LOCUS       NM_001293772            6389 bp    mRNA    linear   ROD 14-FEB-2024
DEFINITION  Mus musculus palladin, cytoskeletal associated protein (Palld),
            transcript variant 1, mRNA.
ACCESSION   NM_001293772 XM_006509501 XM_006509502
VERSION     NM_001293772.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6389)
  AUTHORS   Huang,Z., Zeng,Z., Li,J., Cai,R., He,W. and Hu,S.
  TITLE     [High expression of Circ-PALLD in heart failure is
            transcriptionally regulated by the transcription factor GATA4]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (8), 1371-1378 (2023)
   PUBMED   37712274
  REMARK    GeneRIF: [High expression of Circ-PALLD in heart failure is
            transcriptionally regulated by the transcription factor GATA4].
REFERENCE   2  (bases 1 to 6389)
  AUTHORS   Mastrototaro,G., Carullo,P., Zhang,J., Scellini,B., Piroddi,N.,
            Nemska,S., Filomena,M.C., Serio,S., Otey,C.A., Tesi,C., Emrich,F.,
            Linke,W.A., Poggesi,C., Boncompagni,S. and Bang,M.L.
  TITLE     Ablation of palladin in adult heart causes dilated cardiomyopathy
            associated with intercalated disc abnormalities
  JOURNAL   Elife 12, e78629 (2023)
   PUBMED   36927816
  REMARK    GeneRIF: Ablation of palladin in adult heart causes dilated
            cardiomyopathy associated with intercalated disc abnormalities.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6389)
  AUTHORS   Artelt,N., Ritter,A.M., Leitermann,L., Kliewe,F., Schluter,R.,
            Simm,S., van den Brandt,J., Endlich,K. and Endlich,N.
  TITLE     The podocyte-specific knockout of palladin in mice with a 129
            genetic background affects podocyte morphology and the expression
            of palladin interacting proteins
  JOURNAL   PLoS One 16 (12), e0260878 (2021)
   PUBMED   34879092
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6389)
  AUTHORS   Ouali,B.E.F., Liu,T.Y., Lu,C.Y., Cheng,P.Y., Huang,C.L., Li,C.C.,
            Chiang,Y.C. and Wang,H.V.
  TITLE     Cloning and promoter analysis of palladin 90-kDa, 140-kDa, and
            200-kDa isoforms involved in skeletal muscle cell maturation
  JOURNAL   BMC Res Notes 13 (1), 321 (2020)
   PUBMED   32620172
  REMARK    GeneRIF: Cloning and promoter analysis of palladin 90-kDa, 140-kDa,
            and 200-kDa isoforms involved in skeletal muscle cell maturation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6389)
  AUTHORS   Artelt,N., Ludwig,T.A., Rogge,H., Kavvadas,P., Siegerist,F.,
            Blumenthal,A., van den Brandt,J., Otey,C.A., Bang,M.L., Amann,K.,
            Chadjichristos,C.E., Chatziantoniou,C., Endlich,K. and Endlich,N.
  TITLE     The Role of Palladin in Podocytes
  JOURNAL   J Am Soc Nephrol 29 (6), 1662-1678 (2018)
   PUBMED   29720549
  REMARK    GeneRIF: Taken together, this study demonstrates that palladin
            plays an important role in themorphology and dynamic behavior of
            podocytes in vivo and in vitro.
REFERENCE   6  (bases 1 to 6389)
  AUTHORS   Boukhelifa,M., Parast,M.M., Bear,J.E., Gertler,F.B. and Otey,C.A.
  TITLE     Palladin is a novel binding partner for Ena/VASP family members
  JOURNAL   Cell Motil Cytoskeleton 58 (1), 17-29 (2004)
   PUBMED   14983521
  REMARK    GeneRIF: The actin-associated protein palladin may play an
            important role in recruiting VASP to sites of actin filament
            growth, anchorage, and crosslinking.
REFERENCE   7  (bases 1 to 6389)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   8  (bases 1 to 6389)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 6389)
  AUTHORS   Mykkanen,O.M., Gronholm,M., Ronty,M., Lalowski,M., Salmikangas,P.,
            Suila,H. and Carpen,O.
  TITLE     Characterization of human palladin, a microfilament-associated
            protein
  JOURNAL   Mol Biol Cell 12 (10), 3060-3073 (2001)
   PUBMED   11598191
REFERENCE   10 (bases 1 to 6389)
  AUTHORS   Parast,M.M. and Otey,C.A.
