LOCUS       NM_001384157            7363 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus paralemmin A kinase anchor protein (Pakap), transcript
            variant 8, mRNA.
ACCESSION   NM_001384157
VERSION     NM_001384157.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7363)
  AUTHORS   Maric,D., Paterek,A., Delaunay,M., Lopez,I.P., Arambasic,M. and
            Diviani,D.
  TITLE     A-Kinase Anchoring Protein 2 Promotes Protection against Myocardial
            Infarction
  JOURNAL   Cells 10 (11), 2861 (2021)
   PUBMED   34831084
  REMARK    GeneRIF: A-Kinase Anchoring Protein 2 Promotes Protection against
            Myocardial Infarction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7363)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   3  (bases 1 to 7363)
  AUTHORS   Thakkar,A., Aljameeli,A., Thomas,S. and Shah,G.V.
  TITLE     A-kinase anchoring protein 2 is required for calcitonin-mediated
            invasion of cancer cells
  JOURNAL   Endocr Relat Cancer 23 (1), 1-14 (2016)
   PUBMED   26432469
  REMARK    GeneRIF: Knocking down akap2 expression remarkably decreased
            tumorigenicity and metastatic ability of prostate cancer cells.
            AKAP2 may serve as a critical component of Calcitonin
            receptor-mediated oncogenic actions.
REFERENCE   4  (bases 1 to 7363)
  AUTHORS   Rowton,M., Ramos,P., Anderson,D.M., Rhee,J.M., Cunliffe,H.E. and
            Rawls,A.
  TITLE     Regulation of mesenchymal-to-epithelial transition by PARAXIS
            during somitogenesis
  JOURNAL   Dev Dyn 242 (11), 1332-1344 (2013)
   PUBMED   24038871
REFERENCE   5  (bases 1 to 7363)
  AUTHORS   Gold,M.G., Reichow,S.L., O'Neill,S.E., Weisbrod,C.R.,
            Langeberg,L.K., Bruce,J.E., Gonen,T. and Scott,J.D.
  TITLE     AKAP2 anchors PKA with aquaporin-0 to support ocular lens
            transparency
  JOURNAL   EMBO Mol Med 4 (1), 15-26 (2012)
   PUBMED   22095752
  REMARK    GeneRIF: The AKAP2 protein is direct phosphorylation within a
            regulatory region of aquaporin-0 to modulate water permeability.
REFERENCE   6  (bases 1 to 7363)
  AUTHORS   Castellini,M., Wolf,L.V., Chauhan,B.K., Galileo,D.S.,
            Kilimann,M.W., Cvekl,A. and Duncan,M.K.
  TITLE     Palm is expressed in both developing and adult mouse lens and
            retina
  JOURNAL   BMC Ophthalmol 5, 14 (2005)
   PUBMED   15969763
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7363)
  AUTHORS   Papin,J. and Subramaniam,S.
  TITLE     Bioinformatics and cellular signaling
  JOURNAL   Curr Opin Biotechnol 15 (1), 78-81 (2004)
   PUBMED   15102471
  REMARK    Review article
REFERENCE   8  (bases 1 to 7363)
  AUTHORS   Hu,B., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and Kilimann,M.W.
  TITLE     The paralemmin protein family: identification of paralemmin-2, an
            isoform differentially spliced to AKAP2/AKAP-KL, and of
            palmdelphin, a more distant cytosolic relative
  JOURNAL   Biochem Biophys Res Commun 285 (5), 1369-1376 (2001)
   PUBMED   11478809
REFERENCE   9  (bases 1 to 7363)
  AUTHORS   Neilan,E.G. and Barsh,G.S.
  TITLE     Gene trap insertional mutagenesis in mice: new vectors and germ
            line mutations in two novel genes
  JOURNAL   Transgenic Res 8 (6), 451-458 (1999)
   PUBMED   10767988
REFERENCE   10 (bases 1 to 7363)
  AUTHORS   Dong,F., Feldmesser,M., Casadevall,A. and Rubin,C.S.
