LOCUS       NM_013753               4274 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus phosphatase domain containing, paladin 1 (Pald1),
            transcript variant 1, mRNA.
ACCESSION   NM_013753
VERSION     NM_013753.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4274)
  AUTHORS   Nitzsche A, Pietila R, Love DT, Testini C, Ninchoji T, Smith RO,
            Ekvarn E, Larsson J, Roche FP, Egana I, Jauhiainen S, Berger P,
            Claesson-Welsh L and Hellstrom M.
  TITLE     Paladin is a phosphoinositide phosphatase regulating endosomal
            VEGFR2 signalling and angiogenesis
  JOURNAL   EMBO Rep 22 (2), e50218 (2021)
   PUBMED   33369848
  REMARK    GeneRIF: Paladin is a phosphoinositide phosphatase regulating
            endosomal VEGFR2 signalling and angiogenesis.
REFERENCE   2  (bases 1 to 4274)
  AUTHORS   Egana I, Kaito H, Nitzsche A, Becker L, Ballester-Lopez C, Niaudet
            C, Petkova M, Liu W, Vanlandewijck M, Vernaleken A, Klopstock T,
            Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Rask-Andersen H,
            Johansson HJ, Lehtio J, He L, Yildirim AO and Hellstrom M.
  CONSRTM   German Mouse Clinic Consortium
  TITLE     Female mice lacking Pald1 exhibit endothelial cell apoptosis and
            emphysema
  JOURNAL   Sci Rep 7 (1), 15453 (2017)
   PUBMED   29133847
  REMARK    GeneRIF: Study describes the phenotype of Pald1 +/- and Pald1 -/-
            mice and characterize lung defects linking Pald1 to sex-specific
            endothelial cell apoptosis, development of emphysema and chronic
            obstructive pulmonary disease-like changes in females.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4274)
  AUTHORS   Wallgard E, Nitzsche A, Larsson J, Guo X, Dieterich LC, Dimberg A,
            Olofsson T, Ponten FC, Makinen T, Kalen M and Hellstrom M.
  TITLE     Paladin (X99384) is expressed in the vasculature and shifts from
            endothelial to vascular smooth muscle cells during mouse
            development
  JOURNAL   Dev Dyn 241 (4), 770-786 (2012)
   PUBMED   22354871
  REMARK    GeneRIF: Paladin, a novel putative phosphatase, displays a dynamic
            expression pattern in the vasculature; During embryonic stages it
            is broadly expressed in endothelial cells, while in the adult it is
            selectively expressed in arterial smooth muscle cells
REFERENCE   4  (bases 1 to 4274)
  AUTHORS   Tamplin OJ, Cox BJ and Rossant J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   5  (bases 1 to 4274)
  AUTHORS   Huang SM, Hancock MK, Pitman JL, Orth AP and Gekakis N.
  TITLE     Negative regulators of insulin signaling revealed in a genome-wide
            functional screen
  JOURNAL   PLoS One 4 (9), e6871 (2009)
   PUBMED   19727444
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4274)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Aizawa H, Yuasa S,
            Nakajima D, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   7  (bases 1 to 4274)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122197.4, BC099531.1, AK146489.1 and AC151895.4.
            
            [WARNING] On Apr 1, 2024 this sequence was replaced by NM_013753.3.
            
            On Apr 2, 2008 this sequence version replaced NM_013753.1.
            
            Sequence Note: This RefSeq was created from transcript and genomic
            sequence data because no single transcript from the same strain was
            available for the full length of the gene. The extent of this
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146489.1, AK088577.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC122197.4         99865-100096
            233-1034            BC099531.1         48-849
            1035-2087           AK146489.1         980-2032
            2088-2088           AC151895.4         203301-203301       c
            2089-3991           AK146489.1         2034-3936
            3992-4274           AC151895.4         180549-180831       c
FEATURES             Location/Qualifiers
     source          1..4274
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.19 cM"
     gene            1..4274
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /note="phosphatase domain containing, paladin 1"
