gcagtacctg aggaacatgc
     5221 agaaagagat tctccttact tgttcctctg gccactggga caaggatgtg atctgcaagc
     5281 gtcttgactg tggtgtccca gactcctcct tggtgaatta tgcaaacttc tcctgcttgg
     5341 agggtacaga ctttctgaaa caatgttcca tctcgtgtgt cccaccggct aagctccaag
     5401 gactgaaccc atggctgaca tgtcttgaag atggactctg gtctctccct gaagtctact
     5461 gcaagttgga atgtgaagct cctccagtta ttcccaatgc caatctgctc ctgccacatt
     5521 tcctggaagg caaccatgat gtgggcacca tctgcaaata tgagtgcaaa ccaggctact
     5581 atgtgaagga gacttcagga agtcaaggca agaacaagtt cctgaagatc cagtgcctgg
     5641 atgatggaag ctgggaacaa gggagctgcg tccccgtggt ttgtgagcct cctcctccgg
     5701 tgtttgaagg catgtacgaa tgtactgatg gcttcaagct ggacagccag tgtgtgctca
     5761 actgtaacca ggaaacggaa gggattccca tcctctgcac taaagagggg ttgtggaccc
     5821 aggaattcaa gttgtgtgaa aacctgcaag gagaatgccc accacccacc tcagagctga
     5881 attctgtgga gtacaagtgt ggacagggat atgggatcgg tgcagtgtgc tccccatcat
     5941 gtgtaatccc ccctagtgac cctgtgatac taccagagaa tgtgactact gacactttgg
     6001 agcactggat ggaacctgtc aaagtccaga gtatcgtgtg taccggcagg cgccagtggc
     6061 acccagatcc ctctctggtg cactgcatcc agtcatgtga gcctttccaa gcagatggtt
     6121 ggtgtgacac tattaataac cgggcctact gcaactatga cgggggagac tgctgctctt
     6181 ccacactctc ttccaagaag gtcattccat ttgctgctga ttgtgacttg gatgaatgca
     6241 cctgtcgaga ccccaaggca gaagaaaacc agtaactcta ggagcagagc ccatctcctc
     6301 tgccctgggg gcagactaaa agagaagctc ccgtagcagg atgcaaaggg tgaatgaaca
     6361 agataggttc catggtggaa ggagagccta aaagagagcc tttaagaaat gcaagaaatg
     6421 tttgtaggtg ccaattaatg cattaagtag tccaagtagg gagggattag aggcaattgt
     6481 ttctgtaaaa agacacttgg ttagaaatgg aaggagaaat tgacagaccc ctccccccat
     6541 ctgtactctg ctctatcctt ctctcaatct cctccccact ctgcacgctg tcagtggctc
     6601 agccccaccc aacatgtaaa cccatatcaa aatattagaa gataagctgc cagggactcc
     6661 gtcaataccc atttcagatg gactgtcatc tttcagggct catctattcc agactggccc
     6721 tttgccttcc ttttgtgtgg tctctctcaa ataaggaggt tagctatttc tttataagta
     6781 tttaaacata attatataaa tatattatat attatatttt ttgctgttta ctaagctaca
     6841 gattatccat tgttccacaa atgctgctgt gaagttcatg tccagaggga tactgaagct
     6901 tcgaagacag aaagaaaggt tcctttgcct tcttcccata gatagggatt ggcaggtcgg
     6961 atggggagaa gagagtcgat ggaattctgg atgctagcct gtcagctgat catcatttta
     7021 tgacctggga gctgggccta ctgaaaggag atagacttgg catgctaaga gcaagaggca
     7081 tggaaagtta catgggaacc tatttggcag taggtccagg agaaatagac aatggtttct
     7141 aagtatctac caaaaggagc atacaaactc ttctacgctt ctcagaactc tcagttggag
     7201 ctggtaaaga ccagggtctt ttccacttct ccatgtactt agtccaagta tagctgccag
     7261 ccagccaacc aaccagccag ccagccagcc agccagccag ccagccaacc agccagccaa
     7321 aaagtttgta tgagggctca ttctgtgaac atcaggctta caggaactta caccctcttc
