LOCUS       NM_008775               4241 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus platelet-activating factor acetylhydrolase, isoform
            1b, subunit 2 (Pafah1b2), transcript variant 5, mRNA.
ACCESSION   NM_008775
VERSION     NM_008775.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4241)
  AUTHORS   Page,R.M., Munch,A., Horn,T., Kuhn,P.H., Colombo,A., Reiner,O.,
            Boutros,M., Steiner,H., Lichtenthaler,S.F. and Haass,C.
  TITLE     Loss of PAFAH1B2 reduces amyloid-beta generation by promoting the
            degradation of amyloid precursor protein C-terminal fragments
  JOURNAL   J Neurosci 32 (50), 18204-18214 (2012)
   PUBMED   23238734
  REMARK    GeneRIF: Knockdown of PAFAH1B2 strongly reduced Abeta secretion
            from human cells, and this effect was confirmed in primary cells
            derived from PAFAH1B2 knock-out mice
REFERENCE   2  (bases 1 to 4241)
  AUTHORS   Escamez,T., Bahamonde,O., Tabares-Seisdedos,R., Vieta,E.,
            Martinez,S. and Echevarria,D.
  TITLE     Developmental dynamics of PAFAH1B subunits during mouse brain
            development
  JOURNAL   J Comp Neurol 520 (17), 3877-3894 (2012)
   PUBMED   22522921
REFERENCE   3  (bases 1 to 4241)
  AUTHORS   Liu,J., Chen,R., Marathe,G.K., Febbraio,M., Zou,W. and
            McIntyre,T.M.
  TITLE     Circulating platelet-activating factor is primarily cleared by
            transport, not intravascular hydrolysis by lipoprotein-associated
            phospholipase A2/ PAF acetylhydrolase
  JOURNAL   Circ Res 108 (4), 469-477 (2011)
   PUBMED   21183738
REFERENCE   4  (bases 1 to 4241)
  AUTHORS   Livnat,I., Finkelshtein,D., Ghosh,I., Arai,H. and Reiner,O.
  TITLE     PAF-AH Catalytic Subunits Modulate the Wnt Pathway in Developing
            GABAergic Neurons
  JOURNAL   Front Cell Neurosci 4, 19 (2010)
   PUBMED   20725507
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4241)
  AUTHORS   Zhang,G., Assadi,A.H., Roceri,M., Clark,G.D. and D'Arcangelo,G.
  TITLE     Differential interaction of the Pafah1b alpha subunits with the
            Reelin transducer Dab1
  JOURNAL   Brain Res 1267, 1-8 (2009)
   PUBMED   19272360
  REMARK    GeneRIF: study examined biochemical interactions of Pafah1b Alpha1
            & Alpha2 subunits with the Reelin signaling machinery &
            demonstrated that Alpha2, but not Alpha1, binds Dab1 in a
            phosphorylation-independent manner
REFERENCE   6  (bases 1 to 4241)
  AUTHORS   Koizumi,H., Yamaguchi,N., Hattori,M., Ishikawa,T.O., Aoki,J.,
            Taketo,M.M., Inoue,K. and Arai,H.
  TITLE     Targeted disruption of intracellular type I platelet activating
            factor-acetylhydrolase catalytic subunits causes severe impairment
            in spermatogenesis
  JOURNAL   J Biol Chem 278 (14), 12489-12494 (2003)
   PUBMED   12551946
REFERENCE   7  (bases 1 to 4241)
  AUTHORS   Stojanov,T. and O'Neill,C.
  TITLE     In vitro fertilization causes epigenetic modifications to the onset
            of gene expression from the zygotic genome in mice
  JOURNAL   Biol Reprod 64 (2), 696-705 (2001)
   PUBMED   11159375
REFERENCE   8  (bases 1 to 4241)
  AUTHORS   Forte,T.M., Oda,M.N., Knoff,L., Frei,B., Suh,J., Harmony,J.A.,
            Stuart,W.D., Rubin,E.M. and Ng,D.S.
