LOCUS       NM_001033254            4137 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus p21 (RAC1) activated kinase 6 (Pak6), transcript
            variant 1, mRNA.
ACCESSION   NM_001033254 XM_111790 XM_899876 XM_899879 XM_899882 XM_917429
            XM_924943 XM_924947 XM_924951 XM_924953
VERSION     NM_001033254.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4137)
  AUTHORS   LaHaye S, Majumdar U, Yasuhara J, Koenig SN, Matos-Nieves A, Kumar
            R and Garg V.
  TITLE     Developmental origins for semilunar valve stenosis identified in
            mice harboring congenital heart disease-associated GATA4 mutation
  JOURNAL   Dis Model Mech 12 (6) (2019)
   PUBMED   31138536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4137)
  AUTHORS   Pensold D, Symmank J, Hahn A, Lingner T, Salinas-Riester G, Downie
            BR, Ludewig F, Rotzsch A, Haag N, Andreas N, Schubert K, Hubner CA,
            Pieler T and Zimmer G.
  TITLE     The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics
            of Migrating POA-Derived Interneurons Fated for the Murine Cerebral
            Cortex
  JOURNAL   Cereb Cortex 27 (12), 5696-5714 (2017)
   PUBMED   29117290
REFERENCE   3  (bases 1 to 4137)
  AUTHORS   Civiero L, Cirnaru MD, Beilina A, Rodella U, Russo I, Belluzzi E,
            Lobbestael E, Reyniers L, Hondhamuni G, Lewis PA, Van den Haute C,
            Baekelandt V, Bandopadhyay R, Bubacco L, Piccoli G, Cookson MR,
            Taymans JM and Greggio E.
  TITLE     Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6
            to control neurite complexity in mammalian brain
  JOURNAL   J Neurochem 135 (6), 1242-1256 (2015)
   PUBMED   26375402
  REMARK    GeneRIF: p21-activated kinase 6 (PAK6) as a novel interactor of
            leucine-rich repeat kinase 2 (LRRK2), a kinase involved in
            Parkinson's disease
REFERENCE   4  (bases 1 to 4137)
  AUTHORS   Distler U, Schmeisser MJ, Pelosi A, Reim D, Kuharev J, Weiczner R,
            Baumgart J, Boeckers TM, Nitsch R, Vogt J and Tenzer S.
  TITLE     In-depth protein profiling of the postsynaptic density from mouse
            hippocampus using data-independent acquisition proteomics
  JOURNAL   Proteomics 14 (21-22), 2607-2613 (2014)
   PUBMED   25211037
REFERENCE   5  (bases 1 to 4137)
  AUTHORS   Furnari,M.A., Jobes,M.L., Nekrasova,T., Minden,A. and Wagner,G.C.
  TITLE     Differential sensitivity of Pak5, Pak6, and Pak5/Pak6
            double-knockout mice to the stimulant effects of amphetamine and
            exercise-induced alterations in body weight
  JOURNAL   Nutr Neurosci 17 (3), 109-115 (2014)
   PUBMED   23710594
  REMARK    GeneRIF: data suggest that PAK-6 p21-activated kinase plays a role
            in weight gain unrelated to exercise and caloric intake
REFERENCE   6  (bases 1 to 4137)
  AUTHORS   Furnari MA, Jobes ML, Nekrasova T, Minden A and Wagner GC.
  TITLE     Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice
  JOURNAL   PLoS One 8 (4), e61321 (2013)
   PUBMED   23593460
  REMARK    GeneRIF: functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout
            mice
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4137)
  AUTHORS   Nekrasova T, Jobes ML, Ting JH, Wagner GC and Minden A.
  TITLE     Targeted disruption of the Pak5 and Pak6 genes in mice leads to
            deficits in learning and locomotion
  JOURNAL   Dev Biol 322 (1), 95-108 (2008)
   PUBMED   18675265
  REMARK    GeneRIF: Our results indicate that Pak5 and Pak6 together are not
            required for viability, but are required for a normal level of
            locomotion and activity as well as for learning and memory.
