LOCUS       NM_145962               7365 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pantothenate kinase 3 (Pank3), mRNA.
ACCESSION   NM_145962
VERSION     NM_145962.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7365)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7365)
  AUTHORS   Bao,J., Vitting-Seerup,K., Waage,J., Tang,C., Ge,Y., Porse,B.T. and
            Yan,W.
  TITLE     UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential
            for Spermatogenesis by Selectively Eliminating Longer 3'UTR
            Transcripts
  JOURNAL   PLoS Genet 12 (5), e1005863 (2016)
   PUBMED   27149259
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7365)
  AUTHORS   Zuo,B., Zhu,J., Li,J., Wang,C., Zhao,X., Cai,G., Li,Z., Peng,J.,
            Wang,P., Shen,C., Huang,Y., Xu,J., Zhang,X. and Chen,X.
  TITLE     microRNA-103a functions as a mechanosensitive microRNA to inhibit
            bone formation through targeting Runx2
  JOURNAL   J Bone Miner Res 30 (2), 330-345 (2015)
   PUBMED   25195535
REFERENCE   4  (bases 1 to 7365)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 7365)
  AUTHORS   Alfonso-Pecchio,A., Garcia,M., Leonardi,R. and Jackowski,S.
  TITLE     Compartmentalization of mammalian pantothenate kinases
  JOURNAL   PLoS One 7 (11), e49509 (2012)
   PUBMED   23152917
REFERENCE   6  (bases 1 to 7365)
  AUTHORS   Zhang,Y.M., Rock,C.O. and Jackowski,S.
  TITLE     Feedback regulation of murine pantothenate kinase 3 by coenzyme A
            and coenzyme A thioesters
  JOURNAL   J Biol Chem 280 (38), 32594-32601 (2005)
   PUBMED   16040613
  REMARK    GeneRIF: murine pantothenate kinase 3 is regulated through a
            feedback mechanism by coenzyme A and coenzyme A thioesters
REFERENCE   7  (bases 1 to 7365)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   8  (bases 1 to 7365)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 7365)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 7365)
  AUTHORS   Zhou,B., Westaway,S.K., Levinson,B., Johnson,M.A., Gitschier,J. and
            Hayflick,S.J.
  TITLE     A novel pantothenate kinase gene (PANK2) is defective in
            Hallervorden-Spatz syndrome
  JOURNAL   Nat Genet 28 (4), 345-349 (2001)
   PUBMED   11479594
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK039865.1, CJ127650.1, CD541217.1 and AL596084.13.
            
            On Apr 4, 2007 this sequence version replaced NM_145962.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK039865.1, BC027089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AK039865.1         3-190
            189-545             CJ127650.1         92-448
            546-2492            AK039865.1         548-2494
            2493-2925           CD541217.1         59-491
            2926-7365           AL596084.13        32047-36486
FEATURES             Location/Qualifiers
     source          1..7365
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 21.96 cM"
     gene            1..7365
                     /gene="Pank3"
                     /note="pantothenate kinase 3"
                     /db_xref="GeneID:211347"
                     /db_xref="MGI:MGI:2387464"
     exon            1..453
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..1538
                     /gene="Pank3"
                     /EC_number="2.7.1.33"
                     /note="mPanK3; pantothenic acid kinase 3"
                     /codon_start=1
                     /product="pantothenate kinase 3"
                     /protein_id="NP_666074.1"
