LOCUS       NM_172454               2518 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus pannexin 3 (Panx3), mRNA.
ACCESSION   NM_172454
VERSION     NM_172454.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2518)
  AUTHORS   Feng,Y.H., Tang,R.J., Zhang,Y.Y., Lin,J., Liu,Y.J., Li,Y.K.,
            Li,C.J., Zhou,C., Liu,F. and Shen,J.F.
  TITLE     Contribution of inwardly rectifying potassium channel 4.1 in
            orofacial neuropathic pain: Regulation of pannexin 3 via the
            reactive oxygen species-activated P38 MAPK signal pathway
  JOURNAL   Eur J Neurosci 60 (4), 4569-4585 (2024)
   PUBMED   38992988
  REMARK    GeneRIF: Contribution of inwardly rectifying potassium channel 4.1
            in orofacial neuropathic pain: Regulation of pannexin 3 via the
            reactive oxygen species-activated P38 MAPK signal pathway.
REFERENCE   2  (bases 1 to 2518)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2518)
  AUTHORS   Ishikawa,M., Hasanali,Z.S., Zhao,Y., Das,A., Lavaert,M.,
            Roman,C.J., Londregan,J., Allman,D. and Bhandoola,A.
  TITLE     Bone marrow plasma cells require P2RX4 to sense extracellular ATP
  JOURNAL   Nature 626 (8001), 1102-1107 (2024)
   PUBMED   38355795
REFERENCE   4  (bases 1 to 2518)
  AUTHORS   Wolpe,A.G., Luse,M.A., Baryiames,C., Schug,W.J., Wolpe,J.B.,
            Johnstone,S.R., Dunaway,L.S., Juskiewicz,Z.J., Loeb,S.A., Askew
            Page,H.R., Chen,Y.L., Sabapathy,V., Pavelec,C.M., Wakefield,B.,
            Cifuentes-Pagano,E., Artamonov,M.V., Somlyo,A.V., Straub,A.C.,
            Sharma,R., Beier,F., Barrett,E.J., Leitinger,N., Pagano,P.J.,
            Sonkusare,S.K., Redemann,S., Columbus,L., Penuela,S. and
            Isakson,B.E.
  TITLE     Pannexin-3 stabilizes the transcription factor Bcl6 in a
            channel-independent manner to protect against vascular oxidative
            stress
  JOURNAL   Sci Signal 17 (821), eadg2622 (2024)
   PUBMED   38289985
  REMARK    GeneRIF: Pannexin-3 stabilizes the transcription factor Bcl6 in a
            channel-independent manner to protect against vascular oxidative
            stress.
REFERENCE   5  (bases 1 to 2518)
  AUTHORS   Fu,Y., Miyazaki,K., Chiba,Y., Funada,K., Yuta,T., Tian,T.,
            Mizuta,K., Kawahara,J., Zhang,L., Martin,D., Iwamoto,T.,
            Takahashi,I., Fukumoto,S. and Yoshizaki,K.
  TITLE     Identification of GPI-anchored protein LYPD1 as an essential factor
            for odontoblast differentiation in tooth development
  JOURNAL   J Biol Chem 299 (5), 104638 (2023)
   PUBMED   36963497
REFERENCE   6  (bases 1 to 2518)
  AUTHORS   Penuela,S., Bhalla,R., Nag,K. and Laird,D.W.
  TITLE     Glycosylation regulates pannexin intermixing and cellular
            localization
  JOURNAL   Mol Biol Cell 20 (20), 4313-4323 (2009)
   PUBMED   19692571
  REMARK    GeneRIF: Panx1 can interact with Panx3 in a glycosylation-dependent
            manner. Panx3 can traffic to the cell surface and form functional
            single-membrane channels.
REFERENCE   7  (bases 1 to 2518)
  AUTHORS   Wang,X.H., Streeter,M., Liu,Y.P. and Zhao,H.B.
  TITLE     Identification and characterization of pannexin expression in the
            mammalian cochlea
  JOURNAL   J Comp Neurol 512 (3), 336-346 (2009)
   PUBMED   19009624
  REMARK    GeneRIF: Results show that pannexins 1, 2, and 3 are abundantly
            expressed in the mouse and rat cochlea and demonstrate distinct
            cellular distributions.
            Erratum:[J Comp Neurol. 2010 Apr 1;518(7):1156. Dosage error in
            article text]
REFERENCE   8  (bases 1 to 2518)
  AUTHORS   Penuela,S., Celetti,S.J., Bhalla,R., Shao,Q. and Laird,D.W.