  TITLE     Molecular characterization of a cDNA that encodes six isoforms of a
            novel murine A kinase anchor protein
  JOURNAL   J Biol Chem 273 (11), 6533-6541 (1998)
   PUBMED   9497389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL772328.13, AL772312.6 and AL840629.24.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring Palm2 (paralemmin 2) and
            Akap2 (A kinase (PRKA) anchor protein 2) genes on chromosome 4. The
            readthrough transcript encodes a fusion protein that shares
            sequence identity with each individual gene product. Similar
            readthrough transcription has also been observed in human, as
            described in PMID: 11478809. [provided by RefSeq, Feb 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.71661.1,
                                           SRR7345562.946027.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL772328.13        134585-134666
            83-128              AL772312.6         51385-51430
            129-209             AL772312.6         121025-121105
            210-340             AL772312.6         131005-131135
            341-455             AL772312.6         171431-171545
            456-477             AL772312.6         172538-172559
            478-560             AL840629.24        41212-41294
            561-3036            AL840629.24        138173-140648
            3037-3215           AL840629.24        166635-166813
            3216-3254           AL840629.24        169900-169938
            3255-7363           AL840629.24        176480-180588
FEATURES             Location/Qualifiers
     source          1..7363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 31.66 cM"
     gene            1..7363
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /note="paralemmin A kinase anchor protein"
                     /db_xref="GeneID:677884"
                     /db_xref="MGI:MGI:5141924"
     exon            1..82
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..3353
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /note="isoform 8 is encoded by transcript variant 8;
                     Palm2-Akap2 readthrough transcript; A-kinase anchor
                     protein 2; AKAP expressed in kidney and lung; Protein
                     kinase A-anchoring protein 2; paralemmin 2; A kinase
                     (PRKA) anchor protein 2"
                     /codon_start=1
                     /product="paralemmin-2 isoform 8"
                     /protein_id="NP_001371086.1"
                     /db_xref="GeneID:677884"
                     /db_xref="MGI:MGI:5141924"
                     /translation="MEMAEAELHKERLQAIAEKRKRQTEIEGKRRQLDEQVLLLQHSK
                     SKVLREKWLLQGVPAGTAEEEEARRRQSEEDEFKVKQLEDNIQRLEQEIQALESEESQ
                     ISAKEQIILEKLKETEKSFKDLQKSFSTADGASGWSTVLLQGDELTADPIGTNADMAI
                     QKPPQLSEDANQLRSKQDNCGDSRLEPAASSLSPDHKNMEIGVSVAECKSVPGVTSTP
                     HSKDHSSPFYSPSHNGLLADHHESLDNDVAREIQYLDEVLEANCCDSSVDGTYNGISS
