LOCUS       NM_001114339            7419 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus pantothenate kinase 1 (Pank1), transcript variant 1,
            mRNA.
ACCESSION   NM_001114339
VERSION     NM_001114339.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7419)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7419)
  AUTHORS   Audam,T.N., Howard,C.M., Garrett,L.F., Zheng,Y.W., Bradley,J.A.,
            Brittian,K.R., Frank,M.W., Fulghum,K.L., Polos,M., Herczeg,S.,
            Merkely,B., Radovits,T., Uchida,S., Hill,B.G., Dassanayaka,S.,
            Jackowski,S. and Jones,S.P.
  TITLE     Cardiac PANK1 deletion exacerbates ventricular dysfunction during
            pressure overload
  JOURNAL   Am J Physiol Heart Circ Physiol 321 (4), H784-H797 (2021)
   PUBMED   34533403
  REMARK    GeneRIF: Cardiac PANK1 deletion exacerbates ventricular dysfunction
            during pressure overload.
REFERENCE   3  (bases 1 to 7419)
  AUTHORS   Subramanian,C., Yao,J., Frank,M.W., Rock,C.O. and Jackowski,S.
  TITLE     A pantothenate kinase-deficient mouse model reveals a gene
            expression program associated with brain coenzyme a reduction
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (5), 165663 (2020)
   PUBMED   31918006
REFERENCE   4  (bases 1 to 7419)
  AUTHORS   Yang,L., Zhang,B., Wang,X., Liu,Z., Li,J., Zhang,S., Gu,X., Jia,M.,
            Guo,H., Feng,N., Fan,R., Xie,M., Pei,J. and Chen,L.
  TITLE     P53/PANK1/miR-107 signalling pathway spans the gap between
            metabolic reprogramming and insulin resistance induced by high-fat
            diet
  JOURNAL   J Cell Mol Med 24 (6), 3611-3624 (2020)
   PUBMED   32048816
  REMARK    GeneRIF: P53/PANK1/miR-107 signalling pathway spans the gap between
            metabolic reprogramming and insulin resistance induced by high-fat
            diet.
REFERENCE   5  (bases 1 to 7419)
  AUTHORS   Sharma,L.K., Subramanian,C., Yun,M.K., Frank,M.W., White,S.W.,
            Rock,C.O., Lee,R.E. and Jackowski,S.
  TITLE     A therapeutic approach to pantothenate kinase associated
            neurodegeneration
  JOURNAL   Nat Commun 9 (1), 4399 (2018)
   PUBMED   30352999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7419)
  AUTHORS   Zhang,Y.M., Chohnan,S., Virga,K.G., Stevens,R.D., Ilkayeva,O.R.,
            Wenner,B.R., Bain,J.R., Newgard,C.B., Lee,R.E., Rock,C.O. and
            Jackowski,S.
  TITLE     Chemical knockout of pantothenate kinase reveals the metabolic and
            genetic program responsible for hepatic coenzyme A homeostasis
  JOURNAL   Chem Biol 14 (3), 291-302 (2007)
   PUBMED   17379144
REFERENCE   7  (bases 1 to 7419)
  AUTHORS   Nef,S., Schaad,O., Stallings,N.R., Cederroth,C.R., Pitetti,J.L.,
            Schaer,G., Malki,S., Dubois-Dauphin,M., Boizet-Bonhoure,B.,
            Descombes,P., Parker,K.L. and Vassalli,J.D.
  TITLE     Gene expression during sex determination reveals a robust female
            genetic program at the onset of ovarian development
  JOURNAL   Dev Biol 287 (2), 361-377 (2005)
   PUBMED   16214126
REFERENCE   8  (bases 1 to 7419)
  AUTHORS   Zhang,Y.M., Rock,C.O. and Jackowski,S.
  TITLE     Feedback regulation of murine pantothenate kinase 3 by coenzyme A
            and coenzyme A thioesters
  JOURNAL   J Biol Chem 280 (38), 32594-32601 (2005)
   PUBMED   16040613
REFERENCE   9  (bases 1 to 7419)
  AUTHORS   Rock,C.O., Karim,M.A., Zhang,Y.M. and Jackowski,S.
