LOCUS       NM_019579               5529 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus protein associated with LIN7 1, MAGUK family member
            (Pals1), mRNA.
ACCESSION   NM_019579
VERSION     NM_019579.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5529)
  AUTHORS   Groh,A.C., Moller-Kerutt,A., Gilhaus,K., Hoffken,V., Nedvetsky,P.,
            Kleimann,S., Behrens,M., Ghosh,S., Hansen,U., Krahn,M.P., Ebnet,K.,
            Pavenstadt,H., Ludwig,A. and Weide,T.
  TITLE     PALS1 is a key regulator of the lateral distribution of tight
            junction proteins in renal epithelial cells
  JOURNAL   J Cell Sci 137 (5) (2024)
   PUBMED   38265145
  REMARK    GeneRIF: PALS1 is a key regulator of the lateral distribution of
            tight junction proteins in renal epithelial cells.
REFERENCE   2  (bases 1 to 5529)
  AUTHORS   Gredler,M.L. and Zallen,J.A.
  TITLE     Multicellular rosettes link mesenchymal-epithelial transition to
            radial intercalation in the mouse axial mesoderm
  JOURNAL   Dev Cell 58 (11), 933-950 (2023)
   PUBMED   37080203
REFERENCE   3  (bases 1 to 5529)
  AUTHORS   Sterling,N.A., Park,J.Y., Park,R., Cho,S.H. and Kim,S.
  TITLE     An entosis-like process induces mitotic disruption in Pals1
            microcephaly pathogenesis
  JOURNAL   Nat Commun 14 (1), 82 (2023)
   PUBMED   36604424
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5529)
  AUTHORS   Brault,J.B., Bardin,S., Lampic,M., Carpentieri,J.A., Coquand,L.,
            Penisson,M., Lachuer,H., Victoria,G.S., Baloul,S., El Marjou,F.,
            Boncompain,G., Miserey-Lenkei,S., Belvindrah,R., Fraisier,V.,
            Francis,F., Perez,F., Goud,B. and Baffet,A.D.
  TITLE     RAB6 and dynein drive post-Golgi apical transport to prevent
            neuronal progenitor delamination
  JOURNAL   EMBO Rep 23 (10), e54605 (2022)
   PUBMED   35979738
REFERENCE   5  (bases 1 to 5529)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5529)
  AUTHORS   Wang,Q., Hurd,T.W. and Margolis,B.
  TITLE     Tight junction protein Par6 interacts with an evolutionarily
            conserved region in the amino terminus of PALS1/stardust
  JOURNAL   J Biol Chem 279 (29), 30715-30721 (2004)
   PUBMED   15140881
REFERENCE   7  (bases 1 to 5529)
  AUTHORS   Hurd,T.W., Gao,L., Roh,M.H., Macara,I.G. and Margolis,B.
  TITLE     Direct interaction of two polarity complexes implicated in
            epithelial tight junction assembly
  JOURNAL   Nat Cell Biol 5 (2), 137-142 (2003)
   PUBMED   12545177
REFERENCE   8  (bases 1 to 5529)
  AUTHORS   Makarova,O., Roh,M.H., Liu,C.J., Laurinec,S. and Margolis,B.
  TITLE     Mammalian Crumbs3 is a small transmembrane protein linked to
            protein associated with Lin-7 (Pals1)
  JOURNAL   Gene 302 (1-2), 21-29 (2003)
   PUBMED   12527193
REFERENCE   9  (bases 1 to 5529)
  AUTHORS   Roh,M.H., Makarova,O., Liu,C.J., Shin,K., Lee,S., Laurinec,S.,
            Goyal,M., Wiggins,R. and Margolis,B.
  TITLE     The Maguk protein, Pals1, functions as an adapter, linking
            mammalian homologues of Crumbs and Discs Lost
  JOURNAL   J Cell Biol 157 (1), 161-172 (2002)
   PUBMED   11927608
REFERENCE   10 (bases 1 to 5529)
  AUTHORS   Kamberov,E., Makarova,O., Roh,M., Liu,A., Karnak,D., Straight,S.
            and Margolis,B.
  TITLE     Molecular cloning and characterization of Pals, proteins associated
            with mLin-7
  JOURNAL   J Biol Chem 275 (15), 11425-11431 (2000)
   PUBMED   10753959
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB858385.1, AK032731.1, BC138624.1, AK133187.1, AK040265.1 and
            AW488563.1.
