LOCUS       NM_025571                552 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus presequence translocase-asssociated motor 16 (Pam16),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025571
VERSION     NM_025571.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 552)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 552)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 552)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 552)
  AUTHORS   Richter-Dennerlein,R., Korwitz,A., Haag,M., Tatsuta,T.,
            Dargazanli,S., Baker,M., Decker,T., Lamkemeyer,T., Rugarli,E.I. and
            Langer,T.
  TITLE     DNAJC19, a mitochondrial cochaperone associated with
            cardiomyopathy, forms a complex with prohibitins to regulate
            cardiolipin remodeling
  JOURNAL   Cell Metab 20 (1), 158-171 (2014)
   PUBMED   24856930
REFERENCE   5  (bases 1 to 552)
  AUTHORS   Tagliati,F., Gentilin,E., Buratto,M., Mole,D., degli Uberti,E.C.
            and Zatelli,M.C.
  TITLE     Magmas, a gene newly identified as overexpressed in human and mouse
            ACTH-secreting pituitary adenomas, protects pituitary cells from
            apoptotic stimuli
  JOURNAL   Endocrinology 151 (10), 4635-4642 (2010)
   PUBMED   20719856
REFERENCE   6  (bases 1 to 552)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   7  (bases 1 to 552)
  AUTHORS   Scheible,W.R., Fry,B., Kochevenko,A., Schindelasch,D., Zimmerli,L.,
            Somerville,S., Loria,R. and Somerville,C.R.
  TITLE     An Arabidopsis mutant resistant to thaxtomin A, a cellulose
            synthesis inhibitor from Streptomyces species
  JOURNAL   Plant Cell 15 (8), 1781-1794 (2003)
   PUBMED   12897252
REFERENCE   8  (bases 1 to 552)
  AUTHORS   Jubinsky,P.T., Short,M.K., Mutema,G. and Witte,D.P.
  TITLE     Developmental expression of Magmas in murine tissues and its
            co-expression with the GM-CSF receptor
  JOURNAL   J Histochem Cytochem 51 (5), 585-596 (2003)
   PUBMED   12704206
REFERENCE   9  (bases 1 to 552)
  AUTHORS   Phan,L.K., Lin,F., LeDuc,C.A., Chung,W.K. and Leibel,R.L.
  TITLE     The mouse mahoganoid coat color mutation disrupts a novel C3HC4
            RING domain protein
  JOURNAL   J Clin Invest 110 (10), 1449-1459 (2002)
   PUBMED   12438443
REFERENCE   10 (bases 1 to 552)
  AUTHORS   Jubinsky,P.T., Messer,A., Bender,J., Morris,R.E., Ciraolo,G.M.,
            Witte,D.P., Hawley,R.G. and Short,M.K.
  TITLE     Identification and characterization of Magmas, a novel
            mitochondria-associated protein involved in granulocyte-macrophage
            colony-stimulating factor signal transduction
  JOURNAL   Exp Hematol 29 (12), 1392-1402 (2001)
   PUBMED   11750097
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008380.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008380.1, BY708294.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415129, SAMN02415134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.45 cM"
     gene            1..552
                     /gene="Pam16"
                     /gene_synonym="2010110I09Rik; CGI-136; Magmas; Tim16;
                     Timm16"
                     /note="presequence translocase-asssociated motor 16"
                     /db_xref="GeneID:66449"
                     /db_xref="MGI:MGI:1913699"
     exon            1..96
                     /gene="Pam16"
                     /gene_synonym="2010110I09Rik; CGI-136; Magmas; Tim16;
                     Timm16"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..471
                     /gene="Pam16"
                     /gene_synonym="2010110I09Rik; CGI-136; Magmas; Tim16;
                     Timm16"
                     /note="mitochondria-associated protein involved in
                     granulocyte-macrophage colony-stimulating factor signal
                     transduction; presequence translocase-asssociated motor 16
                     homolog; mitochondria associated granulocyte macrophage
                     CSF signaling molecule; magmas processed gene 1;
                     presequence translocated-associated motor subunit PAM16"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit TIM16"
                     /protein_id="NP_079847.1"
                     /db_xref="CCDS:CCDS37241.1"
                     /db_xref="GeneID:66449"
                     /db_xref="MGI:MGI:1913699"
                     /translation="MAKYLAQIIVMGVQVVGRAFARALRQEFAASQAAADARGRAGHQ
                     SAAASNLSGLSLQEAQQILNVSKLSPEEVQKNYEHLFKVNDKSVGGSFYLQSKVVRAK
                     ERLDEELRIQAQEDREKGQKPKT"
     exon            97..181
                     /gene="Pam16"
                     /gene_synonym="2010110I09Rik; CGI-136; Magmas; Tim16;
                     Timm16"
                     /inference="alignment:Splign:2.1.0"
     exon            182..318
                     /gene="Pam16"
                     /gene_synonym="2010110I09Rik; CGI-136; Magmas; Tim16;
                     Timm16"
                     /inference="alignment:Splign:2.1.0"
     exon            319..384
                     /gene="Pam16"
                     /gene_synonym="2010110I09Rik; CGI-136; Magmas; Tim16;
                     Timm16"
                     /inference="alignment:Splign:2.1.0"
     exon            385..552
                     /gene="Pam16"
                     /gene_synonym="2010110I09Rik; CGI-136; Magmas; Tim16;
                     Timm16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtctccctt gacctctgac ccaccagcaa cccttgagct ggtcccactg ggtcgggaag
       61 cggcacccgt ccccctaaag tggagcgtcc gccatggcca agtacctggc ccagatcatt
      121 gtgatgggtg tgcaggtggt gggcagagcc tttgccaggg ccctgaggca ggagtttgca
      181 gccagccagg cagccgctga cgctcgaggg cgtgctgggc accagtctgc agctgcatcc
      241 aatctctctg gcctcagcct ccaggaagcc cagcagattc tcaacgtctc caagctgagc
      301 cccgaggagg tccagaagaa ttatgaacac ctatttaaag tgaatgataa gtccgtgggt
      361 ggctctttct acctgcagtc aaaggttgtc cgtgcaaagg aacgtctaga tgaggaactc
      421 cgaatacaag cccaggaaga cagagagaaa gggcagaagc ccaaaacgtg actgctgggc
      481 tctccacacc ccagccattg cctcataatt tatagcctag taataaatgt cttttgcgtg
      541 tttctccact gc
//
