LOCUS       NM_026550               1753 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus PAK1 interacting protein 1 (Pak1ip1), mRNA.
ACCESSION   NM_026550
VERSION     NM_026550.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1753)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1753)
  AUTHORS   Panoutsopoulos,A.A., De Crescenzo,A.H., Lee,A., Lu,A.M., Ross,A.P.,
            Borodinsky,L.N., Marcucio,R., Trainor,P.A. and Zarbalis,K.S.
  TITLE     Pak1ip1 Loss-of-Function Leads to Cell Cycle Arrest, Loss of Neural
            Crest Cells, and Craniofacial Abnormalities
  JOURNAL   Front Cell Dev Biol 8, 510063 (2020)
   PUBMED   32984348
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1753)
  AUTHORS   Ross,A.P., Mansilla,M.A., Choe,Y., Helminski,S., Sturm,R.,
            Maute,R.L., May,S.R., Hozyasz,K.K., Wojcicki,P., Mostowska,A.,
            Davidson,B., Adamopoulos,I.E., Pleasure,S.J., Murray,J.C. and
            Zarbalis,K.S.
  TITLE     A mutation in mouse Pak1ip1 causes orofacial clefting while human
            PAK1IP1 maps to 6p24 translocation breaking points associated with
            orofacial clefting
  JOURNAL   PLoS One 8 (7), e69333 (2013)
   PUBMED   23935987
  REMARK    GeneRIF: A mutation in mouse Pak1ip1 causes orofacial clefting
            while human PAK1IP1 maps to 6p24 translocation breaking points
            associated with orofacial clefting.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1753)
  AUTHORS   Stockton,R., Reutershan,J., Scott,D., Sanders,J., Ley,K. and
            Schwartz,M.A.
  TITLE     Induction of vascular permeability: beta PIX and GIT1 scaffold the
            activation of extracellular signal-regulated kinase by PAK
  JOURNAL   Mol Biol Cell 18 (6), 2346-2355 (2007)
   PUBMED   17429073
  REMARK    GeneRIF: Results suggest that the PAK-PIX-GIT1 complex is critical
            for Erk-dependent myosin phosphorylation and vascular permeability.
REFERENCE   5  (bases 1 to 1753)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   6  (bases 1 to 1753)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   7  (bases 1 to 1753)
  AUTHORS   Kim,H.W., Yang,P., Qyang,Y., Lai,H., Du,H., Henkel,J.S., Kumar,K.,
            Bao,S., Liu,M. and Marcus,S.
  TITLE     Genetic and molecular characterization of Skb15, a highly conserved
            inhibitor of the fission yeast PAK, Shk1
  JOURNAL   Mol Cell 7 (5), 1095-1101 (2001)
   PUBMED   11389855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY055321.1, BY788898.1, AK150919.1 and AV225950.1.
            
            On Mar 11, 2009 this sequence version replaced NM_026550.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF386076.1, BC043461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BY055321.1         3-30
            29-252              BY788898.1         15-238
            253-1727            AK150919.1         1-1475
            1728-1753           AV225950.1         289-314
FEATURES             Location/Qualifiers
     source          1..1753
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 20.23 cM"
     gene            1..1753
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /note="PAK1 interacting protein 1"
                     /db_xref="GeneID:68083"
                     /db_xref="MGI:MGI:1915333"
     exon            1..404
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1469
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /note="glycerophosphodiester phosphodiesterase domain
                     containing 1; putative PAK inhibitor Skb15"
                     /codon_start=1
                     /product="p21-activated protein kinase-interacting protein
                     1"
                     /protein_id="NP_080826.2"
