LOCUS       NM_001002005            3434 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pannexin 2 (Panx2), mRNA.
ACCESSION   NM_001002005
VERSION     NM_001002005.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3434)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3434)
  AUTHORS   Sanchez-Pupo,R.E., O'Donnell,B.L., Johnston,D., Gyenis,L.,
            Litchfield,D.W. and Penuela,S.
  TITLE     Pannexin 2 is expressed in murine skin and promotes UVB-induced
            apoptosis of keratinocytes
  JOURNAL   Mol Biol Cell 33 (3), ar24 (2022)
   PUBMED   34985913
  REMARK    GeneRIF: Pannexin 2 is expressed in murine skin and promotes
            UVB-induced apoptosis of keratinocytes.
REFERENCE   3  (bases 1 to 3434)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   4  (bases 1 to 3434)
  AUTHORS   Berchtold,L.A., Miani,M., Diep,T.A., Madsen,A.N., Cigliola,V.,
            Colli,M., Krivokapic,J.M., Pociot,F., Eizirik,D.L., Meda,P.,
            Holst,B., Billestrup,N. and Storling,J.
  TITLE     Pannexin-2-deficiency sensitizes pancreatic beta-cells to
            cytokine-induced apoptosis in vitro and impairs glucose tolerance
            in vivo
  JOURNAL   Mol Cell Endocrinol 448, 108-121 (2017)
   PUBMED   28390953
  REMARK    GeneRIF: Panx2 is an important regulator of the insulin secretory
            capacity and apoptosis in pancreatic beta-cells.
REFERENCE   5  (bases 1 to 3434)
  AUTHORS   Wang,S., Chennupati,R., Kaur,H., Iring,A., Wettschureck,N. and
            Offermanns,S.
  TITLE     Endothelial cation channel PIEZO1 controls blood pressure by
            mediating flow-induced ATP release
  JOURNAL   J Clin Invest 126 (12), 4527-4536 (2016)
   PUBMED   27797339
REFERENCE   6  (bases 1 to 3434)
  AUTHORS   Tang,W., Ahmad,S., Shestopalov,V.I. and Lin,X.
  TITLE     Pannexins are new molecular candidates for assembling gap junctions
            in the cochlea
  JOURNAL   Neuroreport 19 (13), 1253-1257 (2008)
   PUBMED   18695503
  REMARK    GeneRIF: Data show that Panx2 is expressed in the spiral and
            Scarpa's ganglion neurons.
REFERENCE   7  (bases 1 to 3434)
  AUTHORS   Dvoriantchikova,G., Ivanov,D., Pestova,A. and Shestopalov,V.
  TITLE     Molecular characterization of pannexins in the lens
  JOURNAL   Mol Vis 12, 1417-1426 (2006)
   PUBMED   17149368
  REMARK    GeneRIF: Despite similarity in detergent solubility of pannexins
            and connexins, the lack of spatial co-localization in the lens
            membranes suggested a distinct, non-redundant to connexin function
            for these proteins in the lens cell membrane.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3434)
  AUTHORS   Dvoriantchikova,G., Ivanov,D., Panchin,Y. and Shestopalov,V.I.
  TITLE     Expression of pannexin family of proteins in the retina
  JOURNAL   FEBS Lett 580 (9), 2178-2182 (2006)
   PUBMED   16616526
  REMARK    GeneRIF: Panx1 and Panx2 are abundantly expressed in the retina,
            and may therefore contribute to the electrical and metabolic
            coupling, or to signaling between retinal neurons
REFERENCE   9  (bases 1 to 3434)
  AUTHORS   Vogt,A., Hormuzdi,S.G. and Monyer,H.
  TITLE     Pannexin1 and Pannexin2 expression in the developing and mature rat
            brain
  JOURNAL   Brain Res Mol Brain Res 141 (1), 113-120 (2005)
   PUBMED   16143426
  REMARK    GeneRIF: Results reveal a widespread and similar mRNA distribution
            for both pannexin 1 and 2, but indicate that they are inversely
            regulated during the development of the rat brain.
REFERENCE   10 (bases 1 to 3434)
  AUTHORS   Baranova,A., Ivanov,D., Petrash,N., Pestova,A., Skoblov,M.,
            Kelmanson,I., Shagin,D., Nazarenko,S., Geraymovych,E., Litvin,O.,
            Tiunova,A., Born,T.L., Usman,N., Staroverov,D., Lukyanov,S. and
            Panchin,Y.
  TITLE     The mammalian pannexin family is homologous to the invertebrate
            innexin gap junction proteins
  JOURNAL   Genomics 83 (4), 706-716 (2004)
   PUBMED   15028292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ062100.1, BY727115.1, DQ093579.1 and BM942843.1.
