LOCUS       NM_001361248            2820 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protein associated with LIN7 2, MAGUK family member
            (Pals2), transcript variant 5, mRNA.
ACCESSION   NM_001361248
VERSION     NM_001361248.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2820)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2820)
  AUTHORS   Saitoh,Y., Kamijo,A., Yamauchi,J., Sakamoto,T. and Terada,N.
  TITLE     The membrane palmitoylated protein, MPP6, is involved in myelin
            formation in the mouse peripheral nervous system
  JOURNAL   Histochem Cell Biol 151 (5), 385-394 (2019)
   PUBMED   30357511
  REMARK    GeneRIF: The results indicate that the MPP6-Lin7 complex regulates
            myelin formation.
REFERENCE   3  (bases 1 to 2820)
  AUTHORS   Kamijo,A., Saitoh,Y., Ohno,N., Ohno,S. and Terada,N.
  TITLE     Immunohistochemical study of the membrane skeletal protein,
            membrane protein palmitoylated 6 (MPP6), in the mouse small
            intestine
  JOURNAL   Histochem Cell Biol 145 (1), 81-92 (2016)
   PUBMED   26496923
  REMARK    GeneRIF: This paper herein showed the immunolocalization and
            interaction proteins of MPP6 in the mouse small intestine, and also
            that 4.1B in epithelial cells was not essential for the sorting of
            MPP6.
REFERENCE   4  (bases 1 to 2820)
  AUTHORS   Terada,N., Saitoh,Y., Ohno,N., Komada,M., Yamauchi,J. and Ohno,S.
  TITLE     Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in
            Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS
  JOURNAL   Histochem Cell Biol 140 (2), 213-222 (2013)
   PUBMED   23306908
  REMARK    GeneRIF: The findings indicate that the Src-MPP6-4.1G protein
            complex in Schmidt-Lanterman incisures(SLIs) has a role in signal
            transduction in the peripheral nervous system(PNS).
REFERENCE   5  (bases 1 to 2820)
  AUTHORS   Terada,N., Saitoh,Y., Ohno,N., Komada,M., Saitoh,S., Peles,E. and
            Ohno,S.
  TITLE     Essential function of protein 4.1G in targeting of membrane protein
            palmitoylated 6 into Schmidt-Lanterman incisures in myelinated
            nerves
  JOURNAL   Mol Cell Biol 32 (1), 199-205 (2012)
   PUBMED   22025680
  REMARK    GeneRIF: In the mouse sciatic nerve, protein 4.1G colocalized at
            Schmidt-Lanterman incisures (SLI) and the paranodes with a member
            of the membrane-associated guanylate kinase (MAGUK) family,
            membrane protein palmitoylated 6.
REFERENCE   6  (bases 1 to 2820)
  AUTHORS   Karnak,D., Lee,S. and Margolis,B.
  TITLE     Identification of multiple binding partners for the amino-terminal
            domain of synapse-associated protein 97
  JOURNAL   J Biol Chem 277 (48), 46730-46735 (2002)
   PUBMED   12351654
REFERENCE   7  (bases 1 to 2820)
  AUTHORS   Maeda,Y., Fukushima,K., Kasai,N., Maeta,M. and Nishizaki,K.
  TITLE     Quantification of TECTA and DFNA5 expression in the developing
            mouse cochlea
  JOURNAL   Neuroreport 12 (15), 3223-3226 (2001)
   PUBMED   11711860
REFERENCE   8  (bases 1 to 2820)
  AUTHORS   Kamberov,E., Makarova,O., Roh,M., Liu,A., Karnak,D., Straight,S.
            and Margolis,B.
  TITLE     Molecular cloning and characterization of Pals, proteins associated
            with mLin-7
  JOURNAL   J Biol Chem 275 (15), 11425-11431 (2000)
   PUBMED   10753959
REFERENCE   9  (bases 1 to 2820)
  AUTHORS   Van Laer,L., Huizing,E.H., Verstreken,M., van Zuijlen,D.,
            Wauters,J.G., Bossuyt,P.J., Van de Heyning,P., McGuirt,W.T.,
            Smith,R.J., Willems,P.J., Legan,P.K., Richardson,G.P. and Van
            Camp,G.