  TITLE     Characterization of palladin, a novel protein localized to stress
            fibers and cell adhesions
  JOURNAL   J Cell Biol 150 (3), 643-656 (2000)
   PUBMED   10931874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139846.4, AC147616.3 and AC121881.3.
            
            On Jun 18, 2019 this sequence version replaced NM_001293772.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC139846.4         149697-149863       c
            168-1170            AC139846.4         124069-125071       c
            1171-1349           AC147616.3         95902-96080         c
            1350-1416           AC147616.3         88198-88264         c
            1417-1522           AC147616.3         86761-86866         c
            1523-1597           AC147616.3         84379-84453         c
            1598-1739           AC147616.3         78488-78629         c
            1740-1763           AC147616.3         77556-77579         c
            1764-1883           AC147616.3         62716-62835         c
            1884-2226           AC147616.3         60121-60463         c
            2227-2901           AC121881.3         78761-79435         c
            2902-3037           AC121881.3         67878-68013         c
            3038-3136           AC121881.3         64876-64974         c
            3137-3187           AC121881.3         64048-64098         c
            3188-3409           AC121881.3         62544-62765         c
            3410-3559           AC121881.3         61102-61251         c
            3560-3654           AC121881.3         54258-54352         c
            3655-3787           AC121881.3         52074-52206         c
            3788-3995           AC121881.3         45725-45932         c
            3996-4161           AC121881.3         45059-45224         c
            4162-4295           AC121881.3         44393-44526         c
            4296-6389           AC121881.3         40621-42714         c
FEATURES             Location/Qualifiers
     source          1..6389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 31.23 cM"
     gene            1..6389
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /note="palladin, cytoskeletal associated protein"
                     /db_xref="GeneID:72333"
                     /db_xref="MGI:MGI:1919583"
     exon            1..167
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            168..1170
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..4468
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /note="isoform 1 is encoded by transcript variant 1; 90kDa
                     actin-associated protein palladin"
                     /codon_start=1
                     /product="palladin isoform 1"
                     /protein_id="NP_001280701.1"
                     /db_xref="CCDS:CCDS80882.1"
                     /db_xref="GeneID:72333"
                     /db_xref="MGI:MGI:1919583"
                     /translation="MSETSSHDSFYDSLSDVQEEGKSADFFPGLSAFLSQEEINKSLD
                     LARRAIDSSETEDFDSEKEISQIFSKSPISLCETPSHEEPKSGKQTSSERPQDSRRAP
                     VQPLTGDQAERITSPGSKRKPGVSPLLASPSYIRSLRKAEKRGAKNPNPSSKPKTAQQ
                     SKAGPQSQLCDKAASFIEELTSIFREAAKPRNRSPNGESSSPDSGYLSPKNQPSALMS
                     ASASQSPTADQLDQLEMDAEVKQAQGSLCYQAHQASEETLPLAHIPHPQPQKARHLPT
                     APRFIQKLRSQEVAEGSRVYLECRVTGNPTPRVRWFCEGKELYNSPDVQIHCESGELH
                     TLVIAEAFEDDTGRYTCLATNPSGSDSTSAEVFIEGASSTDSDSESLSFISKAGAMPQ
                     AQKKTTSVSLTIGSSAPKTGVTTAVIQPLSVPVQQAHSATSYLCRPDGTTMGCLLPVF