  TITLE     Targeted disruption of the murine lecithin:cholesterol
            acyltransferase gene is associated with reductions in plasma
            paraoxonase and platelet-activating factor acetylhydrolase
            activities but not in apolipoprotein J concentration
  JOURNAL   J Lipid Res 40 (7), 1276-1283 (1999)
   PUBMED   10393212
REFERENCE   9  (bases 1 to 4241)
  AUTHORS   Stojanov,T. and O'Neill,C.
  TITLE     Ontogeny of expression of a receptor for platelet-activating factor
            in mouse preimplantation embryos and the effects of fertilization
            and culture in vitro on its expression
  JOURNAL   Biol Reprod 60 (3), 674-682 (1999)
   PUBMED   10026115
REFERENCE   10 (bases 1 to 4241)
  AUTHORS   Albrecht,U., Abu-Issa,R., Ratz,B., Hattori,M., Aoki,J., Arai,H.,
            Inoue,K. and Eichele,G.
  TITLE     Platelet-activating factor acetylhydrolase expression and activity
            suggest a link between neuronal migration and platelet-activating
            factor
  JOURNAL   Dev Biol 180 (2), 579-593 (1996)
   PUBMED   8954729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB856076.1, BC056211.2 and AC122273.4.
            
            On Jul 23, 2005 this sequence version replaced NM_008775.2.
            
            Transcript Variant: This variant (5) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (d) is
            shorter at the N-terminus compared to isoform a. Variants 4-8 all
            encode the same isoform (d).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153424.1, AK012116.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               BB856076.1         2-403
            403-737             BC056211.2         373-707
            738-4241            AC122273.4         112203-115706
FEATURES             Location/Qualifiers
     source          1..4241
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..4241
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /note="platelet-activating factor acetylhydrolase, isoform
                     1b, subunit 2"
                     /db_xref="GeneID:18475"
                     /db_xref="MGI:MGI:108415"
     exon            1..167
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /inference="alignment:Splign:2.1.0"
     exon            168..255
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..864
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /EC_number="3.1.1.47"
                     /note="isoform d is encoded by transcript variant 5;
                     platelet-activating factor acetylhydrolase IB subunit
                     beta; PAF-AH subunit beta; PAF-AH 30 kDa subunit; PAF
                     acetylhydrolase 30 kDa subunit; platelet-activating factor
                     acetylhydrolase IB subunit alpha2; PAF-AH alpha2"
                     /codon_start=1
                     /product="platelet-activating factor acetylhydrolase IB
                     subunit alpha2 isoform d"
                     /protein_id="NP_032801.2"
                     /db_xref="CCDS:CCDS23139.1"
                     /db_xref="GeneID:18475"
                     /db_xref="MGI:MGI:108415"
                     /translation="MSQGDSNPAAIPHAAEDIQGDDRWMSQHNRFVLDCKDKEPDVLF
                     VGDSMVQLMQQYEIWRELFSPLHALNFGIGGDTTRHVLWRLKNGELENIKPKVIVVWV