                     PEPGAAILVSSLGSPAHSVTEAEPTEKASGRQVPPHIELSRSPSDRMAEGERANGHST
                     DQPQDLLGNSLQAPASPSSSTSSHCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLF
                     EEDEREKEQFCVRKVRPSEEMIELEKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEE
                     QLDEEHLESHRKYKERKEKRAQQEQLQLQQQQQQQLQQQQLQQQQLQQQQLQQQLQQQ
                     QLSTSQPCTAPAAHKHLDGIEHTKEDVVTEQIDFSAARKQFQLMENSRQTLAKGQSTP
                     RLFSIKPYYKPLGSIHSDKPPTILRPATVGGTLEDGGTQAAKEQKAPCVSESQSAGAG
                     PANAATQGKEGPYSEPSKRGPLSKLWAEDGEFTSARAVLTVVKDEDHGILDQFSRSVN
                     VSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETPSALQENSLADF
                     SLPQTPQTDNPSEGREGVSKSFSDHGFYSPSSTLGDSPSVDDPLEYQAGLLVQNAIQQ
                     AIAEQVDKAEAHTSKEGSEQQEPEATVEEAGSQTPGSEKPQGMFAPPQVSSPVQEKRD
                     ILPKNLPAEDRALREKGPSQPPTAAQPSGPVNMEETRPEGGYFSKYSEAAELRSTASL
                     LATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVRQSTPSPRAKNA
                     PSLPSRTTCYKTAPGKIEKVKPPPSPTTEGPSLQPDLAPEEAAGTQRPKNLMQTLMED
                     YETHKSKRRERMDDSSYTSKLLSCKVTSEVLEATRVNRRKSALALRWEAGIYANQEEE
                     DNE"
     exon            83..128
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     exon            129..209
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     exon            210..340
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     exon            341..455
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     exon            456..477
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     exon            478..560
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     exon            561..3036
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3215
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     exon            3216..3254
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..7363
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5223..5228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /note="hexamer: ATTAAA"
     polyA_site      5248
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /note="major polyA site"
     regulatory      7346..7351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /note="hexamer: ATTAAA"
     polyA_site      7363
                     /gene="Pakap"
                     /gene_synonym="53-H12; AA959716; AI649048; AKAP-2;
                     AKAP-KL; Akap2; B130066I24; B230340M18Rik; Gm20459; Palm2;
                     Palm2-Akap2; Palm2akap2; Palm2Akap2; pEN70; PRKA2; R75368"
                     /note="major polyA site"
ORIGIN      
        1 agagtgcccc ggccctggca gaggccagca gcgcccggag ccccgcagca gcgcgccggg
       61 ctgcccggag ccccgcgatg gagatggcag aggcggaatt gcacaaggag aggctgcaag
      121 ccatagcaga aaaaagaaag aggcagacgg aaatagaagg gaagagacga cagcttgacg
      181 aacaggtact gctgcttcag cattccaagt ccaaagtgct tcgggaaaaa tggctgctgc
