LOCUS       NM_013625               5540 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus platelet-activating factor acetylhydrolase, isoform
            1b, subunit 1 (Pafah1b1), transcript variant 1, mRNA.
ACCESSION   NM_013625 XM_918001 XM_925428
VERSION     NM_013625.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5540)
  AUTHORS   Kshirsagar,A., Doroshev,S.M., Gorelik,A., Olender,T., Sapir,T.,
            Tsuboi,D., Rosenhek-Goldian,I., Malitsky,S., Itkin,M., Argoetti,A.,
            Mandel-Gutfreund,Y., Cohen,S.R., Hanna,J.H., Ulitsky,I.,
            Kaibuchi,K. and Reiner,O.
  TITLE     LIS1 RNA-binding orchestrates the mechanosensitive properties of
            embryonic stem cells in AGO2-dependent and independent ways
  JOURNAL   Nat Commun 14 (1), 3293 (2023)
   PUBMED   37280197
  REMARK    GeneRIF: LIS1 RNA-binding orchestrates the mechanosensitive
            properties of embryonic stem cells in AGO2-dependent and
            independent ways.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5540)
  AUTHORS   Ishii,K., Kohno,T., Sakai,K. and Hattori,M.
  TITLE     Reelin regulates the migration of late-born hippocampal CA1 neurons
            via cofilin phosphorylation
  JOURNAL   Mol Cell Neurosci 124, 103794 (2023)
   PUBMED   36435394
REFERENCE   3  (bases 1 to 5540)
  AUTHORS   Argenty,J., Rouquie,N., Bories,C., Melique,S., Duplan-Eche,V.,
            Saoudi,A., Fazilleau,N. and Lesourne,R.
  TITLE     A selective LIS1 requirement for mitotic spindle assembly
            discriminates distinct T-cell division mechanisms within the T-cell
            lineage
  JOURNAL   Elife 11, e80277 (2022)
   PUBMED   36519536
  REMARK    GeneRIF: A selective LIS1 requirement for mitotic spindle assembly
            discriminates distinct T-cell division mechanisms within the T-cell
            lineage.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5540)
  AUTHORS   Brault,J.B., Bardin,S., Lampic,M., Carpentieri,J.A., Coquand,L.,
            Penisson,M., Lachuer,H., Victoria,G.S., Baloul,S., El Marjou,F.,
            Boncompain,G., Miserey-Lenkei,S., Belvindrah,R., Fraisier,V.,
            Francis,F., Perez,F., Goud,B. and Baffet,A.D.
  TITLE     RAB6 and dynein drive post-Golgi apical transport to prevent
            neuronal progenitor delamination
  JOURNAL   EMBO Rep 23 (10), e54605 (2022)
   PUBMED   35979738
REFERENCE   5  (bases 1 to 5540)
  AUTHORS   Dominguez-Sala,E., Andreu-Cervera,A., Martin-Climent,P.,
            Murcia-Ramon,R., Martinez,S. and Geijo-Barrientos,E.
  TITLE     Properties of the epileptiform activity in the cingulate cortex of
            a mouse model of LIS1 dysfunction
  JOURNAL   Brain Struct Funct 227 (5), 1599-1614 (2022)
   PUBMED   35103859
  REMARK    GeneRIF: Properties of the epileptiform activity in the cingulate
            cortex of a mouse model of LIS1 dysfunction.
REFERENCE   6  (bases 1 to 5540)
  AUTHORS   Peterfy,M., Hozier,J.C., Hall,B., Gyuris,T., Peterfy,K. and
            Takecs,L.
  TITLE     Localization of the mouse lissencephaly-1 gene to mouse chromosome
            11B3, in close proximity to D11Mit65
  JOURNAL   Somat Cell Mol Genet 21 (5), 345-349 (1995)
   PUBMED   8619131
REFERENCE   7  (bases 1 to 5540)
  AUTHORS   Reiner,O., Albrecht,U., Gordon,M., Chianese,K.A., Wong,C.,
            Gal-Gerber,O., Sapir,T., Siracusa,L.D., Buchberg,A.M., Caskey,C.T.
            et al.
  TITLE     Lissencephaly gene (LIS1) expression in the CNS suggests a role in
            neuronal migration
  JOURNAL   J Neurosci 15 (5 Pt 2), 3730-3738 (1995)
   PUBMED   7751941
REFERENCE   8  (bases 1 to 5540)
  AUTHORS   Kurtz,A. and Zimmer,A.
