LOCUS       NP_001002005             677 aa            linear   ROD 26-MAR-2025
DEFINITION  pannexin-2 [Mus musculus].
ACCESSION   NP_001002005
VERSION     NP_001002005.2
DBSOURCE    REFSEQ: accession NM_001002005.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 677)
  AUTHORS   Abdel Wadood,N., Hollenhorst,M.I., Elhawy,M.I., Zhao,N.,
            Englisch,C., Evers,S.B., Sabachvili,M., Maxeiner,S., Wyatt,A.,
            Herr,C., Burkhart,A.K., Krause,E., Yildiz,D., Beckmann,A.,
            Kusumakshi,S., Riethmacher,D., Bischoff,M., Iden,S., Becker,S.L.,
            Canning,B.J., Flockerzi,V., Gudermann,T., Chubanov,V., Bals,R.,
            Meier,C., Boehm,U. and Krasteva-Christ,G.
  TITLE     Tracheal tuft cells release ATP and link innate to adaptive
            immunity in pneumonia
  JOURNAL   Nat Commun 16 (1), 584 (2025)
   PUBMED   39794305
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 677)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 677)
  AUTHORS   Sanchez-Pupo,R.E., O'Donnell,B.L., Johnston,D., Gyenis,L.,
            Litchfield,D.W. and Penuela,S.
  TITLE     Pannexin 2 is expressed in murine skin and promotes UVB-induced
            apoptosis of keratinocytes
  JOURNAL   Mol Biol Cell 33 (3), ar24 (2022)
   PUBMED   34985913
  REMARK    GeneRIF: Pannexin 2 is expressed in murine skin and promotes
            UVB-induced apoptosis of keratinocytes.
REFERENCE   4  (residues 1 to 677)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   5  (residues 1 to 677)
  AUTHORS   Berchtold,L.A., Miani,M., Diep,T.A., Madsen,A.N., Cigliola,V.,
            Colli,M., Krivokapic,J.M., Pociot,F., Eizirik,D.L., Meda,P.,
            Holst,B., Billestrup,N. and Storling,J.
  TITLE     Pannexin-2-deficiency sensitizes pancreatic beta-cells to
            cytokine-induced apoptosis in vitro and impairs glucose tolerance
            in vivo
  JOURNAL   Mol Cell Endocrinol 448, 108-121 (2017)
   PUBMED   28390953
  REMARK    GeneRIF: Panx2 is an important regulator of the insulin secretory
            capacity and apoptosis in pancreatic beta-cells.
REFERENCE   6  (residues 1 to 677)
  AUTHORS   Tang,W., Ahmad,S., Shestopalov,V.I. and Lin,X.
  TITLE     Pannexins are new molecular candidates for assembling gap junctions
            in the cochlea
  JOURNAL   Neuroreport 19 (13), 1253-1257 (2008)
   PUBMED   18695503
  REMARK    GeneRIF: Data show that Panx2 is expressed in the spiral and
            Scarpa's ganglion neurons.
REFERENCE   7  (residues 1 to 677)
  AUTHORS   Dvoriantchikova,G., Ivanov,D., Pestova,A. and Shestopalov,V.
  TITLE     Molecular characterization of pannexins in the lens
  JOURNAL   Mol Vis 12, 1417-1426 (2006)
   PUBMED   17149368
  REMARK    GeneRIF: Despite similarity in detergent solubility of pannexins
            and connexins, the lack of spatial co-localization in the lens
            membranes suggested a distinct, non-redundant to connexin function
            for these proteins in the lens cell membrane.
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 677)
  AUTHORS   Dvoriantchikova,G., Ivanov,D., Panchin,Y. and Shestopalov,V.I.
  TITLE     Expression of pannexin family of proteins in the retina
  JOURNAL   FEBS Lett 580 (9), 2178-2182 (2006)
   PUBMED   16616526
  REMARK    GeneRIF: Panx1 and Panx2 are abundantly expressed in the retina,
            and may therefore contribute to the electrical and metabolic
            coupling, or to signaling between retinal neurons
REFERENCE   9  (residues 1 to 677)
  AUTHORS   Vogt,A., Hormuzdi,S.G. and Monyer,H.
