LOCUS       NP_062355                426 aa            linear   ROD 24-OCT-2024
DEFINITION  pannexin-1 [Mus musculus].
ACCESSION   NP_062355
VERSION     NP_062355.2
DBSOURCE    REFSEQ: accession NM_019482.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 426)
  AUTHORS   Molica,F., Ehrlich,A., Pelli,G., Rusiecka,O.M., Montessuit,C.,
            Chanson,M. and Kwak,B.R.
  TITLE     Cold Exposure Rejuvenates the Metabolic Phenotype of Panx1-/- Mice
  JOURNAL   Biomolecules 14 (9), 1058 (2024)
   PUBMED   39334824
  REMARK    GeneRIF: Cold Exposure Rejuvenates the Metabolic Phenotype of
            Panx1[-/-] Mice.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 426)
  AUTHORS   Ehrlich,A., Pelli,G., Pick,R., Clochard,L., Molica,F. and Kwak,B.R.
  TITLE     Pannexin1 deletion in lymphatic endothelium affects lymphatic
            function in a sex-dependent manner
  JOURNAL   Physiol Rep 12 (15), e16170 (2024)
   PUBMED   39085909
  REMARK    GeneRIF: Pannexin1 deletion in lymphatic endothelium affects
            lymphatic function in a sex-dependent manner.
REFERENCE   3  (residues 1 to 426)
  AUTHORS   Kwok,C.H.T., Harding,E.K., Burma,N.E., Markovic,T., Massaly,N., van
            den Hoogen,N.J., Stokes-Heck,S., Gambeta,E., Komarek,K., Yoon,H.J.,
            Navis,K.E., McAllister,B.B., Canet-Pons,J., Fan,C., Dalgarno,R.,
            Gorobets,E., Papatzimas,J.W., Zhang,Z., Kohro,Y., Anderson,C.L.,
            Thompson,R.J., Derksen,D.J., Moron,J.A., Zamponi,G.W. and Trang,T.
  TITLE     Pannexin-1 channel inhibition alleviates opioid withdrawal in
            rodents by modulating locus coeruleus to spinal cord circuitry
  JOURNAL   Nat Commun 15 (1), 6264 (2024)
   PUBMED   39048565
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 426)
  AUTHORS   Vardam-Kaur,T., Banuelos,A., Gabaldon-Parish,M., Macedo,B.G.,
            Salgado,C.L., Wanhainen,K.M., Zhou,M.H., van Dijk,S.,
            Santiago-Carvalho,I., Beniwal,A.S., Leff,C.L., Peng,C., Tran,N.L.,
            Jameson,S.C. and Borges da Silva,H.
  TITLE     The ATP-exporting channel Pannexin 1 promotes CD8+ T cell effector
            and memory responses
  JOURNAL   iScience 27 (7), 110290 (2024)
   PUBMED   39045105
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 426)
  AUTHORS   Obot,P., Cibelli,A., Pan,J., Velisek,L., Veliskova,J. and Scemes,E.
  TITLE     Pannexin1 Mediates Early-Life Seizure-Induced Social Behavior
            Deficits
  JOURNAL   ASN Neuro 16 (1), 2371164 (2024)
   PUBMED   39024558
  REMARK    GeneRIF: Pannexin1 Mediates Early-Life Seizure-Induced Social
            Behavior Deficits.
REFERENCE   6  (residues 1 to 426)
  AUTHORS   Ray,A., Zoidl,G., Weickert,S., Wahle,P. and Dermietzel,R.
  TITLE     Site-specific and developmental expression of pannexin1 in the
            mouse nervous system
  JOURNAL   Eur J Neurosci 21 (12), 3277-3290 (2005)
   PUBMED   16026466
  REMARK    GeneRIF: The Panx1 expresses in the brain, retina and other
            non-neuronal tissues. In the cortex, cerebellum and eye, Panx1 is
            expressed at early embryonic time points and peaks around embryonic
            day 18 followed by a decline towards adulthood.