  TITLE     The murine pantothenate kinase (Pank1) gene encodes two
            differentially regulated pantothenate kinase isozymes
  JOURNAL   Gene 291 (1-2), 35-43 (2002)
   PUBMED   12095677
REFERENCE   10 (bases 1 to 7419)
  AUTHORS   Rock,C.O., Calder,R.B., Karim,M.A. and Jackowski,S.
  TITLE     Pantothenate kinase regulation of the intracellular concentration
            of coenzyme A
  JOURNAL   J Biol Chem 275 (2), 1377-1383 (2000)
   PUBMED   10625688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113244.19, AK017345.1, AF200357.1 and AC125259.8.
            
            On Nov 7, 2013 this sequence version replaced NM_001114339.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1, also known as alpha).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF347700.1, AK017345.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC113244.19        99338-99471         c
            135-1648            AK017345.1         2-1515
            1649-3460           AF200357.1         949-2760
            3461-7419           AC125259.8         2309-6267
FEATURES             Location/Qualifiers
     source          1..7419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 29.79 cM"
     gene            1..7419
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /note="pantothenate kinase 1"
                     /db_xref="GeneID:75735"
                     /db_xref="MGI:MGI:1922985"
     exon            1..932
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             380..2026
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /EC_number="2.7.1.33"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pantothenic acid kinase 1"
                     /codon_start=1
                     /product="pantothenate kinase 1 isoform 1"
                     /protein_id="NP_001107811.1"
                     /db_xref="CCDS:CCDS50424.1"
                     /db_xref="GeneID:75735"
                     /db_xref="MGI:MGI:1922985"
                     /translation="MRGRRAPRPGSTEVPAAARDADTLRARAASPVRGAQLAEDVGTP
                     TGGGEERRGHQLPTAAPRLRESKPQGGSEDRGTADRDLQRGCQSRSPRTAPPVPGMGD
                     RGAQHERAALQSPGAPEGAAAAVNGLLHNGFHPSAASSRDPPAPRFQLPSELQPQPLF
                     AQHDSPAKKCRLRRRMDSGRKNRPPFPWFGMDIGGTLVKLVYFEPKDITAEEEQEEVE
                     NLKSIRKYLTSNTAYGKTGIRDVHLELKNLTMCGRKGNLHFIRFPTCAMHLFIQMGSE
                     KNFSSLHTTLCATGGGAFKFEEDFRMIADLQLHKLDELDCLIQGLLYVDSVGFNGKPE
                     CYYFENPTNPELCQKKPYCLDNPYPMLLVNMGSGVSILAVYSKDNYKRVTGTSLGGGT
                     FLGLCCLLTGCETFEEALDMAAKGDSTNVDKLVKDIYGGDYERFGLQGSAVASSFGNM
                     MSKEKRESISKEDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKL
                     LAYAMDFWSKGQLKALFLEHEGYFGAVGALLELFKMTDTQ"
     exon            933..1285
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1539
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1540..1716
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1840
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1966
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..7419
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3438..3443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /note="hexamer: AATAAA"
     polyA_site      3460
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /note="major polyA site"
