LOCUS       NM_001081238            3750 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus partner and localizer of BRCA2 (Palb2), transcript
            variant 1, mRNA.
ACCESSION   NM_001081238 XM_485999
VERSION     NM_001081238.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3750)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3750)
  AUTHORS   Ma,H., Kang,Z., Foo,T.K., Shen,Z. and Xia,B.
  TITLE     Disrupted BRCA1-PALB2 interaction induces tumor immunosuppression
            and T-lymphocyte infiltration in HCC through cGAS-STING pathway
  JOURNAL   Hepatology 77 (1), 33-47 (2023)
   PUBMED   35006619
  REMARK    GeneRIF: Disrupted BRCA1-PALB2 interaction induces tumor
            immunosuppression and T-lymphocyte infiltration in HCC through
            cGAS-STING pathway.
REFERENCE   3  (bases 1 to 3750)
  AUTHORS   Huo,Y., Sawant,A., Tan,Y., Mahdi,A.H., Li,T., Ma,H., Bhatt,V.,
            Yan,R., Coleman,J., Dreyfus,C.F., Guo,J.Y., Mouradian,M.M.,
            White,E. and Xia,B.
  TITLE     Tumor suppressor PALB2 maintains redox and mitochondrial
            homeostasis in the brain and cooperates with ATG7/autophagy to
            suppress neurodegeneration
  JOURNAL   PLoS Genet 18 (4), e1010138 (2022)
   PUBMED   35404932
  REMARK    GeneRIF: Tumor suppressor PALB2 maintains redox and mitochondrial
            homeostasis in the brain and cooperates with ATG7/autophagy to
            suppress neurodegeneration.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3750)
  AUTHORS   Park,D., Shakya,R., Koivisto,C., Pitarresi,J.R., Szabolcs,M.,
            Kladney,R., Hadjis,A., Mace,T.A. and Ludwig,T.
  TITLE     Murine models for familial pancreatic cancer: Histopathology,
            latency and drug sensitivity among cancers of Palb2, Brca1 and
            Brca2 mutant mouse strains
  JOURNAL   PLoS One 14 (12), e0226714 (2019)
   PUBMED   31877165
  REMARK    GeneRIF: Individual deletion of Palb2, Brca1 or Brca2 genes in
            pancreas per se using Pdx1-Cre was insufficient to cause tumors,
            but it reduced pancreata size. Concurrent expression of mutant
            KrasG12D and p53R270H, with tumor suppressor inactivated strains in
            Palb2-KPC, Brca1-KPC or Brca2-KPC, accelerated pancreatic ductal
            adenocarcinoma (PDAC) development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3750)
  AUTHORS   Brandsma,I., Sato,K., van Rossum-Fikkert,S.E., van Vliet,N.,
            Sleddens,E., Reuter,M., Odijk,H., van den Tempel,N.,
            Dekkers,D.H.W., Bezstarosti,K., Demmers,J.A.A., Maas,A.,
            Lebbink,J., Wyman,C., Essers,J., van Gent,D.C., Baarends,W.M.,
            Knipscheer,P., Kanaar,R. and Zelensky,A.N.
  TITLE     HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required
            for Mouse Spermatogenesis
  JOURNAL   Cell Rep 27 (13), 3790-3798 (2019)
   PUBMED   31242413
REFERENCE   6  (bases 1 to 3750)
  AUTHORS   Huo,Y., Cai,H., Teplova,I., Bowman-Colin,C., Chen,G., Price,S.,
            Barnard,N., Ganesan,S., Karantza,V., White,E. and Xia,B.
  TITLE     Autophagy opposes p53-mediated tumor barrier to facilitate
            tumorigenesis in a model of PALB2-associated hereditary breast
            cancer
  JOURNAL   Cancer Discov 3 (8), 894-907 (2013)
   PUBMED   23650262
REFERENCE   7  (bases 1 to 3750)
  AUTHORS   Bouwman,P., Drost,R., Klijn,C., Pieterse,M., van der Gulden,H.,
            Song,J.Y., Szuhai,K. and Jonkers,J.
