LOCUS       NM_153106               2333 bp    mRNA    linear   ROD 16-FEB-2025
DEFINITION  Mus musculus peptidyl arginine deiminase, type VI (Padi6), mRNA.
ACCESSION   NM_153106
VERSION     NM_153106.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2333)
  AUTHORS   Giaccari,C., Cecere,F., Argenziano,L., Pagano,A., Galvao,A.,
            Acampora,D., Rossi,G., Hay Mele,B., Acurzio,B., Coonrod,S.,
            Cubellis,M.V., Cerrato,F., Andrews,S., Cecconi,S., Kelsey,G. and
            Riccio,A.
  TITLE     A maternal-effect Padi6 variant causes nuclear and cytoplasmic
            abnormalities in oocytes, as well as failure of epigenetic
            reprogramming and zygotic genome activation in embryos
  JOURNAL   Genes Dev 38 (3-4), 131-150 (2024)
   PUBMED   38453481
  REMARK    GeneRIF: A maternal-effect Padi6 variant causes nuclear and
            cytoplasmic abnormalities in oocytes, as well as failure of
            epigenetic reprogramming and zygotic genome activation in embryos.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2333)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2333)
  AUTHORS   Jentoft,I.M.A., Bauerlein,F.J.B., Welp,L.M., Cooper,B.H.,
            Petrovic,A., So,C., Penir,S.M., Politi,A.Z., Horokhovskyi,Y.,
            Takala,I., Eckel,H., Moltrecht,R., Lenart,P., Cavazza,T., Liepe,J.,
            Brose,N., Urlaub,H., Fernandez-Busnadiego,R. and Schuh,M.
  TITLE     Mammalian oocytes store proteins for the early embryo on
            cytoplasmic lattices
  JOURNAL   Cell 186 (24), 5308-5327 (2023)
   PUBMED   37922900
REFERENCE   4  (bases 1 to 2333)
  AUTHORS   Meng,T.G., Guo,J.N., Zhu,L., Yin,Y., Wang,F., Han,Z.M., Lei,L.,
            Ma,X.S., Xue,Y., Yue,W., Nie,X.Q., Zhao,Z.H., Zhang,H.Y., Sun,S.M.,
            Ouyang,Y.C., Hou,Y., Schatten,H., Ju,Z., Ou,X.H., Wang,Z.B.,
            Wong,C.C.L., Li,Z. and Sun,Q.Y.
  TITLE     NLRP14 Safeguards Calcium Homeostasis via Regulating the K27
            Ubiquitination of Nclx in Oocyte-to-Embryo Transition
  JOURNAL   Adv Sci (Weinh) 10 (27), e2301940 (2023)
   PUBMED   37493331
REFERENCE   5  (bases 1 to 2333)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   6  (bases 1 to 2333)
  AUTHORS   Esposito,G., Vitale,A.M., Leijten,F.P., Strik,A.M.,
            Koonen-Reemst,A.M., Yurttas,P., Robben,T.J., Coonrod,S. and
            Gossen,J.A.
  TITLE     Peptidylarginine deiminase (PAD) 6 is essential for oocyte
            cytoskeletal sheet formation and female fertility
  JOURNAL   Mol Cell Endocrinol 273 (1-2), 25-31 (2007)
   PUBMED   17587491
  REMARK    GeneRIF: Inactivation of the PAD6 gene in mice leads to female
            infertility whereas male fertility is not affected.
REFERENCE   7  (bases 1 to 2333)
  AUTHORS   Joshi,S., Davies,H., Sims,L.P., Levy,S.E. and Dean,J.
  TITLE     Ovarian gene expression in the absence of FIGLA, an oocyte-specific
            transcription factor
  JOURNAL   BMC Dev Biol 7, 67 (2007)
   PUBMED   17567914
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2333)
  AUTHORS   Liu,M., Oh,A., Calarco,P., Yamada,M., Coonrod,S.A. and Talbot,P.
  TITLE     Peptidylarginine deiminase (PAD) is a mouse cortical granule
            protein that plays a role in preimplantation embryonic development
  JOURNAL   Reprod Biol Endocrinol 3, 42 (2005)
   PUBMED   16137333
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2333)
  AUTHORS   Chavanas,S., Mechin,M.C., Takahara,H., Kawada,A., Nachat,R.,
            Serre,G. and Simon,M.