                     TKELQNTAASEGQVVVLECRVRGAPPLQVQWFRQGSEIQDSPDFRILQKKPRSTAEPE
                     EICTLVIAESFPEDAGIFTCSATNDYGSVTSTAQLVITSANNENCSYDSTGEPNSDHF
                     QHFPPPPPILETGSYELASQKPSEIQQVNSPNLGFSMAALQMQFNTAERETNGVHPSH
                     GVNGLINGKAYGNKSPPTPTALLSPTKEPPPLLAKPKLDPLKLQQLQNQVRLEQEACA
                     WPPAPPGVPCNSSSSGSSAPPSPPFPPPPPAFPELAACASPVPSEPMSALASRATAMQ
                     SSGSFNYARPKQFIAAQNLGPASGLPTPTSSPSSSSLPSPLSPTPRPFGRAPGPPFVE
                     PEAMWGPSSPSPPPPPPPVFSPSAAYPVPDVFPLPPPPPPLPSSTSHCASPARFGPSQ
                     TPAAFLSALLPSQPPPVAVNALGLPKGVTPAGFPKKSSRTARIASDEEIQGTKDAVIQ
                     DLERKLRFKEDLLNNGQPRLTYEERMARRLLGADSANVFNIQEPEETAANQDAGAPRA
                     SVGGPLDGQKEYKVSSCEQRLISEIEYRLERSPVDESGDEVQDPDVPVENATAPFFEM
                     KLKHYKIFEGMPVTFTCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTT
                     ASTLDDDGNYTIMAANPQGRVSCTGRLMVQAVNQRGRSPRSPSGHPHARRPRSRSRDS
                     GDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDS
                     AHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNLELVVAAKEAHKAPVFM
                     EKLQNTGVADGYPVRLECRVSGVPPPQIFWKKENESLTHSTERVSMHQDNHGYICLLI
                     QGATKEDAGWYTVSAKNEAGIVSCTARLDVYTQWHQQPQTTKPKKVRPSASRYAALSD
                     QGLDIKAAFQPEASPSHLTLNSGLVESEDL"
     exon            1171..1349
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1416
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1522
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1597
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1739
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1763
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1883
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2226
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            2227..2901
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3037
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            3038..3136
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3187
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3409
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            3410..3559
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3654
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            3655..3787
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3995
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            3996..4161
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            4162..4295
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
     exon            4296..6389
                     /gene="Palld"
                     /gene_synonym="2410003B16Rik; 6030492A02"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagttgtct cactaccaca gaccaagcag tccttaatgg acaggcaaga ccgacctcca
       61 ctcaccagga gaaagaggca aagcccctgg gaaatccatt gcctttggga aggcttcaaa
      121 ccaagcaagc attgaaaagt tctgtacaca ccgtaacaca cttaccgaaa gcaaggacac
      181 aggtttcctg tgcctccagc cttcctgcta caagcaacga gtgtgtggag attgctcaaa
      241 tatgtcagag acttcctccc acgactcctt ctatgactcc ttatcagacg tgcaggaaga
      301 gggcaaaagt gctgacttct ttccaggcct ctctgctttc ctcagccagg aagaaataaa
      361 taaaagcctt gacctggcac gcagagctat agacagctct gaaactgaag attttgactc
      421 tgagaaggag atctcgcaga ttttcagcaa gtctcccata agcctctgcg aaactccttc
      481 ccatgaggag ccgaaatcag gcaagcagac ttcctcagaa cgacctcagg atagcaggcg
      541 agcacctgtc cagcctctaa caggagatca agctgaaagg atcacttccc caggttcaaa
      601 gagaaaaccc ggggtatcac ccctgctggc cagccccagc tacatccgga gcctccgcaa
