LOCUS       NM_001252326            4423 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus PAN2 poly(A) specific ribonuclease subunit (Pan2),
            transcript variant 2, mRNA.
ACCESSION   NM_001252326
VERSION     NM_001252326.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4423)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4423)
  AUTHORS   Sha,Q.Q., Zhu,Y.Z., Li,S., Jiang,Y., Chen,L., Sun,X.H., Shen,L.,
            Ou,X.H. and Fan,H.Y.
  TITLE     Characterization of zygotic genome activation-dependent maternal
            mRNA clearance in mouse
  JOURNAL   Nucleic Acids Res 48 (2), 879-894 (2020)
   PUBMED   31777931
REFERENCE   3  (bases 1 to 4423)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 4423)
  AUTHORS   Zheng,D., Ezzeddine,N., Chen,C.Y., Zhu,W., He,X. and Shyu,A.B.
  TITLE     Deadenylation is prerequisite for P-body formation and mRNA decay
            in mammalian cells
  JOURNAL   J Cell Biol 182 (1), 89-101 (2008)
   PUBMED   18625844
REFERENCE   5  (bases 1 to 4423)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (bases 1 to 4423)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4423)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135859.4, BC079841.1, CF170307.1 and AK004773.2.
            
            Transcript Variant: This variant (2) uses a different splice site
            in the coding region, compared to variant 1. The resulting protein
            (isoform 2) is shorter when it is compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079841.1, SRR9219381.319824.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AC135859.4         4005-4141           c
            138-1273            BC079841.1         99-1234
            1274-1739           CF170307.1         131-596
            1740-4057           BC079841.1         1701-4018
            4058-4423           AK004773.2         4686-5051
FEATURES             Location/Qualifiers
     source          1..4423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 76.51 cM"
     gene            1..4423
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /note="PAN2 poly(A) specific ribonuclease subunit"
                     /db_xref="GeneID:103135"
                     /db_xref="MGI:MGI:1918984"
     exon            1..137
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            138..536
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     CDS             255..3830
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /EC_number="3.1.13.4"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ubiquitin specific protease 52; PAB-dependent
                     poly(A)-specific ribonuclease subunit 2; inactive
                     ubiquitin carboxyl-terminal hydrolase 52; ubiquitin
                     specific peptidase 52; AN2 polyA specific ribonuclease
                     subunit homolog; PAB1P-dependent poly(A)-nuclease; PAN
                     deadenylation complex catalytic subunit 2; PAB-dependent
                     poly(A)-specific ribonuclease subunit PAN2; PAN2 polyA
                     specific ribonuclease subunit homolog; poly(A)-nuclease
                     deadenylation complex subunit 2; PAN2-PAN3 deadenylation
                     complex catalytic subunit Pan2"
                     /codon_start=1
                     /product="PAN2-PAN3 deadenylation complex catalytic
                     subunit Pan2 isoform 2"
                     /protein_id="NP_001239255.1"
                     /db_xref="CCDS:CCDS88107.1"
                     /db_xref="GeneID:103135"
                     /db_xref="MGI:MGI:1918984"
                     /translation="MNFEGLDPGLAEFSPAMHSTLDPVLDAHLNPSLLQNVELDPEGV
                     ALEALPVQESVHIMEGVYSELHSVVAEVGVPVSVSHFDLHEEMLWVGSHGGHATSFFG
                     PALERYSSFQVNGGDDIRQIQSLENGILFLTKNNLKYMARGGLIIFDYLLDENEDMHS
                     VLLTDNSTLLVGGLQNHVLEIDLNTVQETQKYAVETPGVTIMRQTNRFFFCGHTSGKV
                     SLRDLRSFKVEHEFDAFSGSLSDFDVHGNLLAACGFSSRLTGLACDRFLKVYDLRMMR
                     AITPLQVHVDPAFLRFIPTYTSRLAIISQSGQCQFCEPTGLANPADIFHVNPVGPLLM
                     TFDVSASKQALAFGDSEGCVHLWTDSPEPSFNPYSRETEFALPCLVDSLPPLDWSQDL
                     LPLSLIPVPLTTDALLSDWPAANSAPAPRRAPPVDAEILRTMKKVGFIGYAPNPRTRL
