LOCUS       NM_008812               4758 bp    mRNA    linear   ROD 21-DEC-2022
DEFINITION  Mus musculus peptidyl arginine deiminase, type II (Padi2), mRNA.
ACCESSION   NM_008812 XM_917285
VERSION     NM_008812.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4758)
  AUTHORS   Ballasy NN, Bering EA, Kokorudz C, Radford BN, Zhao X, Dean W and
            Hemberger M.
  TITLE     Padi2/3 Deficiency Alters the Epigenomic Landscape and Causes
            Premature Differentiation of Mouse Trophoblast Stem Cells
  JOURNAL   Cells 11 (16), 2466 (2022)
   PUBMED   36010543
  REMARK    GeneRIF: Padi2/3 Deficiency Alters the Epigenomic Landscape and
            Causes Premature Differentiation of Mouse Trophoblast Stem Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4758)
  AUTHORS   Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T,
            Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR and Ho IC.
  TITLE     PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis
  JOURNAL   Matrix Biol 102, 70-84 (2021)
   PUBMED   34274450
  REMARK    GeneRIF: PAD2-mediated citrullination of Fibulin-5 promotes
            elastogenesis.
REFERENCE   3  (bases 1 to 4758)
  AUTHORS   Tian Y, Qu S, Alam HB, Williams AM, Wu Z, Deng Q, Pan B, Zhou J,
            Liu B, Duan X, Ma J, Mondal S, Thompson PR, Stringer KA, Standiford
            TJ and Li Y.
  TITLE     Peptidylarginine deiminase 2 has potential as both a biomarker and
            therapeutic target of sepsis
  JOURNAL   JCI Insight 5 (20), 138873 (2020)
   PUBMED   33055424
  REMARK    GeneRIF: Peptidylarginine deiminase 2 has potential as both a
            biomarker and therapeutic target of sepsis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4758)
  AUTHORS   Wu Z, Deng Q, Pan B, Alam HB, Tian Y, Bhatti UF, Liu B, Mondal S,
            Thompson PR and Li Y.
  TITLE     Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal
            LPS-Induced Endotoxic Shock
  JOURNAL   Inflammation 43 (4), 1436-1445 (2020)
   PUBMED   32239392
  REMARK    GeneRIF: Inhibition of PAD2 Improves Survival in a Mouse Model of
            Lethal LPS-Induced Endotoxic Shock.
REFERENCE   5  (bases 1 to 4758)
  AUTHORS   Sun B, Chang HH, Salinger A, Tomita B, Bawadekar M, Holmes CL,
            Shelef MA, Weerapana E, Thompson PR and Ho IC.
  TITLE     Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated
            citrullination
  JOURNAL   JCI Insight 4 (22), 129687 (2019)
   PUBMED   31723060
  REMARK    GeneRIF: Reciprocal regulation of Th2 and Th17 cells by
            PAD2-mediated citrullination.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4758)
  AUTHORS   Arai T, Kusubata M, Kohsaka T, Shiraiwa M, Sugawara K and Takahara
            H.
  TITLE     Mouse uterus peptidylarginine deiminase is expressed in decidual
            cells during pregnancy
  JOURNAL   J Cell Biochem 58 (3), 269-278 (1995)
   PUBMED   7593250
REFERENCE   7  (bases 1 to 4758)
  AUTHORS   Tsuchida M, Takahara H, Minami N, Arai T, Kobayashi Y, Tsujimoto H,
            Fukazawa C and Sugawara K.
  TITLE     cDNA nucleotide sequence and primary structure of mouse uterine
            peptidylarginine deiminase. Detection of a 3'-untranslated
            nucleotide sequence common to the mRNA of transiently expressed
            genes and rapid turnover of this enzyme's mRNA in the estrous cycle
  JOURNAL   Eur J Biochem 215 (3), 677-685 (1993)
   PUBMED   8354274
REFERENCE   8  (bases 1 to 4758)
  AUTHORS   Takahara H, Kusubata M, Tsuchida M, Kohsaka T, Tagami S and
            Sugawara K.
  TITLE     Expression of peptidylarginine deiminase in the uterine epithelial
            cells of mouse is dependent on estrogen
  JOURNAL   J Biol Chem 267 (1), 520-525 (1992)
   PUBMED   1730614
REFERENCE   9  (bases 1 to 4758)
  AUTHORS   Terakawa H, Takahara H and Sugawara K.