                     /db_xref="CCDS:CCDS24543.1"
                     /db_xref="GeneID:211347"
                     /db_xref="MGI:MGI:2387464"
                     /translation="MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVES
                     LKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDK
                     NFSTLQTVLSATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAEC
                     YYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTF
                     LGLCSLLTGCESFEEALEMASKGDSTQADRLVRDIYGGDYERFGLPGWAVASSFGNMI
                     YKEKRETVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLL
                     AYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS"
     exon            454..806
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1060
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1237
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1361
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1487
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..7365
                     /gene="Pank3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7344..7349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pank3"
                     /note="hexamer: AATAAA"
     polyA_site      7363
                     /gene="Pank3"
                     /note="major polyA site"
ORIGIN      
        1 gagagtggag cctcactcta cggagaacta caactcctag cagccccgcg gagagcgagg
       61 cgaggaggcc tgagtcacgt gggcgctggg cctgggcggg ctatttctca gtgcggcggc
      121 ggcggcggcg gcggctcggg ggaccggggc cttttgttcg gagcggctgc ggggggccac
      181 ggagcggcga ggcccgcggc cttccccggc tcgctcggtc ccggccgccc cttgcggggt
      241 tgctgggccg ccccgtgggc cgcctgtggc ctcaggcgcc gccgccccgc cctaggcccg
      301 ccccacccgg cctgagggga ggaaccggcc gggcctcgcc gcgcggccca gccagctccg
      361 gagtattcac ctctcctcgc tgagctctgc acccgaggct acccctcgcg ccttaggccg
      421 acgccatgaa gatcaaggat gccaaaaaac cctctttccc atggtttggc atggacattg
      481 gaggaacgct agtaaagctc tcatactttg aacctattga catcacagca gaggaagaac
      541 aagaggaagt tgagagctta aagagtattc ggaaatactt gacttctaat gtagcatatg
      601 gatctactgg cattcgggat gtacatcttg agctgaagga tttaacactt tttggacgaa
      661 gaggaaactt gcactttatc agatttccaa cccaggacct gcctactttt atccaaatgg
      721 ggagagataa aaatttctca accttacaaa cggtgctgag tgctacagga ggtggtgctt
      781 acaagtttga gaaagatttt cgcacaattg gaaacctcca cctgcacaaa ctggatgaac
      841 ttgactgcct tgtaaagggc ttgctgtaca tagattccgt cagtttcaat ggacaagcag
      901 aatgctatta ttttgctaat gcctcagaac ccgagcgatg ccaaaagatg ccttttaacc
      961 tggatgatcc ttacccactg ctggtagtga atattggctc aggagtcagt attttagcag
     1021 tccattccaa agacaactat aaaagagtga ctgggacaag ccttggaggg ggcacctttc
     1081 ttggtttatg cagtttgttg actggctgtg aaagttttga agaggctctg gaaatggcat
     1141 ccaaaggtga cagcacccaa gctgataggt tggtccgaga tatttatgga ggagattatg
     1201 aaagatttgg tctgccaggt tgggcggtgg catctagttt tggtaatatg atttataagg
     1261 agaaacgaga aactgttagt aaagaggatc tggcaagagc tactttagtt actatcacca
     1321 ataacattgg ttctgtggca cgaatgtgtg ctgttaatga gaaaataaat cgagttgtct
     1381 tcgttgggaa ctttttacgt gtcaatactc tctcgatgaa actgttggca tatgctttgg
     1441 attactggtc aaagggtcaa ctgaaagcat tgtttttaga acatgaggga tactttggag
     1501 ctgttggtgc gcttcttgga ctgccgaatt tcagctaaaa catgggccat ctttactaag
     1561 gaacgcctgc cattcaggaa gagctgatcc agaaaccgca gtcattgtct gtcactggga
     1621 accaaaggat aaaagcctaa ttctacttgt gttcatttta aatgtcagaa tggtgagctt
     1681 tgccgcatgg aaagacctat aatgggaagt atccctcact gattgatgtc ctcttgtatg