      241 agggtgtacc agcgggaaca gcggaggagg aggaagccag gcgcaggcag tctgaagaag
      301 atgaattcaa agtcaagcag cttgaagata acattcagag gctggagcag gaaatacaag
      361 cgctcgaaag tgaagagtcc cagatatccg ccaaagagca gatcatcctg gagaaactga
      421 aggagacgga gaaatccttc aaggacttgc agaagagttt ctccactgct gatggagcat
      481 ctgggtggtc tactgtgttg ctacaaggag atgaactgac tgcagatccc ataggaacca
      541 acgcagacat ggccatccag aagcctcccc agctttctga ggatgctaac cagctgagaa
      601 gcaagcaaga caactgtggt gacagtcgcc tggagcctgc cgccagctct ctctccccag
      661 atcacaaaaa catggaaatt ggggtgtccg tggcagaatg taaaagtgta cctggagtca
      721 cctctacccc ccattccaag gaccactcct cccctttcta ttcgccctca cacaatggcc
      781 tcctcgctga tcaccacgag tctttagaca acgatgtcgc cagagagatc cagtacctag
      841 atgaagtgct ggaggccaac tgctgtgatt cctctgtgga tggaacttac aacggaatct
      901 cctccccaga gcctggtgca gccatactgg taagcagctt aggctcgcct gcccactcag
      961 tcaccgaggc agaacccact gagaaagcat ccggtaggca ggtgcctcct cacatcgagc
     1021 tcagtagaag cccctccgac agaatggctg aaggagaaag agccaatgga cactccactg
     1081 accagcccca agacctgctg gggaacagcc tgcaggcacc tgccagcccc agttcctcta
     1141 ccagctccca ctgctcctcc cgagatgggg agttcacact caccacactg aagaaggagg
     1201 ccaagtttga gctgcgtgcc ttccacgagg acaagaagcc ctccaagctc tttgaggagg
     1261 acgagcgcga gaaggagcag ttctgcgtcc ggaaagtgag gccctccgag gagatgatag
     1321 agctggagaa agagcggagg gagctcatcc ggagtcaggc tgtgaagaag aatcctggca
     1381 tcgccgccaa gtggtggaat cctccccagg agaaaactat tgaggagcag ctggacgagg
     1441 aacatctgga gtcgcacaga aagtacaagg agcgcaaaga gaaaagggcc cagcaggagc
     1501 agctacagtt gcaacagcag cagcagcaac agctgcaaca gcaacagcta caacaacaac
     1561 agctgcaaca gcaacagctg caacaacagc tgcaacagca gcagctgtcc acgtcccagc
     1621 cctgcacagc cccagctgct cacaaacacc tagatggcat tgaacacaca aaggaggatg
     1681 tggtcactga gcagattgac ttctcggctg cacgcaagca gttccagctg atggagaatt
     1741 ccaggcagac actggccaag ggccagagca caccaaggct gttctctatc aagccttact
     1801 acaaacctct tggatccatc cattcggaca agccaccgac catcttgaga ccagctactg
     1861 tcgggggaac tctggaagac ggcggcacac aggcagccaa ggagcagaaa gctccctgtg
     1921 tatctgagag ccagtctgca ggagccggtc cagctaacgc tgccactcag ggaaaggaag
     1981 ggccatacag tgagccttcg aaacgcgggc ccttatctaa actgtgggca gaggatggag
     2041 agttcacaag tgcccgggcc gtcctaactg tagtcaaaga tgaagatcat gggattttgg
     2101 accaattttc aagatcggtc aatgtatctt tgactcagga ggagctggac tcagggttag
     2161 atgagttgtc agtgaggtca caggatacca ctgtcctgga gactctgtcc aatgacttca
     2221 gcatggacaa cataagtgac agtggagctt ctaacgagac acccagtgcc cttcaggaaa
     2281 actcgctggc tgatttctct ctgcctcaga ccccccaaac agacaacccc tccgagggcc
     2341 gagaaggggt ctctaagtca ttcagtgacc atggtttcta ttctccttcc tccacattgg
     2401 gagattctcc gtccgttgat gaccccttgg aatatcaggc tgggctcctg gtgcagaatg
     2461 ccattcaaca agccatagcc gagcaggtgg ataaggctga ggcgcacacc agcaaggaag
     2521 gatcagaaca gcaggagcct gaagcaacgg tagaggaagc tggaagccag acacctggct
     2581 ctgagaagcc ccagggcatg tttgcaccac ctcaggtgtc ctctcctgtt caagagaaaa