            
            On Apr 7, 2010 this sequence version replaced NM_019579.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075698.1, SRR1660813.180875.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BB858385.1         1-43
            44-121              AK032731.1         2-79
            122-2502            BC138624.1         1-2381
            2503-4458           AK133187.1         2396-4351
            4459-5367           AK040265.1         1649-2557
            5368-5529           AW488563.1         1-162               c
FEATURES             Location/Qualifiers
     source          1..5529
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 35.51 cM"
     gene            1..5529
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /note="protein associated with LIN7 1, MAGUK family
                     member"
                     /db_xref="GeneID:56217"
                     /db_xref="MGI:MGI:1927339"
     exon            1..160
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            161..249
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            250..774
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..2435
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /note="MAGUK p55 subfamily member 5; protein associated
                     with Lin-7 1; membrane protein, palmitoylated 3 (MAGUK p55
                     subfamily member 5); membrane protein, palmitoylated 5
                     (MAGUK p55 subfamily member 5)"
                     /codon_start=1
                     /product="protein PALS1"
                     /protein_id="NP_062525.1"
                     /db_xref="CCDS:CCDS26001.1"
                     /db_xref="GeneID:56217"
                     /db_xref="MGI:MGI:1927339"
                     /translation="MTTSYMNGHVTEESDSGIKNLDLASPEEYPKHREMAVDCPGDLG
                     TRMMPVRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNP
                     IFDTEEGIVLESPHYAVNILDVEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNRDFQ
                     NAFKIHNAVTVHMSKASPPFPLIANVQDLVQEVQTVLKPVHQKEGQELTALLNAPHIQ
                     ALLLAHDKVAEQEMQLEPITDERVYESIGHYGGETVKIVRIEKARDIPLGATVRNEMD
                     SVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIP
                     SQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQA
                     YREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLY
                     NANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFA
                     SAVPHTTRNRRDHEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQV
                     INSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREI
                     IEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR"
     exon            775..983
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1061
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1208
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1370
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1448
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1632
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1704
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1776
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1944
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2147
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2258
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2259..5515
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5358..5363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /note="hexamer: AATAAA"
     regulatory      5365..5370
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /note="hexamer: AGTAAA"
     polyA_site      5376