  TITLE     Three types of mouse peptidylarginine deiminase: characterization
            and tissue distribution
  JOURNAL   J Biochem 110 (4), 661-666 (1991)
   PUBMED   1778991
REFERENCE   10 (bases 1 to 4758)
  AUTHORS   Takahara H, Tsuchida M, Kusubata M, Akutsu K, Tagami S and Sugawara
            K.
  TITLE     Peptidylarginine deiminase of the mouse. Distribution, properties,
            and immunocytochemical localization
  JOURNAL   J Biol Chem 264 (22), 13361-13368 (1989)
   PUBMED   2753915
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB850871.1, AK148156.1, AK158382.1, AK168685.1 and AL645625.15.
            
            [WARNING] On May 13, 2023 this sequence was replaced by
            NM_008812.3.
            
            On Apr 2, 2008 this sequence version replaced NM_008812.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D16580.1, AK154814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BB850871.1         2-17
            17-235              AK148156.1         4-222
            236-511             AK158382.1         223-498
            512-544             AK148156.1         499-531
            545-1679            AK168685.1         254-1388
            1680-2021           AK148156.1         1667-2008
            2022-4758           AL645625.15        32614-35350
FEATURES             Location/Qualifiers
     source          1..4758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 73.01 cM"
     gene            1..4758
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /note="peptidyl arginine deiminase, type II"
                     /db_xref="GeneID:18600"
                     /db_xref="MGI:MGI:1338892"
     exon            1..190
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2096
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /EC_number="3.5.3.15"
                     /note="peptidylarginine deiminase II; protein-arginine
                     deiminase type II; PAD type II; peptidyl arginine
                     deiminase, type II; PAD type II"
                     /codon_start=1
                     /product="protein-arginine deiminase type-2"
                     /protein_id="NP_032838.2"
                     /db_xref="CCDS:CCDS18857.1"
                     /db_xref="GeneID:18600"
                     /db_xref="MGI:MGI:1338892"
                     /translation="MQPPIRENMLRERTVRLQYGSRVEAVYVLGTQLWTDVYSAAPAG
                     AKTFSLKHSEGVKVEVVRDGEAEEVVTNGKQRWALSPSSTLRLSMAQASTEASSDKVT
                     VNYYEEEGSAPIDQAGLFLTAIEISLDVDADRDGEVEKNNPKKASWTWGPEGQGAILL
                     VNCDRDTPWLPKEDCSDEKVYSKQDLQDMSQMILRTKGPDRLPAGYEIVLYISMSDSD
                     KVGVFYVENPFFGQRYIHILGRQKLYHVVKYTGGSAELLFFVEGLCFPDESFSGLVSI
                     HVSLLEYMAEGIPLTPIFTDTVMFRIAPWIMTPNILPPVSVFVCCMKDNYLFLKEVKN
                     LVEKTNCELKVCFQYMNRGDRWIQDEIEFGYIEAPHKGFPVVLDSPRDGNLKDFPIKQ
                     LLGPDFGYVTREPLFETVTSLDSFGNLEVSPPVTVNGKEYPLGRILIGSSFPLSGGRR
                     MTKVVRDFLQAQQVQAPVELYSDWLTVGHVDEFMTFIPIPGKKEFRLLMASTSACYQL
                     FREKQKAGHGEAVMFKGLGGMSSKRITINKILSNESLTQENQYFQRCLDWNRDILKRE
                     LALTEKDIIDLPALFKMDENHQARAFFPNMVNMIVLDKDLGIPKPFGPQVEEECCLET
                     HVRGLLEPLGLACTFIDDISAYHKFLGEVHCGTNVRRKPFTFKWWHMVP"
     exon            191..374
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..447
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..509
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            510..627
