LOCUS       NM_172858               4773 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus p21 (RAC1) activated kinase 5 (Pak5), transcript
            variant 3, mRNA.
ACCESSION   NM_172858
VERSION     NM_172858.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4773)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4773)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4773)
  AUTHORS   Shu,P., Wu,C., Liu,W., Ruan,X., Liu,C., Hou,L., Zeng,Y., Fu,H.,
            Wang,M., Chen,P., Zhang,X., Yin,B., Yuan,J., Qiang,B. and Peng,X.
  TITLE     The spatiotemporal expression pattern of microRNAs in the
            developing mouse nervous system
  JOURNAL   J Biol Chem 294 (10), 3444-3453 (2019)
   PUBMED   30578296
REFERENCE   4  (bases 1 to 4773)
  AUTHORS   Morris,D.W., Pearson,R.D., Cormican,P., Kenny,E.M.,
            O'Dushlaine,C.T., Perreault,L.P., Giannoulatou,E., Tropea,D.,
            Maher,B.S., Wormley,B., Kelleher,E., Fahey,C., Molinos,I.,
            Bellini,S., Pirinen,M., Strange,A., Freeman,C., Thiselton,D.L.,
            Elves,R.L., Regan,R., Ennis,S., Dinan,T.G., McDonald,C.,
            Murphy,K.C., O'Callaghan,E., Waddington,J.L., Walsh,D.,
            O'Donovan,M., Grozeva,D., Craddock,N., Stone,J., Scolnick,E.,
            Purcell,S., Sklar,P., Coe,B., Eichler,E.E., Ophoff,R., Buizer,J.,
            Szatkiewicz,J., Hultman,C., Sullivan,P., Gurling,H., Mcquillin,A.,
            St Clair,D., Rees,E., Kirov,G., Walters,J., Blackwood,D.,
            Johnstone,M., Donohoe,G., O'Neill,F.A., Kendler,K.S., Gill,M.,
            Riley,B.P., Spencer,C.C. and Corvin,A.
  CONSRTM   International Schizophrenia Consortium, SGENE+ Consortium; Wellcome
            Trust Case Control Consortium 2
  TITLE     An inherited duplication at the gene p21 Protein-Activated Kinase 7
            (PAK7) is a risk factor for psychosis
  JOURNAL   Hum Mol Genet 23 (12), 3316-3326 (2014)
   PUBMED   24474471
REFERENCE   5  (bases 1 to 4773)
  AUTHORS   Furnari,M.A., Jobes,M.L., Nekrasova,T., Minden,A. and Wagner,G.C.
  TITLE     Differential sensitivity of Pak5, Pak6, and Pak5/Pak6
            double-knockout mice to the stimulant effects of amphetamine and
            exercise-induced alterations in body weight
  JOURNAL   Nutr Neurosci 17 (3), 109-115 (2014)
   PUBMED   23710594
  REMARK    GeneRIF: PAK-7 p21-activated kinase 5 knockout mice are more
            sensitive to the stimulant effects of amphetamine
REFERENCE   6  (bases 1 to 4773)
  AUTHORS   Sapir,T., Sapoznik,S., Levy,T., Finkelshtein,D., Shmueli,A.,
            Timm,T., Mandelkow,E.M. and Reiner,O.
  TITLE     Accurate balance of the polarity kinase MARK2/Par-1 is required for
            proper cortical neuronal migration
  JOURNAL   J Neurosci 28 (22), 5710-5720 (2008)
   PUBMED   18509032
REFERENCE   7  (bases 1 to 4773)
  AUTHORS   Trinidad,J.C., Specht,C.G., Thalhammer,A., Schoepfer,R. and
            Burlingame,A.L.
  TITLE     Comprehensive identification of phosphorylation sites in
            postsynaptic density preparations
  JOURNAL   Mol Cell Proteomics 5 (5), 914-922 (2006)
   PUBMED   16452087
REFERENCE   8  (bases 1 to 4773)
  AUTHORS   Niehof,M. and Borlak,J.
  TITLE     RSK4 and PAK5 are novel candidate genes in diabetic rat kidney and
            brain
  JOURNAL   Mol Pharmacol 67 (3), 604-611 (2005)
   PUBMED   15615695
  REMARK    GeneRIF: PAK5 may provide a molecular rationale for late-stage
            complications in diabetes.