      661 ggctgaaaaa cgaggtgcaa aaaatcccaa tccaagttca aagcccaaaa ctgcccagca
      721 aagcaaggct ggcccccaga gccaactgtg cgacaaggcg gctagtttca tcgaggaact
      781 gacctccata tttagagaag cggcaaagcc aaggaacaga agcccaaatg gtgagtcctc
      841 atcaccagac agtgggtatc tgtctcctaa aaatcagcca tcagccctga tgagtgcctc
      901 agccagtcag agccccactg cagaccagct agatcaactg gagatggacg cagaagtcaa
      961 gcaagcccag ggcagccttt gctaccaggc ccaccaggcc tcggaagaga ccttgccact
     1021 cgctcacatc ccgcacccac agccccagaa agcccgccac ttgccaactg cacctaggtt
     1081 catccagaaa ctgaggagcc aagaagttgc tgaaggaagc agagtttatt tggagtgtag
     1141 agtcacagga aacccaacgc ccagggtcag atggttctgt gaggggaagg agctgtacaa
     1201 cagtcctgac gttcagatcc actgcgagag tggggagctg cacaccttgg tcattgctga
     1261 ggcctttgag gacgacacag gtcgctacac gtgtctggct acaaacccca gtggctcaga
     1321 cagcacatct gcagaggtgt tcattgaagg agccagttca acggactctg acagcgaaag
     1381 cttatctttc atatcaaaag ctggagccat gccacaagct cagaagaaaa caacgtccgt
     1441 ttccttaacg ataggatcct cagctccgaa aacaggagtg accacagctg tgattcagcc
     1501 cctatctgtg cccgtccaac aggctcacag cgctacttca tatctctgcc gacctgacgg
     1561 aaccaccatg ggctgccttc ttcctgtttt tactaaggaa ctacagaaca cagcagcctc
     1621 cgagggccag gtggtggtgc tggaatgcag agtccgaggg gcacccccgc tgcaggtcca
     1681 gtggttccgg caaggaagtg agatccaaga ctctccggac ttcagaattc tccagaaaaa
     1741 acccagatcg acagctgaac ccgaggagat ctgcaccctt gtcattgctg agagtttccc
     1801 tgaagatgca ggcatcttta cctgctcagc cacaaatgac tacggctcag tgaccagcac
     1861 tgcacagctt gttataacct ccgccaacaa cgagaactgt agttacgact caacaggaga
     1921 acccaacagt gatcacttcc aacactttcc acctccccct ccgatcctgg agacaggctc
     1981 ctatgagctg gcatcccaga aaccatctga aatccagcag gtgaacagcc ccaatttagg
     2041 atttagcatg gcagctcttc aaatgcaatt caacactgca gagagggaga ccaacggagt
     2101 ccatcccagc catggagtca acgggctgat taatggcaaa gcttatggca ataaatctcc
     2161 tccaacacca actgccctgc tttcacccac taaggaacca ccgccactcc ttgccaaacc
     2221 caaactggat cctctgaagc ttcagcagct gcagaaccaa gtgcgcctgg aacaggaggc
     2281 ctgcgcctgg cccccagcgc ccccaggtgt cccttgcaac agcagcagca gcggcagcag
     2341 cgcgcccccg tcgccgccct tccccccacc gccaccagcc tttccggagc tcgcggcctg
     2401 tgcgtcgccg gtgccctcgg agcccatgag cgctctggcc tcccgcgcta ccgccatgca
     2461 gtcctccggc tccttcaact acgcgcgccc taagcagttc atcgcggcgc agaacctggg
     2521 tcccgcatcg gggctgccca cgccaacctc cagccccagc tcctccagct tgccgtcacc
     2581 attgtccccc acgcccaggc ccttcggccg cgcgcccggg ccgcccttcg tggaacccga
     2641 ggccatgtgg ggcccgtcct cgccctcgcc gccaccgccg ccacctccgg tcttcagccc
     2701 ctctgcagcc tacccggtgc ccgacgtgtt cccactgcca ccgccgccgc caccgctacc
     2761 tagctccacc tcacactgcg cctcgcccgc ccgcttcggc cccagccaga cgcccgcagc
     2821 cttcctcagc gccctgctgc cctctcagcc accgcctgtc gctgtcaacg ccctggggct
     2881 gcccaaggga gtcacccccg cggggttccc aaagaagtcc agtagaactg ctagaattgc
     2941 ctctgatgag gagattcaag gcacaaagga tgctgtcatc caagacctgg aacggaagct
     3001 tcgcttcaag gaggaccttc tgaacaatgg ccaaccgagg ctaacctatg aggaaagaat
     3061 ggctcgccgc ctgcttggag ccgacagcgc aaacgtcttc aacatccagg agccagagga
     3121 aacggcagcc aatcaggacg ctggggctcc tcgggcttct gtagggggtc ctctggatgg
     3181 tcaaaaggag tacaaagtct ctagctgcga gcagaggctg attagcgaga ttgagtaccg
     3241 gctggagcgc tcccctgtgg atgagtcggg agacgaggtg caggatccag atgtgcctgt
     3301 ggagaacgca acagctccct tctttgagat gaagctgaaa cactacaaga tctttgaggg
     3361 gatgccggtg actttcacgt gtcgagtggc tgggaatcca aagccaaaga tctattggtt
     3421 taaagatggg aagcagattt ctccgaagag cgatcactac accattcaga gagaccttga
     3481 tgggacctgc tctctccaca ccacggcctc taccctagac gacgatggga actacaccat