  TITLE     Loss of p53 partially rescues embryonic development of Palb2
            knockout mice but does not foster haploinsufficiency of Palb2 in
            tumour suppression
  JOURNAL   J Pathol 224 (1), 10-21 (2011)
   PUBMED   21404276
REFERENCE   8  (bases 1 to 3750)
  AUTHORS   Rantakari,P., Nikkila,J., Jokela,H., Ola,R., Pylkas,K.,
            Lagerbohm,H., Sainio,K., Poutanen,M. and Winqvist,R.
  TITLE     Inactivation of Palb2 gene leads to mesoderm differentiation defect
            and early embryonic lethality in mice
  JOURNAL   Hum Mol Genet 19 (15), 3021-3029 (2010)
   PUBMED   20484223
  REMARK    GeneRIF: A key function for PALB2 is to interact with and to build
            up appropriate communication between BRCA1 and BRCA2.
REFERENCE   9  (bases 1 to 3750)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3750)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ560264.1, BC066140.1, BC066139.1, AC124379.3 and BB061170.1.
            
            On Feb 1, 2014 this sequence version replaced NM_001081238.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156701.1, AK157382.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               BQ560264.1         1-102
            103-687             BC066140.1         1-585
            688-741             BC066139.1         536-589
            742-1471            AC124379.3         21599-22328
            1472-2904           BC066139.1         1320-2752
            2905-2941           BC066140.1         1714-1750
            2942-2942           BC066139.1         2790-2790
            2943-3743           BC066140.1         1752-2552
            3744-3750           BB061170.1         240-246
FEATURES             Location/Qualifiers
     source          1..3750
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.42 cM"
     gene            1..3750
                     /gene="Palb2"
                     /note="partner and localizer of BRCA2"
                     /db_xref="GeneID:233826"
                     /db_xref="MGI:MGI:3040695"
     exon            1..227
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..3494
                     /gene="Palb2"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="partner and localizer of BRCA2 isoform 1"
                     /protein_id="NP_001074707.1"
                     /db_xref="CCDS:CCDS40117.1"
                     /db_xref="GeneID:233826"
                     /db_xref="MGI:MGI:3040695"
                     /translation="MEELSGKPLSYAEKEKLKEKLAFLKKEYSRTLARLQRAKRAEKA
                     KNSKKAIEDGVPQPEASSQLSHSESINKGFPCDTLQSNHLDEETGENISQILDVEPQS
                     FNCKQGKEVLHTPRAGDIQGQLLHSTSSPDGKKEQNTLPGTTKTPWEKSSVSQEKEDY
                     FDTNSLALLGKHRKGQESISRKNSRTPVSEKTHLLSLRSQIPDPPALVTGIGEGILIP
                     PSGKSERGIDTLVRGNTVSAEAAVPSCTASNSNHSQHLEHTPPKSGCKITTQGPASST
                     NLVAQDQKMTIFTVNSVVYKAVRAHGQLPGSPNSCSVNDLTHSNLPANSTPNSKSLKS
                     PSNTVDERNEPLQEDEILGPSKNFNLAAVSPPSTESQIHSCTMLEGLLFPAEYYVRTT
                     RRMSDCQRKIALEAVIQSHLGVKKKELKKKTKATKAVVLSSEDTDQSESGMLDTSTGQ
                     SSSGSLSQKLLSPAEVSSPPGPAGKATTPPPGRGHRGKRKSARTSTLGHCQLLFPPCA
                     ALAVNRSKGKFTKHKCQNRGVVIHDFELPDEDFGLLKLEKLKSCSEKLIESPDSKNCG
