LOCUS       NM_011060               3068 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus peptidyl arginine deiminase, type III (Padi3), mRNA.
ACCESSION   NM_011060
VERSION     NM_011060.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3068)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3068)
  AUTHORS   Ballasy,N.N., Bering,E.A., Kokorudz,C., Radford,B.N., Zhao,X.,
            Dean,W. and Hemberger,M.
  TITLE     Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes
            Premature Differentiation of Mouse Trophoblast Stem Cells
  JOURNAL   Cells 11 (16), 2466 (2022)
   PUBMED   36010543
  REMARK    GeneRIF: Padi2/3 Deficiency Alters the Epigenomic Landscape and
            Causes Premature Differentiation of Mouse Trophoblast Stem Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3068)
  AUTHORS   Tonelli Gombalova,Z., Kosuth,J., Alexovic Matiasova,A.,
            Zrubakova,J., Zezula,I., Giallongo,T., Di Giulio,A.M., Carelli,S.,
            Tomaskova,L., Daxnerova,Z. and Sevc,J.
  TITLE     Majority of cerebrospinal fluid-contacting neurons in the spinal
            cord of C57Bl/6N mice is present in ectopic position unlike in
            other studied experimental mice strains and mammalian species
  JOURNAL   J Comp Neurol 528 (15), 2523-2550 (2020)
   PUBMED   32212159
REFERENCE   4  (bases 1 to 3068)
  AUTHORS   Zhang,X., Liu,X., Zhang,M., Li,T., Muth,A., Thompson,P.R.,
            Coonrod,S.A. and Zhang,X.
  TITLE     Peptidylarginine deiminase 1-catalyzed histone citrullination is
            essential for early embryo development
  JOURNAL   Sci Rep 6, 38727 (2016)
   PUBMED   27929094
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3068)
  AUTHORS   U Basmanav,F.B., Cau,L., Tafazzoli,A., Mechin,M.C., Wolf,S.,
            Romano,M.T., Valentin,F., Wiegmann,H., Huchenq,A., Kandil,R.,
            Garcia Bartels,N., Kilic,A., George,S., Ralser,D.J., Bergner,S.,
            Ferguson,D.J.P., Oprisoreanu,A.M., Wehner,M., Thiele,H.,
            Altmuller,J., Nurnberg,P., Swan,D., Houniet,D., Buchner,A.,
            Weibel,L., Wagner,N., Grimalt,R., Bygum,A., Serre,G.,
            Blume-Peytavi,U., Sprecher,E., Schoch,S., Oji,V., Hamm,H.,
            Farrant,P., Simon,M. and Betz,R.C.
  TITLE     Mutations in Three Genes Encoding Proteins Involved in Hair Shaft
            Formation Cause Uncombable Hair Syndrome
  JOURNAL   Am J Hum Genet 99 (6), 1292-1304 (2016)
   PUBMED   27866708
  REMARK    GeneRIF: The two enzymes PADI3 and TGM3, responsible for
            posttranslational protein modifications, and their target
            structural protein TCHH are all involved in hair shaft formation.
REFERENCE   6  (bases 1 to 3068)
  AUTHORS   Chavanas,S., Mechin,M.C., Takahara,H., Kawada,A., Nachat,R.,
            Serre,G. and Simon,M.
  TITLE     Comparative analysis of the mouse and human peptidylarginine
            deiminase gene clusters reveals highly conserved non-coding
            segments and a new human gene, PADI6
  JOURNAL   Gene 330, 19-27 (2004)
   PUBMED   15087120
REFERENCE   7  (bases 1 to 3068)
  AUTHORS   Kanno,T., Kawada,A., Yamanouchi,J., Yosida-Noro,C., Yoshiki,A.,
            Shiraiwa,M., Kusakabe,M., Manabe,M., Tezuka,T. and Takahara,H.
  TITLE     Human peptidylarginine deiminase type III: molecular cloning and
            nucleotide sequence of the cDNA, properties of the recombinant
            enzyme, and immunohistochemical localization in human skin
  JOURNAL   J Invest Dermatol 115 (5), 813-823 (2000)
   PUBMED   11069618
REFERENCE   8  (bases 1 to 3068)
  AUTHORS   Rus'd,A.A., Ikejiri,Y., Ono,H., Yonekawa,T., Shiraiwa,M., Kawada,A.
            and Takahara,H.
  TITLE     Molecular cloning of cDNAs of mouse peptidylarginine deiminase type
            I, type III and type IV, and the expression pattern of type I in
            mouse
  JOURNAL   Eur J Biochem 259 (3), 660-669 (1999)
   PUBMED   10092850
REFERENCE   9  (bases 1 to 3068)
  AUTHORS   Terakawa,H., Takahara,H. and Sugawara,K.