                     RNQIPYRLKESDHEFDNFSQVTESPTGREEEPLHTVSKKYRKVTIKYSKLGLEDFDFK
                     HYNKTLFAGLEPHIPNAYCNCMIQVLYFLEPVRCLIQNHLCQKEFCLACELGFLFHML
                     DLSRGDPCQGSNFLRAFRTIPEASALGLILADSDEASGKGSLARLIQRWNRFILTQLH
                     QDMQELEVPQAYRGAGGSFCSSGDSIIGQLFSCEMENCSLCRCGSETVRASSTLLFTL
                     SYPEDKTGKNYDFAQVLKRSICLEQNTQAWCDNCEKYQPTIQTRNIRHLPDILVINCE
                     VNSSKEADFWRLQAEVAFKIAVKKYGGEMKSKEFALADRKELRSPEGFLCSSIEELKN
                     VWLPFSIRMKMTKNKGLDVCNWADEHEWGPARAEEELGVYVYDLMATVVHILDSRTGG
                     SLVAHIKVGETYHQRKEGVTHQQWYLFNDFLIEPIDKYEAVQFDMNWKVPAILYYVKR
                     NLNSRYNLNIKNPIEASVLLAEASLARKQRKTHTTFIPLMLNEMPQVGDLVGLDAEFV
                     TLNEEEAELRSDGTKSTIKPSQMSVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLT
                     QYSGIKPGDLDAKISSKHLTTLKSTYLKLRFLIDIGVKFVGHGLQKDFRVINLMVPKD
                     QVLDTVYLFHMPRKRMISLRFLAWYFLDLKIQGETHDSIEDARTALQLYRKYLELSKN
                     GTEPESFHKVLKGLYEKGRKMDWKVPEPESQTSPKNAAVFSVLAL"
     exon            537..706
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            707..827
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            828..905
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1173
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1516
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1613
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1730
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1850
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1979
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2179
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2313
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2420
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2519
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2590
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..2729
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..2873
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..2933
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3024
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3182
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3183..3326
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3327..3506
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3507..3600
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3601..3798
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..4423
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4390..4395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /note="hexamer: AATAAA"
     polyA_site      4413
                     /gene="Pan2"
                     /gene_synonym="1200014O24Rik; mKIAA0710; Usp52"
                     /note="major polyA site"
ORIGIN      
        1 ttgcttgggt taggttgagc tagaggcggg ggagtagtag ggaaactgga atttcccgcg
       61 gagctgacgg cgctttctct accccctact cgtttgaatt ccacgcgctc caaaatatcc
      121 gccatggaga aatcttggcc agaatgtcca ttctaggttc actggtgctg tcctcctgaa
      181 ggctgggtca cttgtctgta ggaagcgtgg caagggaggg tgtgactccg gtctgaccag
      241 cggccactat cgtcatgaac tttgagggtc tggatcctgg actggccgaa ttttccccag
      301 ctatgcattc taccctggac ccagtcctgg atgcccacct gaatccaagt ttgctacaga
      361 atgtggagct agacccagag ggagtggcct tggaggctct tcctgtccag gagtcagtgc
      421 acataatgga aggtgtctac tctgagttgc acagcgtggt ggctgaagtg ggagtgcctg
      481 tgtctgtctc ccactttgat ttacatgagg agatgctgtg ggtggggagc catgggggcc
      541 atgccacctc cttcttcggc ccagctctgg agcgctactc atcctttcag gtcaatggtg
      601 gtgacgacat tcggcaaatc cagagcctgg agaacggtat cctcttcctc accaagaaca
      661 acctcaagta catggcccgt ggagggctca ttatatttga ctatttgctg gatgaaaacg
      721 aggatatgca cagcgtcctc ctgacagaca acagcactct gctcgttggg gggctgcaga
      781 accacgtact ggagattgac ctgaacactg tccaggagac tcagaagtat gcagtcgaga
      841 cacccggagt caccatcatg agacagacaa atcgtttctt cttctgtggc cacacatctg
      901 gcaaggtttc cctgcgagac ctccgtagtt ttaaagtgga gcatgaattt gatgccttct
      961 cagggagtct gtcagatttt gatgttcatg gcaacctgct ggctgcctgc ggcttctcca
     1021 gtcgccttac cggcctggcc tgtgaccgtt tcctcaaagt gtacgatctg cgcatgatgc