                     /db_xref="GeneID:27355"
                     /db_xref="MGI:MGI:1351623"
     exon            1..232
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            233..455
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..2841
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /note="isoform 1 is encoded by transcript variant 1;
                     paladin"
                     /codon_start=1
                     /product="paladin isoform 1"
                     /protein_id="NP_038781.2"
                     /db_xref="CCDS:CCDS23877.1"
                     /db_xref="GeneID:27355"
                     /db_xref="MGI:MGI:1351623"
                     /translation="MGTTASTAQQTVSAGTSLEGLQGGSSSSMDSQHSLGGVQSFRAT
                     SLHNSKAKSIIPNKVAPVVITYNCKEEFQIHDELLKAHYRMGRLSDATPEHYLVQGRY
                     FLVRDITEKMDILGTLKSCGAPNFRQVRGGLPVFGMGQPSLLGFRRVLQKLQTDGLKE
                     CIIFCVREEPVVFLRAEEDFVSYTPRDKESLHENLRDPSPGVKAENLELAIQKEIHDF
                     AQLRDNVYHVYHNTEDLRGEPHTVAIRGEDGVCVTEEVFKRPLFLQPTYRYHRLPLPE
                     QGAPLEAQFDAFVSVLRETPSLLPLRDNHGPLPALLFSCQSGVGRTNLGMVLGTLVMF
                     HHSRTTSQLEAASPLAKPLPMEQFQVIQGFICKVPQGKKMVEEVDRAISACAELHDLK
                     EEVLKNQRRLESFRPESRGQECGSQQAVQQRALWSLELYFYLLLFNYYLHEQYPLAFA
                     LSFSRWLCTHPELYRLLVELNSVGPLVPGDLIAKGSLEADDLVSLDALSTVREMDVAN
                     FRRVPRMPIYGTAQPSAKALGNILAYLSDAKRKLRQVVWINLREEVVLECDGHTHSLW
                     PPGPALAPEHLEALEAQLKAHLSAPVPNTKSPTAPRFQKCLTTQEVFSQHQGACLGLT
                     YCRIPVPDFCAPREEDFDRLLEALRAALTKDPGTGFVFSCLSGQGRTTTAMVVAVLAC
                     WHIGGCPEVGEEELVSVPDAKFTKGEFQVVMKVVQLLPDGHHVKKEVDAALDIVSETM
                     TPMHYHLREIIISTYRQAKATKEAQEAQRLQLRSLQYLERYIYLILFNAYLRLEKTSS
                     WQRPFSTWMREVATKAGIYEILNQLGFPELESIEEQPLSRLRYRWQEQSRDPEPCDVG
                     DFL"
     exon            456..558
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            559..738
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            739..903
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1064
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1140
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1292
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1392
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1497
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1593
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1722
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1839
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1995
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2178
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2319
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            2320..2391
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            2392..2532
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2688
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
     exon            2689..4274
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggggggat ccggactcga ggcggggttc tgggggtgat cctggcctcg gtggccccgg
       61 gctggccggg tctgcgccgc ctggacacag caggagctgc ctccgccccc ggatgggctg
      121 ggagggtggg cggagtcatc tggagcccgc gcgggtagtg cccgaagccc gcctcggcgc
      181 cggcagtccc cggccgcata gcgcgacgct ctcccggagc tgcggctgcc aggtctgggg
      241 tcctgaggcc cctggcagac tatgggtaca acggcaagca cagcacagca gacagtctcg
      301 gctggcacgt ccttggaggg cctgcagggt ggcagcagca gcagcatgga cagccagcat
      361 tctcttggtg gcgtgcagtc cttccgtgcc acaagtttac acaacagcaa ggccaagtcc
      421 atcatcccca acaaggtggc ccctgttgtg atcacgtaca actgcaagga ggagttccag
      481 atccacgatg agctgctcaa ggcccattac aggatgggcc ggctctcgga tgccaccccc
      541 gagcactacc tggtgcaggg tcgctatttc ttggtgcgtg acatcaccga gaagatggac
      601 atactgggca ccttgaagag ctgtggggct cccaacttcc ggcaggtgcg gggaggcctc
      661 cctgtgtttg gcatgggaca gcccagcctc ttggggttca ggagggtcct gcagaaactc
      721 cagacggacg gactcaagga gtgcattatc ttctgcgtgc gggaggagcc tgtggtgttc
      781 ttgcgcgctg aggaggactt tgtgtcttac acacctcgag acaaggagag ccttcatgag
      841 aacctcaggg accctagtcc aggggtcaag gctgagaatc tggagctggc catccagaaa
