LOCUS       NM_130887               4309 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus papilin, proteoglycan-like sulfated glycoprotein
            (Papln), transcript variant 2, mRNA.
ACCESSION   NM_130887
VERSION     NM_130887.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4309)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4309)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 4309)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   4  (bases 1 to 4309)
  AUTHORS   Du,J., Takeuchi,H., Leonhard-Melief,C., Shroyer,K.R., Dlugosz,M.,
            Haltiwanger,R.S. and Holdener,B.C.
  TITLE     O-fucosylation of thrombospondin type 1 repeats restricts
            epithelial to mesenchymal transition (EMT) and maintains epiblast
            pluripotency during mouse gastrulation
  JOURNAL   Dev Biol 346 (1), 25-38 (2010)
   PUBMED   20637190
REFERENCE   5  (bases 1 to 4309)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 4309)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
REFERENCE   7  (bases 1 to 4309)
  AUTHORS   Desai,J., Shannon,M.E., Johnson,M.D., Ruff,D.W., Hughes,L.A.,
            Kerley,M.K., Carpenter,D.A., Johnson,D.K., Rinchik,E.M. and
            Culiat,C.T.
  TITLE     Nell1-deficient mice have reduced expression of extracellular
            matrix proteins causing cranial and vertebral defects
  JOURNAL   Hum Mol Genet 15 (8), 1329-1341 (2006)
   PUBMED   16537572
REFERENCE   8  (bases 1 to 4309)
  AUTHORS   Kramerova,I.A., Kawaguchi,N., Fessler,L.I., Nelson,R.E., Chen,Y.,
            Kramerov,A.A., Kusche-Gullberg,M., Kramer,J.M., Ackley,B.D.,
            Sieron,A.L., Prockop,D.J. and Fessler,J.H.
  TITLE     Papilin in development; a pericellular protein with a homology to
            the ADAMTS metalloproteinases
  JOURNAL   Development 127 (24), 5475-5485 (2000)
   PUBMED   11076767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132954.4 and BC132475.1.
            
            On Apr 19, 2011 this sequence version replaced NM_130887.2.
            
            Transcript Variant: This variant (2) lacks an exon in the coding
            region but maintains the reading frame, compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF314171.1, BC137854.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC132954.4         121917-121976       c
            61-4081             BC132475.1         1-4021
            4082-4309           AC132954.4         93226-93453         c
FEATURES             Location/Qualifiers
     source          1..4309
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 38.87 cM"
     gene            1..4309
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /note="papilin, proteoglycan-like sulfated glycoprotein"
                     /db_xref="GeneID:170721"
                     /db_xref="MGI:MGI:2386139"
     exon            1..83
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            84..146
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..3932
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="papilin isoform 2 precursor"
                     /protein_id="NP_570957.2"
                     /db_xref="CCDS:CCDS26031.1"
                     /db_xref="GeneID:170721"
                     /db_xref="MGI:MGI:2386139"
                     /translation="MQLFPLLFSLLLTSTPGSWARNVRRQSDTWGTWGEWSPCSRTCG
                     GGISFRERPCYSQRRDGGTSCVGPARSHRTCHTESCPDGVRDFRAEQCAEFDGTDFQG
                     RRYRWLPYYAAPNKCELNCIPKGQNFYYKHKDAVVDGTPCEPGQRDICVDGVCRVVGC
                     DHKLDSIKQEDKCLQCGGDGSSCYPVTGTFDGNDLSRGYNQIFIIPAGATSIRIEEAA
                     ASRNFLAVKSIRGEYYLNGHWTIEAAQALPVASTVLQYERGVEGDLAPERLQARGPTS
                     EPLVIELLSQESNPGVHYEYYLPANDPGRGFSWSHGSWGDCSAECGGGHQSRLVFCTI
                     DNEAYPDHMCQHQPRPTHRRSCNTQPCPKTKRWKVGPWTPCSVSCGGGVQSRSVYCIS
                     SDGTGGQEAAEETQCAGLVGKPPTTQACNLQHCAVWSVEPWGECSVTCGTGIRKRSVT
                     CRGDEGSPVHAAACLLKDQPTLTEPCVQEACPVFRGQAWHVGSWSLCSKSCGSGIRRR
                     QVVCTIGPPGRCVDLQSSKPAEMEACNRQPCHLPQEVPSIQDPRTRSSDPRMLSGPRV
