LOCUS       NM_173749               2855 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus peptidase domain containing associated with muscle
            regeneration 1 (Pamr1), mRNA.
ACCESSION   NM_173749
VERSION     NM_173749.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2855)
  AUTHORS   Pennarubia,F., Germot,A., Pinault,E., Maftah,A. and Legardinier,S.
  TITLE     The single EGF-like domain of mouse PAMR1 is modified by O-Glucose,
            O-Fucose and O-GlcNAc
  JOURNAL   Glycobiology 31 (1), 55-68 (2021)
   PUBMED   32518939
  REMARK    GeneRIF: The single EGF-like domain of mouse PAMR1 is modified by
            O-Glucose, O-Fucose and O-GlcNAc.
REFERENCE   2  (bases 1 to 2855)
  AUTHORS   Arnes,L., Akerman,I., Balderes,D.A., Ferrer,J. and Sussel,L.
  TITLE     betalinc1 encodes a long noncoding RNA that regulates islet
            beta-cell formation and function
  JOURNAL   Genes Dev 30 (5), 502-507 (2016)
   PUBMED   26944677
REFERENCE   3  (bases 1 to 2855)
  AUTHORS   Sharma,P.R., Mackey,A.J., Dejene,E.A., Ramadan,J.W.,
            Langefeld,C.D., Palmer,N.D., Taylor,K.D., Wagenknecht,L.E.,
            Watanabe,R.M., Rich,S.S. and Nunemaker,C.S.
  TITLE     An Islet-Targeted Genome-Wide Association Scan Identifies Novel
            Genes Implicated in Cytokine-Mediated Islet Stress in Type 2
            Diabetes
  JOURNAL   Endocrinology 156 (9), 3147-3156 (2015)
   PUBMED   26018251
  REMARK    GeneRIF: related to islet dysfunction during the development of
            type 2 diabetes
REFERENCE   4  (bases 1 to 2855)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 2855)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 2855)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   7  (bases 1 to 2855)
  AUTHORS   Nakayama,Y., Nara,N., Kawakita,Y., Takeshima,Y., Arakawa,M.,
            Katoh,M., Morita,S., Iwatsuki,K., Tanaka,K., Okamoto,S.,
            Kitamura,T., Seki,N., Matsuda,R., Matsuo,M., Saito,K. and Hara,T.
  TITLE     Cloning of cDNA encoding a regeneration-associated muscle protease
            whose expression is attenuated in cell lines derived from Duchenne
            muscular dystrophy patients
  JOURNAL   Am J Pathol 164 (5), 1773-1782 (2004)
   PUBMED   15111323
  REMARK    GeneRIF: RAMP may play a role in the regeneration of skeletal
            muscle, and its down-regulation could be involved in the
            progression of Duchenne muscular dystrophy
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY264071.1, BY266233.1, BB620582.1, AA444868.1, AL844605.5 and
            CX564812.1.