     regulatory      4943..4948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /note="hexamer: ATTAAA"
     polyA_site      4962
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
     regulatory      7401..7406
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
                     /note="hexamer: CATAAA"
     polyA_site      7419
                     /gene="Pank1"
                     /gene_synonym="Pank; Pank1b"
ORIGIN      
        1 gggagtagtt tggtcacatt aacgcacgcg cgcctgctca cacactttcg tggggcgggg
       61 atgtagcatg ggtgaccttg tgaaggtact agcccactgg ggataggatt agcaaacctg
      121 aaacctctgc aaatatctgg cttcctccgg cattcctccc gaggcttctg gctgtctcgt
      181 gcctacctca cccagtaccc tttaggctcg ctccgccaca caaagcccca tccgcctatc
      241 tcctcttcgc aaaccccgag aacttcattc cgcacgttga aactcgtcgg tggcggtggc
      301 gggtaggact gggcatgctc agtggcgggg acaggtctgg gaggcgagga agccgcattt
      361 gaagtggctc ggccttggga tgagggggag gcgggctccc cggccggggt ccaccgaggt
      421 tcccgcagct gcgcgcgatg ccgacacgct gcgggcgaga gcagcaagcc cggtgcgcgg
      481 ggcccagctc gccgaagacg tggggacgcc gacgggagga ggggaggagc gccggggcca
      541 ccagctcccg accgcggcgc cgaggctgcg ggagagcaag ccccagggtg gatcggaaga
      601 tcggggaacg gccgaccgtg acctccagcg aggctgccag agccggagcc cgcgcaccgc
      661 tccgccggtc ccgggcatgg gcgaccgcgg cgcgcaacac gagcgcgcgg ccctgcagtc
      721 cccgggggcc cccgagggcg ccgcggccgc cgtgaacggg ctgctgcaca acggcttcca
      781 cccgtcggcc gccagcagcc gcgacccgcc ggccccacgc ttccagctcc cgtccgagct
      841 gcagccgcag ccgctgttcg cccagcatga ttctccggcc aagaaatgcc ggctgcggag
      901 gaggatggac tccgggagga agaacaggcc gccattcccg tggtttggta tggatatcgg
      961 tggaaccctg gttaagctgg tttactttga accgaaggat atcacggcag aggaagaaca
     1021 ggaagaagtg gagaacctga agagcatccg gaagtattta acttctaaca ctgcctacgg
     1081 caaaactggg atccgggacg tccatctgga actgaaaaac ctgaccatgt gtgggcgcaa
     1141 agggaacctg cacttcatcc gcttcccgac ctgtgccatg cacttgttca tccagatggg
     1201 cagcgagaag aacttctcca gcctccacac caccctctgt gccacgggag gtggggcttt
     1261 caagtttgag gaggacttcc gaatgattgc ggacctgcag ctgcataaac tggatgagct
     1321 ggactgtttg attcagggcc ttctttacgt tgactcggtt ggcttcaatg gcaagccaga
     1381 atgttactat ttcgaaaacc ccacaaatcc cgagttgtgt caaaaaaagc catactgttt
     1441 ggataacccg taccctatgt tgctggttaa catgggctca ggcgtcagca tcctggcagt
     1501 gtactccaag gacaactaca aaagagtgac ggggaccagt cttggaggtg ggacattcct
     1561 aggcctatgt tgcttgctga ctggttgtga gacctttgaa gaagctctgg acatggcagc
     1621 taaaggcgac agcaccaatg tggataagct ggtgaaggac atttacggag gagactatga
     1681 gcgatttggc cttcaaggat ctgctgtagc atcaagcttt ggcaacatga tgagcaaaga
     1741 aaagagagag tccatcagca aagaagacct cgcccgggcc acattggtca ccatcaccaa
     1801 caacattggc tccattgctc ggatgtgtgc actgaatgag aatattgaca gagttgtgtt
     1861 tgttgggaac tttctcagaa tcaatatggt ctcaatgaag ttgctagcat atgccatgga
     1921 cttttggtct aaaggacagc tgaaagcact gtttttggaa catgagggtt attttggagc
     1981 tgttggggcc ctgttggaac tgttcaaaat gaccgataca cagtagagga acagcccctc
     2041 gtgcggacag aggactgacg ggccttgcca gagaaggtga catctccgtg gggcagaaac
     2101 caagccacta tggtggatga acctgctgta tttgtaaata acctaaaatc ctagaccttt
     2161 tgctcttagc tttcaagctt atgatacaaa atggggaata taagaatttt ttctgtatac