                     SPVSDGREQQWAPLERPRAQSNPREGQDPNLSSAGRAPTLQRPPHQPPLRPSSGPRDC
                     RHSPHGCCPDGHTPSLGPQWQGCPLAGASCLQSRYGCCPDGVSAAEGPQQAGCTRSHG
                     SDNTGNRPGSRAVASKNPKIHQPQAHEGEPSECRSSRFGCCYDNVASAAGPLGEGCVG
                     QPSYAYPVRCLLPSAQGSCGDWAARWYFVASVGRCNRFWYGGCHGNANNFASEQECMN
                     TCRGQHGPRRPEAGAAGHRAHVDGGQRGPGGQQEPDWHRAGATIPRLPSPSGSPWRRE
                     QEPAPGEPPHIPAYGNRPGGQEIRPRVPGLDREARPAVPPTHSPSYRIRLAGSEPSLV
                     QAAPGQAVQLFCPGNIPSEFQAGWQKEGRPISSNRYQLQADGSLIISRLRPEDAGIYS
                     CGSHRPGHEPQEIQLRVTGGDMAVFPEGQPRHFPEPRNPDLGHGPPHRGTGAEAGGHR
                     VLSPSHPRPATRLRLDRTQPGVVDASPGQRIRLTCRAEGFPVPTIEWQRDGQLVSSPR
                     HQVQPDGSLVISRVDVEDGGYYSCVAFNGQDRDQRWVQLRVLRELTITGLPPAVTVAE
                     GDTARLLCVVAGESVNIRWSRNGLPIQADGHRVHQSPDGTLLIHNLRPRDEGSYTCSA
                     FRGSQAVSRSTEVKVALPAPAAQSRDLGKDCIDQPELANCALILQAQLCGNEYYSSFC
                     CASCSRFQPNAQPVWQQG"
     exon            147..262
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            263..323
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            324..426
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            427..557
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            558..681
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            682..762
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            763..935
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1059
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1186
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1394
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1577
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1719
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1800
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..2062
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2183
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2322
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2797
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2935
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3060
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3061..3214
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3215..3352
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3480
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3589
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3590..3756
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..4309
                     /gene="Papln"
                     /gene_synonym="E030033C16Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctttcgta gtcggtgctg gagaagttga cagttgaccc aggctgggca ccgataaggc
       61 ggctccaggg cttcaagaga caggcagaga tgcagctgtt ccctctcctg ttctcgctgc
      121 tgctgacctc cactccaggg tcttgggctc gaaatgtgag gcgccagagt gacacctggg
      181 gcacctgggg cgaatggagc ccctgcagca ggacctgtgg aggaggcatc agcttccggg
      241 agcgcccctg ctactcccag aggagagacg gaggcaccag ctgcgtgggc cccgcgcgca
      301 gccaccgcac ctgccacacg gagagctgcc cagacggcgt gcgggacttc cgggccgagc
      361 agtgtgcaga gttcgacggc accgacttcc agggtcggcg ctaccggtgg ctgccctact
      421 acgcagcccc taataagtgt gagctgaact gcattcccaa ggggcagaac ttctactaca
      481 aacacaagga cgccgtggtg gatgggacac cctgtgagcc tggccagcgg gacatctgtg
      541 tggacggagt ctgccgagtg gttggctgtg atcacaagct agactcaatc aagcaggagg
      601 acaagtgtct gcagtgtggg ggtgatggct catcctgcta cccggtcaca ggaacctttg
      661 atggcaatga tctcagcaga ggctacaacc aaatcttcat cattccggct ggggccacta
      721 gtattcgcat tgaggaagcc gctgccagca ggaatttcct ggccgtgaag agcatccgtg
      781 gcgagtacta tctcaatggg cactggacca ttgaggcagc ccaggctctt ccggtggcca
      841 gcacagtcct acagtacgaa cggggtgtgg agggggacct ggctcctgag cggctccagg
      901 cacggggccc cacctcagag cccctggtca tcgagctcct cagtcaggag tccaaccccg
      961 gagtacacta cgagtactac ctgcccgcga atgatcctgg ccgaggcttc agctggagcc
     1021 atggctcctg gggagactgc agcgctgagt gtggtggagg tcaccagtcc cgcctggtat