            
            On Dec 21, 2007 this sequence version replaced NM_001002005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ093579.1, SRR7974084.21558.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               CJ062100.1         2-287
            287-378             BY727115.1         191-282             c
            379-3409            DQ093579.1         1-3031
            3410-3434           BM942843.1         453-477
FEATURES             Location/Qualifiers
     source          1..3434
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.57 cM"
     gene            1..3434
                     /gene="Panx2"
                     /note="pannexin 2"
                     /db_xref="GeneID:406218"
                     /db_xref="MGI:MGI:1890615"
     exon            1..574
                     /gene="Panx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..2382
                     /gene="Panx2"
                     /codon_start=1
                     /product="pannexin-2"
                     /protein_id="NP_001002005.2"
                     /db_xref="CCDS:CCDS49695.1"
                     /db_xref="GeneID:406218"
                     /db_xref="MGI:MGI:1890615"
                     /translation="MHHLLEQSADMATALLAGEKLRELILPGSQDDKAGALAALLLQL
                     KLELPFDRVVTIGTVLVPILLVTLVFTKNFAEEPIYCYTPHNFTRDQALYARGYCWTE
                     LRDALPGVDASLWPSLFEHKFLPYALLAFAAIMYVPALGWEFLASTRLTSELNFLLQE
                     IDNCYHRAAEGRAPKIEKQIQSKGPGITEREKREIIENAEKEKSPEQNLFEKYLERRG
                     RSNFLAKLYLARHVLILLLSVVPISYLCTYYATQKQNEFTCALGASPDGPVGSAGPTV
                     RVSCKLPSVQLQRIIAGVDIVLLCFMNLIILVNLIHLFIFRKSNFIFDKLNKVGIKTR
                     RQWRRSQFCDINILAMFCNENRDHIKSLNRLDFITNESDLMYDNVVRQLLAALAQSNH
                     DTTPTVRDSGIQTVDPSINPAEPDGSAEPPVVKRPRKKMKWIPTSNPLPQPFKEQLAI
                     MRVENSKTEKPKPVRRKTATDTLIAPLLDAGARAAHHYKGSGGDSGPSSAPPAASEKK
                     HTRHFSLDVHPYILGTKKAKTEAVPPALPASRSQEGGFLSQTEECGLGLAAAPTKDAP
                     LPEKEIPYPTEPALPGLPSGGSFHVCSPPAAPAAASLSPGSLGKADPLTILSRNATHP
                     LLHISTLYEAREEEEGGPCAPSDMGDLLSIPPPQQILIATFEEPRTVVSTVEF"
     exon            575..2038
                     /gene="Panx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..3412
                     /gene="Panx2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3390..3395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Panx2"
                     /note="hexamer: AATAAA"
     polyA_site      3409
                     /gene="Panx2"
                     /note="major polyA site"
ORIGIN      
        1 gccacgccgc ggagttgccg caggtaaaca gcccccctcc ccggcgggag cgggccgcgc
       61 ggcccaggca ggagagccgc cgccgccccc gggagggacg cagggcgcgg gccggctaca
      121 gcgcacggcg ggggcggcgg cggcccggcg ccctggcagc tcgacccctc tcgcggggcg
      181 gcagaccccc gagccccgcc gcatccccgc tgacatccct cttccagcgc tccgcgcccc
      241 ccccccccac cgtgacctcg gtctccgtcg ccccccgccg ccctctctgg cgcgcggccc
      301 cgcccgcgcc ccccgcccgt accccgccgg gccgcgcccc cgccccccat gcaccacctc
      361 ctggagcagt cggcggacat ggcgaccgcg ctgctggcgg gcgagaagct gagggagctg
      421 atcctgcctg gctcgcagga cgacaaggcg ggcgcgctgg ccgcgctgct gctgcagctc
      481 aagctggaac tgccgttcga ccgcgtggtc accatcggca ccgtgctggt acccatcctg
      541 ctggtcaccc tggtcttcac caagaacttc gcagaggaac caatttactg ttatactccg
      601 cacaacttca cccgtgatca ggcgctgtac gcccgcggct actgctggac agagctgcgg
      661 gacgcgctgc ccggcgtgga tgccagcctc tggccatcgt tgtttgagca caagttcctg