  TITLE     Comparative analysis of the mouse and human peptidylarginine
            deiminase gene clusters reveals highly conserved non-coding
            segments and a new human gene, PADI6
  JOURNAL   Gene 330, 19-27 (2004)
   PUBMED   15087120
REFERENCE   10 (bases 1 to 2333)
  AUTHORS   Wright,P.W., Bolling,L.C., Calvert,M.E., Sarmento,O.F.,
            Berkeley,E.V., Shea,M.C., Hao,Z., Jayes,F.C., Bush,L.A., Shetty,J.,
            Shore,A.N., Reddi,P.P., Tung,K.S., Samy,E., Allietta,M.M.,
            Sherman,N.E., Herr,J.C. and Coonrod,S.A.
  TITLE     ePAD, an oocyte and early embryo-abundant peptidylarginine
            deiminase-like protein that localizes to egg cytoplasmic sheets
  JOURNAL   Dev Biol 256 (1), 73-88 (2003)
   PUBMED   12654293
  REMARK    GeneRIF: localized to egg cytoplasmic sheets; possible role for
            ePAD in cytoskeletal reorganization in the egg and early embryo
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139616.1, BC053724.1 and CJ202890.1.
            
            On Dec 13, 2006 this sequence version replaced NM_153106.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139616.1, BC053724.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1629              AK139616.1         2-1630
            1630-2328           BC053724.1         1628-2326
            2329-2333           CJ202890.1         401-405
FEATURES             Location/Qualifiers
     source          1..2333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 72.26 cM"
     gene            1..2333
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /note="peptidyl arginine deiminase, type VI"
                     /db_xref="GeneID:242726"
                     /db_xref="MGI:MGI:2655198"
     exon            1..155
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..2112
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /EC_number="3.5.3.15"
                     /note="peptidyl arginine deiminase, egg and embryo
                     abundant; arginine deiminase-like protein;
                     protein-arginine deiminase type-6; egg and embryo abundant
                     PAD; peptidylarginine deiminase VI; protein-arginine
                     deiminase type VI"
                     /codon_start=1
                     /product="inactive protein-arginine deiminase type-6"
                     /protein_id="NP_694746.2"
                     /db_xref="CCDS:CCDS38936.1"
                     /db_xref="GeneID:242726"
                     /db_xref="MGI:MGI:2655198"
                     /translation="MSFQNSLSLSLVNPTHALCMVGMEITLDISKCAPDKCKSFTIRG
                     SPRILIHISSSVIAGKEDTVVWRSMNHPTVALVRMVAPSPTVDEDKVLVSYFCPDQEV
                     PTATAVLFLTGIEISLEADIYRDGQLDMPSDKQAKKKWMWGMNGWGAILLVNCSPNAV
                     GQPDEQSFQEGPREIQNLSQMNVTVEGPTSILQNYQLILHTSEEEAKKTRVYWSQRGS
                     SAYELVVGPNKPVYLLPTFENRRKEAFYVEATEFPSPSFSGLISLSLSLVEKAHDECI
                     PEIPLYKDTVMFRVAPYIFMPSTQMPLEVYLCRELQLQGFVDSVTKLSEKSKVQVVKV
                     YEDPNRQSKWLQDEMAFCYTQAPHKTVSLILDTPRVSKLEDFPMKYTLTPGSGYLIRQ
                     TEDHRVASLDSIGNLMVSPPVKAQGKDYPLGRVLIGGSFYPSSEGRDMNKGLREFVYA
                     QQVQAPVELFSDWLMTGHMDQFMCFVPTNDKNNDQKDFRLLLASPSACFELFEQKQKE
                     GYGNVTLFEDIGAEQLLSNGRESKTISQILADKSFREQNTYVEKCISLNRTLLKTELG
                     LEDKDIILIPQLFCLEQLTNVPSNQQSTKLFARPYFPDMLQIIVLGKNLGIPKPFGPK
                     INGTCCLEEKVCGLLEPLGLKCTFIDDFDCYLANIGDVCASAIINRVPFAFKWWKMTP
                     "
     exon            156..333
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            334..406
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            407..474
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            475..583