     1741 tatgatagcc agcgttccat cttaaatgca atacagcctc ttgattgttg aacttttctc
     1801 aatgattttc tatttatttg atgcagccaa cattgtagta ctgtgtgctc agacacaaat
     1861 cttaaaatct cagaaatgtt tgtttatgca aaataattga ttctaaatgt ttgtttgttt
     1921 gttctaaata cttgtttgag tctgttatgt gtgtttagtt actagtgagc aggaagcaac
     1981 atactctcat aatttattgt actggcaatc aaagatcatt ttctgtgact tagaaatgtt
     2041 aagacaatat taagtattaa ctgtgatagt tttataacat atcctcagaa aagcatgtct
     2101 atatgacctc tgcccataag tataattttc tctcagatga tgagttgaaa tactgtcttt
     2161 aaacatgaac ctgaattttt ctattgaatc cctgaagttt ttgcgcatat ttggtggcgc
     2221 tacactttct ttatctcatg cattaatcag tatatgtgtt aaaatgttta ctgtttgtaa
     2281 aattgagggc ataatcacat actttggagt ctatctaatt aagtccttag actgttcaaa
     2341 tggaatatgg ttagagtgag tgacattcta tgctctttct ctaccatgtg tatctcaggc
     2401 ccaaatgtgc atttcttatc attagatctg aactcgggaa gctgatgtgt accttccata
     2461 agcagtagta atggacagaa ttagatgcta tcaaaaagaa tgttttaaag ttaggtggct
     2521 ctgggcagca ttactaaatt acagatggat caatgtttat ggtttttggt cataaaagca
     2581 tcacagacca agaatttgtc tttctgcttg gaatttattc gtgggtttga attcctgttt
     2641 tttataatgt taaaatgtaa cattttggat gccattaatt tggtaagttg aatctgtatg
     2701 ggaaatggac ctatattaat ttctgatatt tctggaaata accttaaaga ggttagattg
     2761 tttacattaa agagtatttc agtgtagttt ctgagacccc agtgttcaaa gtttccagca
     2821 gactgtcaag aggttcttga taaagacagg tctctggagc caggtgtggt ggcctatgct
     2881 tttaatctct gcacttggca ggcagaggca ggcgaatctg agttcaaggg cagcctggtc
     2941 tacagagtaa gttccagaac agccagggct acacagggaa accctgtttc tggggtggta
     3001 aaaaaaaaac aaaaacaaaa aacaacacag atttctgtgt agtttatgga agcatatgac
     3061 gatagtgttt gcccagtgca cattttaagt ctacagtgat gtcactcagt gtttgcgtct
     3121 gacagcctgg cttgttcggg ttgccatgct actgcttact ttgttttaaa ggttgacttg
     3181 agtgtgcaga taagaaaata actcaatgat agaaactgta gattatctag tgtggaaatt
     3241 ctatacatca gcagctatag atttagggct atcttcaaag attaaaaagt gctcacatta
     3301 atttgaccac tttgctttgg tttatataga actaacattt tgcctgtaac tgaaattaac
     3361 tactaagggc catgtaaagt gaactaactc gttcatacat ttaccttttc tcaagtgtaa
     3421 tctgtcatta ctgaattaat gagaacacag aatcataact gataaaggct gccaagattc
     3481 taatctaacc tatattgctc ttgagaaatt ccctgtatgc atgctatcac aaatagaggt
     3541 ttgcttctaa tatcaatcaa cctaattaaa gatctgtgtt cttaaacagt gccatttaat
     3601 agataaaatg taaactatga ataattttat attttctagt aaatgcatta aaagctaaca
     3661 agaaataggt gaaggtcatt ttagtacctt tttaaaaaat ttaccagtat atctaatatg
     3721 ttatttcagt gtgaaattgg cacaaaaaat taattgggag atgtgtttgc ccttttgttt
     3781 tttatttagt tttcagttaa tgtatatttt attcttaatg acacatttca gttttagact
     3841 gaccaccttt cagatttcac agccacatat attagtagtg ttttttctaa agcttctttg
     3901 ttttgttttg tttttgtttg agacagcctc aactagatag agccggttgg ctgggaactg
     3961 gctatgtaga ccaagcaaac cccaaactca aatctatctg cctctgcctc tgcccctgtc
     4021 cctgtctctg cctctgtctg ccaagattaa aggtttgttg ggagtactta caagagagca
     4081 ctattacatg tccttgaaaa ctttgtgaat atgggctttt aaaagaatga gatggggaaa
     4141 aaaaacgata acttcttttt taagtaaaga caagaccatt tgttggggca gtttatttta
     4201 catagataag ctgttactat ttcaaaaata ctatatattg tcatcatgtc atctcttgtg
     4261 tagtatatgg gatttttcta ataactgata ctgataaaat gcttgtaaca catcctaata
     4321 gttagcaatt tccaaactaa tgtatttcct ttatggaagc aaaattaatt ccagggactt
     4381 agtttctaaa gtttctgagt tttgtgcagt caattttgaa agagtaccaa gagacacttt
     4441 ttatctcatt gttatttttt atacatacaa agagtctttc taaaaattct gataactttc
     4501 aaatgctaag agcattgtca gccatggttt tggtggtagt acatgcacac aaatctaaaa