REFERENCE   9  (bases 1 to 4773)
  AUTHORS   Li,X. and Minden,A.
  TITLE     Targeted disruption of the gene for the PAK5 kinase in mice
  JOURNAL   Mol Cell Biol 23 (20), 7134-7142 (2003)
   PUBMED   14517284
  REMARK    Erratum:[Mol Cell Biol. 2004 Jun;24(12):5637]
REFERENCE   10 (bases 1 to 4773)
  AUTHORS   Cotteret,S., Jaffer,Z.M., Beeser,A. and Chernoff,J.
  TITLE     p21-Activated kinase 5 (Pak5) localizes to mitochondria and
            inhibits apoptosis by phosphorylating BAD
  JOURNAL   Mol Cell Biol 23 (16), 5526-5539 (2003)
   PUBMED   12897128
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928792.9, AK163530.1, AK032593.1 and AL845354.13.
            
            [WARNING] On Oct 18, 2024 this sequence was replaced by
            NM_172858.3.
            
            On Mar 31, 2007 this sequence version replaced NM_172858.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1 through 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032593.1, AK163530.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AL928792.9         78755-78947         c
            194-1667            AK163530.1         2-1475
            1668-2765           AK032593.1         1641-2738
            2766-4773           AL845354.13        20443-22450         c
FEATURES             Location/Qualifiers
     source          1..4773
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 67.32 cM"
     gene            1..4773
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /note="p21 (RAC1) activated kinase 5"
                     /db_xref="GeneID:241656"
                     /db_xref="MGI:MGI:1920334"
     exon            1..314
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            315..469
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            470..684
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..2640
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /EC_number="2.7.11.1"
                     /note="serine/threonine-protein kinase PAK 7;
                     p21-activated kinase 5; p21-activated kinase 7; p21
                     protein (Cdc42/Rac)-activated kinase 7; p21 (RAC1)
                     activated kinase 7"
                     /codon_start=1
                     /product="serine/threonine-protein kinase PAK 5"
                     /protein_id="NP_766446.2"
                     /db_xref="CCDS:CCDS16790.1"
                     /db_xref="GeneID:241656"
                     /db_xref="MGI:MGI:1920334"
                     /translation="MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLA
                     DTANRPKPMVDPSCITPIQLAPMKTIVRGNKSCKETSINGLLEDFDNISVTRSNSLRK
                     ESPPTPDQGAASRIQGHSEENGFITFSQYSSESDTTADYTTEKYRDRSLYGDDLDLYY
                     KSSHAAKQNGHAMKMKHGDAYYPEMKSLKTDLAGFPVDYHTHLDSLRKSSEYGDLRWD
                     YQRASSSSPLDYSFQLTPSRTAGTSRCSKESLAYSESDWGPSLDDYDRRPKSSYLHQT
                     SPQPAMRQRSKSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYD
                     RAQMVFSPPLSGSDTYPRGPTKLPQSQSKAGYSSGSHQYPSGYHKASLYHHPSLQTSS
                     QYISTASYLSSLSISSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLD
                     NFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVD
                     MYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLKALSYLHNQGVIH
                     RDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEV
