LOCUS       NM_001357350            1239 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus platelet-activating factor acetylhydrolase, isoform
            1b, subunit 3 (Pafah1b3), transcript variant 2, mRNA.
ACCESSION   NM_001357350 XM_017322026
VERSION     NM_001357350.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Fiedler,E.R.C., Bhutkar,A., Lawler,E., Besada,R. and Hemann,M.T.
  TITLE     In vivo RNAi screening identifies Pafah1b3 as a target for
            combination therapy with TKIs in BCR-ABL1+ BCP-ALL
  JOURNAL   Blood Adv 2 (11), 1229-1242 (2018)
   PUBMED   29853524
  REMARK    GeneRIF: In vivo RNAi screening identifies Pafah1b3 as a target for
            combination therapy with TKIs in BCR-ABL1(+) BCP-ALL.
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Lanctot,A.A., Peng,C.Y., Pawlisz,A.S., Joksimovic,M. and Feng,Y.
  TITLE     Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap
            complex patterns mammalian CNS
  JOURNAL   Dev Cell 25 (3), 241-255 (2013)
   PUBMED   23673330
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Escamez,T., Bahamonde,O., Tabares-Seisdedos,R., Vieta,E.,
            Martinez,S. and Echevarria,D.
  TITLE     Developmental dynamics of PAFAH1B subunits during mouse brain
            development
  JOURNAL   J Comp Neurol 520 (17), 3877-3894 (2012)
   PUBMED   22522921
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Liu,J., Chen,R., Marathe,G.K., Febbraio,M., Zou,W. and
            McIntyre,T.M.
  TITLE     Circulating platelet-activating factor is primarily cleared by
            transport, not intravascular hydrolysis by lipoprotein-associated
            phospholipase A2/ PAF acetylhydrolase
  JOURNAL   Circ Res 108 (4), 469-477 (2011)
   PUBMED   21183738
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Livnat,I., Finkelshtein,D., Ghosh,I., Arai,H. and Reiner,O.
  TITLE     PAF-AH Catalytic Subunits Modulate the Wnt Pathway in Developing
            GABAergic Neurons
  JOURNAL   Front Cell Neurosci 4, 19 (2010)
   PUBMED   20725507
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Sweeney,K.J., Prokscha,A. and Eichele,G.
  TITLE     NudE-L, a novel Lis1-interacting protein, belongs to a family of
            vertebrate coiled-coil proteins
  JOURNAL   Mech Dev 101 (1-2), 21-33 (2001)
   PUBMED   11231056
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Stojanov,T. and O'Neill,C.
  TITLE     In vitro fertilization causes epigenetic modifications to the onset
            of gene expression from the zygotic genome in mice
  JOURNAL   Biol Reprod 64 (2), 696-705 (2001)
   PUBMED   11159375
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Forte,T.M., Oda,M.N., Knoff,L., Frei,B., Suh,J., Harmony,J.A.,
            Stuart,W.D., Rubin,E.M. and Ng,D.S.
  TITLE     Targeted disruption of the murine lecithin:cholesterol
            acyltransferase gene is associated with reductions in plasma
            paraoxonase and platelet-activating factor acetylhydrolase
            activities but not in apolipoprotein J concentration
  JOURNAL   J Lipid Res 40 (7), 1276-1283 (1999)
   PUBMED   10393212
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Ware,J., Russell,S. and Ruggeri,Z.M.
  TITLE     Cloning of the murine platelet glycoprotein Ibalpha gene
            highlighting species-specific platelet adhesion
  JOURNAL   Blood Cells Mol Dis 23 (2), 292-301 (1997)
   PUBMED   9410473
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   Albrecht,U., Abu-Issa,R., Ratz,B., Hattori,M., Aoki,J., Arai,H.,
            Inoue,K. and Eichele,G.
  TITLE     Platelet-activating factor acetylhydrolase expression and activity
            suggest a link between neuronal migration and platelet-activating
            factor
  JOURNAL   Dev Biol 180 (2), 579-593 (1996)
   PUBMED   8954729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156992.13.