     1081 tctgcactat tgacaacgag gcctatccag accacatgtg ccaacaccag cctcggccca
     1141 cccaccgacg ttcatgcaac actcaacctt gtccgaagac caagcgctgg aaggtaggcc
     1201 catggacgcc ctgctcggtc tcctgcgggg gtggagtcca gtctcgctct gtctactgca
     1261 tatcctcaga tgggactggt ggccaggaag ctgctgagga gacccagtgt gctggcctag
     1321 ttgggaaacc ccctaccaca caggcttgca acctgcagca ctgtgcagtc tggagcgtgg
     1381 agccctgggg agagtgctca gttacatgcg ggactggcat caggaagagg agtgtcacct
     1441 gccgagggga cgaggggtct ccggtccatg ctgcagcgtg cttgttgaag gaccagccaa
     1501 ccctcacgga gccctgtgta caagaggcct gccctgtgtt ccgtggccag gcctggcatg
     1561 ttggctcatg gagtctatgc tctaaaagct gtggttccgg cattcggaga aggcaggttg
     1621 tttgtaccat cgggccgcct ggtcgttgtg tggacctgca gtcgtccaag cctgccgaga
     1681 tggaagcctg caacagacag ccctgccatc ttcctcagga ggtccctagt atacaggacc
     1741 caaggacccg ctcctcagac cccaggatgc tttcaggccc tcgagtgtcc ccagtctcag
     1801 atggaagaga gcagcagtgg gctcccctcg agagacccag ggctcagagc aaccccagag
     1861 agggtcaaga ccccaacctg tcatctgcag gccgggcccc aactctgcag cgtcctccac
     1921 accagccacc cctgaggcct agctcagggc cccgtgactg cagacacagc ccccatgggt
     1981 gctgccctga tggccacaca ccatctcttg ggcctcagtg gcaaggctgt cccctggctg
     2041 gggcctcatg tcttcagagc aggtacggat gctgccccga cggggtgtct gcagctgagg
     2101 ggccccaaca ggctggttgt accaggtctc acggcagtga caatacggga aacaggccag
     2161 ggtccagggc agtagcttcc aagaacccca agatccacca accccaggcc catgaaggcg
     2221 agcccagtga gtgtcgaagc tctaggtttg gatgttgcta tgacaatgtg gcttctgcag
     2281 cgggtccgct gggggaaggc tgtgtgggcc agcccagcta tgcttaccca gtgcggtgtc
     2341 tgctgcccag tgctcaaggg tcatgtggag actgggccgc ccgttggtac tttgtggcat
     2401 cggtgggccg gtgtaaccgc ttttggtatg gcggctgtca tggcaacgcc aataactttg
     2461 catcggagca ggagtgcatg aacacctgcc ggggacagca tgggccccgc cgtcctgagg
     2521 caggagccgc tgggcatcgt gcccatgtgg atggtggtca acgtggtcct ggaggccagc
     2581 aggaacctga ctggcacagg gcaggagcca caatcccgag actgccctcc ccttctggaa
     2641 gcccttggcg gagagaacaa gagcctgcgc caggggagcc accccacatc ccagcctatg
     2701 gaaaccggcc tggaggccag gaaatccggc ccagagttcc tggactggac agagaggcta
     2761 ggccagcagt gccgcctaca catagcccct cctacaggat ccgattggca ggctcggaac
     2821 cctccctggt acaggcagct ccagggcagg cggtacaact cttttgccct ggcaacatcc
     2881 cctcggaatt ccaggcaggg tggcagaaag agggccggcc catctcctct aacaggtacc
     2941 agctccaggc agatggctcc ctcatcatca gccgcttgag gccggaggat gctggcatct
     3001 atagctgtgg cagccacagg ccaggccatg agccccagga gatacagctt cgagtcacag
     3061 ggggtgacat ggcagtgttt cctgagggcc agccgaggca tttccctgag cccaggaacc
     3121 cagaccttgg ccatggtcct ccgcaccgtg gaacaggagc agaagcgggg ggccacaggg
     3181 tcctctctcc ctcacacccc aggcctgcca ccaggttacg tctggaccgg actcagcctg
     3241 gagtggtaga tgccagtcct ggccagcgga tccggctgac ctgccgtgct gaaggcttcc
     3301 cggtccctac catcgagtgg caaagagatg ggcagctggt ctcttctccc aggcaccagg
     3361 tgcagcctga tggctctctg gtcatcagcc gagtggatgt ggaagatggg ggctactaca
     3421 gctgtgttgc ttttaatggg caggaccgag accagcgctg ggtccagctc agagttctca
     3481 gggagctgac aatcacaggc ctgcctcctg ctgtgaccgt ggcagagggt gacactgcca
     3541 ggcttctgtg tgtggtggct ggagaaagtg tgaacatccg gtggtccagg aatggcctgc
     3601 caatacaggc cgacggtcac cgtgtgcacc agtccccaga tggcacactg ttgatccaca
     3661 acttgcggcc cagggacgag ggctcttaca catgcagtgc cttccgtggg agccaggctg
     3721 tgagtcgcag caccgaggtg aaggtggccc tcccagcgcc agccgcacag tccagggacc
     3781 taggcaagga ctgcatcgac cagccggagc tggccaactg tgcgttgatc ctgcaggccc
     3841 agctctgtgg caatgaatat tactccagct tctgctgtgc cagctgctcc cgcttccagc
     3901 caaatgccca gcctgtgtgg cagcagggat gaaggctggc tgtggcgcca ggtctggata
     3961 gtttgctggg gagaagggat ggtaagacat ggcttgcaga gggagtcgtc tttcagatcc
     4021 tgcccctctc agaaatccag ggttgagccc cagcagctgc cagtgccggc ttcccttgta
     4081 gtgctcagca gggtctgtct gatatgacca caggctgctg tgaagaagag gaacccttta
     4141 cacctcccct ctatagtatc tactgcaccg aggacctttt atctgaaatg ctttggacca
     4201 aagtgtttta agctattaag tatttgtaga ctttactaat tgaacgtccc taacctaaag
     4261 ttctgaaatg ctccgaagct tcaaagaccc aatcgccatg tcagctttc
//