                     GTNNHENTAEEVAGGIEAIVQLINTRQPQAKIIVLGLLPRGEKPNPLRQKNAKVNQLL
                     KVSLPKLANVQLLDIDGGFVHSDGAISCHDMFDFLHLTGGGYAKICKPLHELIMQLLE
                     ETPEEKQTTIA"
     exon            256..345
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /inference="alignment:Splign:2.1.0"
     exon            346..462
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /inference="alignment:Splign:2.1.0"
     exon            463..585
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /inference="alignment:Splign:2.1.0"
     exon            586..4241
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1325..1330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /note="hexamer: ATTAAA"
     polyA_site      1347
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /note="major polyA site"
     regulatory      3201..3206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /note="hexamer: AATAAA"
     polyA_site      3230
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
     regulatory      4212..4217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /note="hexamer: TATAAA"
     polyA_site      4237
                     /gene="Pafah1b2"
                     /gene_synonym="2610005M20Rik; mus[b]; Pafahb"
                     /note="major polyA site"
ORIGIN      
        1 atttgcccga gtggcagggg gaccggaagt ggaggcgctg ctgcttggtg ctggggcccg
       61 aggaggggac gcgcgccgga acgcggccgt cgggatcaag cgagcgactg aagcgcaacc
      121 cgccgacgcc gcagccgctg agggccccgc acggaccctc tgcctgtgtg tagaatgagc
      181 caaggagact cgaacccagc agctattcca catgccgcag aagatattca aggagatgac
      241 aggtggatgt ctcagcataa taggtttgtt ctggactgta aagacaaaga accagatgtg
      301 ctgtttgtgg gggactccat ggtacagcta atgcagcagt acgagatatg gcgggagctg
      361 ttttccccac ttcatgctct taattttgga attgggggag atacaacacg acatgtttta
      421 tggcgactaa agaatggaga gctggagaac attaagccta aggtcattgt tgtctgggta
      481 gggacaaaca accacgaaaa tacagcagaa gaagtagcag gtgggattga ggctattgta
      541 caacttataa acacgcggca gccacaggcc aagatcattg tgctgggtct gttacctcga
      601 ggtgagaagc ccaacccttt aagacaaaag aatgccaagg tgaaccagct tctcaaggtt
      661 tccctgccga agcttgccaa tgtgcagctc cttgatatag acgggggctt cgtgcactcg
      721 gacggtgcca tctcctgcca cgacatgttt gattttcttc atctcacagg agggggctat
      781 gcaaagatct gcaaacccct ccatgaactg atcatgcagt tgctggagga aacaccggag
      841 gagaagcaga ccaccattgc ttgactggcc catcagtgtt acagcatccc gcttcctcag
      901 atcagttaga ccactggcac tacagaatcc tttcttaagg cactttgcat tgtacaatgt
      961 tcctggatgc ttgtatgttt gaaggggagg agggatttaa attggtcctg tatataaagg
     1021 ttttgtttga gaggagaaaa attagccaag gaagattcat ttgaaaccag aaggggactt
     1081 tttagttgtt tatgacacat ttgtagaatt atcacttttc cctaggacaa catcaagcaa
     1141 gagtacaata tgaagattct tttcttggcc cttttttcta tggattatgt catgtgtgat
     1201 aattatcaca tctacttggc tttaaactta tttttggtcc agttttaagg ttcataagtt
     1261 agtatgttgt gttgttttgt ttgattcatg tatcctcagt atttttatta acacatagca
     1321 tcagattaaa catgcttgtc actccaatat gggagatgct atagttacaa gtgagtttgt
     1381 tcctctcaat cttaagcagt gaaaacaagg tctagggact gtgggatatt gtttttattg
     1441 ctgctgatta tcatgtctgt aatagacccg tgcatgcagc cttccctctg cctccccctc
     1501 atctcctcac aggtgggtta tttacattac aaacttttaa ctcatttttg atctaggaca
     1561 tgcactgccg tcaggacggt cttactgatg gataactcat tctgtgtggt gttctgtgat
