LOCUS       NM_028877               2480 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus paralemmin 3 (Palm3), mRNA.
ACCESSION   NM_028877 XM_486140 XM_986227 XM_986631
VERSION     NM_028877.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2480)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2480)
  AUTHORS   Li,S., Guo,L., Zhao,Y., Qian,P., Lv,X., Qian,L., Wang,Q., Qian,G.,
            Yao,W. and Wu,X.
  TITLE     Silencing of Paralemmin-3 Protects Mice from
            lipopolysaccharide-induced acute lung injury
  JOURNAL   Peptides 76, 65-72 (2016)
   PUBMED   26772416
  REMARK    GeneRIF: PALM3 contributes to the development of acute lung injury
            in mice challenged with lipopolysaccharide.
REFERENCE   3  (bases 1 to 2480)
  AUTHORS   Hu,B., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Kilimann,M.W.
  TITLE     The paralemmin protein family: identification of paralemmin-2, an
            isoform differentially spliced to AKAP2/AKAP-KL, and of
            palmdelphin, a more distant cytosolic relative
  JOURNAL   Biochem Biophys Res Commun 285 (5), 1369-1376 (2001)
   PUBMED   11478809
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156028.2.
            
            On Jan 10, 2023 this sequence version replaced NM_028877.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EF208034.1, BC113196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC156028.2         188180-188239
            61-109              AC156028.2         191063-191111
            110-190             AC156028.2         192905-192985
            191-333             AC156028.2         193460-193602
            334-418             AC156028.2         193711-193795
            419-464             AC156028.2         194837-194882
            465-2480            AC156028.2         195017-197032
FEATURES             Location/Qualifiers
     source          1..2480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 40.25 cM"
     gene            1..2480
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /note="paralemmin 3"
                     /db_xref="GeneID:74337"
                     /db_xref="MGI:MGI:1921587"
     exon            1..60
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2224
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /codon_start=1
                     /product="paralemmin-3"
                     /protein_id="NP_083153.1"
                     /db_xref="CCDS:CCDS40405.1"
                     /db_xref="GeneID:74337"
                     /db_xref="MGI:MGI:1921587"
                     /translation="MALQTPVLSPATPTVMAESALYRQRLEVIAEKRRLQEEIGAARR
                     ELEEEKLRVERLKRKSLRERWLMDGAAEGPERPEEPASKDPQSPEGQAQARIRNLEDS
                     LFSLQSQLQLLQSASTGAQHRPAGRPAWRREGPRPLSQSAMEAAPTAPTDVDKRTSLP
                     DAPVGMSPESPSDPREESIAVLPASRPSTEAIGTSSEANGPCPGHSPLPEQLSLGVSS
                     VTKAKGDGAVEVVWAGLRATENSATGPTDVELEAKVEEVVLEAIGARQGTSSPELPTW
                     VKEGRGVVEVVWEGLGGRDLDVTGESGRDAEATHTSSRRLQEQFEAETCRKEEGASRD
                     SLEGVGQGGPGVEEGSFIWVERVALSEDWEEILMEGLEAPQGAGSAGEPEALIGAQPR
                     GGEASWEVEKREVEKVEGIEEKGRAEKLGAEREDGVAVLPDETQGREENEAEKVERKD
                     SEGPFPAEIATDEEKWEVKTTEGEESLEVEKGGEAEPVTTEKPLVTEKKPEGSLETER
                     KGSEMPLDQEKDGEGSLDRESKTTEILLDGEIGDKSSLDETKGSKKLLDEKTGGEGSL
                     DEEAEGSKKLLDREADGIEPFSEVDKTSGAKDDVSPEEQGKANEGAEFQAEDASPPGA
                     TVCVQDEPRSEEQGQQEPEKQEGLVEGAASKPEPCTEREGPPGDATLLLAETPAPEQP
                     VESQPLLHQEASSTNPGDHPAPTYAPAQQLELAEAKEASGPKQKTCQCCVVM"
     exon            61..109
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            110..190
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            191..333