      901 gagatccatg actttgccca attgagagat aatgtgtacc acgtatacca caacacagag
      961 gacctgcgcg gggagccgca caccgtggcc atccgaggtg aggatggcgt gtgcgtgacc
     1021 gaggaggtgt ttaagcggcc gctcttcctg cagcccacct acagatacca ccgcctcccc
     1081 ttgccagagc aaggggcccc cctggaagcc cagtttgatg cctttgtcag cgttcttcgg
     1141 gagaccccca gccttctgcc actcagagat aaccacgggc ctctgcctgc cctcctgttc
     1201 agctgccagt caggtgtagg cagaaccaac ctaggcatgg tcctgggaac cctcgtcatg
     1261 ttccaccaca gtaggaccac ctcccagcta gaggcagcct ccccgttggc caaacccctg
     1321 cccatggagc agtttcaggt gatccagggc ttcatctgta aggtgccaca ggggaagaaa
     1381 atggtggagg aggtggatcg agcgatcagt gcctgtgcag agttgcatga cctgaaggag
     1441 gaggtcctaa aaaaccagag gaggctggaa agcttcaggc cagagagccg gggacaggaa
     1501 tgtggtagtc agcaagctgt ccagcagagg gcgctgtgga gcctggagct gtacttctat
     1561 ctgctcctat ttaactacta tctgcatgag cagtaccccc tggcctttgc cctcagtttc
     1621 agtcgatggc tgtgtaccca tcctgagctg taccgtctgc tggtggagct gaattcagtg
     1681 gggcccttgg tccctgggga cctcatcgcc aagggctccc tggaagcaga tgatcttgtg
     1741 tccctggatg cacttagcac cgtcagagag atggacgtgg ccaacttccg gcgtgtacct
     1801 cgaatgccta tctatggcac cgcacagcct agtgccaagg ccttaggcaa catcctggct
     1861 tacctgtctg acgccaagag gaagcttcgg caggtggtct ggatcaacct gagggaggag
     1921 gttgtgttag agtgtgacgg tcacacgcac agcttgtggc ctcccggacc agccctggcc
     1981 cctgagcatc tggaggctct ggaggcccag ctgaaggccc acctgagcgc acctgtcccc
     2041 aacaccaaga gccctactgc ccccaggttc cagaagtgcc tgaccacaca ggaggtcttc
     2101 agccagcacc agggggcctg ccttggcctt acctactgcc gtatccctgt gccagacttc
     2161 tgcgcccctc gggaggagga ctttgaccgg ctgcttgagg ccctgcgagc tgctctcacc
     2221 aaggacccgg gcacaggctt tgtcttcagc tgcctcagtg gccagggccg gaccacaact
     2281 gccatggtgg tagccgtgct ggcctgctgg cacattgggg gctgtcctga ggtgggcgag
     2341 gaggagctag tgagcgtgcc tgatgccaag ttcaccaaag gcgagtttca ggtggtgatg
     2401 aaggtggtac agctgctgcc cgacggccac cacgtgaaga aggaggtgga tgcggcgttg
     2461 gacattgtca gcgagactat gacacctatg cactaccacc ttcgggagat catcatatcc
     2521 acctaccgac aggcaaaggc taccaaagag gcacaggaag ctcagaggtt gcagctgcgg
     2581 agcctgcagt acctggagcg ctacatctac ctgatcctct ttaatgccta ccttcgcttg
     2641 gagaagacca gctcctggca gaggcctttc agcacctgga tgcgggaggt ggcaaccaaa
     2701 gctggcatct atgagatcct caaccagctg ggcttccctg agctggagag catcgaagag
     2761 cagcccctgt cgaggctccg ctaccgctgg caggagcaga gtcgagaccc agagccctgt
     2821 gatgttgggg acttcctgta ggccttcttt ggagacccag agccctgtga tgctggggac
     2881 ttcctatagg ccttcttctt gccccttgct aggcaggttg ggggacctga gggtctcatt
     2941 gcttcggatg gacacttgtc cgcttcttgg tgagacttga ggggccgaga gcctttggga
     3001 agaggtgttt tttttgtagg gtgtaagatg gcaccaccat tttctgtcaa ccttcggggt
     3061 gcgtaatggc ctctggccag gcctagcaca tgtacctcac agaccaactg gcaagcagcc
     3121 ttcagggagc tcgatcccca aacagccagt caccacctct gtcccctctt cactgttggt
     3181 cgtcagactg cctgagtgga cagcaggctg gtcgcgtttg tattttcact tccttcctct
     3241 gactggcttg ctcttgtctc tcagtctttc atcccaggca gctgcctgag gtaggtgagg
     3301 aggatggtga gccaggcagg tctacaataa aggcagctct gtccggctcc ttctggctcg
     3361 tgagtgtcac cggcctggaa gactgaggga atggctcccc tctctcctcc ccgtctttcc
     3421 ccagttcctt ccctatgttg gcccatgtgc ccagggagtt ggaagcatca gggagaccct
     3481 cttagtgtgg ggaaggaagt cagagaccat tgacacagtg aagaggcagg atcatgtgtt
     3541 ggaagcctgt tagcaggacc aaggtgactc ttgggagaga ctcttgtgga cacaggccgt
     3601 ggtggcttgt cagaccttaa gggtccaggc ccacccctgc caggatccct ggtctgcttt
     3661 ctccaggaca cactgggaca ctgctgagta atgagcagct tattacacac aatgggaaga
     3721 ggggcagaga gggctgtgtt tggttgagtc tcggctggga ctgaagtttg ccataagtag
     3781 tggttgtaca tccaggagcc tggctacctg tcttacccct tgaaggacaa ggatgaatct
     3841 ctgggtagct gtccttcagg aagatgccag ctgtgctatt tgaagaggcc aaagttgttc
     3901 ccagcctggg gagagtggtg accctcttag ctgaattctt ttgcaagctg ctgtatgtct
     3961 gtccacgcct tctcaggttt gctggtgtct attttgtaca agtcagtgct tttcagaaaa
     4021 ggtctagcca gtgagtcaga ggccagagag acccttcaca ctcttgtggt tggcactgac
     4081 ttggagatat gctgggacca atggcagatc actttacctc tctgcctcag tgtcactgtc
     4141 tgtaaaattg gagaataata cttgcctacc tacctcacag gggtgttgtg aggaatcctt
     4201 tatggttttc tgtttttttg tttttgtttt tgtacagagc ttttgagcat taaaaccatc
     4261 taaacatgta acat
//