     3541 catggctgcc aaccctcagg gtcgcgtcag ttgtacagga aggctaatgg tacaggctgt
     3601 caaccaaaga ggccgcagtc cccgctctcc ctcaggccat cctcatgcca gaaggcctcg
     3661 ctctcgatca cgggacagtg gagatgaaaa cgagcccatt caggagcgat tcttcagacc
     3721 tcacttcctg caggctcctg gagacctgac cgttcaggaa ggcaagctct gcaggatgga
     3781 ctgcaaggtc agtgggttac caaccccaga tctcagctgg caactagatg gaaagcccat
     3841 acgccccgac agtgctcaca agatgctggt ccgtgagaat ggggtccact ccctcattat
     3901 agagccagtc acgtcccggg acgccggcat ctacacatgt attgccacca acagagcagg
     3961 acagaactcg tttaacctgg agcttgtggt tgctgctaag gaagcacaca aggcccctgt
     4021 gtttatggag aagctacaga acacgggggt tgctgatgga tacccagtgc ggctggaatg
     4081 ccgtgtctcg ggagtgccgc cacctcagat attttggaag aaagaaaatg aatcgctcac
     4141 tcacagcact gagcgagtaa gcatgcacca ggataatcat ggctacatct gcctgctcat
     4201 ccagggagcc acaaaggaag acgctgggtg gtacactgtg tccgccaaga acgaagcagg
     4261 cattgtgtcc tgcactgccc ggctggatgt ctacacccag tggcaccagc agccacagac
     4321 caccaagcca aaaaaagtac ggccctcggc cagtcgctac gcagcacttt cggaccaggg
     4381 actagacatc aaagccgctt tccaacctga agccagccca tctcacctga ctctgaacag
     4441 cggcttggta gaaagtgaag acctgtgatg ggcgcccttg ttgaagctga aaactgaacg
     4501 ccagcgcttc caccagccta ctcctctgtc gcattatggg aaaggcagaa gtatactttt
     4561 gacttaggaa attgaaaaaa aaaaaaaaca aaacaccaaa atcatatttt tcttacttaa
     4621 tagagagtct aagtaggtga tgcttataga aatgtacaca ttgcacagaa aattcacatt
     4681 tattgtccaa gttaagactt ttggaactgc tgtgattaaa atggtctgaa atgccaaaat
     4741 gccaaaagaa accaaccgtt caaaggtaac cacaattgat gttatttaag tgcctttaaa
     4801 tacaagctat aggtgctata gcatggcagt gtgaatgttg gaaagatacg atgactttga
     4861 agcacagcgt ctacagatgg cccagtgaac ctcatgcgct atggggggga tgagaaagag
     4921 aagggtggag acagccgagg gaatgccttg tctttgcaaa ctgcttatgt tacatcagaa
     4981 agagggaagt ccttgcctta aattctgttc atatcaggag ttttccttgt ctgttatctt
     5041 atcaggaagc ttgcttacaa tctgtggtga ataaaagatt accttaaagt taataaaggg
     5101 ttctggagaa agcagacatt tattacagtc cattccacaa gaggcatcca aaccatgacc
     5161 aaggcatgtg gcatttgggg gaggcaggtt tggaaggcac agaaagaagg aaggaaggag
     5221 ctgctgccca catggggatc tcagatccat ttaggtgaaa catcagggcc aggccaggct
     5281 ctgctctggt tttccccgaa tccttgaaaa cacaggtgta gaaaacactg cagttaacct
     5341 gtcaaggact ctagggggac accaggaggt gtggagcgca tgcgtggtag aaacttccat
     5401 gtagctgacg tgtgtagtag ttgaagatat tagtgtgtag agcaagttgg acatgataga
     5461 ggtggcaggg gggccatctg agaagtggcc ggaagggtct agtctgcctg agggaaaagg
     5521 agacttgata gagaacaagc ttgtgcaaga cagtgaactt cttttccatt ggcactagag
     5581 gtaggtgccg agtggaagtt actagttcct tgtctccatg gaacccagcc ttaggagggt
     5641 cccaggctct gagcatctgt gaggccagct gcaaagactg ctttttgaat gcacgagtct
     5701 gcatcggcta gcctgagttg attctgacca gacttgatga ctttaagtcg gaaccaattt
     5761 ttttttttta agtgagagaa aataatttgg cctgatagtc taaaccatga ggctttaaag
     5821 gtactctgct atgaaaagaa aacactgtgt ttgttcctca tgcaaaacat atctattgtt
     5881 cattatttat aaaggtgttg aacttcttag ctcagttact caagtcatac atagtacttc
     5941 ttaaaacgat tttatatctg taagcacccc gtatattttg tattactgcc tcacttgtac
     6001 agctttctac ttttgtaaga acaccaacca agcaagtttt agcaggcttg aacactgggt
     6061 ggcaggtgtt cctgtgcagt gtggtacaag tctctttgac cacatacaca ttgctattgg
     6121 gggatttaaa ttgccatgca gggtctcatg ggcctatctc tgttgtagaa ttgcggccta
     6181 tatcatatca taattgccaa atttttctga atgtgacttt ttttttttcc taatttgctg
     6241 ggcttgggat taacttgcat tcttttgcca ccttttatgt tgtatttatg aaaaaaacaa
     6301 aaacaagcaa aaaaataagt accgtacttt ggattgttgt gctgttgtaa tgtggactta
     6361 acatcaataa ataaatattt aacagatga
//
