LOCUS       NP_038781                859 aa            linear   ROD 19-NOV-2024
DEFINITION  paladin isoform 1 [Mus musculus].
ACCESSION   NP_038781
VERSION     NP_038781.2
DBSOURCE    REFSEQ: accession NM_013753.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 859)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 859)
  AUTHORS   Nitzsche,A., Pietila,R., Love,D.T., Testini,C., Ninchoji,T.,
            Smith,R.O., Ekvarn,E., Larsson,J., Roche,F.P., Egana,I.,
            Jauhiainen,S., Berger,P., Claesson-Welsh,L. and Hellstrom,M.
  TITLE     Paladin is a phosphoinositide phosphatase regulating endosomal
            VEGFR2 signalling and angiogenesis
  JOURNAL   EMBO Rep 22 (2), e50218 (2021)
   PUBMED   33369848
  REMARK    GeneRIF: Paladin is a phosphoinositide phosphatase regulating
            endosomal VEGFR2 signalling and angiogenesis.
REFERENCE   3  (residues 1 to 859)
  AUTHORS   Egana,I., Kaito,H., Nitzsche,A., Becker,L., Ballester-Lopez,C.,
            Niaudet,C., Petkova,M., Liu,W., Vanlandewijck,M., Vernaleken,A.,
            Klopstock,T., Fuchs,H., Gailus-Durner,V., Hrabe de Angelis,M.,
            Rask-Andersen,H., Johansson,H.J., Lehtio,J., He,L., Yildirim,A.O.
            and Hellstrom,M.
  CONSRTM   German Mouse Clinic Consortium
  TITLE     Female mice lacking Pald1 exhibit endothelial cell apoptosis and
            emphysema
  JOURNAL   Sci Rep 7 (1), 15453 (2017)
   PUBMED   29133847
  REMARK    GeneRIF: Study describes the phenotype of Pald1 +/- and Pald1 -/-
            mice and characterize lung defects linking Pald1 to sex-specific
            endothelial cell apoptosis, development of emphysema and chronic
            obstructive pulmonary disease-like changes in females.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 859)
  AUTHORS   Wallgard,E., Nitzsche,A., Larsson,J., Guo,X., Dieterich,L.C.,
            Dimberg,A., Olofsson,T., Ponten,F.C., Makinen,T., Kalen,M. and
            Hellstrom,M.
  TITLE     Paladin (X99384) is expressed in the vasculature and shifts from
            endothelial to vascular smooth muscle cells during mouse
            development
  JOURNAL   Dev Dyn 241 (4), 770-786 (2012)
   PUBMED   22354871
  REMARK    GeneRIF: Paladin, a novel putative phosphatase, displays a dynamic
            expression pattern in the vasculature; During embryonic stages it
            is broadly expressed in endothelial cells, while in the adult it is
            selectively expressed in arterial smooth muscle cells
REFERENCE   5  (residues 1 to 859)
  AUTHORS   Tamplin,O.J., Cox,B.J. and Rossant,J.
  TITLE     Integrated microarray and ChIP analysis identifies multiple Foxa2
            dependent target genes in the notochord
  JOURNAL   Dev Biol 360 (2), 415-425 (2011)
   PUBMED   22008794
REFERENCE   6  (residues 1 to 859)
  AUTHORS   Huang,S.M., Hancock,M.K., Pitman,J.L., Orth,A.P. and Gekakis,N.
  TITLE     Negative regulators of insulin signaling revealed in a genome-wide
            functional screen
  JOURNAL   PLoS One 4 (9), e6871 (2009)
   PUBMED   19727444
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 859)
  AUTHORS   Kalen,M., Wallgard,E., Asker,N., Nasevicius,A., Athley,E.,
            Billgren,E., Larson,J.D., Wadman,S.A., Norseng,E., Clark,K.J.,
            He,L., Karlsson-Lindahl,L., Hager,A.K., Weber,H., Augustin,H.,
            Samuelsson,T., Kemmet,C.K., Utesch,C.M., Essner,J.J., Hackett,P.B.
            and Hellstrom,M.
  TITLE     Combination of reverse and chemical genetic screens reveals
            angiogenesis inhibitors and targets
  JOURNAL   Chem Biol 16 (4), 432-441 (2009)
   PUBMED   19389629
REFERENCE   8  (residues 1 to 859)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   9  (residues 1 to 859)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122197.4 and AC151895.4.
            
            On Apr 2, 2008 this sequence version replaced NP_038781.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088577.1, AK146489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..859
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.19 cM"
     Protein         1..859
                     /product="paladin isoform 1"
                     /note="paladin"
                     /calculated_mol_wt=96633
     Region          1..34
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70261.1)"
     Site            89
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70261.1)"
     Region          94..385
                     /region_name="PTP_paladin_1"
                     /note="protein tyrosine phosphatase-like domain of
                     paladin, repeat 1; cd17659"
                     /db_xref="CDD:350497"
     Region          479..736
                     /region_name="PTP_paladin_2"
                     /note="protein tyrosine phosphatase-like domain of
                     paladin, repeat 2; cd17660"
                     /db_xref="CDD:350498"
     CDS             1..859
                     /gene="Pald1"
                     /gene_synonym="mKIAA1274; MMPAL; Pald"
                     /coded_by="NM_013753.3:78..2657"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23877.1"
                     /db_xref="GeneID:27355"
                     /db_xref="MGI:MGI:1351623"
ORIGIN      
        1 mgttastaqq tvsagtsleg lqggssssmd sqhslggvqs fratslhnsk aksiipnkva
       61 pvvityncke efqihdellk ahyrmgrlsd atpehylvqg ryflvrdite kmdilgtlks
      121 cgapnfrqvr gglpvfgmgq psllgfrrvl qklqtdglke ciifcvreep vvflraeedf
      181 vsytprdkes lhenlrdpsp gvkaenlela iqkeihdfaq lrdnvyhvyh ntedlrgeph
      241 tvairgedgv cvteevfkrp lflqptyryh rlplpeqgap leaqfdafvs vlretpsllp
      301 lrdnhgplpa llfscqsgvg rtnlgmvlgt lvmfhhsrtt sqleaaspla kplpmeqfqv
      361 iqgfickvpq gkkmveevdr aisacaelhd lkeevlknqr rlesfrpesr gqecgsqqav
      421 qqralwslel yfylllfnyy lheqyplafa lsfsrwlcth pelyrllvel nsvgplvpgd
      481 liakgslead dlvsldalst vremdvanfr rvprmpiygt aqpsakalgn ilaylsdakr
      541 klrqvvwinl reevvlecdg hthslwppgp alapehleal eaqlkahlsa pvpntkspta
      601 prfqkclttq evfsqhqgac lgltycripv pdfcapreed fdrllealra altkdpgtgf
      661 vfsclsgqgr tttamvvavl acwhiggcpe vgeeelvsvp dakftkgefq vvmkvvqllp
      721 dghhvkkevd aaldivsetm tpmhyhlrei iistyrqaka tkeaqeaqrl qlrslqyler
      781 yiylilfnay lrlektsswq rpfstwmrev atkagiyeil nqlgfpeles ieeqplsrlr
      841 yrwqeqsrdp epcdvgdfl
//