     4561 caccacctct cccccaaaag gttgcctttt aactagactt ctccagtcat ctgtatacac
     4621 acacaggcat tgccttcctc ggctcctctg aggaggtgga ggaggagtgg atttctcctg
     4681 tggttaaagt ctttgccaag gcaaggctag taatatgcat gataattgaa agccagcccc
     4741 tcaagggatt ctcattattt gcaaatactg gactcttcca aggctctaaa tggatggcac
     4801 ccttgagtgc aggtgattgc tgtgtgttag gcatccactc ctaaaaataa agctgttttg
     4861 tgggtgacat tctcgaggga gggaagttca tctggctata gtttctaaat atcctttata
     4921 taactacttt gttagaaaca aagttctttc ttatttagtt tatcatatct tcttttgttg
     4981 agcactttat ctttgttagt gttttgcatt tttgaatata attcagaaat tctaggttat
     5041 gcaaagaatt tataaagcat aattaaaatg agtgtatatt actttgcatt caacttcagt
     5101 tttgtggtgt gtgtaaacaa aataacagca aaacgttttt aaaatactct gataactaag
     5161 gtgattgcct ctaaacgtct atgttgtctt ttcccaccca agctcctatg ttagagtgca
     5221 cttcattgtg acagcaatgc tggccagcta gcttcatgtg tgtcaccaga taatctcttg
     5281 tttgattttt gctttttgag acagggtctc tgtgtagttc tggctgtcct ataactttgt
     5341 tatgtagacc aggtgcctca aacccagaga tcctcttgtc tctgctttcc aagtgctagc
     5401 aacaaaagca tgtgccagca catccggcct gcatcacaaa aattttgttt tacaacctat
     5461 aacaggaatt gtctcacact gtcagtaata cagtgatata atctcttttt ttccccttta
     5521 aagtattaag atagccagtt caatacagca acatgaaaaa gtgtccccaa gtttttgctg
     5581 ccttttattc tacttgcaaa attaaaatat tctcccattg gacacactgt gctgtcgtac
     5641 atattcagta catgtgacgt tctgctttga acagtgtttt acagtgttct ggtcattggc
     5701 ctagcttctt cacgtctctc tttagttgtt gaccaggact tcggtggcca ccgtgagaat
     5761 gacaccgttg ccaggagcca gagcaaacag ttgctccatt cctggcaggg ctcaagatga
     5821 cttacacatt gcagacctat catgtgctag agctcatttt tagtgcttca tagtgtttta
     5881 gtaattcatt attagtacat gtggataagt acttacaaaa ccaggaaaaa aagttattgt
     5941 cattactgcc tgtaatagct acgtgtgtaa cctcaaaatc atatagggat tgttattctt
     6001 catttgtaca agatgaaaat tcagagatgt tgaagtatta gctatatttg gaattttagt
     6061 agcccctctc tttgacctgt ttttctaatc attgtgtggt cacaggagag ggtgaacact
     6121 ttaaagctct tctgaaagga ttgtatttgt ctgacacacg gttccagcac catttacaaa
     6181 atgaaaatga aaatggaatc ccctgcacat aggttggatg gattacagtc ctacctaata
     6241 aggcacagaa gaccttaaga tctctttgtg agctgactgg agcagacctg ggtctgaccc
     6301 agtgtctttc tgaagtcagc gtgggctgat gctgaaatct gcagcttggg gatctgactg
     6361 aactcacaaa ctagtttgtc ttccgaacaa aggcttactg cagctgctgt taattttatg
     6421 tttaaaagac ctggtaaaga atgtaacttc cacagaaagc attttcattt ttacataaca
     6481 ttaccataag tgatgtaaaa tagttttgag atctcaattg ttttggttgt atgcttcaaa
     6541 actgtcattg tgactgggtg tcatcaggat atcacagtgg ctcattcaat acttaattaa
     6601 ccctgcttct aagccatttg aaaattggcc agtttttttt ctgaataaac ccttagagtt
     6661 tccagcattt agaagaaaaa taattttatg aaatctaacg ctcatgctgt agtgtcccat
     6721 ttctgcctgt aatcgctgga ccctgcagtg agtgaggttc aaacactttt gtctctttca
     6781 cccactgtgt tggagttaag tgaactccag gcatttaaac tgaaatgaaa ggtatgcttg
     6841 ttaattcttg agtcctgaag aaatcattcc taggtgttgc tgttccagct tagggcttcc
     6901 tttcctcaca cacgtcgctc agtgcaagct gccttactct ctgttggttg catcattcct
     6961 gtcaggttta agctttgttt atgtttagat tcttctaata ttaaatctta tgtaaaaatg
     7021 tatgatgtac tataaacttt atgcataaca aaactaagtt atagcctatt gtaacctata
     7081 aaacacttct tgtaaatgat ctaatttatt tttccattta tgtacagttt cttaatgtaa
     7141 atttaaaaga tatttgttgt gccctgctct gtaaacattc ccttaatgct tatttgcatg
     7201 aaagactttt gggttctatt tgtttgtact atgtagctgt aagctgggtt tgggtgtcta
     7261 ccttttctgt agtttctaac ttttttaatt tgttaatatt ctaaatacgt gttagaatca
     7321 tgctttttat accctacttt ccaaataaat tatctcttta ctaca
//
