LOCUS       NM_023128               2651 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus paralemmin (Palm), transcript variant 1, mRNA.
ACCESSION   NM_023128
VERSION     NM_023128.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2651)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2651)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2651)
  AUTHORS   Kalebic,N., Gilardi,C., Stepien,B., Wilsch-Brauninger,M.,
            Long,K.R., Namba,T., Florio,M., Langen,B., Lombardot,B.,
            Shevchenko,A., Kilimann,M.W., Kawasaki,H., Wimberger,P. and
            Huttner,W.B.
  TITLE     Neocortical Expansion Due to Increased Proliferation of Basal
            Progenitors Is Linked to Changes in Their Morphology
  JOURNAL   Cell Stem Cell 24 (4), 535-550 (2019)
   PUBMED   30905618
REFERENCE   4  (bases 1 to 2651)
  AUTHORS   Albrecht,I., Bieri,R., Leu,A., Granacher,P., Hagmann,J.,
            Kilimann,M.W. and Christofori,G.
  TITLE     Paralemmin-1 is expressed in lymphatic endothelial cells and
            modulates cell migration, cell maturation and tumor
            lymphangiogenesis
  JOURNAL   Angiogenesis 16 (4), 795-807 (2013)
   PUBMED   23709172
  REMARK    GeneRIF: Paralemmin-1 is expressed in normal and tumor-derived
            lymphatic endothelial cells. It represses cell migration and delays
            the formation of tube-like lymphatic structures by modulating cell
            adhesion, filopodia formation and plasma membrane blebbing.
REFERENCE   5  (bases 1 to 2651)
  AUTHORS   Zhou,P., Zhang,Y., Ma,Q., Gu,F., Day,D.S., He,A., Zhou,B., Li,J.,
            Stevens,S.M., Romo,D. and Pu,W.T.
  TITLE     Interrogating translational efficiency and lineage-specific
            transcriptomes using ribosome affinity purification
  JOURNAL   Proc Natl Acad Sci U S A 110 (38), 15395-15400 (2013)
   PUBMED   24003143
REFERENCE   6  (bases 1 to 2651)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   7  (bases 1 to 2651)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 2651)
  AUTHORS   Andreu,N., Escarceller,M., Feather,S., Devriendt,K., Wolf,A.S.,
            Estivill,X. and Sumoy,L.
  TITLE     PALML, a novel paralemmin-related gene mapping on human chromosome
            1p21
  JOURNAL   Gene 278 (1-2), 33-40 (2001)
   PUBMED   11707320
REFERENCE   9  (bases 1 to 2651)
  AUTHORS   Kutzleb,C., Sanders,G., Yamamoto,R., Wang,X., Lichte,B.,
            Petrasch-Parwez,E. and Kilimann,M.W.
  TITLE     Paralemmin, a prenyl-palmitoyl-anchored phosphoprotein abundant in
            neurons and implicated in plasma membrane dynamics and cell process
            formation
  JOURNAL   J Cell Biol 143 (3), 795-813 (1998)
   PUBMED   9813098
REFERENCE   10 (bases 1 to 2651)
  AUTHORS   Burwinkel,B., Miglierini,G., Jenne,D.E., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A., Ring,H.Z., Francke,U. and
            Kilimann,M.W.
  TITLE     Structure of the human paralemmin gene (PALM), mapping to human
            chromosome 19p13.3 and mouse chromosome 10, and exclusion of coding
            mutations in grizzled, mocha, jittery, and hesitant mice
  JOURNAL   Genomics 49 (3), 462-466 (1998)
   PUBMED   9615234
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082163.1, AK037044.1 and AC151828.3.
            
            On Jun 17, 2009 this sequence version replaced NM_023128.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037044.1, Y14771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AK082163.1         3-146
            145-373             AK037044.1         2-230
            374-374             AC151828.3         216023-216023
            375-2651            AK037044.1         232-2508
FEATURES             Location/Qualifiers
     source          1..2651
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2651
                     /gene="Palm"
                     /note="paralemmin"
                     /db_xref="GeneID:18483"
                     /db_xref="MGI:MGI:1261814"
     exon            1..169
                     /gene="Palm"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1316
                     /gene="Palm"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paralemmin-1"
                     /codon_start=1
                     /product="paralemmin-1 isoform 1"
                     /protein_id="NP_075617.3"
                     /db_xref="CCDS:CCDS23991.1"
                     /db_xref="GeneID:18483"
                     /db_xref="MGI:MGI:1261814"
                     /translation="MEVLATDTASQQERLQAIAEKRRKQAEIESKRRQLEDDRRQLQY
                     LKSKALRERWLLEGTPSSASEGDEDMRKQMQEDEQKARGLEESITRLEKEIDVLEFGE
