LOCUS       NM_026420               1488 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus polyadenylate-binding protein-interacting protein 2
            (Paip2), transcript variant 1, mRNA.
ACCESSION   NM_026420
VERSION     NM_026420.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1488)
  AUTHORS   Zhao,L.W., Zhu,Y.Z., Chen,H., Wu,Y.W., Pi,S.B., Chen,L., Shen,L.
            and Fan,H.Y.
  TITLE     PABPN1L mediates cytoplasmic mRNA decay as a placeholder during the
            maternal-to-zygotic transition
  JOURNAL   EMBO Rep 21 (8), e49956 (2020)
   PUBMED   32558204
REFERENCE   2  (bases 1 to 1488)
  AUTHORS   Rong,Y., Ji,S.Y., Zhu,Y.Z., Wu,Y.W., Shen,L. and Fan,H.Y.
  TITLE     ZAR1 and ZAR2 are required for oocyte meiotic maturation by
            regulating the maternal transcriptome and mRNA translational
            activation
  JOURNAL   Nucleic Acids Res 47 (21), 11387-11402 (2019)
   PUBMED   31598710
REFERENCE   3  (bases 1 to 1488)
  AUTHORS   Yu,C., Ji,S.Y., Sha,Q.Q., Dang,Y., Zhou,J.J., Zhang,Y.L., Liu,Y.,
            Wang,Z.W., Hu,B., Sun,Q.Y., Sun,S.C., Tang,F. and Fan,H.Y.
  TITLE     BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition
            licensing factor in oocytes
  JOURNAL   Nat Struct Mol Biol 23 (5), 387-394 (2016)
   PUBMED   27065194
REFERENCE   4  (bases 1 to 1488)
  AUTHORS   Khoutorsky,A., Yanagiya,A., Gkogkas,C.G., Fabian,M.R.,
            Prager-Khoutorsky,M., Cao,R., Gamache,K., Bouthiette,F.,
            Parsyan,A., Sorge,R.E., Mogil,J.S., Nader,K., Lacaille,J.C. and
            Sonenberg,N.
  TITLE     Control of synaptic plasticity and memory via suppression of
            poly(A)-binding protein
  JOURNAL   Neuron 78 (2), 298-311 (2013)
   PUBMED   23622065
  REMARK    GeneRIF: this study demonstrated that activity-dependent
            degradation of PAIP2A relieves translational inhibition of
            memory-related genes through PABP reactivation and conclude that
            PAIP2A is a pivotal translational regulator of synaptic plasticity
            and memory.
REFERENCE   5  (bases 1 to 1488)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   6  (bases 1 to 1488)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 1488)
  AUTHORS   Hamatani,T., Falco,G., Carter,M.G., Akutsu,H., Stagg,C.A.,
            Sharov,A.A., Dudekula,D.B., VanBuren,V. and Ko,M.S.
  TITLE     Age-associated alteration of gene expression patterns in mouse
            oocytes
  JOURNAL   Hum Mol Genet 13 (19), 2263-2278 (2004)
   PUBMED   15317747
REFERENCE   8  (bases 1 to 1488)
  AUTHORS   Onesto,C., Berra,E., Grepin,R. and Pages,G.
  TITLE     Poly(A)-binding protein-interacting protein 2, a strong regulator
            of vascular endothelial growth factor mRNA
  JOURNAL   J Biol Chem 279 (33), 34217-34226 (2004)
   PUBMED   15175342
  REMARK    GeneRIF: PAIP2 is a crucial regulator of VEGF mRNA and has a role
            in regulating angiogenesis
REFERENCE   9  (bases 1 to 1488)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1488)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB842021.1, AK009909.1 and AI449635.1.