  TITLE     Diverse subcellular distribution profiles of pannexin 1 and
            pannexin 3
  JOURNAL   Cell Commun Adhes 15 (1), 133-142 (2008)
   PUBMED   18649185
  REMARK    GeneRIF: Collectively, diverse expression and distribution profiles
            of Panx1 and Panx3 suggest that they may have multiple cellular
            functions.
REFERENCE   9  (bases 1 to 2518)
  AUTHORS   Penuela,S., Bhalla,R., Gong,X.Q., Cowan,K.N., Celetti,S.J.,
            Cowan,B.J., Bai,D., Shao,Q. and Laird,D.W.
  TITLE     Pannexin 1 and pannexin 3 are glycoproteins that exhibit many
            distinct characteristics from the connexin family of gap junction
            proteins
  JOURNAL   J Cell Sci 120 (Pt 21), 3772-3783 (2007)
   PUBMED   17925379
  REMARK    GeneRIF: These studies show that Panx1 and Panx3 have many
            characteristics that are distinct from Cx43 and that these proteins
            probably play an important biological role as single membrane
            channels.
REFERENCE   10 (bases 1 to 2518)
  AUTHORS   Baranova,A., Ivanov,D., Petrash,N., Pestova,A., Skoblov,M.,
            Kelmanson,I., Shagin,D., Nazarenko,S., Geraymovych,E., Litvin,O.,
            Tiunova,A., Born,T.L., Usman,N., Staroverov,D., Lukyanov,S. and
            Panchin,Y.
  TITLE     The mammalian pannexin family is homologous to the invertebrate
            innexin gap junction proteins
  JOURNAL   Genomics 83 (4), 706-716 (2004)
   PUBMED   15028292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB849008.1, AK036933.1 and AK028288.1.
            
            On Feb 1, 2006 this sequence version replaced NM_172454.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036933.1, AK028288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BB849008.1         15-58
            45-739              AK036933.1         1-695
            740-742             AK028288.1         707-709
            743-2518            AK036933.1         699-2474
FEATURES             Location/Qualifiers
     source          1..2518
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.79 cM"
     gene            1..2518
                     /gene="Panx3"
                     /gene_synonym="3230401P04; 4833413G11Rik"
                     /note="pannexin 3"
                     /db_xref="GeneID:208098"
                     /db_xref="MGI:MGI:1918881"
     exon            1..348
                     /gene="Panx3"
                     /gene_synonym="3230401P04; 4833413G11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..1346
                     /gene="Panx3"
                     /gene_synonym="3230401P04; 4833413G11Rik"
                     /codon_start=1
                     /product="pannexin-3"
                     /protein_id="NP_766042.2"
                     /db_xref="CCDS:CCDS22984.1"
                     /db_xref="GeneID:208098"
                     /db_xref="MGI:MGI:1918881"
                     /translation="MSLAHTAAEYMLSDALLPDRRGSRLKGLRLELPLDKMVKFITVG
                     FPLLLMSLAFAQEFSSGSPISCFSPSNFSVRQAAYVDSSCWDSLAHHTQDKAGQYKVK
                     SLWPHKALPYSLLALAVAMYLPVLLWQYVAVPSLSSDLLFIISELDKSYNRSIRLVQH
                     MLQIRQSSSDPHVFWDELEKARKERYFEFPLLERYLECKQRSHWLVATYLLRNALLLL
                     FTSATYLYLGQFHLDVFFQDEFNCFIKTGLLHDETHVPELITCRLTSLSVFQIVSVSS
                     AAIYTILVPVIIYNLTRLCRWDKGLLSIYEMLPAFDLLSRKMLGCPINDLNVILLFLR
                     ANISELISFSWLSVLSVLKDTTTQKHNIDTVVDFMTFVAGLEPSKPKHLTQHTYDEHA
                     "
     exon            349..491
                     /gene="Panx3"
                     /gene_synonym="3230401P04; 4833413G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            492..706
                     /gene="Panx3"