  TITLE     The mouse homolog of the human Miller-Dieker chromosomal region
            (MDCR) maps to mouse chromosome 11 in close proximity to Mov9 and
            D11Nds1
  JOURNAL   Mamm Genome 6 (2), 145-146 (1995)
   PUBMED   7767001
REFERENCE   9  (bases 1 to 5540)
  AUTHORS   Peterfy,M., Gyuris,T., Basu,R. and Takacs,L.
  TITLE     Lissencephaly-1 is one of the most conserved proteins between mouse
            and human: a single amino-acid difference in 410 residues
  JOURNAL   Gene 150 (2), 415-416 (1994)
   PUBMED   7821822
REFERENCE   10 (bases 1 to 5540)
  AUTHORS   Ledbetter,D.H., Ledbetter,S.A., vanTuinen,P., Summers,K.M.,
            Robinson,T.J., Nakamura,Y., Wolff,R., White,R., Barker,D.F.,
            Wallace,M.R. et al.
  TITLE     Molecular dissection of a contiguous gene syndrome: frequent
            submicroscopic deletions, evolutionarily conserved sequences, and a
            hypomethylated 'island' in the Miller-Dieker chromosome region
  JOURNAL   Proc Natl Acad Sci U S A 86 (13), 5136-5140 (1989)
   PUBMED   2740347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ895724.1, AK144908.1, AK168929.1 and BE456911.1.
            
            On Dec 1, 2010 this sequence version replaced NM_013625.3.
            
            Transcript Variant: This variant (1) encodes a functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U95116.1, AK147237.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               BQ895724.1         1-137
            138-1925            AK144908.1         127-1914
            1926-5510           AK168929.1         1566-5150
            5511-5540           BE456911.1         35-64               c
FEATURES             Location/Qualifiers
     source          1..5540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.76 cM"
     gene            1..5540
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /note="platelet-activating factor acetylhydrolase, isoform
                     1b, subunit 1"
                     /db_xref="GeneID:18472"
                     /db_xref="MGI:MGI:109520"
     exon            1..386
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     exon            387..596
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     exon            597..681
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     exon            682..756
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     exon            757..963
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1132
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1235
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1464
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1566
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1723
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..5517
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1882..1887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /note="hexamer: AATAAA"
     polyA_site      1906
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /note="major polyA site"
     regulatory      5498..5503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /note="hexamer: ATTAAA"
     polyA_site      5517
                     /gene="Pafah1b1"
                     /gene_synonym="LIS-1; Lis1; Mdsh; MMS10-U; Ms10u; Pafaha"
                     /note="major polyA site"
ORIGIN      
        1 ggtgacgtca gggcgttggg gcagctcctg tgacagacgg agctggagcg gcggggcggc
