LOCUS       NM_001305804            2702 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus pantothenate kinase 4 (Pank4), transcript variant 1,
            mRNA.
ACCESSION   NM_001305804
VERSION     NM_001305804.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2702)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2702)
  AUTHORS   Dibble,C.C., Barritt,S.A., Perry,G.E., Lien,E.C., Geck,R.C.,
            DuBois-Coyne,S.E., Bartee,D., Zengeya,T.T., Cohen,E.B., Yuan,M.,
            Hopkins,B.D., Meier,J.L., Clohessy,J.G., Asara,J.M., Cantley,L.C.
            and Toker,A.
  TITLE     PI3K drives the de novo synthesis of coenzyme A from vitamin B5
  JOURNAL   Nature 608 (7921), 192-198 (2022)
   PUBMED   35896750
REFERENCE   3  (bases 1 to 2702)
  AUTHORS   Sun,M., Chen,C., Hou,S., Li,X., Wang,H., Zhou,J., Chen,X., Liu,P.,
            Kijlstra,A., Lin,S. and Ye,J.
  TITLE     A novel mutation of PANK4 causes autosomal dominant congenital
            posterior cataract
  JOURNAL   Hum Mutat 40 (4), 380-391 (2019)
   PUBMED   30585370
  REMARK    GeneRIF: the association of a new entity of an autosomal dominant
            cataract with mutations in PANK4, which influences cell
            proliferation, apoptosis of lens epithelial cells, crystallin
            abnormalities, and fiber cell derangement, subsequently induces
            cataract.
REFERENCE   4  (bases 1 to 2702)
  AUTHORS   Sacksteder,C.A., Qian,W.J., Knyushko,T.V., Wang,H., Chin,M.H.,
            Lacan,G., Melega,W.P., Camp,D.G. 2nd, Smith,R.D., Smith,D.J.,
            Squier,T.C. and Bigelow,D.J.
  TITLE     Endogenously nitrated proteins in mouse brain: links to
            neurodegenerative disease
  JOURNAL   Biochemistry 45 (26), 8009-8022 (2006)
   PUBMED   16800626
REFERENCE   5  (bases 1 to 2702)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2702)
  AUTHORS   Zhou,B., Westaway,S.K., Levinson,B., Johnson,M.A., Gitschier,J. and
            Hayflick,S.J.
  TITLE     A novel pantothenate kinase gene (PANK2) is defective in
            Hallervorden-Spatz syndrome
  JOURNAL   Nat Genet 28 (4), 345-349 (2001)
   PUBMED   11479594
REFERENCE   7  (bases 1 to 2702)
  AUTHORS   Shibata,K., Gross,C.J. and Henderson,L.M.
  TITLE     Hydrolysis and absorption of pantothenate and its coenzymes in the
            rat small intestine
  JOURNAL   J Nutr 113 (10), 2107-2115 (1983)
   PUBMED   6619987
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX004788.7.
            
            On May 10, 2022 this sequence version replaced NM_001305804.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               BX004788.7         45927-46059
            134-216             BX004788.7         50920-51002
            217-431             BX004788.7         51363-51577
            432-615             BX004788.7         51784-51967
            616-708             BX004788.7         52237-52329
            709-862             BX004788.7         52664-52817
            863-1044            BX004788.7         53163-53344
            1045-1126           BX004788.7         53939-54020
            1127-1227           BX004788.7         54259-54359
            1228-1383           BX004788.7         56420-56575
            1384-1496           BX004788.7         58052-58164
            1497-1584           BX004788.7         58373-58460
            1585-1736           BX004788.7         58993-59144
            1737-1792           BX004788.7         59941-59996
            1793-1842           BX004788.7         60183-60232
            1843-1947           BX004788.7         60711-60815
            1948-2048           BX004788.7         61282-61382
            2049-2117           BX004788.7         61516-61584
            2118-2258           BX004788.7         61884-62024
            2259-2702           BX004788.7         62285-62728
FEATURES             Location/Qualifiers
     source          1..2702
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4"
     gene            1..2702
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /note="pantothenate kinase 4"
                     /db_xref="GeneID:269614"
                     /db_xref="MGI:MGI:2387466"
     exon            1..133
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            134..216
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            217..431
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            432..615
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            616..708