            
            On Mar 14, 2009 this sequence version replaced NM_173749.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088017.1, BC057685.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                BY264071.1         2-80
            80-267              BY266233.1         30-217
            268-778             BB620582.1         135-645
            779-1216            AA444868.1         26-463
            1217-1271           AL844605.5         61446-61500
            1272-1376           AL844605.5         64471-64575
            1377-1803           CX564812.1         31-457
            1804-2855           AL844605.5         67250-68301
FEATURES             Location/Qualifiers
     source          1..2855
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 54.13 cM"
     gene            1..2855
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /note="peptidase domain containing associated with muscle
                     regeneration 1"
                     /db_xref="GeneID:210622"
                     /db_xref="MGI:MGI:2445082"
     exon            1..244
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2334
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /note="regeneration associated muscle protease; inactive
                     serine protease PAMR1; regeneration-associated muscle
                     protease homolog; peptidase domain-containing protein
                     associated with muscle regeneration 1"
                     /codon_start=1
                     /product="inactive serine protease PAMR1 precursor"
                     /protein_id="NP_776110.3"
                     /db_xref="CCDS:CCDS16468.1"
                     /db_xref="GeneID:210622"
                     /db_xref="MGI:MGI:2445082"
                     /translation="MELDRWAQLGLVFLQLLLISSLPREYTVINEACPGAEWNIMCRE
                     CCEYDQIECLCPGKKEVVGYTIPCCRNEDNECDSCLIHPGCTIFENCKSCRNGSWGGT
                     LDDFYVKGFYCAECRAGWYGGDCMRCGQVLRASKGQILLESYPLNAHCEWTIHARPGF
                     IIQLRFGMLSLEFDYMCQYDYVEVRDGDNSDSPIIKRFCGNERPAPIRSTGSSLHVLF
                     HSDGSKNFDGFHAVFEEITACSSSPCFHDGTCLLDTTGSFKCACLAGYTGQRCENLLE
                     ERNCSDLGGPVNGYKKITEGPGLLNERHVKIGTVVSFFCNGSYVLSGNEKRTCQQNGE
                     WSGKQPVCMKACREPKISDLVRRRVLSMQVQSRETPLHQLYSTAFSKQKLQDASTKKP
                     ALPFGDLPPGYQHLHTQVQYECISPFYRRLGSSRRTCLRTGKWSGRAPSCIPICGKIE
                     STPSPKTQGTRWPWQAAIYRRTSGVHDGGLHKGAWFLVCSGALVNERTVVVAAHCVTE
                     LGKATIIKTADLKVVLGKFYRDDDRDEKSIQNLRVSAIILHPNYDPILLDTDIAVLKL
                     LDKARISTRVQPICLATTRDLSTSFQESHITVAGWNILADVRSPGFKNDTLHYGMVRV
                     VDPMLCEEQHEDHGIPVSVTDNMFCASKDPSTPSDICTAETGGIAALSFPGRASPEPR
                     WHLVGLVSWSYDKTCSNGLSTAFTKVLPFKDWIERNMK"
     exon            245..421
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            422..550
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            551..665
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            666..883
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            884..991
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1204
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1271
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1504
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1797
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..2855
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2824..2829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /note="hexamer: AACAAG"
     polyA_site      2855
                     /gene="Pamr1"
                     /gene_synonym="5930437L24; E430002G05Rik; Ramp"