REFERENCE   8  (bases 1 to 4137)
  AUTHORS   Li X and Minden A.
  TITLE     Targeted disruption of the gene for the PAK5 kinase in mice
  JOURNAL   Mol Cell Biol 23 (20), 7134-7142 (2003)
   PUBMED   14517284
  REMARK    Erratum:[Mol Cell Biol. 2004 Jun;24(12):5637]
REFERENCE   9  (bases 1 to 4137)
  AUTHORS   Qu J, Li X, Novitch BG, Zheng Y, Kohn M, Xie JM, Kozinn S, Bronson
            R, Beg AA and Minden A.
  TITLE     PAK4 kinase is essential for embryonic viability and for proper
            neuronal development
  JOURNAL   Mol Cell Biol 23 (20), 7122-7133 (2003)
   PUBMED   14517283
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC079572.1, AK158913.1 and AL845470.6.
            
            [WARNING] On Oct 5, 2023 this sequence was replaced by
            NM_001033254.4.
            
            On Mar 14, 2009 this sequence version replaced NM_001033254.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059912.1, AK158944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-802               BC079572.1         1-802
            803-2640            AK158913.1         1077-2914
            2641-4137           AL845470.6         80416-81912
FEATURES             Location/Qualifiers
     source          1..4137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.41 cM"
     gene            1..4137
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /note="p21 (RAC1) activated kinase 6"
                     /db_xref="GeneID:214230"
                     /db_xref="MGI:MGI:2679420"
     exon            1..447
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
     exon            448..531
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
     exon            532..637
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
     exon            638..846
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
     CDS             643..2691
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /EC_number="2.7.11.1"
                     /note="PAK-6; p21-activated kinase 6; p21 protein
                     (Cdc42/Rac)-activated kinase 6"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 6"
                     /protein_id="NP_001028426.2"
                     /db_xref="CCDS:CCDS16580.1"
                     /db_xref="GeneID:214230"
                     /db_xref="MGI:MGI:2679420"
                     /translation="MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL
                     DTLRRPKPVVDPSRITRVQLQPMKTVVRGSSVPTEGYISGLLNDIQKLSVISSNTLRG
                     RSPTSRRRAQSLGLLGDDQWAADPDMYLQSPQSEHTDPHGLYLSCNGGTPAGHRQVPW
                     PEPQSPQALPNGMAAKAQSLGPAEFQGASQRCLQQLGACLQSSPPGTSPPMATGRRGV
                     KVAKHSSEEARPQSCLVGSAIGRPGGEGSPSPKNQESSLKHRLFRSMFLSTPATGAAS
                     SSKPVPLPQNKPNSAFRPPQKDSSSNLVAKAQSLPSEQPMGTFSPLTTSDTSSPQKSL
                     RTAPAAGPLPGRSSPAGSPRTRHAQISTSNLYLPQDPTVAKGALGGEDTGIVTHEQFK
                     AALRMVVDQGDPRLLLDSYVKIGEGSTGIVCLAREKHSGRQVAVKMMDLRKQQRRELL
                     FNEVVIMRDYQHLNVVEMYKSYLVGEELWVLMEFLQGGALTDIISQVRLNEEQIATVC