                     DIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSMLRGFLDLMLV
                     REPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH"
     exon            685..1470
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1962
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2096
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2223
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2349
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2484
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..4773
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4735..4740
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /note="hexamer: AATAAA"
     polyA_site      4762
                     /gene="Pak5"
                     /gene_synonym="2900083L08Rik; PAK-5; PAK-7; Pak7"
                     /note="major polyA site"
ORIGIN      
        1 tttcctacag cgggctgctc ctaaaacccg gagcagctga gtggtctcag cggacagtcc
       61 tcctaggggc gaagccaggc ggcttgggca tgctcagtag ctgggagagg tttgggagga
      121 gagtaaaaag ctttgactct gcccccaccc cctcctctag cccccgcccc ccttgcccct
      181 tcccagccgt agtagttccc tggcgtgcgc ccgtggagag caggaacatg gcgcttggag
      241 cgatataaca gatgtagcag cagcggagaa gcagatgagg taccgcgact tctctgctga
      301 cagccagcca ccagaaatac actgtggtga aatgcttctg tctgttgcca aaatgaacac
      361 tgaagaaaaa tgaagaaaac tgaagaacac caacaaaaag tttgcacaac agaagtagcc
      421 aaactcttct ggaatcttta attcgtcccc ggccttcgta aaacaaaaag tttttacatc
      481 atgtttggga agaaaaagaa aaagatcgaa atatctggcc catccaactt tgaacacagg
      541 gttcatactg gatttgatcc acaagagcag aagtttactg gccttcccca gcagtggcac
      601 agcctgttag cagacacagc caacaggccc aagcccatgg tggacccatc atgcatcaca
      661 cccatacagc tggctcccat gaagacaatc gtcagaggaa ataaatcctg caaggaaacc
      721 tctatcaatg gtctgctaga ggattttgac aacatctccg tgactcgctc caactctcta
      781 aggaaagaaa gcccacccac cccagatcag ggagcagcta gccgcattca aggccactcg
      841 gaagagaacg gcttcatcac tttctcacaa tattccagtg aatccgatac gactgcggac
      901 tacacaactg aaaagtacag agacaggagt ctctatggag atgacctgga tctgtactat
      961 aaaagcagcc atgcagccaa gcaaaatggg catgccatga agatgaaaca tggagacgct
     1021 tactaccctg agatgaagtc tttgaaaacc gacctggccg gattccctgt cgactatcac
     1081 acccacttgg actctctgag aaaatcaagt gaatatggtg accttaggtg ggattatcag
     1141 agagcctcta gtagctcccc tctggactac tcattccagc tcacgccttc tagaactgca
     1201 gggaccagca ggtgctccaa ggagagtctg gcatacagtg aaagtgattg gggacccagc
     1261 ctggatgact atgacaggag gccaaaatca tcatacctgc atcagacgag ccctcagcca
     1321 gccatgcgcc agagatccaa gtccggctca gggcttcagg aacccatgat gccatttgga
     1381 gcaagtgcat ttaaaactca tcctcaagga cactcgtaca actcctacac ctaccctcga
     1441 ttgtccgagc ccacaatgtg cattccaaag gtggattacg atcgagcaca gatggtcttc
     1501 agtcctccac tgtcagggtc cgacacttac cccagaggcc ccaccaaact acctcaaagt
     1561 caaagcaaag caggctactc ttcaggcagc caccagtacc cttctgggta ccacaaagca
     1621 tctctatacc accatccatc cctgcaaacc agttctcagt acatctccac cgcttcttac
     1681 ttaagctctc tcagtatctc ctcgagcacc taccctccac ctagctgggg ctcctcctca
     1741 gaccagcagc cctcaagggt atcccatgaa caattccgag ctgccctgca actggtggtc
     1801 agcccaggag accccaggga atatttggat aactttatta aaatcggaga agggtcgaca
     1861 ggcatcgtgt gcattgcaac agagaaacac acaggcaagc aagtggcagt gaagaaaatg
     1921 gacctccgaa agcagcagag acgggaactc ctttttaatg aggtcgtgat aatgcgtgat
     1981 taccaccatg acaacgtagt tgacatgtac aacagctacc ttgttggaga tgagctctgg