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            709..862
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1044
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1126
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1227
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1383
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1496
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1584
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1736
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1792
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1842
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1947
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2048
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2117
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2258
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..2702
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /note="hexamer: AATATA"
     polyA_site      2702
                     /gene="Pank4"
                     /gene_synonym="D030031I12Rik; Gm42363"
                     /note="major polyA site"
ORIGIN      
        1 actttcaaaa tggcggagcg tggagcgagt ggcggcggga gcggcgggga cagtctggac
       61 aagagcatca cgctgccccc cgacgagatc ttccgcaacc tggagaacgc caagcgcttc
      121 gccattgata taggtggatc attgaccaag ttggcatact attccaccgt acagcacaaa
      181 gtggccaaag tgagatcttt tgaccacccg ggaaaggacg tggagcagga tcatgagcca
      241 ccctatgaga tctcagtcca ggaggagatc acagctcgcc tgcatttcat caagtttgag
      301 aatacctaca tggaagcctg cctggacttc atcagagacc acctagtcaa cactgagacc
      361 aaggtcatcc aggccactgg gggtggagcc tacaagttca aggacctcat cgaggagaag
      421 ctgcgtctga aggtggacaa agaggatgta atgacctgct tgattaaagg gtgcaacttc
      481 gtgctgaaga acatcccgca tgaggccttc atgtaccaga aagactcaga cccagagttt
      541 cgatttcaga caaatcaccc caacatcttc ccctacctcc tagtcaacat tggctctggc
      601 gtctccatcg tgaaggtgga gacagaggac cggtttgagt ggattggtgg aagctccatt
      661 ggaggaggca ccttctgggg cctcggggct ctgctcacca aaacaaagaa gtttgatgag
      721 ctgctgcagc tggcttccag aggccggcat gccaacgttg acatgctggt ccaggacatc
      781 tatggtgggg cccaccagac cctgggcctg agtggcaatc tcatcgcaag cagttttggg
      841 aagtcagcca ctgctgacag agagttctcc aaagaagaca tggccaagag cctgctgcac
      901 atgatcagca atgacatcgg gcagctcgcc tgtctgtacg ccaagctcca cggcttggac
      961 agggtctact ttgggggctt cttcatccgg ggtcaccccg tgaccatgcg cacaatcacc
     1021 tacagcatta acttcttctc caagggtgaa gtccaggcac tcttcctgag acatgaaggc
     1081 tacctgggag ccatcggggc atttttaaaa ggagccgagc aagacaatcc taaccagtac
     1141 agctggggtg agaactacgc agccagctcc gggctgatga gcacgtcgcc cgagctgtgc
     1201 ccgacacagc gggcaaggag cggcacattt gacctgctgg aaatggaccg gctggagagg
     1261 cccctggtca acctgcccct cctcctggac ccgtcctcct atgtgcctga cacagtagac
     1321 ctcactgatg atgctctggc ccgtcagtac tggctcacgt gctttgagga ggccctggat
     1381 ggggtggtga agcgagctgt ggccagccag ccagagtcca tggatgcagt tgagagggca
     1441 gagaaattcc ggcagaaata ctggggcaaa ctgcagaccc tccggcacca gccctttgct
     1501 tatgggacac tgactgtgcg cagcctgttg gacacaagag aacactgttt gaatgaattc
     1561 aacttcccag atccctactc caaggtgaag cagaaagaaa acggcctcgc actaaaatgc
     1621 tttcagagcg tgacgcgctc gctggactca ctaggctggg aagagcggca gctggccctg
     1681 gtgaaggggc tcttagctgg gaatgtcttt gactggggag ccaaggctgt gtctgatgtc
     1741 ctggaatcgg acccccagtt tgggtttgaa gaagcaaaga gaaaattgca agaacggccc
     1801 tggctcgtgg attcctacac caagtggctc cagaggttaa aggggccccc tcataaatgt
     1861 gccttaattt tcgcagataa cagtggaata gacatcattt tgggagtctt cccctttgtc
     1921 agggagctac tctttagagg gacagaggtc atcttggcat gcaactcagg ccctgccctg
     1981 aacgatgtga cctacagtga gtctctcatt gtggcagaac gcattgcagc catggacccc
     2041 atcatctgca ctgctctgag agaagatagg ctgctgctgg tgcagaccgg ttccagctct
     2101 ccatgcctag acctcagctt gtgtacatct cggacaacaa cttgcatggt tttacctttt
     2161 gccatgtggg ttctgtggac caaactcaag tcattggtag aaaagtgcct aagcccattg
     2221 agcatcctgc tggcctgttc agtgctttct gcaaagagcc gtctagacaa gggactggct
     2281 gtgctggtgc gagagcgtgg tgccgacctg gtcgtcatcg agggaatggg ccgtgccatc
     2341 cacaccaact accatgcatt gctgcgctgc gagagtctga agctggcagt ggtaaagaac
     2401 gcttggctgg cagagcgtct aggtggccag ctcttcagtg tcatcttcaa gtacgaggtt
     2461 cctaccaagt gagataccca ctctgccaga cgtgtctgca tatccctcat caggaatgtg
     2521 atttacttcg aggaacctgt gttcacaccg gagtattgac tgacagtgcg tgtaccaggg
     2581 acacccaacc cagcatttgt cctgtgggac actagtgttg gaatgtattt aactgttaaa
     2641 taatctttta tatatataca catatacata tatatataaa tatatacata cacatgtgct
     2701 ca
//