                     ERLPREGNHAALEELQRDSETEGLEEELTVPPGEAYRPGPTLRRQPGSKDLSSSIVLF
                     TPADTAAPNDSGRPPPSLCSPAFPILGMTPALGSQAAGETLSTEAAQPCSTSQPPLLG
                     DTNSLVNNSKQCNSSACSPKPDTNLQASGRQGQPACDSDSGPQATPLPVESFTFRENQ
                     LCGNACLELHEHSTEQTETADRPACDNLNPGNLQLVSELKNPSSSCSVDVSAMWWERA
                     GAKEPCIVTACEDVVSLWKPLNSLQWEKVHTWHFTEVPVLQIVPVPDVYNLICVALGS
                     LEIREIRALLCSSGDDSEKQVLLKSGDIKAMLGLTKRRLVSSTGTFCNQQIQIMTFAD
                     DGSSKDEQLLMPPDETVLTFAEVQGTQEALLGTTTVNSIVIWNLKTGQLLKKMHIDDS
                     YQASVCHGAYSEKGLLFVVVSQPCAKESQALGSPVFQLLVINPKTAQSVGVLLCSLPQ
                     GQAGRFLEGDVKDHVAAAVLTSGTIAIWDLLLGHCTALLPPVSDQSWSLVKWSGTDSH
                     LLAGQKDGNIFIYRYF"
     exon            228..287
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..381
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..1776
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..2447
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2519
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2681
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2767
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2929
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3046
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3134
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3283
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     exon            3284..3750
                     /gene="Palb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3726..3731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Palb2"
                     /note="hexamer: AATAAA"
     polyA_site      3747
                     /gene="Palb2"
                     /note="major polyA site"
ORIGIN      
        1 aattggccag agcggctagc gcgcggaacc tgtgtggctc ggcaggaaca tagtgggggt
       61 gaactaggtc cccgttcttc ccaggggttc ctcttggccc taggaagccc tggctgggtc
      121 cccgtgacca caggcccgag gctggagacg gctgctcctt gcgttcggct tccaacccga
      181 tggaagagct ttccgggaag cccctcagct atgcggagaa ggaaaagttg aaggaaaagc
      241 tagcattttt gaaaaaggaa tacagcagga cacttgctcg acttcagcgt gccaaaagag
      301 ctgagaaggc taagaactct aagaaagcca tagaagatgg tgtgccccag ccagaagctt
      361 cctcacagct aagccactct gaatctataa ataaaggctt tccttgtgac acattgcaaa
      421 gcaaccatct ggatgaggag actggagaaa acatctctca gatacttgat gttgaacctc
      481 aatcctttaa ctgtaaacaa ggcaaagaag tattacatac accaagagca ggtgacattc
      541 aaggacaact tttgcatagc accagcagcc ctgatggcaa gaaagagcag aacacgcttc
      601 cggggacaac aaagacgccg tgggagaagt catctgtttc acaggagaag gaagattatt
      661 ttgacactaa ttctctggcg ctccttggta agcatcgaaa agggcaagaa tcaatcagta
      721 ggaagaattc taggactccc gtgagtgaaa agactcacct tttaagtctc aggtctcaga
      781 tccctgaccc tccagcactt gttacaggaa ttggagaggg tatattaatt ccgccatctg
      841 gcaaatcaga aaggggaatt gatacacttg tgagaggaaa tactgtctcc gcggaggctg
      901 cagttccttc atgtactgcg tcaaacagca atcacagtca gcaccttgag catacacctc
      961 ctaaaagtgg ctgcaaaatt actactcagg gcccggcttc atccacaaac ctggtggcac
     1021 aagaccaaaa aatgactata tttacagtaa actcagtagt atataaagct gtgcgtgccc
     1081 atggtcagct gccaggaagt cccaattctt gttctgtaaa tgatctcacg catagtaact
     1141 tgccagcaaa tagtacccca aactctaaat ctttaaaatc tcccagtaac actgttgatg