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..753
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..932
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1036
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1148
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1256
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1408
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1553
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1647
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1733
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1862
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..4758
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4721..4726
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
     regulatory      4731..4736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
     polyA_site      4758
                     /gene="Padi2"
                     /gene_synonym="mKIAA0994; Pdi; Pdi2"
ORIGIN      
        1 gctcggcagc gagcgcaggc gcagcagcgg agggcttacc tgcagcaggt gcttattcct
       61 gggagcagca cggaatgcag ccgcctatac gggaaaatat gctgcgggaa cggaccgtgc
      121 ggctgcagta tgggagccgc gtggaggcgg tgtacgtgct gggcacgcag ctctggaccg
      181 atgtctacag tgcagcacct gctggggcca aaaccttcag cctgaagcac tcggaaggtg
      241 tgaaggtgga ggtcgtacgt gatggagagg cagaggaggt ggtcaccaac ggcaagcagc
      301 gctgggccct gtcacccagc agcacactgc ggctcagcat ggcccaggcc agcacagagg
      361 ccagcagcga caaggtcact gtcaactact atgaagagga gggcagcgcc cccattgacc
      421 aggctgggct cttcctcacg gccattgaga tctcgctgga tgtggacgca gatcgggatg
      481 gagaggtgga gaagaacaat cctaagaagg catcctggac ctggggtcct gagggccaag
      541 gggctatcct gctggtgaat tgtgaccgag acacaccctg gttgcccaag gaggactgta
      601 gtgacgaaaa ggtctacagc aagcaagacc tccaggacat gtctcagatg atcctgcgca
      661 ccaaaggccc tgaccgcctg cccgccgggt atgaaatagt cctctacatc tccatgtcag
      721 actcggacaa agtgggcgtc ttctacgtgg agaacccgtt ctttggccag cgctatatcc
      781 acatcctggg ccggcagaag ctctaccacg tggtcaagta caccggcggt tctgcggagt
      841 tgctgttctt tgtggaaggc ctctgtttcc ccgacgagag tttctcaggc ctggtttcta
      901 tccacgtcag tctgctggag tatatggccg agggcatccc gttgaccccc atcttcacag
      961 acactgtgat gttccggatt gcaccctgga ttatgacccc caacatcttg cctcctgtgt
     1021 cagtgttcgt gtgctgcatg aaggataatt acctgttcct gaaagaggtg aagaacttgg
     1081 tggagaaaac caactgcgaa ctgaaagttt gtttccagta catgaaccgc ggtgaccgct
     1141 ggatccagga tgaaatcgag tttggctaca ttgaggcacc ccacaaaggc ttcccagtag
     1201 tgctggactc ccctcgagat ggaaacctga aggacttccc cattaagcaa ctcctgggcc
     1261 cagatttcgg ctatgtgacc cgggagcccc tctttgagac tgtcaccagc ctcgactcct
     1321 tcgggaatct ggaggtcagt cccccagtga ccgtgaatgg caaggagtac ccgcttggcc
     1381 ggatcctcat cggaagcagt ttccccctgt ctggaggcag gaggatgacc aaggtggtac
     1441 gcgacttcct gcaggcccag caggtgcagg cgcccgtgga actctactcc gactggctga
     1501 ctgtaggcca cgtcgatgag tttatgactt tcatccccat cccaggcaaa aaggaatttc
     1561 ggctgctcat ggccagcacc tccgcctgct accagctctt ccgagaaaag cagaaggcag
     1621 gccacgggga ggccgttatg ttcaagggcc tgggaggcat gagcagcaag cgcatcacca
     1681 tcaacaagat cctgtccaat gagagcctca cgcaggagaa ccagtacttc cagcgctgtc
     1741 tggactggaa ccgcgacatc cttaagaggg agctagcgct gactgagaag gacattattg
     1801 acctgcccgc gctcttcaag atggatgaaa atcaccaggc cagggctttc ttccctaaca
     1861 tggtgaacat gatcgtgcta gacaaggacc tgggcatccc caagcctttc gggccccagg
     1921 tggaggagga gtgctgcctg gagacgcacg ttcgaggcct gctggagccc ctgggcctcg
