LOCUS       NM_019482               2112 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus pannexin 1 (Panx1), mRNA.
ACCESSION   NM_019482
VERSION     NM_019482.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2112)
  AUTHORS   Molica,F., Ehrlich,A., Pelli,G., Rusiecka,O.M., Montessuit,C.,
            Chanson,M. and Kwak,B.R.
  TITLE     Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1-/- Mice
  JOURNAL   Biomolecules 14 (9), 1058 (2024)
   PUBMED   39334824
  REMARK    GeneRIF: Cold Exposure Rejuvenates the Metabolic Phenotype of
            Panx1[-/-] Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2112)
  AUTHORS   Ehrlich,A., Pelli,G., Pick,R., Clochard,L., Molica,F. and Kwak,B.R.
  TITLE     Pannexin1 deletion in lymphatic endothelium affects lymphatic
            function in a sex-dependent manner
  JOURNAL   Physiol Rep 12 (15), e16170 (2024)
   PUBMED   39085909
  REMARK    GeneRIF: Pannexin1 deletion in lymphatic endothelium affects
            lymphatic function in a sex-dependent manner.
REFERENCE   3  (bases 1 to 2112)
  AUTHORS   Kwok,C.H.T., Harding,E.K., Burma,N.E., Markovic,T., Massaly,N., van
            den Hoogen,N.J., Stokes-Heck,S., Gambeta,E., Komarek,K., Yoon,H.J.,
            Navis,K.E., McAllister,B.B., Canet-Pons,J., Fan,C., Dalgarno,R.,
            Gorobets,E., Papatzimas,J.W., Zhang,Z., Kohro,Y., Anderson,C.L.,
            Thompson,R.J., Derksen,D.J., Moron,J.A., Zamponi,G.W. and Trang,T.
  TITLE     Pannexin-1 channel inhibition alleviates opioid withdrawal in
            rodents by modulating locus coeruleus to spinal cord circuitry
  JOURNAL   Nat Commun 15 (1), 6264 (2024)
   PUBMED   39048565
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2112)
  AUTHORS   Vardam-Kaur,T., Banuelos,A., Gabaldon-Parish,M., Macedo,B.G.,
            Salgado,C.L., Wanhainen,K.M., Zhou,M.H., van Dijk,S.,
            Santiago-Carvalho,I., Beniwal,A.S., Leff,C.L., Peng,C., Tran,N.L.,
            Jameson,S.C. and Borges da Silva,H.
  TITLE     The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector
            and memory responses
  JOURNAL   iScience 27 (7), 110290 (2024)
   PUBMED   39045105
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2112)
  AUTHORS   Obot,P., Cibelli,A., Pan,J., Velisek,L., Veliskova,J. and Scemes,E.
  TITLE     Pannexin1 Mediates Early-Life Seizure-Induced Social Behavior
            Deficits
  JOURNAL   ASN Neuro 16 (1), 2371164 (2024)
   PUBMED   39024558
  REMARK    GeneRIF: Pannexin1 Mediates Early-Life Seizure-Induced Social
            Behavior Deficits.
REFERENCE   6  (bases 1 to 2112)
  AUTHORS   Ray,A., Zoidl,G., Weickert,S., Wahle,P. and Dermietzel,R.
  TITLE     Site-specific and developmental expression of pannexin1 in the
            mouse nervous system
  JOURNAL   Eur J Neurosci 21 (12), 3277-3290 (2005)
   PUBMED   16026466
  REMARK    GeneRIF: The Panx1 expresses in the brain, retina and other
            non-neuronal tissues. In the cortex, cerebellum and eye, Panx1 is
            expressed at early embryonic time points and peaks around embryonic
            day 18 followed by a decline towards adulthood.
REFERENCE   7  (bases 1 to 2112)
  AUTHORS   Weickert,S., Ray,A., Zoidl,G. and Dermietzel,R.