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
     polyA_site      5391
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /note="major polyA site"
     regulatory      5496..5501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
                     /note="hexamer: AATACA"
     polyA_site      5515
                     /gene="Pals1"
                     /gene_synonym="3830420B02Rik; Mpp5"
ORIGIN      
        1 tgaggagggg gcggggactg gagactccga ggtgggagga atcgggagtt tctggattct
       61 ttatccagtg ttttgagggc cgccagacgg agggctgttg cttgggctgc gttgaggagc
      121 gagggaggga gagaggatcg gcggccgccg gggcttggag aaaaaagaaa gctaacctga
      181 atattgggag aggaaaaaaa cagagaagag aaataaggat agaagaaaag attttccagt
      241 ttgaataata tttccctcat ggatacattt catagcatta ttatgtgata tgagaagtta
      301 tttttctttc tttgaagtaa catggatttt atactacaga atcaagagaa ttggctttat
      361 agcaaatttt gatatataaa aagtggtaca ggtttttata gataaccatg acaacatcat
      421 atatgaatgg gcatgtaaca gaggaatcag acagcggaat aaaaaatctt gatcttgcat
      481 caccagagga atatccgaag caccgagaga tggctgttga ctgccctgga gatttgggca
      541 ccagaatgat gccagtgcga agaagtgcac agttagagcg gattcgacaa caacaggagg
      601 atatgagacg taggcgcgaa gaggaaggga aaaagcaaga acttgaccta aattcttcca
      661 tgagacttaa gaaactagct caaattcctc caaagactgg aatagataac cctatatttg
      721 acacggaaga aggaattgtt ttagaaagtc ctcactatgc tgtgaacata ttagacgttg
      781 aagacttgtt ctcttcactt aaacacatcc aacacacttt ggttgattct cagagccagg
      841 aggatatctc actgctttta cagcttgtac aaaacagaga ttttcagaat gcattcaaga
      901 tacacaatgc tgtcacagta cacatgagca aggccagccc tccgtttcct cttatcgcca
      961 atgtacaaga ccttgtacaa gaggtacaaa ctgtcttaaa gccagtccat cagaaggaag
     1021 gacaagaact aactgccttg ttgaatgctc cacatattca ggcactttta ctggcccatg
     1081 ataaggttgc tgagcaggaa atgcagctag agcccattac agatgagaga gtttatgaaa
     1141 gtatcggcca ttacggggga gaaactgtaa aaatagttcg tatagaaaag gctcgggata
     1201 ttccattggg tgccacagtt cgtaatgaaa tggattctgt catcataagc cggatagtga
     1261 aaggaggcgc cgcagagaag agtggcctcc tgcacgaagg agacgaagtt ctggagatca
     1321 acggcattga aatccggggc aaggatgtca atgaggtttt tgacttgttg tctgatatgc
     1381 atggtacttt gacatttgtt ctgattccta gtcaacagat caagccccct cctgccaaag
     1441 aaactgtaat ccatgtgaaa gctcattttg actatgaccc ctcagatgac ccttatgttc
     1501 catgtcgaga gttagggctg tcttttcaaa aaggagatat acttcatgtg atcagtcaag
     1561 aagatccaaa ttggtggcag gcctatagag agggagacga agataatcag cctctagctg
     1621 gacttgttcc aggcaaaagc tttcagcagc aaagggaagc catgaagcaa actatagaag
     1681 aagataagga gccagagaaa tcaggaaaac tgtggtgtgc aaagaagaat aaaaagaaga
     1741 ggaaaaaggt tttatataat gccaataaaa atgatgatta tgacaatgaa gagatcttaa
     1801 cgtatgagga aatgtcactt tatcaccagc cagcaaatag gaaaagacct atcatcttga
     1861 tcggtccaca gaactgtggc cagaatgaac tgcgccagag actaatgaat aaggaaaaag
     1921 accgctttgc atctgccgtt cctcatacaa ctcggaatag gcgagaccat gaagtagctg
     1981 ggagagatta ccactttgtt tctcggcaag catttgaagc agacatagca gctggcaagt
     2041 tcattgaaca tggtgaattt gagaaaaatc tgtatggaac cagcatagac tctgtacgac
     2101 aagtaatcaa ctctggcaag atatgtctct taagtcttcg cacacagtcc ttgaagaccc
     2161 tccggaattc agatttgaaa ccatatatca tcttcattgc accaccttca caagagagac
     2221 ttcgggcgtt gttagccaag gaaggcaaga acccaaagcc tgaagaatta agggagatca
     2281 ttgagaagac gagagagatg gagcagaaca acggacacta cttcgacact gcaattgtga
     2341 attcagatct tgataaagcc tatcaggaat tgcttaggct cattaacaaa ctggatactg
     2401 aacctcagtg ggtgccatcc acctggctaa ggtgaaggaa aggactgttc tgtgtcatca
     2461 tgatgaactt tatttggcaa accgccaaca ggaggatagc cttaacgctg agagttcatg
     2521 tcttaaacta gtgagaaagg tccattaggc aatttgtaca taacacttcc tgcacattgc