REFERENCE   7  (residues 1 to 426)
  AUTHORS   Weickert,S., Ray,A., Zoidl,G. and Dermietzel,R.
  TITLE     Expression of neural connexins and pannexin1 in the hippocampus and
            inferior olive: a quantitative approach
  JOURNAL   Brain Res Mol Brain Res 133 (1), 102-109 (2005)
   PUBMED   15661370
  REMARK    GeneRIF: Expression of pannexin1 in the hippocampus and inferior
            olive.
REFERENCE   8  (residues 1 to 426)
  AUTHORS   Baranova,A., Ivanov,D., Petrash,N., Pestova,A., Skoblov,M.,
            Kelmanson,I., Shagin,D., Nazarenko,S., Geraymovych,E., Litvin,O.,
            Tiunova,A., Born,T.L., Usman,N., Staroverov,D., Lukyanov,S. and
            Panchin,Y.
  TITLE     The mammalian pannexin family is homologous to the invertebrate
            innexin gap junction proteins
  JOURNAL   Genomics 83 (4), 706-716 (2004)
   PUBMED   15028292
REFERENCE   9  (residues 1 to 426)
  AUTHORS   Bruzzone,R., Hormuzdi,S.G., Barbe,M.T., Herb,A. and Monyer,H.
  TITLE     Pannexins, a family of gap junction proteins expressed in brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13644-13649 (2003)
   PUBMED   14597722
  REMARK    GeneRIF: the different expression patterns of Px1 and Px2 in the
            brain indicate that pannexins form cell type-specific gap junctions
            with distinct properties that may subserve different functions
            [pannexin 2]
REFERENCE   10 (residues 1 to 426)
  AUTHORS   Panchin,Y., Kelmanson,I., Matz,M., Lukyanov,K., Usman,N. and
            Lukyanov,S.
  TITLE     A ubiquitous family of putative gap junction molecules
  JOURNAL   Curr Biol 10 (13), R473-R474 (2000)
   PUBMED   10898987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC049074.1.
            
            On Feb 1, 2006 this sequence version replaced NP_062355.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049074.1, AK053871.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..426
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 4.52 cM"
     Protein         1..426
                     /product="pannexin-1"
                     /calculated_mol_wt=48036
     Site            41..61
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIP4.3)"
     Site            107..127
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIP4.3)"
     Site            198
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:30814251; propagated from
                     UniProtKB/Swiss-Prot (Q9JIP4.3)"
     Site            217..237
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIP4.3)"
     Site            254
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:17925379; propagated from
                     UniProtKB/Swiss-Prot (Q9JIP4.3)"
     Site            278..298
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JIP4.3)"
     Site            375..378
                     /site_type="cleavage"
                     /note="Cleavage, by CASP3 or CASP7.
                     /evidence=ECO:0000305|PubMed:32238926; propagated from
                     UniProtKB/Swiss-Prot (Q9JIP4.3)"
     CDS             1..426
                     /gene="Panx1"
                     /coded_by="NM_019482.2:442..1722"
                     /db_xref="CCDS:CCDS22832.1"
                     /db_xref="GeneID:55991"
                     /db_xref="MGI:MGI:1860055"
ORIGIN      
        1 maiahlatey vfsdfllkep tepkfkglrl elavdkmvtc iavglpllli slafaqeisi
       61 gtqiscfsps sfswrqaafv dsycwaavqq ksslqsesgn lplwlhkffp yilllfaill
      121 ylpalfwrfs aaphlcsdlk fimeeldkvy nraikaaksa rdldlrdgpg ppgvtenvgq
      181 slweiseshf kypiveqylk tkknsshlim kyiscrlvtf vvillaciyl syyfslssls
      241 deflcsiksg vlkndstipd rfqckliavg ifqllslinl ivyallipvv vytffipfrq
      301 ktdilkvyei lptfdvlhfk segyndlsly nlfleenise lksykclkvl eniksngqgi
      361 dpmllltnlg mikmdiidgk iptslqtkge dqgsqrvefk dldlsseaaa nngeknsrqr
      421 llnpsc
//