       61 ggcggagtcc ggcggccgag atagcgagtg agggagcgaa ggagcagcga gccgagagtc
      121 cagggagcga ggaggacccg gaggggagcg ctcaggcgcg agcgagagga cgagcgaacg
      181 ctgggctagg gctcgagccc cggaacggcc gaggagcccg cccgcggccc tcccctcccc
      241 ctccccggga ccgggcccag cgcgccatcc tccccctccc tccctccctc cctccttcct
      301 cccttccctc tccctccccc tcccccgctg gtggatggga gtgaaggacg gaagaggccc
      361 tgcggaggcg gtggtgcagc gctccggtgg aatgaacctt acttgttgac tggttgctga
      421 ttggattcac ttgaaaaaaa gaatcatttt tccctctgtg gaagccacat agtggcatat
      481 ttaattcaaa tccagggatc acaacttttg atttttctgg agggacatac cactatatca
      541 aataagcttg acattacagc caaaatggtg ctgtcccaga gacaacgaga tgaactaaat
      601 cgagctatag cagattatct tcgttcaaat ggctatgaag aggcatattc cgtttttaaa
      661 aaggaagctg aactagatat gaatgaagaa ttagataaga agtatgctgg tcttttggaa
      721 aaaaaatgga catctgttat tagattacaa aaaaaggtaa tggaattaga atcaaaacta
      781 aatgaagcaa aagaagaatt tacgtcgggt ggtcctcttg gtcagaaacg ggacccaaaa
      841 gaatggattc cccgtccacc tgagaaatac gcattgagtg gtcataggag tccagttact
      901 cgagtcattt tccatcctgt gttcagtgtt atggtctctg cttcagagga tgctacaatt
      961 aaggtgtggg attatgagac tggagatttt gagcgaactc tcaagggcca tacagactct
     1021 gtacaggaca tttcctttga ccacagtggc aagcttctgg cttcctgttc agcagatatg
     1081 acgattaaat tatgggattt tcagggtttt gaatgcatca gaaccatgca cggtcacgat
     1141 cacaatgtct cttcagtagc catcatgcct aatggagatc atatagtgtc tgcctcaagg
     1201 gataaaacta taaagatgtg ggaagtgcaa actggctact gtgtgaagac attcacagga
     1261 cacagagaat gggtacgtat ggtgcggcca aatcaggatg gcactctgat agccagctgt
     1321 tccaatgacc agactgtgcg tgtgtgggtt gtagcaacaa aggaatgcaa ggctgagctc
     1381 cgagaacatg aacatgtggt ggaatgcatt tcctgggctc cagaaagttc atattcttcc
     1441 atctctgaag caacaggatc tgagactaaa aaaagtggca agcctggacc tttcttgcta
     1501 tctggttcca gagacaaaac tattaagatg tgggacgtca gtactggcat gtgccttatg
     1561 actcttgtgg gtcatgataa ctgggtacgt ggagttctgt tccattctgg ggggaagttt
     1621 attttgagtt gtgctgatga caagaccctc cgtgtatggg attataagaa caagcgatgc
     1681 atgaagaccc tcaatgcgca tgaacacttt gttacctcct tggatttcca taagacggca
     1741 ccctatgtgg ttactggcag tgtagatcaa acagtaaagg tgtgggagtg ccgttgattg
     1801 agtcacattt ggttcttcct cccttttttc ctctggatgc actctgatga taccatggtt
     1861 accccatttg agctctgttt aaataaatat tgtcctttca tgtaaattat tctggatgta
     1921 gattgaactt attaaatgtt acacacaaag tattcatgca tggtgaatcc aaattgtata
     1981 ctgtaaattt acatatgttg tctagaagta ccatagggtt taaaaacctg ggctggcatt
     2041 ggtcacacca ggcctacaag ggcagaagtt aaataaattg aactagggca ctaaactgaa
     2101 tagttgacag tgtcatttta tgttggatta ttaattactg tttttcttcc tgctatctgt
     2161 tggtgcctga cttgatggcc tcattttggg gaaagtggtg gttattaggg ctttttctga
     2221 aatgtgtatc tatgtaacat cacttaagtg tgcttactaa atctttaagg gtgttagata
     2281 ataagactgc aattcagaat ctttgctcca tctgtgtaat ggggattaca catgaagttt
     2341 ttgtcatgac ccctttgcca aatcaatagg atatgtttgt tttggcagcc tatcaagcaa
     2401 aggctagtgg tttatttatg taagaaaatg atcgtaattc tcaagaaaaa tctcagcagc
     2461 taatagtgaa tcctttttca tttgggtctt actgctttgt aaacaggtca ggaagcactg
     2521 tcctacttta ggcttctctt cacactagac atgcgagttg tattctccag actgttggac
     2581 tgtgtagtga tgtgactccc cagtagaatt tgatcttccc attgagtgtt atggtacaga
     2641 tcactatgtg tttatgatgt ttttagggat gtgcaatgtg catgtcagaa ttatgaatgc
     2701 tgacaaagct gggtgcgcat tttaaaggag tggaaggaac agtttccaac atgaccctga
     2761 taacaattcg aactgtttca cttacaagct ataaaaaaaa gtgacagggt gtaatgaagc
