LOCUS       NM_030240               1448 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus PAXIP1 associated glutamate rich protein 1A (Pagr1a),
            mRNA.
ACCESSION   NM_030240
VERSION     NM_030240.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Lee,J.E., Cho,Y.W., Deng,C.X. and Ge,K.
  TITLE     MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling
            Induction of C/EBPbeta and C/EBPdelta
  JOURNAL   Mol Cell Biol 40 (17), e00209-20 (2020)
   PUBMED   32601106
  REMARK    GeneRIF: MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by
            Controlling Induction of C/EBPbeta and C/EBPdelta.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Starnes,L.M., Su,D., Pikkupeura,L.M., Weinert,B.T., Santos,M.A.,
            Mund,A., Soria,R., Cho,Y.W., Pozdnyakova,I., Kubec Hojfeldt,M.,
            Vala,A., Yang,W., Lopez-Mendez,B., Lee,J.E., Peng,W., Yuan,J.,
            Ge,K., Montoya,G., Nussenzweig,A., Choudhary,C. and Daniel,J.A.
  TITLE     A PTIP-PA1 subcomplex promotes transcription for IgH class
            switching independently from the associated MLL3/MLL4
            methyltransferase complex
  JOURNAL   Genes Dev 30 (2), 149-163 (2016)
   PUBMED   26744420
  REMARK    GeneRIF: a PTIP-PA1 subcomplex functions independently from the
            MLL3/MLL4 complex to mediate transcription during CSR
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Scoville,D.W., Cyphert,H.A., Liao,L., Xu,J., Reynolds,A., Guo,S.
            and Stein,R.
  TITLE     MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB
            Transcription Factors to Regulate Islet beta-Cell Function
  JOURNAL   Diabetes 64 (11), 3772-3783 (2015)
   PUBMED   26180087
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Kumar,A., Lualdi,M., Loncarek,J., Cho,Y.W., Lee,J.E., Ge,K. and
            Kuehn,M.R.
  TITLE     Loss of function of mouse Pax-Interacting Protein 1-associated
            glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression
            and defects in chorion and amnion development
  JOURNAL   Dev Dyn 243 (7), 937-947 (2014)
   PUBMED   24633704
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Lee,J.E., Wang,C., Xu,S., Cho,Y.W., Wang,L., Feng,X., Baldridge,A.,
            Sartorelli,V., Zhuang,L., Peng,W. and Ge,K.
  TITLE     H3K4 mono- and di-methyltransferase MLL4 is required for enhancer
            activation during cell differentiation
  JOURNAL   Elife 2, e01503 (2013)
   PUBMED   24368734
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Wang,C., Lee,J.E., Cho,Y.W., Xiao,Y., Jin,Q., Liu,C. and Ge,K.
  TITLE     UTX regulates mesoderm differentiation of embryonic stem cells
            independent of H3K27 demethylase activity
  JOURNAL   Proc Natl Acad Sci U S A 109 (38), 15324-15329 (2012)
   PUBMED   22949634
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Gong,Z., Cho,Y.W., Kim,J.E., Ge,K. and Chen,J.
  TITLE     Accumulation of Pax2 transactivation domain interaction protein
            (PTIP) at sites of DNA breaks via RNF8-dependent pathway is
            required for cell survival after DNA damage
  JOURNAL   J Biol Chem 284 (11), 7284-7293 (2009)
   PUBMED   19124460
  REMARK    GeneRIF: subset of PTIP.PA1 complex is recruited to DNA damage
            sites via the RNF8-dependent pathway and is required for cell
            survival in response to DNA damage.
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
  REMARK    GeneRIF: PA1 (also known as C16orf53 in human and 2900092E17Rik in
            mouse) binds PTIP directly and requires PTIP for interaction with
            the MLL3- and MLL4-containing histone H3 K4 methyltransferase
            complex.