     7381 atacttggcc agttgctgtc tctccttgtt gcaagtctca aggtctggcc aattgttcac
     7441 agccacatca ctaactgttg atttttctga gaaaagaaaa tgctttggag atttggaaat
     7501 gtgggggagg agataagaga tgaaagaacg gggagttaga agagcgaaag gctgtcagag
     7561 aggtgaaagg tcagagaggt gagaggtcaa gattaaatga ggtctgagga taaaaggata
     7621 gaatgagtga acaagcccct gatccaagtc tccaaaagag gccagggatc cttcgagcaa
     7681 agagataaat cttattcaag tgcaaaatct gaagtttgtg gcccagtaag caacatgtgg
     7741 agcgagggtg acactctgtg gggagaaaga agaatttcaa ctatttaggg tccatgctct
     7801 ctttaccatt tcttgttcaa tagctgtatg gactatgcac aaaacagtca cattaacact
     7861 tctctgttta tccagactat tctcatactt ttctataggc tctgtccttg gtatgttttc
     7921 ttatagcagt ttctagatca cacctagaaa gagagtcagg acatagtttc tttcctttaa
     7981 tgacggtctt gttctcttac agagacccta gttttttcct ccagtggaaa ctaagaccaa
     8041 gcaaaacttg gagtcacttt tggtatctcc aaaacctctc ctcctcttcc ttctactctt
     8101 ttgtcatcaa gactgaagca actaatctat agaatgagaa aggaaacttt tttttatcat
     8161 cataagcaca attatccctg ctctatatga agagcaatat tctgcagtga ctggatatgg
     8221 caatatacat acagttacct atgaatatgt ggatcatgga caacaaagcc attgagaagg
     8281 ggaaaggcag tgttagtctt ctactcctag caataaggta aacagtgctt aaatactgtt
     8341 tactatctag gtcacactta ttaccctttg tcaggaaata ccattcatat tctgaatctc
     8401 ataagtttaa tatggaaaga aaaatagaaa agtttaggtt ctctactaca tatttcaatt
     8461 cctatttctg tatctcatta aggtgagtat gaaaagacca atagaaaaat ttaaattctc
     8521 tactaaacac acacacacac acacacacac acacacacac acactgtttc cttagagaac
     8581 attcaaattc ctggatgtgt gtcaactttt gccttaggaa aatcctgaca gagacagagc
     8641 aatagttacc ttgggcacaa cttagtgcac agagactgcc attcccaaga gcactcatgg
     8701 gcacagacta cccaccagta tctgtccatg ctcagtctcc tcattaagtc cactaagact
     8761 aacagagacc ccatgcttca ctttaagata ctttgttctt tttggcaaca ttcaccctgc
     8821 cctgggaagg caagaggaca gtttctgggg tgtgtgtaaa gctccccagg ctgaaggcca
     8881 tttagccatc atcagccaga gacagagacg ggagtcttat ctagactttg tcccttggct
     8941 ccagtatttg aagaaactta agtccctaat aaagaaaatg atcagagatc ctaggaacaa
     9001 gtcatgtttg cccccaggtg gttgtattca gttctcctta gacatccata atgtcatcca
     9061 gggccctcca cagaggctcc tctgcctgtt tctttattac aaagttacct gtctatttct
     9121 agttcctggt aaccacagtt ttgagatcaa catggcccaa aggtggctgg cttcaatagt
     9181 agcatggcag ccttcaatca cagatacaga aaagagatca gcaggggcaa agagcagatc
     9241 tgggcaaata aggcagcgag tagagtcttc ttggttcttt tctttccttt ccaacattta
     9301 aggccttagt ctttgacaca tcatctattc tgtgtgatca ccattgagtg tgtcagttag
     9361 cacccaaggg gacagtttga tggcaaacac agtgaaaggg gctgatctac tgtattgtaa
     9421 tgtaaaacag ctacatccag ttattttata agattataaa acgttcatta aaaaatcagc
     9481 acataaaata tgaa
//