            
            On Feb 24, 2023 this sequence version replaced NM_001357350.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB193508.1, CO043245.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               AC156992.13        80007-80587
            582-671             AC156992.13        80784-80873
            672-788             AC156992.13        81522-81638
            789-911             AC156992.13        81716-81838
            912-1239            AC156992.13        82583-82910
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 13.73 cM"
     gene            1..1239
                     /gene="Pafah1b3"
                     /gene_synonym="mus[g]; Pafahg"
                     /note="platelet-activating factor acetylhydrolase, isoform
                     1b, subunit 3"
                     /db_xref="GeneID:18476"
                     /db_xref="MGI:MGI:108414"
     exon            1..581
                     /gene="Pafah1b3"
                     /gene_synonym="mus[g]; Pafahg"
                     /inference="alignment:Splign:2.1.0"
     exon            582..671
                     /gene="Pafah1b3"
                     /gene_synonym="mus[g]; Pafahg"
                     /inference="alignment:Splign:2.1.0"
     exon            672..788
                     /gene="Pafah1b3"
                     /gene_synonym="mus[g]; Pafahg"
                     /inference="alignment:Splign:2.1.0"
     exon            789..911
                     /gene="Pafah1b3"
                     /gene_synonym="mus[g]; Pafahg"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1239
                     /gene="Pafah1b3"
                     /gene_synonym="mus[g]; Pafahg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1220..1225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pafah1b3"
                     /gene_synonym="mus[g]; Pafahg"
                     /note="hexamer: ATTAAA"
     polyA_site      1239
                     /gene="Pafah1b3"
                     /gene_synonym="mus[g]; Pafahg"
                     /note="major polyA site"
ORIGIN      
        1 acacacaccc ccgtaggtgg tctcttccgg agttttctgg ccctgcagca aatgatttcc
       61 tcctcggacg gagggcgcta gattgtccct ggtccctgtc ggctttacag gtaccctgcc
      121 cctttccgtc cactctgggt tgtgtctctc ttgtctgcgc cccctcttcc cctgccacga
      181 gtgccgcttg gtctcgcctg cccctccccc ctgcgttggg cccccgtggc cgcaaggggt
      241 cccggcggga agcggcagac gagcccactt tgcggcctcc atcgggggag gggagcgagg
      301 attccttcct acgtgacggt ttctagtctg cgaaaggagg cggcgtctgg gctcggcctt
      361 cgccctacgc gcgagcgagc gcggcaggac ggtccattgt gttggcccga gaggtagggg
      421 tgggcgtggc ggatccacgt cctcgcggag ctttcccggg cggactccac tctcatcccc
      481 agggggctgc ggtgctgagg atgagtgggg aaggggagaa cccggccagc aagcccacgc
      541 ctgtgcaaga cgtgcagggt gacgggcgct ggatgtctct gcaccatcgg tttgtagcgg
      601 acagcaaaga caaggaaccc gaagtagtct ttatcgggga ctccttggtt cagctaatgc
      661 accaatgtga gatctggcgg gagctcttct cacctctgca tgcacttaac tttggcattg
      721 gtggtgacag cacacagcat gtactctggc ggcttgagaa cggggagctg gagcacatcc
      781 ggcccaagat tgtggtggtc tgggtgggca ccaacaacca tagccacaca gcagaacaag
      841 tgacaggtgg catcaaagcc atcgtacaac tggtgaacaa gctgcagccc caggcacggg
      901 tggttgtgct gggcctgctt ccgagaggcc agcaccccaa cccacttcga gagaaaaacc
      961 gacaggtaaa cgagctggtt cgggcagcac tggctggcta cccccgagcc cacttcttag
     1021 atgcagaccc tgggtttgtg cattctgatg gcaccataag tcaccatgac atgtatgatt
     1081 acctacacct gagccgcctg gggtacacac ctgtctgccg ggccctgcac tccttgcttc
     1141 ttcgtctctt ggcccaagat cagggccaag gcatccctct gccagagaca gcatcctaag
     1201 catctttcct tcccttgata ttaaatgctt cttctcctc
//