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            334..418
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            419..464
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            465..2480
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /note="hexamer: AATGAA"
     polyA_site      2426
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
     regulatory      2452..2457
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      2480
                     /gene="Palm3"
                     /gene_synonym="4432412L15Rik"
                     /note="major polyA site"
ORIGIN      
        1 acacctctgc tgggcagtga tggctctgca gaccccggtg ttgtctccgg ccacacccac
       61 ggtcatggcg gagagcgccc tctatcggca gcggctggag gtcatcgctg agaagcggcg
      121 gctgcaggag gagatcggcg ccgcgcgtcg cgagctggag gaggagaaac tccgcgtgga
      181 gcggctcaag aggaaatctc tccgagaacg ttggctcatg gacggggcag ctgaagggcc
      241 agaacggccg gaggaacccg cctccaagga cccacagtcg cctgagggac aggcccaggc
      301 tcgaattcgc aacctggaag acagtttgtt ttcactccag tcacagctac agctgttgca
      361 aagtgcgtcc acaggtgctc aacacagacc tgctggtagg cccgcctggc gcagagaggg
      421 tccccgtcct ctctctcagt ctgccatgga agcagctcct accgccccga ctgatgtgga
      481 caagcgaact tccctgccag atgctccagt gggcatgtcc cctgagtctc cttctgatcc
      541 cagggaggag tcgattgcgg ttctaccagc ctcgaggcca tccactgaag ctatagggac
      601 atcttcagaa gccaatggcc cctgccctgg gcacagccct ctcccagagc agctgagtct
      661 aggggtgtcg agtgtcacta aggccaaagg agatggtgca gtggaggtgg tttgggctgg
      721 gcttagagcc actgagaaca gtgccacagg ccccacagat gtggagctgg aggctaaggt
      781 ggaagaagtg gttctggagg ccattggggc caggcagggc accagcagcc ctgagctccc
      841 cacttgggtg aaggagggca ggggtgtagt ggaagtggtc tgggaggggc tgggaggcag
      901 ggatcttgat gtcacagggg agtcaggcag ggatgcagag gccacacaca ccagttccag
      961 gagactccag gagcaatttg aggctgaaac ttgcagaaaa gaagaaggtg cttccagaga
     1021 tagtcttgag ggtgttgggc agggaggtcc tggagtagag gagggatcct tcatttgggt
     1081 ggagagagtg gccctcagcg aagactggga ggagattttg atggagggtt tggaagcacc
     1141 gcagggggca gggtctgcag gagaacctga ggctttgatt ggagcacagc ccagaggagg
     1201 tgaagcgtcc tgggaggtag agaagagaga agtagagaaa gttgagggca tagaagagaa
     1261 gggaagggca gaaaagctcg gggcagagag ggaggatggt gtagctgtgc tgccagatga
     1321 gacccaggga agagaggaaa acgaggcaga aaaggtagag agaaaagaca gtgagggccc
     1381 ctttccagca gagatagcaa cagatgagga aaagtgggag gtgaaaacga cggaaggtga
     1441 agagtcgttg gaagtagaaa agggaggtga ggcagagccg gtcaccactg agaagccatt
     1501 ggtgacagaa aaaaagccag agggctcact ggagacagag agaaaaggaa gtgagatgcc
     1561 attggaccag gagaaagatg gtgagggctc attggacaga gaatcaaaaa caactgagat
     1621 actattggat ggagagatag gagataagag ctcattggat gaaactaaag gaagcaagaa
     1681 actattagat gagaagacag gaggtgaggg ctcattggat gaagaagctg aaggaagtaa
     1741 gaaactattg gacagggagg cagatggcat cgagccattc tctgaggtgg acaagacctc
     1801 aggcgccaag gatgatgtga gtccagaaga gcaaggcaaa gccaacgaag gagcagagtt
     1861 ccaggcggag gatgccagcc caccaggagc cactgtttgt gtccaggacg agcccaggtc
     1921 agaggagcaa ggacagcaag aaccagagaa gcaagaaggc ctggtagaag gggcagccag
     1981 taagcctgag ccctgtactg agcgagaggg tcccccaggg gatgctaccc tgctcctagc
     2041 tgagacccca gccccggagc agcctgtgga aagccagcca ctgctccatc aggaagcgtc
     2101 cagcactaac cctggtgacc accctgcacc tacgtatgcc cctgcccagc agcttgagct
     2161 ggctgaggcc aaagaagcta gtggtcccaa gcagaagacg tgccagtgtt gtgtggtcat
     2221 gtgagcctac gcctgccgcc agcaccccac tcctcctctc acagctacct cgctgcctgg
     2281 cacccagcag aaggtcccag gcatagacag ggtaccacag gactggtagt ggcacccagg
     2341 agccggaggg ccctgtgctt ttagattccc tgcccactgc ctgtggccct gactcccttc
     2401 tgcaatgaag cctttatact tgaaaattaa atgttaaggc actctggctt taagaaaaaa
     2461 aagatttatt tattaattta
//