     2221 tgtattttta aaaaaaaaaa aaacaagaaa ttgtgcagcg tggccaaacc taaccaattt
     2281 catgcattaa ctttgaaaac ttgtatgatg ttcattcaga ggggcctgaa atgaaagcgc
     2341 tgtccatttt tcttctgggg tttactgatc agtgtggtaa ttttaacttc atttagtaat
     2401 tactctagga gattttgcct ttacttatat tttttcatga cgtttcatga tttgctgttg
     2461 gtttcaaatg aaactacgaa tctggtatgt tgcactgtga acactttgtt ctctctctct
     2521 ctctcaaatc ttttctgttg caatgtctta ggacaaaaaa aaaagaaaag aaaagaaaaa
     2581 aggatccccc ccttctgttt ttgttcctcg tgatttctct cttctctgtc tgtatgcttt
     2641 tctcattgta attgctcctg tcaatcaagg tgctgaccaa ctcaacacaa agttaaacac
     2701 atatctgcag ttctaaacat gtgaccctgt gagaagactt taaacgaagg ggttaatgaa
     2761 agtggcgaac attgaacatt gtgtgcagtt ttatctttgt cttcttacac ccctcaccac
     2821 tgtcatgtcc catcggattt actttacact acactgtaat agtctgagat gacttgccct
     2881 catttgcata tgccgtatga agggcagcaa acccctgtat aaatttggag gggctcccat
     2941 agctgatctg attgatcacc ccagactcag ggcaaaagta ctgggtcgag atatcagtta
     3001 gaaataatgg tctgttttat atatgtttgt acctaggaag ggtgtaacga gatatcctaa
     3061 gtaataatgt tgaagattgt ttctttttct ttttcttttt ttcctgattt ctgttttagt
     3121 atttaaactg agatcggtac tttatttcat ttctaaaact ttaatataat ttatgatacg
     3181 ctcgcatata tggacatttc atcctgagag gttttcatta agatagatgg gtcactttca
     3241 aatgaggatg ttgtacacac gccgtaacag gagatctagt gatcttttgg atcaagggtt
     3301 cccttccaag ggctttttga aaggctactc cttggtcagt cttcacctct ctaccttgtg
     3361 gagccccgct cttcatttcc atatccttga gtcttgaaga agctgatgct aatggaagaa
     3421 ttcacttgtc tggtttaaat aaagccggtt tgtgttggga tgttcttagt gtacatgtta
     3481 ttttcatttc ttatacctcg tctgtatatt tatctgtttt acatgtaaag taactgtatg
     3541 ttgatgttgt ggtcgctgct gctgttttcc tttctgctac atagctcgta acatgaggct
     3601 tccccacaag tgtgtgtgtg ggggggtcca aacagccttc agctatggct gcaggccagc
     3661 agaaggattt ctaaaaattg tcctttattg cacttttatt attgactgct taatgccaaa
     3721 ataccactgt gatttttggt gattctgaac cagtttcaat ttttttcttg ttacaaatac
     3781 actgtcaacc tctacttagc tttaaaagat tcactcaact acagtgttct cgaaagacat
     3841 tatctctgta ttatctaccc tagtgccttt taatggtctc tcctcccttc tttagtcttt
     3901 caggggacag cagacctgag acctgaaggt cgtggtcctg caaaggaaac cagggcaagt
     3961 aactgtgcct atatgtttat taatcatctg aaatcacttg gtctctccct accaacatcc
     4021 agaagcctgg agctgggtgt gatggtgcac atttgtaatc ccagcacaaa ggaggctaaa
     4081 ataagagtat cagtgtgagg tcaaggctag cctgggctat atggagttcc aggctagtct
     4141 tcatatgcac cccacaccac tcccatccca ccccgtttat ttcttcctcc ctccacccat
     4201 ctcagttcct cagtctcttc ctccctttct tttcctctcc ctcttttatt cacacacaca
     4261 cacacacaca cacacacaca cacacacaca cacacacata cacaccacac accgttgata
     4321 tagatcaaca gttctcagtc tatgaattgt gaaccttttg ggagtaaatg acacctttgg
     4381 gagtcagaca agtcactggg gtagcgtatc agatatccta catagcagat atttacatta
     4441 agatttataa tagtcgcaac attacagcta tgaagtagca acaacaaatt tcatgatgag
     4501 ggggaggggt catcacaaca tgaggagctg taataaaggg tcacagcatt aggaagcttg
     4561 aaaaccactg gtatagatga agaaataaat tttccattaa gttatcaacc cagagtgttg
     4621 gttatataga gctaacttgt ttttataatg ccctcattgt gtcctgaaga tttttcacac
     4681 ttttaaaatg actttcctta gattcaccat cacaatggaa tatgacaaga attaaaaaca
     4741 aacaaacaaa taaaaacctt gtgctatgtg aatcaggaga gtcagacact gaggagtgtg