                     /note="major polyA site"
ORIGIN      
        1 ggttccccta gctgagggtg ggagagcccg gcgggctgaa acccgagctc tgtttcagct
       61 ggagcttggg gaggtcccgg caagagcaga gcccgctgcc ctgttctcgc ctaggcatcc
      121 ctccagtcac tcccctccag tcactcggta ccgacacagc aacgggaaac gatggagcta
      181 gacagatggg cgcagttggg gctggtgttc ctgcagctcc ttctcatctc atcgttgcca
      241 agagagtaca cggtcattaa tgaagcctgt cccggagctg agtggaacat catgtgtaga
      301 gaatgttgtg aatatgatca gattgaatgc ctctgcccag gaaagaagga agtggtgggt
      361 tacaccatcc catgctgcag gaatgaggat aatgaatgtg actcctgtct aattcaccca
      421 ggttgtacca tctttgaaaa ctgcaagagc tgccgcaatg gctcctgggg cggaactctg
      481 gatgacttct acgtgaaggg attctactgc gcagagtgca gggcaggctg gtacggagga
      541 gactgcatgc gatgtggcca ggttcttcga gcctcaaagg gtcagatctt gttggagagc
      601 tatcccttaa acgctcactg tgaatggact attcatgcca gacctgggtt tatcatccag
      661 ttgaggtttg gtatgctgag cctagagttt gactacatgt gccaatatga ctatgtggag
      721 gtccgcgatg gggataatag tgacagccct atcatcaagc gtttctgtgg caacgagagg
      781 ccagctccca tcaggagcac tggctcttca ctccatgtcc ttttccattc tgatggctcc
      841 aagaacttcg atggcttcca cgctgtcttt gaggagatca cagcgtgctc ctcatcccct
      901 tgtttccatg atggcacatg cctccttgac accactgggt ctttcaagtg tgcctgcctg
      961 gctggctaca ctgggcagcg ctgtgaaaat ctacttgaag aaagaaactg ctcagacctt
     1021 ggggggccag tcaatgggta caagaaaatc acagaaggtc ctggacttct caatgagcgc
     1081 catgtaaaaa ttggcacggt tgtgtctttc ttttgtaacg gctcatacgt tctgagtggc
     1141 aatgagaaac gaacttgcca gcagaatgga gagtggtcag gaaagcaacc tgtctgcatg
     1201 aaagcctgcc gggaaccgaa gatctcagac ctggtgagaa ggagagtcct ttcgatgcag
     1261 gttcagtcaa gggagacacc attacatcag ctttattcca cggctttcag caagcagaaa
     1321 ttgcaggatg cctctaccaa aaagccagcc cttccatttg gagacctgcc ccctggatac
     1381 caacatctgc acacccaagt ccagtatgag tgcatctcgc ccttctaccg ccgcctggga
     1441 agcagcagga ggacatgcct gagaactggg aagtggagtg ggcgggcccc gtcctgtatc
     1501 ccaatctgtg gaaaaatcga gagcactcct tctccaaaga cccaaggcac ccgctggcca
     1561 tggcaggcag ccatctaccg gaggaccagt ggtgtacacg atggtggtct gcacaaaggt
     1621 gcatggttct tggtctgcag tggtgccctg gtgaatgaac ggactgtggt tgtggctgcc
     1681 cactgtgtga ctgagctggg gaaggccacc atcatcaaga cagcagacct caaggttgtc
     1741 ttgggaaaat tctacaggga cgatgatcgg gatgagaaga gcatccagaa tttacgggtt
     1801 tctgctatca ttctgcaccc caactatgac cctatcctgc ttgacactga catcgctgtt
     1861 ctgaagctcc tagacaaagc tcgcatcagt acccgtgtcc aacccatctg cctggctacc
     1921 actcgggacc tcagcacctc tttccaggaa tcccacatca ctgtggctgg ctggaacatc
     1981 ctggcagatg tgaggagccc tggctttaag aatgatacct tacattatgg aatggtcaga
     2041 gtggtagacc caatgctttg tgaggaacag catgaagacc atggcattcc agttagtgtc
     2101 actgacaaca tgttctgtgc cagcaaagat cccagtaccc cttctgacat ctgcactgca
     2161 gagacagggg gcatcgctgc tttgtccttc ccaggccgag catcccccga gccacgctgg
     2221 catttggtgg ggctggtcag ctggagctat gacaagacat gtagcaatgg cctatccaca
     2281 gccttcacaa aggtgttgcc gttcaaagac tggattgaga gaaacatgaa atgaaccagc
     2341 cacaaggcca ctgagaagcc ttttcctagc atccgtctgt acatatgttg tatagaacaa
     2401 tgcgggcctg aagtgtaatt ttgcccacca tcttggctac tgaaaggctc ctggtttcag
     2461 ggacttatct caatagaggg tgaacagagt ttacttcatc agggaactgt ctccctgact
     2521 gcttgggaat catctaaaag atgccaggtc ttgcaacaac tggatttctt caaagaagac
     2581 catgtgacta gaaggagaac ctcttgctcc tgctccactc agagtgatgt gactgtcaat
     2641 cagtttgggt tgagaaggtt gatttgggga ggcctgggct gcacctggct tctgtcaaag
     2701 ttccaaagaa caaacaactt agactagccc agggcaaagg agattgggtg tggcaccctg
     2761 tgtaaattgt cacaagattg tctgatcctt tccctttcca atcttctgta cacatttcaa
     2821 taaaacaagg tctgctccct gacctacaaa acaaa
//