  TITLE     Three types of mouse peptidylarginine deiminase: characterization
            and tissue distribution
  JOURNAL   J Biochem 110 (4), 661-666 (1991)
   PUBMED   1778991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB013849.1, AL807805.7 and AK220522.1.
            
            On Sep 6, 2007 this sequence version replaced NM_011060.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB013849.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AB013849.1         2-62
            62-133              AL807805.7         74775-74846         c
            134-314             AL807805.7         67726-67906         c
            315-618             AK220522.1         557-860
            619-619             AL807805.7         62382-62382         c
            620-3068            AK220522.1         862-3310
FEATURES             Location/Qualifiers
     source          1..3068
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 72.5 cM"
     gene            1..3068
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /note="peptidyl arginine deiminase, type III"
                     /db_xref="GeneID:18601"
                     /db_xref="MGI:MGI:1338891"
     exon            1..133
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2036
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /EC_number="3.5.3.15"
                     /note="peptidylarginine deiminase III; PAD type III;
                     PROTEIN-ARGININE DEIMINASE TYPE III (PEPTIDYLARGININE
                     DEIMINASE III)"
                     /codon_start=1
                     /product="protein-arginine deiminase type-3"
                     /protein_id="NP_035190.3"
                     /db_xref="CCDS:CCDS18855.1"
                     /db_xref="GeneID:18601"
                     /db_xref="MGI:MGI:1338891"
                     /translation="MSLQRIVRVSLEHPTSAVCVAGVETIVDIYGAVPEGTDMFEVYG
                     TPGVDIYVSPSMERSRERADTRRWCFNKGLEIIVIMNSPSNDLNDSHVQIAYHSSREH
                     LPLAYAVLYLTCVDITLDCDMNCADRQDRSFVDKRQWVWGPDGYGAILLVNCDRDNVD
                     SNAQDNCDQYVRCLQDLEDMSVMVLRTQGPEALFEDHRLILHTSSCDAERARVFHVCG
                     PEDSCESYKCVLGPDRMSYEVPRLKGYEERFFVEGLSFPDAGFPGLISFHVTLLDDSN
                     EDFSETPIFTDTAVFRVAPWIMTPSTLPPLEVYVCRVRNNTCFVEAVEELARKAGCKL
                     TICPQAENRNDRWIQDEMELGYVQAPHKTLPVVFDSPRNGELQGFPYKRILGLDFGYV
                     TREPKDSSVSGLDSFGNLEVSPPVVANGKEYPLGRILIGGNLPGSRGRRVTQVVRNFL
                     HAQKVQPLVELFVDWLAVGHVDEFLSFVPAPDGKGFRLLLASPGACFRLFQEKQKWGH
                     GRSLLFEGVIGDRRVQTVSINQILNNQSLINFNKFAQSCIDWNREVLKRELGLAEGDI
                     IDIPQLFKTEKRKAVAFFPDLVNMLVLGKHLGIPKPFGPIINGRCCLEEKVRSLLEPL
                     GLHCTFIDDFTPYHMLHGEVHCGTNVRREPFAFKWWHMVP"
     exon            134..314
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            315..387
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            388..449
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            450..567
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            568..693
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            694..872
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            873..976
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1088
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1196
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1348
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1493
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1596
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1676
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1802
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..3068
                     /gene="Padi3"
                     /gene_synonym="mKIAA4171; Pad3; Pdi3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgctgggt ttggtggcca aagcccccat cctaggccgg catgtctcta cagaggattg