  TITLE     Nonsyndromic hearing impairment is associated with a mutation in
            DFNA5
  JOURNAL   Nat Genet 20 (2), 194-197 (1998)
   PUBMED   9771715
REFERENCE   10 (bases 1 to 2820)
  AUTHORS   Guthridge,M.A., Seldin,M. and Basilico,C.
  TITLE     Induction of expression of growth-related genes by FGF-4 in mouse
            fibroblasts
  JOURNAL   Oncogene 12 (6), 1267-1278 (1996)
   PUBMED   8649829
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153618.4.
            
            On Aug 24, 2022 this sequence version replaced NM_001361248.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.227169.1,
                                           SRR1660811.86043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AC153618.4         91202-91467         c
            267-332             AC153618.4         58545-58610         c
            333-451             AC153618.4         56437-56555         c
            452-604             AC153618.4         43495-43647         c
            605-754             AC153618.4         39594-39743         c
            755-982             AC153618.4         38680-38907         c
            983-1024            AC153618.4         25411-25452         c
            1025-1156           AC153618.4         23809-23940         c
            1157-1256           AC153618.4         22054-22153         c
            1257-1325           AC153618.4         21670-21738         c
            1326-1487           AC153618.4         18458-18619         c
            1488-1690           AC153618.4         7601-7803           c
            1691-1819           AC153618.4         5687-5815           c
            1820-2820           AC153618.4         3175-4175           c
FEATURES             Location/Qualifiers
     source          1..2820
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.13 cM"
     gene            1..2820
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /note="protein associated with LIN7 2, MAGUK family
                     member"
                     /db_xref="GeneID:56524"
                     /db_xref="MGI:MGI:1927340"
     exon            1..266
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            267..332
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            333..451
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            452..604
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            605..754
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            755..982
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1024
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1156
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1256
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1325
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1487
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1690
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1819
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2820
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2023..2028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /note="hexamer: AATAAA"
     polyA_site      2043
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /note="major polyA site"
     regulatory      2248..2253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /note="hexamer: AAGAAA"
     polyA_site      2265
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
     regulatory      2803..2808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
                     /note="hexamer: TATAAA"
     polyA_site      2820
                     /gene="Pals2"