                     /gene_synonym="3230401P04; 4833413G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            707..2518
                     /gene="Panx3"
                     /gene_synonym="3230401P04; 4833413G11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2332..2337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Panx3"
                     /gene_synonym="3230401P04; 4833413G11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2352
                     /gene="Panx3"
                     /gene_synonym="3230401P04; 4833413G11Rik"
                     /note="major polyA site"
ORIGIN      
        1 agatatgtag agaaccattt cttggtccta gcacagagat gtgaggctgg tgctgggaca
       61 ctctccgctg aaaactagct gcctgaagct gtcactccac tgtacctgga tcgcttaggg
      121 tagcattttc ctctgtatcc ccccaagtcc ccattctcag cagcatcatg tcgctcgcac
      181 acactgctgc agagtacatg ctctctgatg ccctgctgcc tgaccgcagg ggctctcggc
      241 tcaaaggact gcgcctggaa ctgcccctgg ataagatggt caagttcatt actgtgggct
      301 ttcccttgct gctgatgtct ctagctttcg cccaggagtt ctcatcaggg tctccgatca
      361 gctgtttctc tcccagcaac ttcagtgtca ggcaggctgc atacgtggat agctcatgct
      421 gggactcgct ggctcaccat acgcaggaca aggctggcca gtacaaggtg aaatctctct
      481 ggcctcacaa ggctcttccc tactctctac tggctctggc tgtggccatg tatctgccag
      541 tgttgctgtg gcaatatgta gctgtgccct ccctcagctc tgacctgctg ttcatcatca
      601 gtgagctgga caagtcttac aaccgttcca tccgcctggt gcagcacatg ttgcagatcc
      661 ggcagagcag ctctgacccc catgtcttct gggatgagct agagaaggcc cggaaggaac
      721 ggtactttga atttcccttg ctagagcggt acctggaatg caagcagcgc tcccattggc
      781 tagtggccac ctacctcctg aggaacgccc tcttactcct ctttacctca gccacttacc
      841 tgtaccttgg ccaattccat ttagatgtct tctttcaaga cgaatttaac tgcttcatca
      901 agacagggct gctacatgat gagacccatg tgccagagct gatcacatgc aggctgacct
      961 ccctgtctgt attccagatt gtgagtgtct ccagtgcagc aatatacacc atattggtcc
     1021 cagtgataat atacaacctc acacggctat gtcggtggga caaaggactc ctatccatct
     1081 atgagatgct cccagctttt gatctcctca gtagaaagat gctaggatgc cccatcaatg
     1141 acctcaatgt gattcttctt ttcctccgag ctaatatctc tgagctcatc tcttttagct
     1201 ggctgagtgt cttaagtgtg ttgaaggata caaccaccca gaaacacaac atcgacacag
     1261 tggttgactt tatgaccttt gtggctggct tagaaccctc aaaacctaaa catctcaccc
     1321 aacatacata tgatgaacac gcatagttta aaaaaagaaa cacagataag ttttatagaa
     1381 agtaactctc cttcttcaca agctatgcag agtaaaagac agaaaaataa taaggatgtc
     1441 cacgtaaaat ggttaagaga ttggattcag ctgaaatatc ctgtattttt aagaagataa
     1501 aaatcaacac atgaaaattc agtgtgaagt ctgggagtca agagtcaaag aactgaaaag
     1561 ttcagtttag aacattcaga ggacagtagt gctaaaggaa caagctgaag caaagtgcaa
     1621 ttattgaact cagaaaaatt ctaaaggcca tttatggagg gaaattctca caaggcccac
     1681 ccgctctaga agtcatgctt cccttcccac aatgggcagg gtagaacaat ttaataagag
     1741 attaataagg atatgaaccc ctgaaactct ttgatttggc ctgcccatct tgctttgtgg
     1801 acattttcag ccttgccaag cactctatag cctgctaatg agacaagaaa taatgatggc
     1861 tttaacttgt aatctgcttt tgggacataa ggacagagac aaagccataa gttgaatctt
     1921 taggagtcca atacgctttt tatgatataa actgaggatt cttttccacg agggctcaga
     1981 ttatggacta tgaacacctt ctaaaatctt aatgaagcct aggtgtattc ctaatagtcc
     2041 aaagcatact acagccaacc agtgaaggtc aggaggtgaa aaggctgctg ccaagcctga
     2101 atacctgatt tcaatgcctg ggacccaaat ggtgaaagga tagaaccgat tctccaagtt
     2161 accttctgat ctccatacac aagaaaagta aacaaaggag tattaacatg caagtcccat
     2221 cgatccactt ctatacattc tccattcact gtttcctcct ggcatctaat tgtcacagct
     2281 tagctctgat tcaaaagacg gtgctctatc cccagtaccc tcgtgactct taataaatat
     2341 ttttaaactg tatattatgt atttcttgag agaatttttt tatacaagtc atttagatcc
     2401 ctcttcatat aggtaataga aaagtcaggt tgcttctgac aaattcatgt caattgccat
     2461 aaagcaagcc aagagcttat agatgttcac agatgacatt aataaaagtt tcatgtca
//