     2821 gtgcatagaa tatactgggt tttttttttc tcatgttttg tttatatgta aatgtttata
     2881 agtatatggg cctatctgta agtggatatg tctatatatg tatatcacac acatataacc
     2941 tccatgttgt tgggtcttaa gtttttgaag aagtgctaaa acttacgcat agagtaaatc
     3001 ttgctgggga acaccaacca cagccatgct aaactcttct gctgtttctg actctgagga
     3061 gcttttctaa gagaaagtca cttcctttgt tctcccctct aatgtggcca gtcaccatgt
     3121 tacgcattcc tcataggctg tatattttga tccagagttt ctacagtagg tttaagagaa
     3181 ttttgcccat gacttttgga acactattcc attgtcaatt tttaataaag aatttatcac
     3241 ctagctaatc aacttttttt tctttttaag aaaatcaatt tgaaaggtta acagaaacaa
     3301 tgacataaca gtgacagtct aacaatgata attttttttt tctggactgc attttattcg
     3361 tttgtataat agatttttta aaaatccctt taagtattga atggaaattt ggttcctgaa
     3421 aggacaaagg gtgagaatta atgtcctgta gatatacaca agagattagg ctctgacaga
     3481 agctcactgt ctagcttgtg tgcttttgtt tgttcacttg tttgttctta atattcctca
     3541 gagatttctc tagaaaggaa aagtgttttg agaattaagt ggttattttt gaggacaaaa
     3601 actccatcgt gactcccata aacaacactg taggttggct tttaggacaa cattgcctca
     3661 cagccctgct tacattaaga agtctttttc tcctagctgt tctgactgga tttttctcca
     3721 aaagctatag aaaatacctt cgttctcatt tgctgctatt tcctgtccta tttcaagaat
     3781 ataaatacat agaaatggtg catcttaaca tttgtttgta tgtgttaaaa tgtcttgttt
     3841 tttaattcag ttttagcatg tagcaacatg aattgtttaa gggtaagcca caacatctag
     3901 acatcattca tagaaacaat aaagaatggt accaatgtag aggagcaaag ctgctgggtt
     3961 tcctcccctg cagcagtgac tcactgacaa cggaggagag agtgctctgt aacaaagctg
     4021 tccttacttg ggagaatgcc acagcctgct gcttagctga gttaccagac atcatccatt
     4081 taagcagcag aaaacattga atctcaggga tggtccacag ctggatccaa acttaacgag
     4141 ccctgtttga ataatgaagg gtggcggggc aacatccaca tctggcatcg gatttgcaaa
     4201 ggtttctcac actgttgttt gacactgccc tgttgatgcc cttactctta tgttactgtt
     4261 ttctctgtct gctgtctaac cctgtgcctt gcctgggata aggacaatga taaagttact
     4321 ggtttgggtt gtaagtagag gactttatga attggttagc ggttcactgc tgctttgtta
     4381 ctttcttgag tcagattggc tgcttactaa ataaaaagct gatagaattg tgtactcgga
     4441 tggttgttga ttgtgtgtgt aaacagacat tccagtgcca cctatagcac agcgtgccca
     4501 agaagtccta accgcatgga gagtgcaagc tgcaggttgg tttgtgtaga catgacctga
     4561 agaatagttg cttttcacat gacatcttgc actttaggag actaagaccg tcctgttctg
     4621 tctgcatgtg gtgtgaccaa tggtgtgctc agagcactac ccacaatcac tagtattagc
     4681 aagccgtccc gggccgtgat gcactattag tcctttggaa gctttggctt taggctcacc
     4741 aagcccagtc tcctgtttgc ctctttctgt tctttgtgaa cttccagata ataccactca
     4801 ctaaagttta tttttttgtt gtttgttttt taatttaaaa gaaaaaaact atttaaaaat
     4861 aaggacattt tgtttgttga cagtggtggc ttgataatcc ttaagcaaca agttgaaata
     4921 gaaggaaaag gcacttgaaa aggttactct tcctgtccag ctgtatataa acccagtgtg
     4981 ttgattaatc tagatggtgc aaaaaggaat gtcatggtag acaagcaaca tgggcaaaat
     5041 tgcaagaaag gttttgggtt ttttccagtg ggctgggttg ggtgggatgg ggtaagctgg
     5101 actcacaagt cacgactgga cgggcctttt tatcctttca ctgtatcatg taagtagctg
     5161 ctttcttgcc tgcttatcct tcaggcatcc ccaaagctca ctctgaagac gttagaaata
     5221 aacacaaact ctacgagtta gaagccggtc ctgacactga catgaaggca aacattgatt
     5281 tcatatgaac gttgcagagg tggtcattgg agaaaacagt tcccagattg ttaagagttc
     5341 accgaagata tcgacaaaat tttaaaaatc agtaaaggaa tgtatataat attgctcttg
     5401 tgttttacag taagatttgt tgctctcaga ctgtgtaaaa caaaatttat ccatgttttc
     5461 tgcatattaa aaatcttatt gtaccaattg gtaaactatt aaatgcctat aaaactaaaa
     5521 aaaaaaaaaa aaaaaaaaaa
//
