LOCUS       NP_001078845            1789 aa            linear   ROD 28-JAN-2025
DEFINITION  pappalysin-2 precursor [Mus musculus].
ACCESSION   NP_001078845 XP_355248
VERSION     NP_001078845.1
DBSOURCE    REFSEQ: accession NM_001085376.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1789)
  AUTHORS   Basu,S., Mautner,L., Whiting,K., Hasenpusch-Theil,K., Borkowska,M.
            and Theil,T.
  TITLE     Identification of Pappa and Sall3 as Gli3 direct target genes
            acting downstream of cilia signaling in corticogenesis
  JOURNAL   Cereb Cortex 34 (12) (2024)
   PUBMED   39716738
REFERENCE   2  (residues 1 to 1789)
  AUTHORS   Wang,J., Noguchi,S., Takizawa,T., Negishi,Y., Morita,R., Luo,S.S.
            and Takizawa,T.
  TITLE     Placenta-specific lncRNA 1600012P17Rik is expressed in
            spongiotrophoblast and glycogen trophoblast cells of mouse placenta
  JOURNAL   Histochem Cell Biol 158 (1), 65-78 (2022)
   PUBMED   35486179
REFERENCE   3  (residues 1 to 1789)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1789)
  AUTHORS   Rubio,L., Vargas,A., Rivera,P., Lopez-Gambero,A.J., Tovar,R.,
            Christians,J.K., Martin-de-Las-Heras,S., Rodriguez de Fonseca,F.,
            Chowen,J.A., Argente,J. and Suarez,J.
  TITLE     Recombinant IGF-1 Induces Sex-Specific Changes in Bone Composition
            and Remodeling in Adult Mice with Pappa2 Deficiency
  JOURNAL   Int J Mol Sci 22 (8), 4048 (2021)
   PUBMED   33919940
  REMARK    GeneRIF: Recombinant IGF-1 Induces Sex-Specific Changes in Bone
            Composition and Remodeling in Adult Mice with Pappa2 Deficiency.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1789)
  AUTHORS   Lloyd,K.A., Parsons,B.N., Burkitt,M.D., Moore,A.R.,
            Papoutsopoulou,S., Boyce,M., Duckworth,C.A., Exarchou,K., Howes,N.,
            Rainbow,L., Fang,Y., Oxvig,C., Dodd,S., Varro,A., Hall,N. and
            Pritchard,D.M.
  TITLE     Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric
            Neuroendocrine Tumors
  JOURNAL   Cell Mol Gastroenterol Hepatol 10 (1), 113-132 (2020)
   PUBMED   32004755
  REMARK    GeneRIF: Netazepide Inhibits Expression of Pappalysin 2 in Type 1
            Gastric Neuroendocrine Tumors.
REFERENCE   6  (residues 1 to 1789)
  AUTHORS   Christians,J.K., Hoeflich,A. and Keightley,P.D.
  TITLE     PAPPA2, an enzyme that cleaves an insulin-like
            growth-factor-binding protein, is a candidate gene for a
            quantitative trait locus affecting body size in mice
  JOURNAL   Genetics 173 (3), 1547-1553 (2006)
   PUBMED   16702428
  REMARK    GeneRIF: The refinement of the target region to four genes and the
            finding that the QTL affects IGFBP-5 levels suggest that PAPPA2 may
            be involved with normal postnatal growth
REFERENCE   7  (residues 1 to 1789)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   8  (residues 1 to 1789)
  AUTHORS   Veal,E., Groisman,R., Eisenstein,M. and Gill,G.
  TITLE     The secreted glycoprotein CREG enhances differentiation of NTERA-2
            human embryonal carcinoma cells
  JOURNAL   Oncogene 19 (17), 2120-2128 (2000)
   PUBMED   10815803
REFERENCE   9  (residues 1 to 1789)
  AUTHORS   Veal,E., Eisenstein,M., Tseng,Z.H. and Gill,G.
  TITLE     A cellular repressor of E1A-stimulated genes that inhibits
            activation by E2F
  JOURNAL   Mol Cell Biol 18 (9), 5032-5041 (1998)
   PUBMED   9710587
REFERENCE   10 (residues 1 to 1789)
  AUTHORS   Rougeon,F., Chambraud,B., Foote,S., Panthier,J.J., Nageotte,R. and
            Corvol,P.
  TITLE     Molecular cloning of a mouse submaxillary gland renin cDNA fragment
  JOURNAL   Proc Natl Acad Sci U S A 78 (10), 6367-6371 (1981)
   PUBMED   6171818
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162173.4, AC115116.6 and AC158910.3.