                     /db_xref="CCDS:CCDS36638.1"
                     /db_xref="GeneID:68083"
                     /db_xref="MGI:MGI:1915333"
                     /translation="MELVAGSYEQVLFGFTVQRGPAKSGHQETWTPVADFTHHSHTAS
                     LSVLASNSRYVVSGSKDETIHIYDMKRKVEHGALVHHAGTVTCLKFHGNQHLISGAED
                     GHICIWDVKRWKCLKTFKAHRGHVTFLSIHPSGKLALSVGTDKTLRTWNLIEGRSAFI
                     KNIKENAHIVEWSPSGGKYIVVVQNKVDVYRLGTASVSGTITNGKRISSVTFLSDSVL
                     AVAGDEEVVRIFDCDSLECLCEFRAHENRVKDMVSFEVPDHHVLVTASNDGFIKMWTL
                     PQDKKVPPSLLCEAKTGARLTCLTVWLDRAANGMASLPPAAEPCPDQPKTIEKESGDT
                     VQEETSEPNSEKSDVSGDSKQPTKGNSPVTAKKRKMATMSEKKRKKKM"
     exon            405..567
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..688
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..763
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..816
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            817..962
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1060
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1160
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1284
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1753
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1703..1708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /note="hexamer: AGTAAA"
     polyA_site      1733
                     /gene="Pak1ip1"
                     /gene_synonym="5830431I15Rik; 5930415H02Rik; Gdpd1; PIP1"
                     /note="major polyA site"
ORIGIN      
        1 agaagttccc tcccatttcc caaggccggc ggagcccacg gcttcccagg acttgcctgc
       61 ttgacacaac ttttctttct ctctgctctg agagcctcct cccgcggctt ccttccttaa
      121 gctcgtcgca gaagggtcac gtgacgtccc acgtaacgga ggacggagcg cgtcctccgt
      181 tattgccatt tgcaggcgcc taaaaggtgc ccccgggcgg tgacgtataa ctcgcgcgcc
      241 ggctgaggaa gggaagggcc agcctccgca gccatcgggt ctccacgccg gcgtctcttg
      301 cccggcacga gtgctgcgga atggagctgg tcgccggcag ctacgagcag gtcctgtttg
      361 ggttcacggt acagcgcggg cccgcgaaga gtggccatca ggagacatgg actcctgtgg
      421 ctgatttcac tcaccactcg cacactgcct ccctgtcggt gctggcctcc aacagtcgct
      481 atgtagtctc tggcagcaaa gatgagacga ttcacattta tgacatgaaa aggaaggtgg
      541 agcatggggc tctggtgcat cacgctggca cagtaacttg cctgaaattc catggcaacc
      601 agcacttaat cagtggggca gaagacggcc acatctgcat ctgggatgtg aagagatgga
      661 agtgcctgaa gacctttaaa gctcacaggg gacatgtcac tttcctttct atccacccgt
      721 ctggcaagtt ggctctgtct gttggcaccg ataaaacatt aagaacatgg aatcttatag
      781 agggaagatc agctttcata aaaaatataa aggaaaatgc tcacatagtg gagtggtccc
      841 caagtggagg gaagtacata gttgttgtgc agaataaagt ggatgtctat cggctgggca
      901 cggcgtctgt gagcggcacc atcacaaacg gaaagaggat ctcttctgtt acctttctct
      961 cagactctgt ccttgcagtg gctggagatg aagaagttgt gaggattttt gactgtgatt
     1021 ccctagagtg cctctgtgaa ttcagagctc atgagaacag ggtaaaagac atggtcagtt
     1081 ttgaagtccc agaccatcac gttcttgtca cagcatcaaa tgatggcttc atcaaaatgt
     1141 ggacgcttcc acaggataag aaagttcctc catctttgct gtgtgaggcc aaaactggtg
     1201 ccaggctgac atgtcttact gtgtggttag acagagcagc aaatggaatg gcgagccttc
     1261 ctccagcagc agagccctgc cctgaccaac ctaagacaat cgaaaaggaa tctggtgaca
     1321 cagttcagga agaaacatca gaacctaact cggagaaatc tgatgtaagt ggtgacagca
     1381 agcagccaac aaaaggaaat agcccagtga cagccaagaa gaggaaaatg gcaaccatgt
     1441 cggaaaagaa gagaaagaag aaaatgtaac tcacgtggca aatcccagat ttctcctccc
     1501 tatctgaatg tccttttgac ggaattctcc atgtccctgt gagaagaaaa tatctccttc
     1561 cgtagaaaat gtgcagctta agaaaaagaa ccgctcttta ggtggtgctt tgttttgtta
     1621 aatgataaac gttattttgg cagatggcat tttattatag attgtaatat atagtgattg
     1681 tttactttag ctgttcagag caagtaaaga tctgaaaatt gtatttgaaa taatacagag
     1741 cttaattaca ttt
//