     2641 gggatatatt accaaagaac ctccctgcgg aggacagggc actcagggaa aaggggccct
     2701 cccagccacc cacggctgcg cagcccagcg gtccagtcaa catggaagag accaggcctg
     2761 aaggagggta cttcagcaag tattcagagg cagctgagct gagaagcaca gcctccctcc
     2821 tggcgactca agagtctgat gtcatggttg ggcccttcaa actgaggtca aggaagcagc
     2881 ggactttgtc catgatcgaa gaagagatcc gggcagccca ggaaagggag gaggagctaa
     2941 agcggcagag acaagtgagg caaagcaccc caagccccag ggccaagaac gccccatcgc
     3001 tgccttctag gaccacctgc tacaagactg ctccagggaa aatagagaaa gtcaaacctc
     3061 ctccatcccc cacaactgaa ggtcccagct tacagcctga cttagcccct gaagaggctg
     3121 ccggaaccca gcggcccaag aacctgatgc agaccctcat ggaagactat gagacccaca
     3181 aatctaaaag gcgcgagaga atggatgata gtagttacac ctctaagtta ctgtcttgca
     3241 aggtgacttc cgaggtcctg gaggccacac gggttaatcg gaggaagagt gctctggcct
     3301 tgcgctggga ggcagggatt tacgctaacc aggaagagga ggacaacgaa taaactgcct
     3361 tcagcccagg aaacttctct gctgaaggaa tttctgcaga gaaaccagga aattattgaa
     3421 tcagaagcat tttaatagac tacttattaa agtgcataca aactcaacaa ccctcatgta
     3481 gaccagaagc tgcaatacac catgataaaa aaacaaaaaa caaaataaaa acaaaaaaac
     3541 aaagaagcaa agcgaagcaa acaggatgtt cacccatcaa actgagacca ggggcagaag
     3601 agaaaggata tctttgtgac tcaaagaagc ccctggcttt ggactattcc acaactgatc
     3661 caaagggaca cagatgtgac aaaggagtca atatagttgc tgcaggcaga actgaaggca
     3721 gccttggatg ggtgttgcag aggagcaggc agtgacatgg ccattccaag gcaacccgca
     3781 gggtccagcc tggtgcaccc gctgcgctcc ggctatcctc cacatcagct tcccatcccg
     3841 gtctcacctg aggcatcaga agtgttgggt tgactccatt ttctccagca gccataaaaa
     3901 tgaatggtgt ttctttccat aattgcccca aagaggggaa gtggggattc aatcgctctt
     3961 acatgtagtc atttgaagtt ggggacacct aatggtcaca atatataaag tccgtatttt
     4021 taaggcaata tctcttcatg ttgcagatgc aatcaattct acagcaggag gttgagaaca
     4081 gtgggggatt gtggggggtg gggggggggg ggagagccaa accaaaaggg ttattagctt
     4141 taggactttg tctgctttta ttgttgactt atcagcttag ggaaacacac tttcacgatt
     4201 acgtttcttc atatgaaaag tatatttagt gagcaatgac tatttttatg atgagacggg
     4261 ggaacaggaa cacagatgaa acctgtacac atttgaacag cttggttcag gatggtaggg
     4321 gtatttttag aatggcaata attgaaaata aaaaggggag cagactcagc cttagaaagg
     4381 tagatggtca gaaataaggt gtttataact attttctatt ttaaagtgag ccttagaggt
     4441 ggttgtggca taggatgagt tgttttggat ctgagagagg aaaccttaaa cacatgggga
     4501 tagaaagaga aaggggtgag agggacaaag aaagaaagga aggaaggggg ggagattatt
     4561 tttgcttgaa caaccagtgt ttttcaggat gacaaagaga aaaatataga aatttaagtg
     4621 caaacgtgga atcagctaca aatcctaaag atggtgtgta tgcctttgtg tgcttgtata
     4681 aagcatgtgt gttggtgaat aaaggtatgc cagtggggtg tgtgtgtgtg tgtgtgtgtg
     4741 tctgtgtatc gtgacacatg ggtgtacagt atttcctcca tagctgcctg tcggcttcag
     4801 gaatgaatga caattttctt ttttatgaaa agggatataa cggcacaggg cggatgcagt
     4861 atttctatta ttgagctgac ctaacacggt atttgcatga gttgcagttg tgaagttttg
     4921 agcagttttg tattggtaat ttgacattta gaacacactt tatttattct catgctttgt