  TITLE     Expression of neural connexins and pannexin1 in the hippocampus and
            inferior olive: a quantitative approach
  JOURNAL   Brain Res Mol Brain Res 133 (1), 102-109 (2005)
   PUBMED   15661370
  REMARK    GeneRIF: Expression of pannexin1 in the hippocampus and inferior
            olive.
REFERENCE   8  (bases 1 to 2112)
  AUTHORS   Baranova,A., Ivanov,D., Petrash,N., Pestova,A., Skoblov,M.,
            Kelmanson,I., Shagin,D., Nazarenko,S., Geraymovych,E., Litvin,O.,
            Tiunova,A., Born,T.L., Usman,N., Staroverov,D., Lukyanov,S. and
            Panchin,Y.
  TITLE     The mammalian pannexin family is homologous to the invertebrate
            innexin gap junction proteins
  JOURNAL   Genomics 83 (4), 706-716 (2004)
   PUBMED   15028292
REFERENCE   9  (bases 1 to 2112)
  AUTHORS   Bruzzone,R., Hormuzdi,S.G., Barbe,M.T., Herb,A. and Monyer,H.
  TITLE     Pannexins, a family of gap junction proteins expressed in brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13644-13649 (2003)
   PUBMED   14597722
  REMARK    GeneRIF: the different expression patterns of Px1 and Px2 in the
            brain indicate that pannexins form cell type-specific gap junctions
            with distinct properties that may subserve different functions
            [pannexin 2]
REFERENCE   10 (bases 1 to 2112)
  AUTHORS   Panchin,Y., Kelmanson,I., Matz,M., Lukyanov,K., Usman,N. and
            Lukyanov,S.
  TITLE     A ubiquitous family of putative gap junction molecules
  JOURNAL   Curr Biol 10 (13), R473-R474 (2000)
   PUBMED   10898987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049074.1.
            
            On Feb 1, 2006 this sequence version replaced NM_019482.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049074.1, AK053871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2112
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.52 cM"
     gene            1..2112
                     /gene="Panx1"
                     /note="pannexin 1"
                     /db_xref="GeneID:55991"
                     /db_xref="MGI:MGI:1860055"
     exon            1..622
                     /gene="Panx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             442..1722
                     /gene="Panx1"
                     /codon_start=1
                     /product="pannexin-1"
                     /protein_id="NP_062355.2"
                     /db_xref="CCDS:CCDS22832.1"
                     /db_xref="GeneID:55991"
                     /db_xref="MGI:MGI:1860055"
                     /translation="MAIAHLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVG
                     LPLLLISLAFAQEISIGTQISCFSPSSFSWRQAAFVDSYCWAAVQQKSSLQSESGNLP
                     LWLHKFFPYILLLFAILLYLPALFWRFSAAPHLCSDLKFIMEELDKVYNRAIKAAKSA
                     RDLDLRDGPGPPGVTENVGQSLWEISESHFKYPIVEQYLKTKKNSSHLIMKYISCRLV
                     TFVVILLACIYLSYYFSLSSLSDEFLCSIKSGVLKNDSTIPDRFQCKLIAVGIFQLLS
                     LINLIVYALLIPVVVYTFFIPFRQKTDILKVYEILPTFDVLHFKSEGYNDLSLYNLFL
                     EENISELKSYKCLKVLENIKSNGQGIDPMLLLTNLGMIKMDIIDGKIPTSLQTKGEDQ
                     GSQRVEFKDLDLSSEAAANNGEKNSRQRLLNPSC"
     exon            623..762
                     /gene="Panx1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..983