REFERENCE   9  (bases 1 to 1448)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC003932.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003932.1, SRR1660815.177766.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.27 cM"
     gene            1..1448
                     /gene="Pagr1a"
                     /gene_synonym="2900092E17Rik; PA1; PAGR1"
                     /note="PAXIP1 associated glutamate rich protein 1A"
                     /db_xref="GeneID:67278"
                     /db_xref="MGI:MGI:1914528"
     exon            1..910
                     /gene="Pagr1a"
                     /gene_synonym="2900092E17Rik; PA1; PAGR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             432..1193
                     /gene="Pagr1a"
                     /gene_synonym="2900092E17Rik; PA1; PAGR1"
                     /note="PAXIP1-associated protein 1; PTIP-associated 1;
                     PTIP-associated protein 1; PAXIP1-associated
                     glutamate-rich protein 1"
                     /codon_start=1
                     /product="PAXIP1-associated glutamate-rich protein 1A"
                     /protein_id="NP_084516.1"
                     /db_xref="CCDS:CCDS21854.1"
                     /db_xref="GeneID:67278"
                     /db_xref="MGI:MGI:1914528"
                     /translation="MSLALGHGTIAGSTAAPLSEEGEVTSGLQALAVEDTGGPSVSAS
                     KAEEEGKGSQEEAGREGSRPEEALEAPSAASDERAEGEAEDWCVPCSDEEVELPANGQ
                     SWMPPPSEIQRLYELLATQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEK
                     PHMPTEFDFDDEPMTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQIL
                     RTGRDLFSLDSEGPSPTSPPLRSSGNSLFPRQRKY"
     exon            911..993
                     /gene="Pagr1a"
                     /gene_synonym="2900092E17Rik; PA1; PAGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1412
                     /gene="Pagr1a"
                     /gene_synonym="2900092E17Rik; PA1; PAGR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1380..1385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pagr1a"
                     /gene_synonym="2900092E17Rik; PA1; PAGR1"
                     /note="hexamer: AATAAA"
     polyA_site      1398
                     /gene="Pagr1a"
                     /gene_synonym="2900092E17Rik; PA1; PAGR1"
                     /note="major polyA site"
ORIGIN      
        1 ggagcctccg cgcgccattt ctctgcgcct gcgtactgag atgctgcgca gcctgggagg
       61 cgggttttag ctccaggttt gtaccgctgc tgagtagacg cgaactaggt ttgcccggtc
      121 taaaaagatg acttccatcc cggtgatgga gaaggcgatg tgaaagcgag aaaacaggcc
      181 cttccctttc cagctccgag cgtgtttcct gcgggtccct gggaacggca gaattctggg
      241 tccgtggggt ggggtctgtc cttgcagggg tttgagcgcc ccctcctggg gacggtgctc
      301 tggccgcagt cagctgttgg actgactggc gatttcctag acctagaaag gctctccagc
      361 ctttcgggtg aggcgcactg gtttggtact ctagaatctc ctctattgct gggcttcttc
      421 tctagtactc tatgtccctt gccctgggcc atggaaccat tgcaggcagc acagcagcgc
      481 ctctgtctga agaaggggaa gtgacttccg gcctccaagc tctggcggtg gaggacactg
      541 gaggtccctc tgtctcggct agtaaggccg aggaagaggg gaaaggcagt caggaggagg
      601 ccgggcgtga gggatccagg cctgaggagg cactagaagc tcccagcgct gcgagcgacg
      661 agcgtgcgga gggagaagcc gaagactggt gcgtgccctg cagcgatgag gaggtggagc
      721 tgccggccaa tgggcagtcc tggatgcccc caccctccga gatccagcgg ctctatgaac
      781 tgctggctac ccaaggtact ctggagcttc aagcagagat cctaccccgc cggccgccta
      841 ccccagaggc ccagagtgaa gaggagagat cagacgagga gccagaggcc aaagaagagg
      901 aggaggaaaa gccgcacatg cctacagaat ttgactttga tgatgagcca atgacaccaa
      961 aggactcact gattgacagg agacggacac caggaagctc agcccggagc cagaaacggg
     1021 aggcgcgtct ggataaggtc ctctcagaca tgaagcgcca taagaaacta gaggagcaaa
     1081 tcctccggac cgggagagac ctcttcagct tagactcaga gggccccagc cccaccagcc
     1141 ctccactccg atcctcagga aacagtctct ttcccagaca gcggaagtac tgactggtgc
     1201 tgctcctgcc tacaggtgca gactgttttg tgctgggcat ggccagcctt tcccaaccca
     1261 ggctctgggg aacttgtaat ggggaaggcc tcaggctccc agcgcagtgc ctctcaggag
     1321 agtgcctgtg tgttctgttt agtgtctgtt cgcagttttg agctggatgt gctaaatcta
     1381 ataaaagatg cccgatgagt tgggcgtggt ggaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaa
//
