LOCUS       NM_011061               2640 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus peptidyl arginine deiminase, type IV (Padi4), mRNA.
ACCESSION   NM_011061 XM_915100
VERSION     NM_011061.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2640)
  AUTHORS   Sun,T., Wang,P., Zhai,X., Wang,Z., Miao,X., Yang,Y. and Wu,J.
  TITLE     Neutrophil extracellular traps induce barrier dysfunction in
            DSS-induced ulcerative colitis via the cGAS-STING pathway
  JOURNAL   Int Immunopharmacol 143 (Pt 1), 113358 (2024)
   PUBMED   39388893
REFERENCE   2  (bases 1 to 2640)
  AUTHORS   Chowdhury,C.S., Kinsella,R.L., McNehlan,M.E., Naik,S.K., Lane,D.S.,
            Talukdar,P., Smirnov,A., Dubey,N., Rankin,A.N., McKee,S.R.,
            Woodson,R., Hii,A., Chavez,S.M., Kreamalmeyer,D., Beatty,W.,
            Mattila,J.T. and Stallings,C.L.
  TITLE     Type I IFN-mediated NET release promotes Mycobacterium tuberculosis
            replication and is associated with granuloma caseation
  JOURNAL   Cell Host Microbe 32 (12), 2092-2111 (2024)
   PUBMED   39637864
REFERENCE   3  (bases 1 to 2640)
  AUTHORS   Murphy,B., Miyamoto,T., Manning,B.S., Mirji,G., Ugolini,A.,
            Kannan,T., Hamada,K., Zhu,Y.P., Claiborne,D.T., Huang,L., Zhang,R.,
            Nefedova,Y., Kossenkov,A., Veglia,F., Shinde,R. and Zhang,N.
  TITLE     Myeloid activation clears ascites and reveals IL27-dependent
            regression of metastatic ovarian cancer
  JOURNAL   J Exp Med 221 (12) (2024)
   PUBMED   39570374
REFERENCE   4  (bases 1 to 2640)
  AUTHORS   Tan,H., Zhang,S., Zhang,Z., Zhang,J., Wang,Z., Liao,J., Qiu,X. and
            Jia,E.
  TITLE     Neutrophil extracellular traps promote M1 macrophage polarization
            in gouty inflammation via targeting hexokinase-2
  JOURNAL   Free Radic Biol Med 224, 540-553 (2024)
   PUBMED   39277122
REFERENCE   5  (bases 1 to 2640)
  AUTHORS   Van Roy,Z. and Kielian,T.
  TITLE     Tumor necrosis factor regulates leukocyte recruitment but not
            bacterial persistence during Staphylococcus aureus craniotomy
            infection
  JOURNAL   J Neuroinflammation 21 (1), 179 (2024)
   PUBMED   39044282
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2640)
  AUTHORS   Nguyen,C., Singson,E., Kim,J.Y., Cornelius,J.G., Attia,R.,
            Doyle,M.E., Bulosan,M., Cha,S. and Peck,A.B.
  TITLE     Sjogren's syndrome-like disease of C57BL/6.NOD-Aec1 Aec2 mice:
            gender differences in keratoconjunctivitis sicca defined by a
            cross-over in the chromosome 3 Aec1 locus
  JOURNAL   Scand J Immunol 64 (3), 295-307 (2006)
   PUBMED   16918699
REFERENCE   7  (bases 1 to 2640)
  AUTHORS   Liu,M., Oh,A., Calarco,P., Yamada,M., Coonrod,S.A. and Talbot,P.
  TITLE     Peptidylarginine deiminase (PAD) is a mouse cortical granule
            protein that plays a role in preimplantation embryonic development
  JOURNAL   Reprod Biol Endocrinol 3, 42 (2005)
   PUBMED   16137333
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2640)
  AUTHORS   Cuthbert,G.L., Daujat,S., Snowden,A.W., Erdjument-Bromage,H.,
            Hagiwara,T., Yamada,M., Schneider,R., Gregory,P.D., Tempst,P.,
            Bannister,A.J. and Kouzarides,T.
  TITLE     Histone deimination antagonizes arginine methylation
  JOURNAL   Cell 118 (5), 545-553 (2004)
   PUBMED   15339660
REFERENCE   9  (bases 1 to 2640)
  AUTHORS   Chavanas,S., Mechin,M.C., Takahara,H., Kawada,A., Nachat,R.,
            Serre,G. and Simon,M.
  TITLE     Comparative analysis of the mouse and human peptidylarginine
            deiminase gene clusters reveals highly conserved non-coding
            segments and a new human gene, PADI6
  JOURNAL   Gene 330, 19-27 (2004)
   PUBMED   15087120
REFERENCE   10 (bases 1 to 2640)
  AUTHORS   Rus'd,A.A., Ikejiri,Y., Ono,H., Yonekawa,T., Shiraiwa,M., Kawada,A.
            and Takahara,H.
  TITLE     Molecular cloning of cDNAs of mouse peptidylarginine deiminase type
            I, type III and type IV, and the expression pattern of type I in
            mouse
  JOURNAL   Eur J Biochem 259 (3), 660-669 (1999)
   PUBMED   10092850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK137625.1, AB013850.1, AI645912.1 and BY544067.1.