                     /gene="Panx1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1642
                     /gene="Panx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..2075
                     /gene="Panx1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2050..2055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Panx1"
                     /note="hexamer: AATAAA"
     polyA_site      2075
                     /gene="Panx1"
                     /note="major polyA site"
ORIGIN      
        1 cccgcgtagg ttccggaaga gctcggttct gtagccgagc gcgcagggcg ggcgcgggca
       61 gctgtagcga agagctttgt tcccggcacg ttgttgcccc tgcgcgctcg gagtggccgg
      121 agggagtcct ggtgtcgcgc gcgccgggcc cgcgggggct tagcacggga gtgattgcta
      181 ccgccggagc tccggggctc gtgcaccctg cgttgcttgg ggcggtccca ggcagctgca
      241 gctcccgtgc ggtccctgcg gggtaggtgc agcgacagcc aaggcggtac aatgctgggc
      301 ccgcccggga gcccgggaag ggaaagcgga agccgcgcgc ccggtcggtg accgcgcgga
      361 ttcggcgtct cgccccggct gccggcagca ccggcgcctg ccctcggctg cccgtcccgc
      421 ggcacccggt gcgccttgac catggccatc gcccacttgg ccacggagta tgtgttctcg
      481 gacttcttgc tgaaggagcc caccgagccc aagttcaagg ggctgcgact ggagctggcg
      541 gtggacaaga tggtcacatg tattgccgtg ggtctacctc tgctgctcat ctcgctggcc
      601 ttcgctcagg agatctccat cggtacccag ataagctgct tctccccgag ttctttctcc
      661 tggcgacagg ctgcctttgt ggattcatac tgctgggctg ctgtacagca gaagagctcc
      721 ctgcagagcg agtctggaaa cctcccactg tggctgcaca agttcttccc ctacatccta
      781 ctgctgtttg ccatactcct gtacctgccc gcactcttct ggcgcttctc tgcagctcca
      841 cacctctgct cagacctgaa gtttatcatg gaggaacttg acaaagtcta caaccgcgcc
      901 atcaaggctg ccaagagtgc tcgagatttg gacctaagag acggacctgg acccccagga
      961 gtgactgaga atgtggggca gagtctgtgg gagatatctg aaagccactt caagtaccca
     1021 atcgtggagc agtacttgaa gacaaaaaag aactctagtc atttaatcat gaaatacatt
     1081 agctgccggc tggtgacatt tgtggttata ctgttggcat gtatctactt gagctattac
     1141 ttcagcctct cttcactctc ggacgagttt ctgtgcagca tcaaatcagg cgtcctgaaa
     1201 aatgacagca ccatccccga tcgcttccag tgcaagctca tcgccgtggg catcttccag
     1261 ctgctcagcc tcattaacct cattgtgtat gctctgctga ttcccgtggt cgtctacacg
     1321 ttcttcatcc cattccggca gaaaacggac attctcaaag tgtatgaaat cctgcccacc
     1381 ttcgatgttc tacatttcaa gtctgaaggc tacaatgact tgagcctcta caaccttttt
     1441 ctggaagaga acataagtga gctcaaatcg tacaagtgtc tgaaggtgct ggagaacatt
     1501 aaaagcaatg ggcagggcat tgaccccatg ctactcctga caaacctggg catgattaag
     1561 atggacatca ttgatggaaa aattcccacg tccctacaga ccaagggaga ggaccagggc
     1621 agccagagag tggagttcaa agatttggac ctgagcagcg aggctgcagc aaacaatggg
     1681 gagaagaact ctcgccagag gcttctgaat ccgtcctgct aatggtttcc ttcttgaatt
     1741 tcaagcctgt gacttctgtg gctgacgcac ccctgttgga tctgtagtta gtttgcagta
     1801 gatgtttttg gtattgatgt agtgtgtgtc ctaccaatct ctaatagaca taatggccaa
     1861 cagcgtcata gaagaataga ttagaaacgt cccacaagag taagtgtgct ttgtgtgaag
     1921 tcctcattgc agggctgtta agagcacaga gcctcagcca cagaggagca gcattctgga
     1981 ctggcaggtg ctagaggacc tggggcttct agagagcaag cacatggaag atgctttgtt
     2041 ttgtgaggta ataaacatgt gaggatgaaa cttaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2101 aaaaaaaaaa aa
//