                     EAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKLSDFGFCAQISKDVPKRKSLVGTP
                     YWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAMKRLRDSAPPKLKN
                     SYKVSPVLRDFLDRMLVREPQERATAQELLDHPFLLQTGLPECLVPLIQLYRKQTSTC
                     "
     exon            847..1503
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..2001
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2135
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2262
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2388
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2523
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
     exon            2524..4137
                     /gene="Pak6"
                     /gene_synonym="4732456M09"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccaccgcca ctgagtcacc cacccaccct ggcttttctt ccttccccct ttgcatctga
       61 ttatttgggg agctgaaaac ttggaggtgt ccctgaggcc cgccccttct aactctcccc
      121 gccctacctc ggcttggagg aaaatggaac tcgcccggaa gctgccacta ccccctaagg
      181 acatggaagg cacggaggga gccagaggtg cccatggaga gacctcggct ggcagaatac
      241 aatagcagac atggtgttcg ggctgcccgt gtgtcctctg aaggttctgg gagagaaggg
      301 gagtctagtc cacaccgact ggagtccttc tgggctgcct ttgcgctcac ctctcaaggg
      361 gatctttctg taaaaggaaa cgtgtggctt ccagggtcac tggtatttgg agagcaagac
      421 tggattggca taggcaggcc tgtgcaggta gcaccaagct tctgggctcc agacaagcac
      481 cagcctacag tgggagaggg tgaggcccag ctgcccagaa ggagtgccaa ggccggcaga
      541 ggactggccc tggaaggtcc cgggatctcc cgtcacctcc atgctctaga gagctgaccg
      601 cagaagggag aaaggagcgg agagaaggcc acaggaggca ccatgttccg caagaaaaag
      661 aagaaacgtc ctgagatatc agccccgcag aacttccagc atcgtgtcca cacctccttt
      721 gaccccaagg aaggcaagtt tgtgggtctg cccccacaat ggcagaacat tctggatact
      781 ctgaggcggc ccaagcctgt ggtggatcct tctcgaatca cacgggtgca gttgcagccc
      841 atgaagacag tggtacgggg cagctcagtg cccacggagg gctacatctc cgggctgctc
      901 aacgacattc agaagttgtc agttatcagc tccaacaccc tgcgtggacg cagccccacc
      961 agccggcggc gggcacagtc cctggggctg ctgggagatg atcagtgggc tgctgacccc
     1021 gatatgtacc tccaaagccc ccagtcggag cacactgatc cccatggcct ctacctcagc
     1081 tgcaatgggg gcacaccagc aggtcacagg caggtgccct ggccagaacc acagagcccg
     1141 caggccctgc ccaatgggat ggctgccaag gcgcagtcac tgggccctgc tgagttccag
     1201 ggtgcctcac aacgctgcct gcagcagctg ggtgcctgcc tgcagagttc cccacccggt
     1261 acctcacccc ctatggccac agggaggcgt ggggtgaagg ttgccaagca tagctccgaa
     1321 gaggcccggc ctcagtcctg cctggtgggc tccgccattg gcaggccagg tggagaaggc
     1381 agccctagcc ctaagaacca ggaaagcagc ctcaagcacc ggctcttccg aagcatgttc
     1441 ctgtccactc ctgccacagg cgcggcaagc agcagcaagc cggtccctct gccacagaac
     1501 aagcccaatt ctgctttccg accaccacaa aaagactcct cttcaaacct ggtagccaag
     1561 gcccagtcct tgccctcaga gcagcccatg gggaccttca gtcctctgac cacctcagat
     1621 accagcagcc cccagaagtc cctccgcaca gctccagccg ctggtccact tccaggccgg
     1681 tcttctccag caggctcccc ccgtacccgg catgctcaga tcagcaccag caatctctac