     1621 gtagggtctg tgtaatgttc atcatccaga gttctgcttg tcatcccctc cccccccaac
     1681 ctgttgtttt tctttgtttt gggtgtaggg gtggtcagaa ttgtttccca ttccataatg
     1741 cctgatgtta ttttcaagtt ttatattatc ttaaggtgta tatgtttgtt ttcgttttat
     1801 atatattata tataaataga tctattttac agtactggaa tcaaacccag gacctagcac
     1861 atactaagca agtactctgc cactgtttgc ttgcttgctt gtttttttta attcttaaat
     1921 tctgtcagca aaaaaaaagt tttttttcca tgggaaacag ggaagctgct ctcacaatag
     1981 atgtactatc cttatcattt tttttccttt tttgtttttg tttttcaaga cagggtttct
     2041 ctgtatagtc ctgactggcc tgaagctctg taaatcaggc tggccttcaa tttagagatc
     2101 acttgtctct gcctcccaag cgctggaatt aaaggcgtgc gccaccacac ctgctttagc
     2161 tttgctatct ttattctacc attttaataa aggtaaacta agttcctgtt ttggtctttg
     2221 agacagggtc tcatagtgta gctctgccta gcctggaatt tacattgtag gccaggctag
     2281 tgttgaactc acagagatct gcctgcctct ggactcctga agactgacag taaaggcatg
     2341 catgtattac catggaggta gctcattgat cttttaaggt tcctcatata atttaatgtc
     2401 tttatcaaga ttttaagaga gctctttaca ttcctactgg tttgcttgag ctatacaaac
     2461 tgccacttga gagaacaata gattattggt catccaatat gcctatggac ccgtataaac
     2521 tggatctaca aacattttaa ctggaccagg ttggggattg aagtaattca ttaaatgtgc
     2581 tctgcaaaga ttttgcttaa tggttacatt cggtagctat gatctaggtt tttatgttct
     2641 gccttcagag cagccatcag ggctggtaga ggagctattg ttggtttgtg ctgagacctg
     2701 cacctgactg agaaagatag aagttgaggt ggttttttcc tggtgagcat ctgtgtagga
     2761 atttaaggca tagtgttatg aatgtatcat gtcttcatta gcaacaggaa aatatacacg
     2821 gtgtttacta aaattgttta ctacagtaaa attccctttt atttttttag tagtccaagt
     2881 tcttgagttt ttcaagacag attgttttct gaaccgagct atcattttag gaaggagagt
     2941 taattaagcc agaattttgt gtgtaaaaag agcatttttt acccaggtgt ttgtgtgttc
     3001 ctcggagagt gggagtatgg tccaagtgaa tccattcggt cactcccgta gcatgccctt
     3061 gtagtttctc ttgaccaagg atgaactagt cctgtgagct ggccgtcagc tcctgcatat
     3121 gtgtataaac ctcagatgtt actacgtttt atacctacca gagctcttca agcaatagta
     3181 tttgaaccac tagcctttta aataaaactc tgtcctattg ctaacatgca gatatggagt
     3241 ccactgtcat ttcttgccag gtttatttgt gctggtttag gggtaaaatt gttaaaattg
     3301 ttggtcagtt tttctttggt tgacatccca gattgcttca gtgacaaact ggttagtctt
     3361 tgtgtgtttt taaagacgtg aacagaacta ctttgccatt ggctaagggc ctggcagcca
     3421 gcagagacac tgctttgttt tggttttttg gtaggtgggg tggtgatgtt cttaggcaga
     3481 gtctacagta ccctggctgt ccttgaactt tggtgatcct cctgtctctg tctctccagt
     3541 actggaatta caggcctatt tcaccatgct tgacttattc tgttcctttc ccaacatttt
     3601 tcttctcttg agacagggtc tcagtgtagt acagtctgtc ttaccatgag ctgtggatgc
     3661 ccttgaactc ggtccttctg cgccatgtct ctactgtagc aggttggaga tgccctggca
     3721 ttgtagatta ccattggcag tgctctggcc accatgtcag gtctgctagg attgttgagg
     3781 acttctatcc aatcctgata cttctgtcaa aaacctcacc cagcaaaata agtcttgact
     3841 agctagctca tggccagttc tttaaagaat tataattcat tgttttaaaa agtcccaatt
     3901 tctgtttgca ttttcaattt aatcacttaa cagttgtatg ctgtgtctga aacctgtctg
     3961 tgctaaggtg tgtgaatatt gccagttttc tatttattac agtgatgaag aaactagaaa
     4021 cttaggaaag gggagcacag ccagctcctg actctgagca gcttgtgtgg gaacaatgag
     4081 tgggggcttg ccagtgagct tcctctccgg gaccactgca gcaggctgac tgaacctccc
     4141 caagggagct tgtgactatg ctttggcaaa ggcttcctga ctagaatcca ttctgtccag
     4201 tgctcattta atataaaagt caacatttca ctgcaaactt a
//