     2041 gtggtcatgg agtttctaga aggtggtgcc ttgacagaca ttgtcactca taccagaatg
     2101 aatgaagagc agatagctac tgtctgcctg tcagttctga aagctctgtc ctaccttcat
     2161 aaccaaggag tgattcacag ggacataaag agtgactcca ttcttctgac aagcgatggc
     2221 cggataaagt tatctgactt tggtttctgt gctcaagttt ccaaagaggt gccaaagagg
     2281 aagtcactgg tgggtacccc atactggatg gcacctgagg tgatttccag gctaccttat
     2341 gggacagagg tggacatctg gtccctcggg ataatggtga tagagatgat tgatggggag
     2401 cccccctatt tcaatgagcc tcctctgcag gccatgagga ggatccggga cagtttacct
     2461 ccaagagtga aggacctaca caaggtttct tccatgctcc gaggattcct agatcttatg
     2521 ttggtgaggg agccctctca aagagccaca gctcaagaac tccttggaca tccattctta
     2581 aaattggcag gtccaccatc ttgcattgtt cctctcatga gacaatacag acatcactga
     2641 gaggattcac acaggatgca aagctaggca aagacatgag aatgattcag gagaacatga
     2701 ggaaacccac agaacatgca aagacctgtg ctttctaaac cagctgattg gtggaacagt
     2761 gtgatgacct gaccggcagg gttcgacaga ccagggcatc ttctagtgtc ttaaataata
     2821 ggcatctctc cactgacagc tggcatggtc atttggagca tggctttaat taataagtca
     2881 ttattataca ttttcagccc ttccagtaaa tcagaaggac tcagtacaaa ctccgttacg
     2941 atatatccta gccacatgca gggtaccaca taggattttc tatattgaaa gaatactttt
     3001 ctggcaaaat aaaaaaaaaa aagataaaga aaggaagaaa agaaaataaa aagcactttt
     3061 tttcttaatg gtagcagtgt aatgtatttt gcaatgaatt tgtaactttt ctgtacgata
     3121 gttttgataa tttatagtac tttgatgtca cgtagccatt gtctcggttg aagtaacact
     3181 tgtttactag caggagtttg aacaaagcct ttcctacttt tttatccctt tcagagaacc
     3241 aacgattctt taggaacttt gaatactaaa tgaccctcag tcaccgtcag ctttagcaga
     3301 atatctttct tatcttaaca agtgtcttat gtagtggaag aagagttagg agggatggtg
     3361 atggtgcgga cacttcgctt acccagccaa atataacaaa ataaaatttg agccacagaa
     3421 tcgccaaacg attccttgag ataatgctaa gtattttgaa aaattacatt tccttcaagg
     3481 attctgggaa caccccattg gttttttttg tagagcaaga tatttccctt gatgcccacc
     3541 ttcaaatagg catggcatcc tcagtggcca aatttccctc ccagggagta attttagcgc
     3601 tgggatcttt ggactcagat ctccaggtag aatgtttcag tgagaccatg gaaataccag
     3661 gctcacaaag ggagaatgaa caaggcaagt tgtttggttt tgtccgtcac tgtttctaag
     3721 actttgtatg ctagcacacc aaactcttgt ctgtatttac cttcatgcca cagtatttat
     3781 cactgttatt catgtattgt gcggaaagtc tgaacggatg atagaggatg aattagcaag
     3841 ggggtacttt accaagtatg gtctaacttc agtggtgacc atgttataat gtgtttctga
     3901 cataaggaga gttgtgctgc tgtctcgatc ttcctgaatg ttgataaaaa tgaatgacta
     3961 ctacaataca ttttgtgttg cttgttggat gaatttgcat gttaactgta ggccagtata
     4021 gatttgcctt taaaactctg gaagcgctac atagtcatca ttagtttcta ttaattatgc
     4081 atcagacaaa agccatttgt taccaaactg gaaaaccaga ggctttattt aatgactttg
     4141 catactgtaa caaatatgaa aatatatttg tgaagatact ctggttgctc taagcataat
     4201 taagaatttt ttgtaattaa taggttgata attatttatt ttaatttaaa aggaaaaaag
     4261 gcataaaatg accttctgct gattagctgt tcaatttttc cccaaactgg aaatgctcta
     4321 caataaatag aatctataac tttgttttat aaaacacaga agatcaatgt tttatgaaaa
     4381 ctgttaagat cttaatacaa atatgtgaga gtaacggcaa tctcaattcc caaaatggta
     4441 gtcctaaaat gtcacaaaaa agtgtcataa ttcaaccagg actatgtagg ggaggaaaga
     4501 gagtaaacca gaatcatttt aaaccagaat caacattgaa aaattcattg caaactctgc
     4561 agaaataaca gattttggac tcaaacaaat ttcgacggtg taatggaaaa aaattttttt
     4621 tctgtaattt tcttatcatt gggcattttt ttacagtatt tggtgagttt actaaatgtt
     4681 actgtagctt aaaggaatct gtgagcagtg agcattggca gaagctgcac cacaaataaa
     4741 gtaagtgttt gcctttttcc caccgtgctg ttg
//