            
            On Sep 6, 2007 this sequence version replaced NM_011061.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK137625.1, AB013850.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-857               AK137625.1         2-858
            858-1464            AB013850.1         851-1457
            1465-1930           AK137625.1         1468-1933
            1931-2048           AB013850.1         1924-2041
            2049-2448           AI645912.1         79-478
            2449-2640           BY544067.1         249-440
FEATURES             Location/Qualifiers
     source          1..2640
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 72.34 cM"
     gene            1..2640
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /note="peptidyl arginine deiminase, type IV"
                     /db_xref="GeneID:18602"
                     /db_xref="MGI:MGI:1338898"
     exon            1..115
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            116..296
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            297..363
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            364..431
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            432..549
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..675
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            676..854
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            855..958
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1070
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1178
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1333
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1478
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1581
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1649
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1790
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..2640
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2265..2270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /note="hexamer: AATAAA"
     polyA_site      2284
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /note="major polyA site"
     regulatory      2454..2459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
                     /note="hexamer: ATTAAA"
     polyA_site      2472
                     /gene="Padi4"
                     /gene_synonym="Pad4; Pdi4"
ORIGIN      
        1 gcctgctgac cgagcgagca aggatggccc aaggcgcggt gatccacgtg gcccccgagc
       61 agcccactca cgccgtgtgt gtggtgggca cagcgacccc gctggatgtc cgcggttctg
      121 ctcctaaggg ctacacaacc ttcggcatca cagcctctcc aggagtcatc gtagatgtca
      181 tccatggtcc tccagtcaag aagagtacca tgggggcctc caaatggcct ctggaccctg
      241 agctggaggt gaccctacag gtgaaagcag ccagcagcag aacagatgat gaaaaggttc
      301 gagtttcata ctatggaccc aagacctccc cagtccaagc cctgatctac atcactgggg
      361 tggaactgtc cctgagcgca gatgtcaccc gcacaggcag agtgaagcca gcccaagccg
      421 ggaaggatca gagcacctgg acctggggcc cgggcggccg tggcgccatc ctgttggtga
      481 actgtgacaa agaggaccct caggcctccg gaatggactt tgaggatgac aagatcttgg
      541 acaacaaaga cctgcaggac atgtctccaa tgaccctaag cacgaagacg cccaaagact
      601 tctttgaaaa gtatcagctg gtgttggagg tgcccaaggc caagatgaac agagtgagag
      661 tcttccgggc cacacggggc aaactgccgt cccggtacaa ggtggccctg ggaccacaac
      721 agttctcgta ttgcctggag ctgcccggcg gccagcacag cacagacttc tatgtggaag
      781 gccttgcttt cccagacgca gacttcaaag ggctcattcc cctcaccatc tccctgctgg
      841 acaagtctaa cccggagctc cccgaggccc tggtgttcca agacagtgtg acgttccgtg
      901 tggccccctg gatcatgacc cccaacactc agccccccca ggaggtgtac gtgtgcaggg
      961 tttctgacaa tgaagacttc ctaaagtcac tagctactct gaccaagaaa gccaagtgca
     1021 agctgactgt gtgccccgag gaggagaata tagatgacca atggatgcag gacgaaatgg
     1081 agattggcta catccaggcc ccacacaaga cgctgcctgt ggtctttgac tccccgaggg
     1141 acagaggcct gaaggatttc cctgtcaagc gagttatggg tccaaatttt ggctatgtga
     1201 cccgaaagct ctatatgtca gagctcactg ggctggatgc ctttgggaac ctggaggtga
     1261 gtcccccagt cactgtcaga gggaaggagt acccactggg cagaattctc atcgggaata
     1321 gcggttactc cagcagcgag agccgggaca tgcaccaggc cctgcaggac ttcctgagcg
     1381 cccagcaggt gcaggccccc gtgaggctct tctccgattg gctctttgtg ggtcacgtgg
     1441 atgagttctt gagctttgtc ccagcgcggg acaagcaggg ttttcggctg ctgctgtcca
     1501 gccccagagc ttgctatcag ctgttccagg agctacagag ccagggccac ggggaggcga
     1561 cactgttcga aggactcaag aggaaaaggc agacaatcaa tgaaattctg tccaacaaga
     1621 aattaagaga ccagaatgcc tatgtggaga gctgtatcga ctggaaccgg gcggtgctga
     1681 agcgggagct gggcctggca gagggtgaca tcatcgacat tccgcagctc ttcaagctcg
     1741 cggggaactc cagagggaac tctaaggccc aggccttctt cccaaacatg gtgaacatgc
     1801 tggtcctggg caagtacctg ggcatcccca agccctttgg gcccatcatc gatggccact
     1861 gctgcctgga ggaggaggtg cgttcccacc tggagccgct gggtctgcac tgcaccttca
     1921 tcaacgactt ctacacctac cacgtgtaca acggggaggt tcactgtggc accaatgtgc
     1981 gcaggaagcc cttcaccttc aagtggtggc acatggtgcc ctgagtcact accccaggca
     2041 gcctccctcg aggactgtcc tggccagagg tggctgctcc ccacccccac ccccaccccg
     2101 cagcgaggtg cagcaagaga tctggggatg gttgggcttc cacagaggtg gccactgtcc
     2161 ctgctgtgac atgtttgctt cacccacatc tggctcctgt cccatctctg tgtgtcctca
     2221 aatggtcctt gcatagcaag ctcagctctg cttagagatg ctgcaataaa gatgtagttt
     2281 tgtatcttta gtttaccacg gagttccaca cccccagccc caccctccgc aaagcacatt
     2341 ggaatcaatt tcaaagcacc aatgaggtga aaaagcttca actatggctg gcagctcttt
     2401 tgacttattt actctgccgt atgtgtctct ctctttatat atatttaata aaaattaaaa
     2461 aaaaaaaaca aaccacggct ggcaagatgg ctcagcgggt aagagcattg actgcaggtc
     2521 atgagttcaa atcccagcaa ccacatggtg gctcacaacc atctgtaacg agatctgact
     2581 cccttttctg gcgtgtctga agacagctac agtgtactta catataataa ataaatctta
//