       61 tgcgtgtgtc tctggagcac cccaccagcg ctgtgtgtgt ggcaggggtt gagaccatcg
      121 tggacattta tggggcggtt cctgagggca cagacatgtt tgaggtctac gggacaccgg
      181 gagtggacat ctatgtgtct cccagcatgg agaggagccg agagcgagct gacaccaggc
      241 ggtggtgctt caacaagggc ctggagatta ttgtaatcat gaactcccct agcaatgacc
      301 tcaacgacag ccatgttcag atagcctacc actccagccg agagcatttg cccctggcct
      361 atgcagtact ctacctcacc tgtgtggaca tcaccctaga ctgtgacatg aactgtgcgg
      421 accggcagga caggagcttc gtggataaga ggcagtgggt gtgggggcct gatgggtacg
      481 gagccatctt gctggtgaac tgtgatcggg acaatgtcga ctctaatgcc caagataact
      541 gtgaccaata tgtgcgttgc ctgcaagatc tggaagacat gtccgtcatg gtcctacgga
      601 cccagggccc cgaagccctc tttgaggacc acaggcttat cctccacacc tccagctgtg
      661 atgcagagcg ggcacgggtc ttccatgtct gcggccccga ggattcctgt gagtcctata
      721 agtgtgttct gggcccagac aggatgtcct atgaggtgcc ccgcctgaag ggctatgagg
      781 agcgcttctt cgtggagggc ctctccttcc cggatgcagg cttcccaggg ctcatttcct
      841 tccatgtcac tctgctggat gattctaatg aggacttctc cgagaccccc atcttcaccg
      901 acacagcagt gttccgggtg gccccctgga tcatgacacc cagcaccctg ccacccctag
      961 aggtgtacgt gtgccgggtg aggaataaca cctgctttgt ggaagccgtg gaggagctgg
     1021 ctaggaaggc gggctgcaaa ctcaccatct gtcctcaggc agagaaccgg aacgaccgct
     1081 ggatccagga tgagatggag ctggggtatg tgcaggcgcc acacaagacc ttgccggtgg
     1141 tcttcgattc tccgaggaac ggagagctgc agggcttccc ttacaaaagg atcctgggtc
     1201 tagatttcgg ctatgtgaca cgggaaccta aagacagttc tgtgagtggt ctggactctt
     1261 ttggcaacct ggaggtcagc ccacccgtgg tggccaatgg gaaggagtat cccttgggga
     1321 gaatcctcat cgggggcaac ctgcctgggt cgagaggccg cagagtgacc caggtggtgc
     1381 gaaacttcct ccatgcccag aaagtgcaac ctctggtgga gctgtttgtg gactggctgg
     1441 ctgtgggcca cgtggatgag ttcctgagct tcgtccctgc acccgacggg aagggcttcc
     1501 ggctcctcct ggccagccct ggcgcctgct tcaggctatt ccaggaaaag cagaagtggg
     1561 gccatggccg gtccctgctt ttcgagggtg tcattggcga caggcgggtc cagaccgtct
     1621 ccatcaatca gattcttaac aaccagagcc ttatcaactt taataagttt gcacagagct
     1681 gtatcgactg gaaccgcgag gtactgaagc gggagctggg cctggcggag ggtgacatca
     1741 tcgacatccc gcagctcttc aagacggaga agaggaaggc agtagcgttc ttccccgact
     1801 tggtgaatat gctggtcctg ggcaagcacc tgggcatccc caagcccttc gggcccatca
     1861 tcaatggtcg ctgctgcctg gaggagaagg tgcgctccct gctggagccg ctgggtctgc
     1921 actgcacctt catcgatgac ttcacgccat accacatgct gcacggggag gttcactgtg
     1981 gcaccaacgt gcgccgggag cccttcgcct tcaagtggtg gcacatggtg ccctgagcca
     2041 ccacccatcc cccaccctcc ccccaggatg gggtgtccgc ctggcagatg gagactggga
     2101 cagaccccag aacaacaagc agctaaagac ccccggtttc tagactgaat gcccagggtg
     2161 acccaagccc ctcagaagcc ttttctcttg aaatgtctgc ctttatctgc cactcattca
     2221 gatcccagac gtgaatcctc ttggtgtccc caagaaaggg ccctgtgtct accagactct
     2281 catggggatc aacgtgaccc atggcgatag ctttaaacac catccccaca aactcctctg
     2341 tttgtgggta aatccactcg gatgtctaga ggctttgacc ttgtcagcat cttggcctgc
     2401 acttcctatg gtggaaggcc caggggtttg gttttggcca ctgtctcctg ccctgcaggg
     2461 gatggtttta aagtcagaca attttacata ttcttgtacg agtagactac tccacatgag
     2521 agagtctacc ccaggaagca ccccagggtc cattcaagtc caagtgtgac catcattctt
     2581 actgcaagct cccggccagg accggccttt actgagctgt cacacagtgg gtacctctag
     2641 gtgcttttgg gatggcaggt atctcttagc cttacaagct ccccatcatc tgatgcccag
     2701 gaatcgggtt gtccaaatcc tcttgaaatt tctctgaagt gaagcggctg ggggcagggg
     2761 gaaggggggc agcgctgttg atggttagga aaactggatt cccagagaaa tctaagacag
     2821 gaccgaccct gggggtcgcc cccatctcga ggaggatgct cagctggcct gggggctctg
     2881 cacaggagaa gagaccactg gctgacttaa ctctgagctt tctgcctata cagccatcct
     2941 gcaggttgcc atagaggcag gactcagtgg gacagttgaa cctctccaca tactgggaga
     3001 agggaggggc gtggctgtct caagatgtgt tctgtgagtc cagcttgcca aaaaataaac
     3061 agaagcac
//