     4801 gcttgctatt gtgaaatagc tccggttcag atacagctta gacaacgact aactgaaaac
     4861 aagttgccaa aattctcttt aaactcaagt ttgctcacct gtaaaataca gcaaatagtt
     4921 ttacattcat gttttaatat acattaaaat gtgtcatctg tgtttgttgt ttttttttta
     4981 agatacttta aatcaatgac ttaaataagt cattccacgc tttctcagtt gtgaagagag
     5041 acatggtaca gaaagaaccc catgatggaa cgtgaccaca attctaaaat cccacactct
     5101 cagagtttgc catcatgatc gacttggcgg ccagagctgc ttgggcatta ttataacaat
     5161 gagacgcctc caatactctg tagcagaact gttcatgtat gatttcaggg cagtcttttg
     5221 ggggtggtaa atgataaaat ggttctgaat tttataaagg atgggtagtc ttgagaattt
     5281 ctgttaagat caatcatatg aagattatta cagagtcact ccaggttact taaaagagct
     5341 ggggagggat tggaaaccaa ggtgaacagg atacaacccc gctgcccagc agagtagaca
     5401 gcaagattgc aaggcaaagt gtgtaatgag acagagacat tcattctttc caaatgcagc
     5461 aataaacgaa gggaggtccc atgctcacaa acgttacatt ctagaaggaa aaaaataggt
     5521 ccttatataa tacataataa atatataatg tcatgttaca tcactgccac aaggaaaaag
     5581 taggttaagg tgatgttcct tttattgggg agaatagtta tatgatagaa aaagagaagg
     5641 gaggagactc tttgatgaag ttgatcaaag acaacctctc attggaaatg gcctgaacag
     5701 agacttaatt gaaaatggaa cctgccgggc atggtggcgc acaccatcaa tcccagcact
     5761 caggaggcag aggcaggtgg atttctgagt tcgaagccag ctcggtctac aaagtgagtt
     5821 ccaggacagc cagggctata cagagaagcc ctgtcttgaa aaacctaaat aaatacatac
     5881 atacatacat aaatttaaaa aataaaacat atggaaccat actgatccac tgggtagggg
     5941 ggtgggggta tttttcccac tccaggtaaa taggagtggg tgtttagggg atctgtaaga
     6001 ggctttgtca taaagggtaa aacattgcca gagggttggg aaactcagtt tcaggagcat
     6061 ccccagacaa catcctcctc agagtaggac ttagaagaaa acagaggggg ctacactggc
     6121 gggagaaatg gggctggagg tttctcctca gtgatagtgc tgagagaggt tttgtgaaaa
     6181 tttaaccaag tgtggatcag gaggggaggg attctcagct aaaggaagct aaatgaggga
     6241 aaaatagcct gcctgcctgg tttacagaca agaaactggg tgcaaggaga gtggcagcca
     6301 tctgcttatg aaaggacttt tatcccatgc taaaggtttt agacttcttt gtagtcagca
     6361 tgaggctatt gaagcatttc aagtcaaggg aagctagaag tagcctgcct tcgaagtaac
     6421 ggagcaaatt gtcctccgga gggaaatcta taagccagtt attgcacaga caaacaccac
     6481 cttcccatta tctggctcac tgttcctatt atgcaagtct caagcaaaat ctgcatgatg
     6541 gaccacgttc tcactgtagt tactgagagg gctacaactc taccatgaac caggtcagtg
     6601 aataaacaag aaggttctgg caccaggggt tcaccctaaa gtcttaatca cttgcaagat
     6661 tgttgtatgg aaagaaattt tctcccagtg accagcagat gactgcaaat tctgagaaag
     6721 atttgtatac cgtcctgtgt tcactgggct aactaggtgc tctttcattc attctcccat
     6781 gctttagttt ttactagaag ctcatgactc agggtgcacc gtgcaacact cagggtgccc
     6841 tcagccaaga acaagactgc agactcctgc tttcttgggc tttccttcta gtagggaggt
     6901 agatattatg tgtataagcc aagacacagg aagctttcag agcatttgat gccccgaaaa
     6961 ggggaaggaa ctgaaatgat gggggaggag agggacccac ttggtcagat ggtccggatg
     7021 tgcagatagg atggagtcac ggtctggtct ttggggggta tggcatgctc tccttggttt
     7081 cctttttaaa tgaatccttt cttgggacag tttggtttga attgttcact tgaatcttca
     7141 ctgtttatgc ttttactatc agagtcactt cggagtttcc aatgtataac ttcagcactt
     7201 tgtggattta tatatgatat gttgatcttt tcttcctcaa ccaccccaca aacacttaca
     7261 ctcataatga actagttact atagtttctg aaaggtctct gccagcgatc cggtgtaacg
     7321 atttatgtag agcccttcca aggcaaccct ggaaggctgc ttttcaagga ttcgtcaatt
     7381 gcaatattaa aaaaaataaa cataaacttt gcattaaaa
//