            
            On Apr 25, 2007 this sequence version replaced XP_355248.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164134
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1789
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 68.49 cM"
     Protein         1..1789
                     /product="pappalysin-2 precursor"
                     /note="pregnancy-associated plasma preproprotein-A2;
                     placenta-specific 3; pregnancy-associated plasma
                     protein-E"
                     /calculated_mol_wt=196537
     sig_peptide     1..20
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2307
     Region          283..440
                     /region_name="Laminin_G_3"
                     /note="Concanavalin A-like lectin/glucanases superfamily;
                     pfam13385"
                     /db_xref="CDD:463865"
     Region          <586..613
                     /region_name="Notch"
                     /note="LNR domain; cl02419"
                     /db_xref="CDD:470573"
     Region          635..832
                     /region_name="ZnMc_pappalysin_like"
                     /note="Zinc-dependent metalloprotease, pappalysin_like
                     subfamily. The pregnancy-associated plasma protein A
                     (PAPP-A or pappalysin-1) cleaves insulin-like growth
                     factor-binding proteins 4 and 5, thereby promoting cell
                     growth by releasing bound growth factor; cd04275"
                     /db_xref="CDD:239802"
     Site            order(734..735,738,744)
                     /site_type="active"
                     /db_xref="CDD:239802"
     Region          1113..1152
                     /region_name="myxo_disulf_rpt"
                     /note="Myxococcus cysteine-rich repeat; TIGR02232"
                     /db_xref="CDD:200169"
     Region          1523..1586
                     /region_name="Sushi"
                     /note="Sushi repeat (SCR repeat); pfam00084"
                     /db_xref="CDD:459664"
     Region          1720..1756
                     /region_name="NL"
                     /note="Domain found in Notch and Lin-12; smart00004"
                     /db_xref="CDD:197463"
     CDS             1..1789
                     /gene="Pappa2"
                     /gene_synonym="PAPP-A2; Pappe; PLAC3"
                     /coded_by="NM_001085376.3:393..5762"
                     /db_xref="CCDS:CCDS48409.1"
                     /db_xref="GeneID:23850"
                     /db_xref="MGI:MGI:3051647"
ORIGIN      
        1 mmcwkvlris lvvltgwals ttnseqgwtr kkflaqkehl nqvllegerc wlgykvrrpr
       61 tapqhhlfgv ypsrlenypr sypvgtqqqt lyaewsqrsp erqapsgipr dltenpagar
      121 resqqpaapw vgdgpigqsq llrnddtylg eggskealge paiqgsseia vstiatfayq
      181 kgptaetqrk gqsksrlprq vqkrqaedmt gdpqntpqgf qlwpkeplkh gdsdsplegt
      241 iqngggaslr rvetfnsqgg lpvlyftgkr erlllrpevl aeipreaftv eawvrpeggq
      301 snpaiiagvf dncshtvndk gwalgirsgk dkgwrdarff fslrtdrmkk ativtghsry
      361 qpgmwthvaa tydgqhtaly vdgtrvassr dqfgplnspf mascrslilg gdssedghyf
      421 rgylgtlviw stalsqthlq hsplhpsaad elttliltat fdplmeqwap frddlyprle
      481 vlqdsesqpe ilsplqpppc gqtacdnvel isqynkhgpl rrekviryqv vniyddeglh
      541 pivsdhqirr qhealnqafs ryniswqlsv hrvhnstlrh rvvlvnceps kigndhcdpe
      601 cehpltgfdg gdcrlqgrcy swnrrdglch vecnnmlndf ddgdccdpev tdvrktcfdp
      661 dspkraymsv kelkealqln sthflnvyfa ssvredlags atwpwdkeal shlggvvlnp
      721 tyygmlghtn imihevghvl glyhvfkgvs erescddpcr etvpsmetgd lcadtaptpk
      781 sklcrdpepa ndtcgftlfp gapfnnymsy tddectdnft pnqvarmhcy ldlvyqqwse
      841 sqkptpipip pmvigqthks ltihwlppis gvvydrapds mcsactedgt frqyvykass
      901 grvcdssgyw tpeeavgppd vdqpcepslq awspelhlnh mnmtvpcpae gcslellfqy
      961 pvqadtltlw vtylsmnssk affdieille hkksmhlgpl ntfcdiplti klhmdekvmg
     1021 akvytfderm eidaalltsr pnsslcsgck pmsyqvlrep pfssglpmvv thphrkftdt
     1081 evipgqmyqy qvqaeavgel geaspplshi hggpycgdgk versigemcd dgdllngdgc
     1141 sraceleegf ncagepslcy ryegdgvced fekesiitdc glhtpegyld qwasqaysyh
     1201 edkekcpvsl vtgephsmic tswhpdsspy hsfpgwfpcv fslkkdqdag seqakdslqk
     1261 dneiwlevcf nrpgvavaiy iflasdgvtp gehqqatvtl ylidvsgsnh slgtyglscq
     1321 qnplvinvsh hvnvypqhts smllnfsspl vgisavalrt ssqtsssaps ncipeqnyeg
     1381 kscaqrpcge qgrcapllld htdmvnctss spghmecait cqrgyvlqts sgqylrnmqk
     1441 eilltcssgh wdkdvickrl dcgvpdsslv nyanfscleg tdflkqcsis cvppaklqgl
     1501 npwltcledg lwslpevyck leceappvip nanlllphfl egnhdvgtic kyeckpgyyv
     1561 ketsgsqgkn kflkiqcldd gsweqgscvp vvceppppvf egmyectdgf kldsqcvlnc
     1621 nqetegipil ctkeglwtqe fklcenlqge cppptselns veykcgqgyg igavcspscv
     1681 ippsdpvilp envttdtleh wmepvkvqsi vctgrrqwhp dpslvhciqs cepfqadgwc
     1741 dtinnraycn ydggdccsst lsskkvipfa adcdldectc rdpkaeenq
//