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            584..709
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            710..885
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            886..989
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1101
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1209
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1364
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1521
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1645
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1716
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1878
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2333
                     /gene="Padi6"
                     /gene_synonym="ePAD; P75; Pad6; Padi5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctaggca attactctgg tgggtaagga ctgctgacag tggctagctt ggtaagccca
       61 gccatgtctt ttcagaactc actcagcctg tctctggtca atcccaccca tgccctctgc
      121 atggtaggca tggaaatcac cttggacatc agcaagtgtg caccagacaa gtgcaagtct
      181 ttcaccatcc gtggttcccc caggatcttg atccacatct ctagctccgt catcgctggc
      241 aaagaggaca ctgtggtctg gaggtcaatg aaccatccca cagtggcatt ggtgaggatg
      301 gtggcgccca gccccactgt ggatgaagac aaggtgctgg tctcctactt ctgtcctgac
      361 caagaagtcc ccacggccac agctgtgctg tttctcaccg gcatcgagat ctccctggag
      421 gcagacatct atcgagatgg acaactggac atgccaagtg ataagcaagc taagaaaaaa
      481 tggatgtggg gtatgaacgg ctggggagcc atcctgcttg tgaattgtag ccctaatgct
      541 gtgggccagc ctgatgaaca gtcctttcag gagggcccca gagaaataca gaacctgtct
      601 cagatgaatg taactgtgga gggccccacc agcatcctac agaattacca gttgatccta
      661 catacctccg aagaagaggc gaagaagaca agagtctact ggtctcagag aggctcctct
      721 gcgtatgaac tggtggtggg acccaacaag cctgtctatc tcctgcctac ctttgagaac
      781 cgtaggaaag aggctttcta cgtagaagcc acggaattcc catctcccag cttctcgggc
      841 ctgatctcct tgtcactctc cctagtagaa aaggctcacg acgagtgcat cccagagatt
      901 ccgctctata aggatacagt gatgttccgg gtggcacctt atatcttcat gcccagcacc
      961 cagatgcctc tagaggttta cctgtgcagg gagctacagc tgcaaggctt tgtggactca
     1021 gtgaccaagc tgagcgagaa gagcaaagtg caggtggtaa aggtctatga ggaccccaac
     1081 cgccagagca agtggctcca ggacgagatg gctttctgct atactcaggc tcctcacaag
     1141 acggtgtcat tgatccttga caccccaagg gtttccaagc tggaagactt ccccatgaaa
     1201 tacacactga cccctggctc tggctacctg atccgacaaa ctgaggacca ccgggtggct
     1261 agcctggatt ccatcgggaa cctgatggta tctccgcctg tcaaggctca gggcaaagac
     1321 taccctctag ggagggtcct cattggtggc agcttttacc ccagctctga gggccgggac
     1381 atgaacaagg gcctgcgaga attcgtgtat gcccagcagg tgcaggcccc tgtggaactc
     1441 ttctcggact ggctgatgac cggtcacatg gatcaattca tgtgctttgt ccctaccaat
     1501 gataaaaaca acgaccagaa ggacttccgc ctgctgctgg ccagccccag tgcctgcttt
     1561 gagctgttcg aacagaagca gaaggaaggc tatgggaacg tgaccctgtt tgaagacatt
     1621 ggagcagaac agctcctttc taatgggagg gagagcaaaa ctatttccca aatcctggct
     1681 gacaagagtt ttcgagagca gaacacctat gttgagaagt gtatcagcct gaaccgcacc
     1741 ctcctgaaga cagaactggg attggaggac aaggacatca tcctgatccc gcagctcttc
     1801 tgcctggagc agctgacgaa tgtcccctcc aaccagcaga gcaccaaact cttcgcgagg
     1861 ccgtacttcc ccgacatgct gcagataatc gtgttgggca agaaccttgg aatccccaag
     1921 ccctttgggc ccaaaatcaa tggcacctgc tgcctagaag agaaagtgtg tggattactg
     1981 gagcccctgg gtctcaagtg caccttcatt gatgattttg actgctacct ggccaacata
     2041 ggggacgtct gtgccagtgc catcataaac agggtgccat ttgcattcaa gtggtggaag
     2101 atgaccccat aaacccctgg ccctggcacg gccagtccgc gccagtacgg atggcctttg
     2161 ccatagatag tagtgggtgc gagcgttgtt gttgcactgg gttgaaggga cggagagctg
     2221 ggagttaggg tctctcacat ctaccagctt gacacttctg gaggggaaaa gggaaaagag
     2281 cgcctatgta aacaaattgc catagagcca ataaagcatg gtattctgaa tgt
//