     1981 cctgcacgtt catcgatgac atctccgcct accacaagtt cctgggagag gttcactgtg
     2041 gcaccaatgt ccgcaggaag ccgttcacct tcaagtggtg gcacatggtg ccctgactgc
     2101 cttttccttt tcctcctccg ctgcggtctc tgggtccttc ctgtaccccc aagtccttcc
     2161 cctacaagaa gcagatggga ttgggggata tatgtgcctt gctgtcccct ggagaaggac
     2221 ctcagtgtcc actgaagccc cacccccacc ccagtaagcc cagccatcct ccacctaaaa
     2281 ctagtgggac atgtggttag tgtgcagagc cctggccagg gaaaggggac atcaacaaat
     2341 catgtagtca gattgtcccc aggaattctc agcctctact ccaggccaga atgagggaag
     2401 ggagaaggga ggctctgagg tcattggctc tcccagcatc catctgacat tcaaggtaga
     2461 ccaggagagg gtcctggagt accttggatg gtaccctcac ttcaagctca cctccctcgg
     2521 ggtctcctgg tggctggctc cctgcacctg ttcattcctt acagtttccc gtacacgttg
     2581 cgtccccact ccctgagggt ccaatcattc agcacagaat cttccagaaa taggtcttag
     2641 cagaggagcg ttcttcactt tctgtggatg cgggctgccc aaatttagga gaaaggggag
     2701 gtctcagact agcatccacg gtctaaagtt cggtatatga agatgctcct gcctgtcaat
     2761 gctatttctg ttctctcacc tggtcctcaa ttctctggcc agttcttggg ctcattgctc
     2821 ttcctatttt ggacattgac cttcctgttc tggacatttg tccctccagc agctacacag
     2881 ccagatccag gcctcccgag agcctgagaa gcagcctatc tctcctcatg gatgctggcc
     2941 ccagtgtcca aggatgctgg ccacgttcca gcctcagtgc tccctttcca gctagctgct
     3001 gctccagagg aggaatttcc cagcatgctt tccaaaggct cccatccaga tacaggcaaa
     3061 tttacccctc ggcttccatt agaaagaccc ccaggagctg cagagatggc tcagcaatta
     3121 aaaatgctcc ctgctcttgg agaggaccca agtgcagttc tcaacacctg caactgtctg
     3181 taatcccaga tccagaggct ccagtacccc gttctggccc ctgagggcac tgcacacatg
     3241 tgtacaaacc catacacata aatacatttg ttagggtctg gagagatagg gcccggtggt
     3301 gcacaatctg ctattgcaga gtaccggggt tcagttctca gcacccaggt ggtggctcac
     3361 aactacctat aactctagtt ccagggggtc caatgctctc atctgacctc cacgggcttc
     3421 tgcacataca tggttcacat acacacactc aagcacacat ccaagtaaag taaaataaat
     3481 gatatttaaa aaataaaaaa aaattttaaa taaaaaaggt cctttaaggc caagaagata
     3541 ggaaatatta attctacttt gaaaggttaa acagctccat tttataacca aagaaagggt
     3601 tacagaccta cattattttt ttttattaaa gatttattta tttattttat gtatatgagt
     3661 acactgcagc tgtcttcaga cacaccagaa gagggcgtca gatcccatta cagatggttg
     3721 tgagccacca tgtggttgct gggaattgaa cttaggacct ctgggcgagc agtcaatgct
     3781 cttaaccact gagccatctc tccagcccca gacctacatt cttaggggaa caagattttt
     3841 accttggatt atttcctcag ctatgcaatc aacgggttgt atgctactga gcagtgggca
     3901 cagacttaga ctccgataac ataagctaac cgtagactcg cttgtcccct gcagacaaag
     3961 cgcacatcta cgtggccgca cttgcccttg ctgtggtagg ctctttggga acactaccca
     4021 gtatatccaa taagcatacg ctcaacagtc actgccttcg agagttaggg tcgtgtcttc
     4081 ttctccatcc agttgggcca acagccatgc caggtcgggc ctcagagcct ccaaagctgc
     4141 catcatctgt ctctggagac agtggtccct gctcttgagg gcaaagcccc aaatcctgtc
     4201 tcctgctcca gagtagaaaa cacgggcacc tctctgaggg agctgatgtg gagaggtggg
     4261 ggcttgtggt gttcggttaa agtgacttta ctgcttttat ttttatctgg ggtgggagga
     4321 agtgagcacc tcccatatgg cagccgcgtg gctttgtaga ctgctacaat actccctggt
     4381 ggcattggtt gtctcagaaa tttctggaac tccaggactc agacactgcc tgtcccatct
     4441 cacttactca cccagtgtga ctccccccca agtgtggatg cccccttgcc tcccctgggt
     4501 ggactccttg ctcttcccca cccccactgt gttttgtttt gttttgtttt taacttaggc
     4561 ccagatgctt ctgggctaca ccagttcctg tttcgatgtg agttttgaaa tgctccgtga
     4621 agggctgagg gacggcagga agatggcggg agccaggcag taccaacttc ctggcgaaga
     4681 agccaagatg gagactgaga agtgtttggg gaagagccaa aataaagagc aataaaataa
     4741 gccgtccacg ggaagcta
//