     4981 gtccctgcct cgtgtttcac agaggatacc agcttcactc ttcctgtcac ttcagggaat
     5041 atgataggga cgctcactaa ttaggtgccc cgagtttctg aatgagaaaa tgtttcattt
     5101 ctggtgggga aggggaggcg ggaggagggg gagaaggcgt ggaaggggaa ggaggaagaa
     5161 aaaagaacta accagccttc attatttttc ctttatttta aagctatttc ttacaagcaa
     5221 taattaaatc cgaccttgct aaaattcatt tttgttttta tgttattatg tcataagttc
     5281 taatatgtta ttctaataag tatcgactcc acaatattta tatgtacact ccacacgcta
     5341 tctttgcttt gcttttgttt ttgtattaaa ctagtattga ctttggggaa aagcttattc
     5401 actgataagt agtgggcaca aaataaaaag atggagttgt cttatggtta ataaggatgc
     5461 aaaactccaa ggcagatact gcagttgcta gccaaaatcg tacgttggaa gtgcacaccg
     5521 tcttagatgg ttcattcttt taaccataaa atgctagcca ctgaggacag aaagcaaagg
     5581 ctgcagggag tgtgctttat agtgagggag gcgggcccag aagcaaatgt ctcagattag
     5641 aagtcccact aggtagatgg gcccactgga gaaggatcgt ctttgtctaa ggatttccag
     5701 ttggaggccc cagatgcccg gcctgtttac acagtgagat gaaagttcct tccctagggg
     5761 aacacaggga ttaggatgca tggggcgggg gaggtagcta ccttctctag gggcctcccc
     5821 acctcaaaga caacagtggc agagcccatg gagagcaggc tagtactagg agcggtacaa
     5881 gaaagcaaac aagctatgcc atgtcttctg gtgtctgcta gagaccgtgg aagcatcatg
     5941 acttccttaa atttcttgtc ctgtttagaa gggaaatgtg gacctttgtg gaggccacac
     6001 tgaggaaaga attggcagcc ggtgcccaca ctccgtggag ttacttctgt ggcagatgaa
     6061 gtggtctttt ggcggcagta gattgagtgg gaagttctga agtttgaggg aatagactcc
     6121 attagtaggt gagacaccct gtctcttccc gctcacaggg cttttatcgc tggcctctcc
     6181 atttcccagt tgtgctcttt tctctgaact gccctccaaa gatggccatc tgtttcctag
     6241 ctttcctccc tgacagttct agtgcattct attaagatgg aaagcacagt tccatcagag
     6301 agccagcttt tctctgtgtt ctttgagggt attttaaaaa aattttttga ggggcgggtg
     6361 tttgtttttt ctcattcagg aaacatttga gccattgctt tggacatatc actgtgctag
     6421 gctctaggat cccacgtggg ccccagtcac tttcccagga tggagctgat ccctggagga
     6481 aagtcttcct tccctgcccc ttaaccctga gatgaagagg ctcgacatta gtccagcctc
     6541 ggatgctcgg ctctaccctg catcagcaca tacgctgctt agtctcagct gtaagaaata
     6601 tttagcttct gtagatgtta aaaaccttcc tgaaggaact ccacactgca gtgtttatac
     6661 tccagagcac tttcctccag agcctgtgac ttgacagcct ggcctttctc ctctagagat
     6721 gagggatgca gggtctgtcg gtggcagagg ctgggtggca ctgggactac atggtgcatg
     6781 tcccttcctc ttacccatgc atgctgccca ccctaggcaa tggcatagaa gcagtatata
     6841 gatcagtatc cactcacaca cacttataca catacacact cggtgtgctt gcacacacac
     6901 acacacacac acatacacac acacacacac acgaacaagg aacaccaaaa cagtgttgat
     6961 tgttgtgttt aaagacatgt ttttttttca cctgaagaat ggacttaaac tatgtattta
     7021 aaaaaaaata gcctcagtgt tagagatggt gaatgtatcc agtttcagtt acaaaaacaa
     7081 tttcctgaat tttaagcatt cagtgagctg ccaattttga ttttgtgttg ctttttatcc
     7141 aaatggcttt ctcttttctt ttactttttt cttttttctt tgtaaattgg aggaagtggg
     7201 gggcggggag cagcaatatt gtgtttgaaa aattatactc tgtacctggc tttcctgtgt
     7261 tatgttaacc acttcaatgt ttttattctg ctttggtttt atagtgtctg tgaggcattc
     7321 gatgcaacta tacagttatt ttctcattaa aactcaacgt gta
//