     2581 tttaggggac cttgacttgt ttggagactg aaaatggaaa ctttcttcag agcatttttg
     2641 atttatcctg gtaaaacctt ttgttttcac ctttctgact ctttgcctct gggtcagatg
     2701 tctataaaaa acatgtatgt atatatgcaa tagtccattg tctcacatag atatgaatat
     2761 taacattatt taacatttaa cttaaatgac ttcatgggat tgagagaagg ggctgtgctt
     2821 ctgtgcgctg agaataacag tattttctta aacaactgac ttggtcatca gaaatatttc
     2881 ttaaaaaaga aaagaaaaaa ggtgccactt tagtttggag caacttttta agtttaaatt
     2941 tattggtttt atcttttcat tctgaaaatc attccattaa aagtactagt tttgctgggc
     3001 atggaaatgc acgcctttag tcccacactc aagagacaga ggcaggtaga gctctgagtt
     3061 cagggccaga ctggtttaca gagtgagttc caggccagtc aagtctacac agagaaacct
     3121 tgtctcaaaa aaccaaaaat aaaaaaatag agaatgcagc ctccagtgta gttacaagta
     3181 tacaaaagat gctgacattt ttaaagatag aattttccaa attactttat taaattgtga
     3241 tgatttgata gtcttgactc cttgttctga taaagagttc atataaaact atgttgacca
     3301 ttaaaacttc ttccttgtga tgcaaatttt ttttatgtca gtgaaaggac ataacacatt
     3361 tgacagtttc tgtattttca tatctgagca cagagttgta tctatgactg tgctatatag
     3421 ttatcaaact ggaaatcagt actgtatact gatatttaat agattaataa atagttgtgt
     3481 tctgcattgg aataaagttt tatacataca tacacactga ggaaatactg acaactaact
     3541 tagagatcat aaggaagtaa gtcattgagc attttagaaa aggacatcag gagttttatt
     3601 aagcgtgtac agacaagttt ttatcctaac agtcttcctt gtgagtgaaa tacagcagct
     3661 tgctaaatct taaatgttca tgctaacggg atttttgtac tgtctcttta gctatagctt
     3721 taaaattgtc tacaaatcca caaagaaagt taccttgtag tcgtctcaag cctttaagga
     3781 gaatgttctg tgtgacaacc aacctcaaat gtgaatgtct tgattttatg tagctacaga
     3841 atttcatgtt cccaaaacta aacactggaa tgacactgat gtgtcactta gcacaagcag
     3901 ttggtgttga tgtcttgtca gtgctgtttg tgtctgattt ctcttctgga taatcttatt
     3961 ggaacaaatg tagagtgttt gtgatgtctt tttatgttca gttttgcatg gcttttgtag
     4021 ttggctggca agtgtgtcta ttagaaatac tttcaaaata attttcctta ggaataagca
     4081 cattcttggg ttgagggaag gaatgctatg ctatacggtc tgaagtctga acactcccag
     4141 tttacagcag gaaaagttaa cgccttgtca gcactgacgg tcaggtcact tagcacgtaa
     4201 gggattaaat ctgtccaggt tttcactggt tttcccctca ggaatgaaag gtagtctatg
     4261 gtcagtagag ctttgtgatc tgcgtgccga ccaaaaatac tgcctggtga gacttggtga
     4321 atacctgtaa ccctatagga agatctaaag tttaaggctg gtctaagtta catcagacta
     4381 tctcaaaata aataaataaa tatctttttt taatgagaaa gaaaagcatg gatgaaagga
     4441 tgaatattgg atttaagtaa agttttaagt tagtgtcagt ggggctatgt gctatcaaga
     4501 ctctcacaca gacctttaca gcagagccta tacccaggca cttgccatgc caccatgtag
     4561 tttttgactg agattctcca ggtcagcgag atcctatact ttacttgtaa gtcatgatag
     4621 gatagtgtac atcctgagct tttgtaaatc ctaatggtta tgaatgtact aatgctcaac
     4681 atagtcctaa acagtgaaaa gttagcctct gctttaaaaa aaagccttgt tttacctgtg
     4741 attgtatgcc attagggcca attcaatttc ctatccctct gtggttctga ctggaaactg
     4801 ctgtgccagg aagccctagc cacttacaga aaaatcgtgg ttggctggga acacagctca
     4861 gtcggtaaag tatcgcctag tatgcacaaa accctggctg tggcagaaag ccagcatggg
     4921 tgttcatggg tgtaatccca gcacttggaa agtggaagca gacagatctg cagctcaagg
     4981 ttaccatcag ctacaggaga ccctgtctca aaaacaaagt aggtaactcc agctaatgac
     5041 atgtccccgg gaaatccaaa caaggaagta ccttcatttt tttcatactt aagaataaat
     5101 aggtagtact ttgacttgtc cacattagct ttctgtgaaa atctagtgta tggattattt
     5161 tccttctctc atggcctaag gagtaaatat tgataaggaa tgatttgaat gtaatttttt
     5221 cgaatgtgtg gaaaatatga agcagggatt tatccttaat gaaggtagcc actgacattt
     5281 gttgttgatc tccctttgta ctgtcttgtt tctgcactcg tcattttgag atattatact
     5341 gcacaatgta ttataaaaat aaaaagtaaa actatatttc aaattgtaaa agccactgga
     5401 cactttctta tgtttatatc caaggtctgt gtacatatag actactctcc ttcaagggat
     5461 tgtcaggatc aacactgctg gaaactctta ggtggaatac aaattacagt gtaaaaaaaa
     5521 aaaaaaaaa
//