  TITLE     Pannexin1 and Pannexin2 expression in the developing and mature rat
            brain
  JOURNAL   Brain Res Mol Brain Res 141 (1), 113-120 (2005)
   PUBMED   16143426
  REMARK    GeneRIF: Results reveal a widespread and similar mRNA distribution
            for both pannexin 1 and 2, but indicate that they are inversely
            regulated during the development of the rat brain.
REFERENCE   10 (residues 1 to 677)
  AUTHORS   Baranova,A., Ivanov,D., Petrash,N., Pestova,A., Skoblov,M.,
            Kelmanson,I., Shagin,D., Nazarenko,S., Geraymovych,E., Litvin,O.,
            Tiunova,A., Born,T.L., Usman,N., Staroverov,D., Lukyanov,S. and
            Panchin,Y.
  TITLE     The mammalian pannexin family is homologous to the invertebrate
            innexin gap junction proteins
  JOURNAL   Genomics 83 (4), 706-716 (2004)
   PUBMED   15028292
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ062100.1, BY727115.1, DQ093579.1 and BM942843.1.
            
            On Dec 21, 2007 this sequence version replaced NP_001002005.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ093579.1, SRR7974084.21558.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.57 cM"
     Protein         1..677
                     /product="pannexin-2"
                     /calculated_mol_wt=74483
     Site            54..74
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IMP4.2)"
     Region          58..>150
                     /region_name="Innexin"
                     /note="cl03000"
                     /db_xref="CDD:470716"
     Site            86
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q6IMP4.2)"
     Site            126..146
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IMP4.2)"
     Site            231..251
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IMP4.2)"
     Site            296..316
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IMP4.2)"
     Region          394..425
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IMP4.2)"
     Site            416
                     /site_type="cleavage"
                     /note="Cleavage, by CASP3 or CASP7.
                     /evidence=ECO:0000269|PubMed:34985913; propagated from
                     UniProtKB/Swiss-Prot (Q6IMP4.2)"
     Region          485..512
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6IMP4.2)"
     Site            593
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6IMP4.2)"
     Site            604
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6IMP4.2)"
     CDS             1..677
                     /gene="Panx2"
                     /coded_by="NM_001002005.2:349..2382"
                     /db_xref="CCDS:CCDS49695.1"
                     /db_xref="GeneID:406218"
                     /db_xref="MGI:MGI:1890615"
ORIGIN      
        1 mhhlleqsad matallagek lrelilpgsq ddkagalaal llqlklelpf drvvtigtvl
       61 vpillvtlvf tknfaeepiy cytphnftrd qalyargycw telrdalpgv daslwpslfe
      121 hkflpyalla faaimyvpal gweflastrl tselnfllqe idncyhraae grapkiekqi
      181 qskgpgiter ekreiienae kekspeqnlf ekylerrgrs nflaklylar hvlilllsvv
      241 pisylctyya tqkqneftca lgaspdgpvg sagptvrvsc klpsvqlqri iagvdivllc
      301 fmnliilvnl ihlfifrksn fifdklnkvg iktrrqwrrs qfcdinilam fcnenrdhik
      361 slnrldfitn esdlmydnvv rqllaalaqs nhdttptvrd sgiqtvdpsi npaepdgsae
      421 ppvvkrprkk mkwiptsnpl pqpfkeqlai mrvensktek pkpvrrktat dtliapllda
      481 garaahhykg sggdsgpssa ppaasekkht rhfsldvhpy ilgtkkakte avppalpasr
      541 sqeggflsqt eecglglaaa ptkdaplpek eipyptepal pglpsggsfh vcsppaapaa
      601 aslspgslgk adpltilsrn athpllhist lyeareeeeg gpcapsdmgd llsipppqqi
      661 liatfeeprt vvstvef
//