                     SAPAASKENSAAPSPGRPQSASPAKEEQKSETLVNAQQTPLGTPKENRTSTPVRSPGG
                     STMMKAAMYSVEITVEKDKVTGETRVLSSTTVLPRDPLPQGVKVYEDETKVVHAVDGI
                     AENGIQPLSSSEVDELIHKADEVTLSEAGSTAGPAEPRGLAEDVTRTTPSRREITGVE
                     AQPGEATSGPPGIQPGQEPPVTMVFMGYQNVEDEAETKKVLGLQDTIKAELVVIEDAA
                     TPREPAPLNGSAAELPATKEENQTGPTTTPSDTQDLDMKKPRCRCCSVM"
     exon            170..221
                     /gene="Palm"
                     /inference="alignment:Splign:2.1.0"
     exon            222..302
                     /gene="Palm"
                     /inference="alignment:Splign:2.1.0"
     exon            303..433
                     /gene="Palm"
                     /inference="alignment:Splign:2.1.0"
     exon            434..584
                     /gene="Palm"
                     /inference="alignment:Splign:2.1.0"
     exon            585..606
                     /gene="Palm"
                     /inference="alignment:Splign:2.1.0"
     exon            607..663
                     /gene="Palm"
                     /inference="alignment:Splign:2.1.0"
     exon            664..795
                     /gene="Palm"
                     /inference="alignment:Splign:2.1.0"
     exon            796..2651
                     /gene="Palm"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagaggcgg cgcgcacacg agcccacccg gccgcgcccg gacaataccc ggcgcgctgg
       61 ggacgatgcc cgccccggtg ccgcccccgc gccgcacagc cccggccgcc aggccctaga
      121 gtcggccctg ccccgcgctg caccgcccac ggacctcgcg ggagatggag gtcctggcaa
      181 cagacacggc gtcccagcag gagcggcttc aagccatcgc tgagaagcgt aggaagcagg
      241 cagagattga gagcaagcgg agacaactgg aggatgaccg aagacagctg cagtacctga
      301 agtccaaggc actgagggaa cgctggctgc tggaggggac accatcctca gcctcagagg
      361 gcgacgagga catgaggaaa cagatgcagg aggatgagca gaaagcccgg ggcctggagg
      421 aatccatcac caggctcgag aaagagatcg atgttctgga gtttggagag tcagccccag
      481 ctgcctcaaa ggagaattca gcagccccca gcccaggccg gccccagtct gcaagcccag
      541 ccaaggagga gcaaaagtca gaaaccttgg tgaacgctca gcagactccg ttgggtaccc
      601 caaaagagaa tcgcacgtcc acaccggtgc ggagtccagg gggatccaca atgatgaaag
      661 cagccatgta ctcggtggag atcacggtcg agaaggacaa ggtgaccggg gagaccaggg
      721 tgctgtccag caccacagtg ctcccccggg acccactccc tcagggcgtg aaagtctacg
      781 aggacgaaac aaaagtggtc catgccgtgg acggcatcgc tgagaacggg atccagcctc
      841 taagttcctc cgaggtggac gaactcattc acaaggccga tgaggtcaca ctgagcgagg
      901 cagggtccac agctgggcca gcggagcctc ggggactcgc agaggatgtc accaggacca
      961 cgccgtccag aagggagatc acaggagttg aggctcaacc aggagaggcc acatcaggcc
     1021 caccaggcat ccagcccggt caggagcccc cggtcaccat ggtcttcatg ggttatcaga
     1081 acgtggaaga tgaagcagaa accaagaagg tactgggcct gcaggacacc atcaaggctg
     1141 aactggtggt gattgaagac gcggccacgc ccagggagcc cgcacctctc aatggcagcg
     1201 ctgctgagct cccggccacc aaggaggaga accagacggg gcccacgacc acgcccagcg
     1261 acacccagga tcttgacatg aagaagcctc gctgtagatg ttgttctgtc atgtgagccg
     1321 tcggggcacc ctagtccccg gtccccgtcc tatgctccac actcaaaccc agcagcccgg
     1381 ccctccccgg cgcctgccca ccctcaccct ccgcctcaca ggccccagac acgtgtgtga
     1441 tccctatgca cctcgagtct cgggtggggg gtgctctgcc cgtcaccaca ctccacactc
     1501 accccgaacc tctgagccgt gggtcacccc ttggtgagag acaggccagc ccatatcagc
     1561 ccctctaaga atggggaccc ctcagtccag gtcacagcag gtttacacag gcggcttatg
     1621 cccaccgtgg tcccagcctg gtgtcccctt gccgccccag gccagcctgt ctgtgcctta
     1681 tcgttacttt tggggagtct tcgaggggac cagaaagggt ctccctggcc aaggcgccag
     1741 cgacctaatg tgggcaggtg gagtgaggcc acagttcttt ggggactcaa agtcttgaag
     1801 ttctagggag gaggatgggc acctgtggat cccctcccat aggtagcaga gctcaaagca
     1861 ggggaaactc ttcaccgggg atagaacaat cacccgcagg atggagtcat tgttggccag
     1921 ccaagccact ccctgtcctg agtcccaccc ccacccccac catgcacaca ctgggccctt
     1981 cttcctggtg ctaattttgg gagctttggg gtcacctctg ccctcttctc tagttggttt
     2041 ggaccagggt cctgggtttc ccacataccc ccatacccta gaagtcagtg ggtatgtctg
     2101 ccagcgccac aaaacctagc atatccaggc aggtttaggc tgctccacac acactttggg
     2161 tgggagtaag ggaccccccc ccatctgcca cctggcctga cgggagcctg gcagagggtc
     2221 accaaccttc gggcaggcag cagtagccac tttggtcccc agaggcacaa ccctgcacac
     2281 aggagctgac tcaacttcaa aggaccacgc ctggtctagg tccctttcct tgggacccca
     2341 gcctggtgtg cagcagggtg cagggcctcc tgcgggcccc gtcactaccc gcagctacag
     2401 taggggctca agcagaggcc acggggtctg tgtcctgtcc ttcccgtggc ctggaggaga
     2461 ggcgcacttt cctgagggtg agctatggcc gtggtcatgg cacccccgtc ttcctcctcc
     2521 tttgagtctg cctgagttcc tcaagccctg agcctcggct gaagtgccct tgctgccccc
     2581 ttctgctttt gacgtgtggc aaggccccgc ccttcacccc catgttcttg actttcccag
     2641 agaaacaaat t
//