     1741 ctgccccagg accccacagt ggccaagggg gccctgggtg gcgaagacac gggcattgtg
     1801 acccatgaac agttcaaggc tgcgctcagg atggtggtgg accagggtga ccctcggctg
     1861 ctgctggaca gctacgtgaa gattggggag ggctccacgg gcattgtgtg tctggcccgg
     1921 gagaagcact caggtcgcca ggtagcagtc aagatgatgg acctcaggaa gcagcaacgc
     1981 agggagctgc tctttaatga ggtggtgatc atgcgtgact accagcacct caacgtggtg
     2041 gagatgtaca agagttacct ggtaggagag gagctgtggg tgttgatgga gttcctgcag
     2101 ggcggggccc tcacagacat catctcccaa gtcagactga atgaggagca gattgccact
     2161 gtgtgtgaag ctgtgcttca ggccttggct tacctgcacg cccagggtgt catccaccga
     2221 gatatcaaga gtgattccat cctgctgacc cttgatggca gggtgaagct ctcagacttt
     2281 gggttctgtg ctcagatcag caaagatgtt cccaagagaa agtccctggt aggaactcca
     2341 tactggatgg ctcctgaagt gatctccaga tccctgtacg ctactgaggt ggatatctgg
     2401 tctctgggca tcatggtgat tgagatggtg gatggagaac ccccctactt cagtgactcc
     2461 ccagtgcaag ccatgaagag gctgcgggac agcgccccac ccaagctaaa gaactcttac
     2521 aaggtctctc cagtgctgcg agacttcctg gatcggatgc tggtacggga accccaagag
     2581 cgagccacgg cccaggagct tctggatcac ccgtttctgc tgcagacggg gctgcctgag
     2641 tgtctggtgc ctctgataca gctctaccgc aagcagacct ccacctgctg agcccgcacc
     2701 cagggtgcac ctgccacctg tgcccacagg caaaggacac tggacagccg ttccattggc
     2761 aaggcctacc cgccttgccc tctcagtgtt ctctccaaag atcgaatgtg aagctccgca
     2821 ccttccctcc tgcccttttg cccgctgggc caggccggac ctgcccccct tggtttcact
     2881 ccccagagtc ccagttgcct ttgggatgac agtgacccct tctgcaggtt tggccctttg
     2941 ttatttgcac agggatgttt ctaagaaacg cggagagtgg tgctcttggc cgcaagccag
     3001 caaagccgac aggctgctgc agatttttaa aggcagtgtc cacagtgacc tggggcaacc
     3061 aagagggtgc atgctccatc tccacatgga cacttgctat tctcaactga agcttcaaac
     3121 cctggagtcc cagagggcca cggggaagga tttcgctgcc tgaatccttc ttcctcctct
     3181 ggtctgactt ctggaagccc cacttgcacc tgtttcctgt ctgttccctg gcactgcctc
     3241 gccctagaaa acctctacgg aactgtgaat agcctgtgtg tagaccatga gagcagccag
     3301 gggggaatct tctgagagag agtggggttg gcagtaaacg tggttccatt gtccaggatg
     3361 tagagaacat tctctctctc tctctctctc tctctctctc tctctgtgtg tgtgtgtgtg
     3421 tgtgtgtgtg tgtgtgtgtg taaacttccc ccagtggccc aggtccttcc agtcacccac
     3481 agagagcctc agaagagctg tccacctctt ttctaccaag ctccattctg aaggaatctg
     3541 ctttttggac ctggctttct gcctctcaag tctcatgtta ttacctaaac agggaagggg
     3601 tgtgtgtatg tcaagtctaa cacatgctgg gggccctcaa agtttctgag tttctcccat
     3661 actgaggcag gaatagtaag ggaataaact ttgttttacc tgtcagcaac ttcttagcgg
     3721 ccagatcagg gacccctcct tttcagaacc ctgggctggg acagaaaggt gaaccacctc
     3781 ccggaggggg tccctcatgc cgagcgaggg atgggcacct cctctgtgag cctgctgccc
     3841 cagctgtcct gttgatactt ccctgcctcc ttgacctccc tcccttccca ccttcctggc
     3901 tgttgtgaga cagggaatgc caaggaagaa ctctagtgtc tggacccgat ccagataata
     3961 tttttagact cctctgttcc ctgatgacct gcattagggc aaaaaaaaaa aaaaattgca
     4021 aggtcttttt ttttttttta agggtcagag ttttaaaaaa acaaaagcat ccttccctag
     4081 acatttttgt gacttgtttg cacttgtgcc tgttttaaat taaactaaat gttcgaa
//