     1081 gtgccatcac acctcttcaa gtgcacgtgg atccggcctt cttacgattc atccccacat
     1141 acacttcccg ccttgctatc atctcccagt caggtcaatg ccagttttgt gaacccacag
     1201 gcctggccaa cccagccgac attttccatg tgaatcccgt gggacctttg ctaatgacgt
     1261 ttgatgtgtc agccagcaag caggccctgg cctttgggga ttctgagggc tgcgtgcatc
     1321 tctggactga ttcccctgag ccgtccttca acccctactc ccgagagact gagtttgccc
     1381 tgccctgtct tgtggactcc ttgccgcctc tggactggag ccaggatctg ctgccgcttt
     1441 ccctcattcc cgtcccactt accactgatg cactgctctc tgactggcct gctgccaact
     1501 ctgctcccgc tcccaggcga gcaccacctg tggatgcaga aattcttcga accatgaaga
     1561 aagtgggctt cattggctat gctcccaacc ctcgcaccag gctgcgcaac cagattccct
     1621 atcgactaaa ggagtcagac catgaatttg acaacttcag ccaagtcacg gagtcaccga
     1681 cagggcgaga agaggagcct ctccacacag tttctaagaa ataccggaag gtaaccatca
     1741 aatattccaa gctaggcctg gaagactttg acttcaaaca ctacaataag actctgtttg
     1801 ctgggttaga gcctcacatc cccaatgcct actgtaactg catgatccag gtgctctatt
     1861 tcttggagcc tgttcgctgt ctgatccaga accacctttg ccaaaaggag ttctgcctag
     1921 cgtgcgagct cggcttcctc ttccacatgc tagacctctc tcgtggcgat ccttgtcagg
     1981 gcagtaattt cctccgagct ttccggacca tccctgaggc ctcagctctg ggtctcatcc
     2041 ttgctgactc agatgaggct tcaggcaagg gcagtctggc ccggctcatc cagaggtgga
     2101 accgcttcat cctcactcag ctacatcagg atatgcagga gctggaagtg ccccaggctt
     2161 atcgaggtgc tggaggcagt ttctgctcat caggagactc catcattggg cagctgttca
     2221 gttgtgagat ggagaactgc agtctttgcc gctgcggcag cgagactgtg cgggcctcgt
     2281 ccaccctact cttcacactc tcctaccctg aggataaaac cgggaagaac tatgactttg
     2341 ctcaggtgct gaagcgaagt atctgcctgg agcagaacac acaggcctgg tgtgacaact
     2401 gtgagaagta ccagcccaca attcagacca gaaacatccg acatctgcca gatattcttg
     2461 tcattaactg tgaagtgaat agctcaaaag aggctgattt ctggagactg caagctgagg
     2521 ttgccttcaa aatagcggtg aaaaagtacg gcggggaaat gaagagcaaa gagtttgctt
     2581 tagctgatcg gaaggaactg aggagtccag agggctttct gtgttcctcc atcgaggagc
     2641 tgaagaatgt ctggcttcca ttttccatcc gcatgaagat gaccaagaac aaaggactgg
     2701 atgtttgcaa ctgggctgac gagcatgagt ggggtccggc cagggcagag gaggagcttg
     2761 gtgtctatgt atatgacctg atggctactg tggtacacat cctggactca cgaacaggcg
     2821 gcagcttggt ggctcacatc aaagtcggtg agacctacca ccagcgcaag gagggcgtga
     2881 ctcatcagca gtggtatctc ttcaatgact tccttattga acctattgat aagtatgaag
     2941 ccgtgcagtt tgacatgaat tggaaagtac ctgctatcct gtattatgtc aaaaggaatc
     3001 tcaattccag atacaatctg aatatcaaga accccattga ggccagtgtg ctgctggcag
     3061 aagcctcgct ggcacggaag caacggaaaa cacacacgac ctttattcca ttgatgctga
     3121 atgagatgcc acaggtcggg gacctggtgg gcctggatgc cgagtttgtc actcttaatg
     3181 aggaagaagc agagttacgc agtgatggta ccaagtccac cattaagcca agccagatgt
     3241 cagtagcaag gatcacctgt gttcggggcc aagggcctaa cgagggcatc cccttcattg
     3301 atgactacat ctccacgcag gagcaggtag tagattactt gactcagtac tcggggataa
     3361 agccaggaga ccttgatgcc aaaatctcct caaagcacct cacaaccctc aagtctacct
     3421 acttaaagct tcgctttctc attgatattg gagtcaagtt tgtgggtcat ggtctgcaga
     3481 aggacttccg ggtcatcaac ctcatggtgc ccaaggacca agttcttgac acagtctacc
     3541 tgttccacat gccccgaaaa cgaatgattt ccctacgatt cctggcctgg tattttctag
     3601 acctgaagat tcaaggtgag acccatgaca gcattgagga tgcccgcaca gcccttcaac
     3661 tctaccggaa gtatctggag ctgagcaaga acggcaccga gcccgagtcc ttccacaagg
     3721 tgctcaaggg tctctatgag aagggccgaa agatggactg gaaggtgcct gagcctgaaa
     3781 gccagacaag tcccaagaat gcagctgtct tctcagtgct ggcactgtga gctgccttcc
     3841 ctttcagtgc tgtccccaga actgagaggt ggcttctcaa gtcggcttta ccctgtccac
     3901 ttccagaact ggatctgctc agggtctaca gatggtgcta ttaatagaac tggaaagcag
     3961 caaaattgtt gcaaaggttc tagctgccag attccccctt tatcctctgc aaaacagtgg
     4021 gccagaaaca aagcctaaag tgacccaggt ggagtgattg gtgttcgtaa taaatatcct
     4081 gggcaactga tatctgtaca aaagagctct agaaccagaa ctctcagttc ccagtctgct
     4141 agagaactga agtcctggac agtcacaggg tacagagacc caggcagctc cagcatctag
     4201 ctgcttgaga gacggtggct gggtggacca gcttgtagag tctcaatggg ccaatcaaac
     4261 cggtgtgcag gaagctgagc tactggcttc attcctgacc acagctgaga agtatctgtc
     4321 ttccatacat tctatctcga gttttgtttt attttttaaa aattttgctt aaaacagcat
     4381 gttttataaa ataaaagtat ttttatctca ttagaaaacc gct
//