     1201 agagaaatga acctcttcag gaagatgaaa ttcttggtcc atctaagaac ttcaacctgg
     1261 cagcagtctc tcctccttcc acagaaagtc aaatacattc ttgtactatg cttgaaggcc
     1321 ttctgtttcc tgcagaatac tatgttagaa caacccgtcg tatgtcagat tgtcagagaa
     1381 aaatagctct ggaagctgta attcaaagtc atttgggtgt caaaaagaaa gagcttaaaa
     1441 agaaaaccaa agctactaag gcggtcgtcc tctccagtga agacactgac cagagtgaaa
     1501 gtggcatgct ggacacgagc acgggacagt ccagttcagg aagcctctct cagaaactgc
     1561 tctcaccagc tgaggtcagc tctcctccag gacctgctgg aaaggccacc acaccgccac
     1621 ctggtagagg acacagaggg aaacgaaaat cagcccgcac ctccacactg ggtcactgcc
     1681 agctgctttt tcctccttgt gccgcactgg ctgttaacag gtccaagggc aaattcacca
     1741 agcataaatg tcagaacaga ggcgtggtta ttcatgactt tgagttacct gatgaagact
     1801 ttgggcttct taaacttgaa aaattgaagt cctgctcgga aaaactgatt gagtctcctg
     1861 actcaaaaaa ctgtggtgag aggcttccta gagaaggaaa ccatgctgct ctggaggaac
     1921 tgcaaagaga ttcggagacg gagggcttgg aagaggagct cactgttcca ccaggagaag
     1981 cgtaccgtcc agggccaacc ctgagaaggc agccagggag caaggacctt tcttcatcca
     2041 tagtgctttt cactcctgca gacactgctg cgcctaacga cagtggcagg cctcctccct
     2101 ccctgtgctc acctgctttc cccatcttag gcatgactcc agctcttggc tcccaagcag
     2161 ccggtgagac tctatctact gaagctgcac agccttgctc tacatcccaa cctcctctct
     2221 tgggagacac aaacagtctt gtcaataaca gtaaacagtg caacagttca gcctgctcac
     2281 caaaaccgga caccaacctg caagcgtcag gtaggcaagg acaacctgcc tgtgacagtg
     2341 actctggccc ccaagcaaca cctctacctg ttgagtcatt cactttcaga gaaaatcagc
     2401 tttgtggaaa tgcatgcctc gagttacatg aacattccac tgaacagact gaaactgcag
     2461 atcgccctgc ttgtgacaat ctaaacccag gaaacctaca gttggtttca gagttaaaga
     2521 atccttccag ttcctgctct gtggatgtga gcgccatgtg gtgggaaaga gctggtgcta
     2581 aggagccatg tatcgtaact gcttgtgaag atgtagtttc tctttggaaa cccttgaatt
     2641 ctctgcagtg ggagaaagtt catacctggc acttcacaga ggttccagta ttacaaatag
     2701 ttccagtgcc tgatgtttac aatcttatat gtgtagcttt gggaagtttg gaaatcagag
     2761 aaatcagggc gttgctgtgc tcttctggtg atgacagtga aaagcaagtc ctcctgaaat
     2821 ctggagatat aaaagctatg cttggcctga caaagcggag gctagttagt agcactggga
     2881 ccttttgcaa tcaacaaata caaatcatga catttgctga cgacggaagc agcaaagatg
     2941 aacagctttt gatgcctcct gatgagactg tactgacttt tgctgaagtc caagggacgc
     3001 aggaagctct gcttggtact accactgtga acagcattgt gatctggaat ttaaaaaccg
     3061 gccagctcct gaagaagatg cacattgatg actcctacca ggcttcggtc tgtcacggag
     3121 cctattctga gaaggggctc ctgtttgttg ttgtgagtca accttgtgcc aaagagagcc
     3181 aggcccttgg aagccctgtg ttccagctgc tggtgattaa ccctaagacg gcccagagtg
     3241 tgggtgttct gctgtgttcc cttcctcagg ggcaggctgg aaggttcctg gaaggggatg
     3301 tgaaagatca tgtcgcagca gcagtcctga cttctgggac aattgccatt tgggatttgc
     3361 ttctgggtca ctgcacggct ctcctcccac ctgtctctga ccagagttgg tctttggtta
     3421 aatggtcggg tacagattct cacttgctag ctggacaaaa ggatggaaat atatttatat
     3481 accgatactt ttaagaggca aatagtttgg aggttttttg ttttttgttt ttgtttttgt
     3541 tttttttaag aatacaatat ctgaatgaca tttaatgtga ttacttgaat gtatttccca
     3601 cacacttaat tttcttctga tagtgactac tgactgaaca tttgtttata gttattttca
     3661 ggttaatagt tttaagtcat tctttgcaca tttgctatta cagctgtaca taaccagtga
     3721 atgttaataa atatttattt tgatacattc
//