                     /gene_synonym="Mpp6; P55t"
ORIGIN      
        1 tggacacatt tgcctgaaag cagaaaggtg cctgccttct cttcccccac ttctattttg
       61 gccggacggc aggccggagg ggagtagatg caagatcgga cagcgcggtg acagcttgtg
      121 gattggttgg ggtgtctttg gttatttttc ttgctggggg gactcttttt tttttttttt
      181 aacactttat tgggagttta ttctcaaggt accagttcct gggatcgcag ctcgagaaaa
      241 cattcattaa gctccccttt tctgggtaac acaaggcaca ttaacatcag gaagaagtct
      301 atgagaagac ctcaaagctt cacacgaaat cgaaatgcag caagttttgg aaaaccttac
      361 agagctgccc tcatctacag gagcagagga gatagaccta attttcctca aggggattat
      421 ggagaatcct attgtgaagt cacttgctaa ggctcatgag agacttgaag attcaaagtt
      481 agaagctgtg agtgacaata acttggaatt agtgaatgaa attcttgaag atatcactcc
      541 tctgattagt gtggatgaaa atgtggcaga gctagttggg atactcaagg agcctcactt
      601 ccagtcgctc ctggaggccc atgatattgt ggcatcaaag tgttatgatt cgcctccttc
      661 cagcccagaa atgaatattc cttctctcaa taatcaattg ccagtagatg ccatccgtat
      721 tctcggtatt cacaaaaaag ctggagagcc attgggtgta acatttagag ttgaaaataa
      781 tgatctggta atcgcccgaa tccttcatgg aggaatgata gatcgacaag gtctgcttca
      841 cgtgggagat atcattaagg aagtcaatgg tcatgaggtt ggaaacaatc caaaggaatt
      901 acaagaatta ttgaaaaata ttagtggaag tgtcacccta aaaattttac caagttacag
      961 agatactatt actcctcagc agagttacgt caatatggag aggcacccag cccacgtccg
     1021 tcaggtattt gtcaagtgtc attttgatta taatccattc aatgataacc tgataccctg
     1081 caaagaagca ggactaaaat tttccaaagg agaaattctt cagattgtaa acagagaaga
     1141 cccaaattgg tggcaggcta gccatgtgaa agagggagga agtgctggtc tgattccaag
     1201 ccagttcctg gaagagaaga gaaaggcatt tgttcgccga gactgggaca attcaggacc
     1261 cttttgtgga actataagca acaagaaaaa gaaaaagatg atgtacctca caaccaggaa
     1321 tgcagagttt gatcgtcatg aaattcagat ctatgaggaa gtagcaaaaa tgccaccctt
     1381 ccaacggaaa acgttagttt tgatcggagc tcaaggtgtg ggcagaagga gcttgaaaaa
     1441 caggttcata gtactgaatc ctgctagatt tggaacaacg gtgccattta cttcacggaa
     1501 gccaagagaa gacgaaaagg atggacaagc atataaattt gtgtcccgat cagagatgga
     1561 agcagatatt aaggctggga agtatttgga gcatggggag tacgaaggaa acctgtatgg
     1621 aaccaagatc gactctattc tcgaggttgt ccagactggg cggacttgca ttttggacgt
     1681 caacccacaa gcactgaaag tgttaaggac ttctgaattc atgccttatg tggtgtttat
     1741 tgctgctcca gagctagaga ccttgcgtgc catgcacaag gctgtggtgg atgcgggaat
     1801 caccaccaag cttttgacgg actctgactt gaagaaaaca gtggatgaaa gtgcccgaat
     1861 tcagagagca tacaaccact actttgattt gatcatcgta aatgacaatc tagacaaagc
     1921 ctttgagaaa ctacaaactg ccattgagaa actgaggatg gagccacagt gggtcccaat
     1981 tagctgggtg tactgatgat tcaataaggt taacaacaga taaataaaac tttaaaacag
     2041 tgactcaaca agtcagcctt ctgctgggcg agcacatgca gaggtggaag gcgcctgcgc
     2101 atcaaggcat ttttattgtg tagattgaaa taacagtgca ctaggtggaa tttttatata
     2161 tttgtggttg ggaaggtgta ctaatatata atttctctta atttttctaa ctttttatgg
     2221 ataaaacctt tctattcata ccacataaag aaatgcgttc aagcattttg taagttttga
     2281 tttagtaccc ttgctttttc atcaaaggaa ttttcagatc attctctcaa acattgatct
     2341 cacattttca ctgtgataat gaatacttga aatagttttg taatgctgtc attcttgtaa
     2401 gtggttagtg aagggtcaat tattctctta ttagaaaaaa atagttattg accttcctca
     2461 gactccttac agaagcagaa tttagatatc agtgcaacgg ctaagtccac tactatctta
     2521 atctgctcag tgccacctct tagtccagag tatggcggct gctcattcta tttgtaagat
     2581 aaatccaccc ccaccccacc ccactcccat ctctctctag tcaacacaat gaagagcaat
     2641 agcttgcact ctctatggga ttattttcat ttgtcgcagt gatgtgctga tgccgactaa
     2701 tgttgcatat tagctatgga gctcgggtgg aagcatggtc atgcacacag agagtgcctt
     2761 atcctgcaaa cttaacttag agaacattta cttattttca aatataaaat ttcaaaccta
//