            
            On Oct 28, 2017 this sequence version replaced NM_026420.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167545.1, AK146327.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BB842021.1         2-51
            51-1474             AK009909.1         2-1425
            1475-1488           AI449635.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..1488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.16 cM"
     gene            1..1488
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /note="polyadenylate-binding protein-interacting protein
                     2"
                     /db_xref="GeneID:67869"
                     /db_xref="MGI:MGI:1915119"
     exon            1..143
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            144..307
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..544
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /note="Pabp-interacting protein 2; PAIP-2; poly(A)-binding
                     protein-interacting protein 2"
                     /codon_start=1
                     /product="polyadenylate-binding protein-interacting
                     protein 2"
                     /protein_id="NP_080696.1"
                     /db_xref="CCDS:CCDS29143.1"
                     /db_xref="GeneID:67869"
                     /db_xref="MGI:MGI:1915119"
                     /translation="MKDPSRSSTSPSIINDDVIINGHSHEEDNPFAEYMWMENEEEFN
                     RQIEEELWEEEFIERCFQEMLEEEEEHEWFIPARDLPQTMDQIQDQFNDLVISDGSSL
                     EDLVVKSNLNPNAKEFVPGVKY"
     exon            308..487
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            488..1475
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      688..693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      717
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /note="major polyA site"
     regulatory      815..820
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      836
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
     regulatory      1455..1460
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1475
                     /gene="Paip2"
                     /gene_synonym="2310050K10Rik"
                     /note="major polyA site"
ORIGIN      
        1 acttccgggc aggggtgttt gtttggactg gagaagggag gcggcgggca aagcgcacgt
       61 cgagcggggg agcggcgctg cctgtggaga tccgcggagg ccgacaggat tcgttggcta
      121 ccgtccccgc tgccgtgcac tgggttaaaa acgacaacga gcaccaacca tgaaagatcc
      181 aagtcgcagc agtactagcc caagcatcat caatgacgat gtgattatta acggtcattc
      241 tcatgaagag gataatccat ttgcagagta catgtggatg gaaaatgaag aggaattcaa
      301 cagacaaata gaagaggagt tgtgggaaga agaatttatt gaacgctgtt tccaagaaat
      361 gctggaagag gaagaagaac atgaatggtt tattccagct cgagatctcc cacaaactat
      421 ggaccaaatc caagaccagt ttaatgacct tgttatcagt gatggctctt ctctggaaga
      481 tcttgtggtc aagagcaatc tgaatcccaa tgcaaaggag tttgttcctg gggtgaagta
      541 ctgacatgtc tgagcagccg gccgcttttg gtggatgtag cacagtttcc acactgggaa
      601 ggcagtgtta gaagactcca ttgtaaaagc tctcgtcact gtgttacact tacgcattgc
      661 caaagttttt gttagtcttg catgcttaat aaaagtgctg agactgttac taagtaagga
      721 gctgtcacac aattactgaa agtagaattg gccacgtggc ttaatgtaaa gacagcaatg
      781 ggagaagcac cagtcaactg tgacaaagaa ccaaattaaa tcacctccaa atctcattga
      841 attgtctgtc tttgaggcta aactggtccc ttaagggtta gttgacacgt tttaatgtct
      901 acactttgta taaatttaaa ttaggttctg attgttaaac agatttctca gttgcatttg
      961 tccatcaaaa ataacctctt ctggagaaaa tctgttaaat tttgaagtaa gtaatttcac
     1021 aagaatgtct ttgaggttac aaggtgatgg tcagatagga gctagtctgg cttttgcctg
     1081 gtgtattatc atgttaggaa tactgagttc tcccagtgtt aatcttgagg aaatacagtt
     1141 tgaggcttgc atcttctgaa gattgattgc atcatcgcca tcatgtgtga agtctaacac
     1201 aggacccaca ccagcccata atccaactga agcactcaaa agacggtagc atgactctgg
     1261 tgctcttcct tgctttgtta accatcatga ctatagtctg cagcacaact tttcttttaa
     1321 caaagctaga acagttttgg cttcttaaac ttcatatttg agtaggttaa gctgccatac
     1381 gtgttcagtg tgaatagtgt ttaagttgaa aatattgtaa aaaaattata ttttttcaaa
     1441 aatatttaaa aaaaaataaa tgatagtaga accgaaaaaa aaaaaaaa
//