      721 ccctacgcgc tgctggcctt tgccgccatc atgtatgtgc ccgcgctggg ctgggagttc
      781 ctcgcctcca cgcgcctcac ctcggagctc aacttccttc ttcaggagat cgacaactgc
      841 taccaccgag cggccgaagg tcgcgcaccc aagattgaga agcagatcca gtccaagggg
      901 cccggcatca cggagcgcga gaagcgagag atcattgaga acgccgagaa ggagaagagc
      961 ccggagcaga atctgtttga gaagtacctg gaacgccggg gccgcagcaa cttcctggcc
     1021 aagctgtact tggcacggca cgtcctgatc ctgctgctca gcgtggtgcc catctcctac
     1081 ctatgcacat actacgccac ccagaagcag aacgagttca cctgtgccct gggcgcctca
     1141 cctgacgggc cggtgggtag cgctgggccc acggtgcgcg tcagctgtaa gctaccgtct
     1201 gtgcagctgc agcggatcat tgcaggtgtg gacatcgtct tgctctgctt catgaacctc
     1261 atcatcctag tcaacctcat ccacctcttc atcttccgca agagcaactt catcttcgac
     1321 aaactaaaca aggtgggtat caagacgcgc cggcagtggc gccgctcgca gttctgcgac
     1381 atcaacatcc tggccatgtt ctgtaacgag aaccgcgacc acatcaagtc gctgaaccgg
     1441 ctggacttca tcaccaacga gagcgacctc atgtacgaca atgtggtgcg gcagcttctg
     1501 gctgccttgg ctcagtctaa ccacgacacc acgcccactg tgcgggactc tggcatccag
     1561 accgtggacc ccagcatcaa ccctgcggag cctgatggtt ctgctgagcc acccgtggtc
     1621 aagcggcccc gtaagaaaat gaagtggatc cccaccagca acccgctgcc acagcccttc
     1681 aaggagcagc tggccattat gcgcgtggaa aacagcaaga ctgagaagcc caagcccgtg
     1741 cgcaggaaga cagccacaga cacacttatt gccccgctgc tggacgctgg tgcccgtgct
     1801 gcccaccact acaagggcag tggaggtgat tcaggcccct cctctgcccc gcctgctgcc
     1861 tctgagaaaa agcatacccg ccacttctcc ttggacgtgc atccctatat cctaggtacc
     1921 aagaaggcca agactgaggc ggtaccccct gccctaccag cctcccgcag ccaagaaggt
     1981 ggcttcctgt cccagacaga ggaatgtggg ctgggcctag ctgcagcacc caccaaagat
     2041 gctccactcc ccgagaagga aatcccgtac cccacagagc ctgccctgcc agggctccca
     2101 tctgggggat cattccatgt ctgctcaccc cccgcagccc ccgccgctgc ttccctgtca
     2161 ccaggcagtc tgggcaaggc tgaccctctc accatcctga gccggaacgc cactcacccc
     2221 ctgctccaca tcagcacgct gtatgaggcc cgggaagagg aggaaggagg cccctgtgcc
     2281 ccctcagaca tgggcgacct cctcagcata cccccgcccc agcagatcct catcgccacc
     2341 ttcgaggagc cgagaacagt tgtgagtact gtggagtttt gaggggcagg gcctcccagg
     2401 ccaccaaaaa ctctctgcat gagccaggga tggcccagct gagcctaggc ttgggtagga
     2461 tcgaactctg ttcacccggt actgcccaca cacaccccag cctcctgtct gcatgccacg
     2521 gggcccagca ccccttccac ctggctcacc atggcatcca caagtgcagg ctggggcttg
     2581 ggtgcaaggt gggatagggt gcccacccca gcaccaggcg cctccacagt gtgctgctgg
     2641 gctgaaagat gaagaaaagt ttattttttt tagtgggttt ggttgtgggc tgacacaact
     2701 cagcataccc agttgggccc agcctagggg aagtgaggaa ggtgctgggg aaggtggcac
     2761 tggcctcagg acagaccccc aggggtcact cacttaaggg acctgatgcc ttgggggcgg
     2821 gggggaaccg agggctgccc caggtccgaa tcaacatgca ctttctccgc gtagcctgac
     2881 acacacttta tttttcctat gattactgta agtgctgagc ttatttatca tcaggagaat
     2941 gagggtgcat ttaaaccaga ggatgatgtg tgtgagtggc ctgagcagag gcggatgtaa
     3001 aaagtgccaa gtgagcaggt gtgggtacaa gcacctgcct gagtgattga gtttgccaga
     3061 gaggtgcagt gcccgtgtgc aagtaagctc gcgaacaagc agggggcaaa tgtgttgtga
     3121 gtgagcctga gtatgtgtga gtgtgcgagc gaacgaacga gcgagcgagc gagcgagcgg
     3181 cacccatgtg agcagtgggc gagagcaggc gtaggccagg gtgcagacga gggaaagaat
     3241 acaacgcaat aaccacaccc ccttcccccg ggtccccagc tgctggctgg accgcttccc
     3301 gtgggagtcc aggccccact ggccccgccc ctattacctc agccacgcgc cacgtgacga
     3361 agtattaaca aggtagcact gagcatatca ataaatacta ttctgataac tcaaaaaaaa
     3421 aaaaaaaaaa aaaa
//
