LOCUS       NM_011059               3756 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus peptidyl arginine deiminase, type I (Padi1), mRNA.
ACCESSION   NM_011059
VERSION     NM_011059.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3756)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3756)
  AUTHORS   Zhang,X., Liu,X., Zhang,M., Li,T., Muth,A., Thompson,P.R.,
            Coonrod,S.A. and Zhang,X.
  TITLE     Peptidylarginine deiminase 1-catalyzed histone citrullination is
            essential for early embryo development
  JOURNAL   Sci Rep 6, 38727 (2016)
   PUBMED   27929094
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3756)
  AUTHORS   Chavanas,S., Mechin,M.C., Takahara,H., Kawada,A., Nachat,R.,
            Serre,G. and Simon,M.
  TITLE     Comparative analysis of the mouse and human peptidylarginine
            deiminase gene clusters reveals highly conserved non-coding
            segments and a new human gene, PADI6
  JOURNAL   Gene 330, 19-27 (2004)
   PUBMED   15087120
REFERENCE   4  (bases 1 to 3756)
  AUTHORS   Guerrin,M., Ishigami,A., Mechin,M.C., Nachat,R., Valmary,S.,
            Sebbag,M., Simon,M., Senshu,T. and Serre,G.
  TITLE     cDNA cloning, gene organization and expression analysis of human
            peptidylarginine deiminase type I
  JOURNAL   Biochem J 370 (Pt 1), 167-174 (2003)
   PUBMED   12416996
REFERENCE   5  (bases 1 to 3756)
  AUTHORS   Rus'd,A.A., Ikejiri,Y., Ono,H., Yonekawa,T., Shiraiwa,M., Kawada,A.
            and Takahara,H.
  TITLE     Molecular cloning of cDNAs of mouse peptidylarginine deiminase type
            I, type III and type IV, and the expression pattern of type I in
            mouse
  JOURNAL   Eur J Biochem 259 (3), 660-669 (1999)
   PUBMED   10092850
REFERENCE   6  (bases 1 to 3756)
  AUTHORS   Terakawa,H., Takahara,H. and Sugawara,K.
  TITLE     Three types of mouse peptidylarginine deiminase: characterization
            and tissue distribution
  JOURNAL   J Biochem 110 (4), 661-666 (1991)
   PUBMED   1778991
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL807805.7.
            
            On Nov 17, 2006 this sequence version replaced NM_011059.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB013848.1, AK037182.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AL807805.7         109819-110037       c
            220-400             AL807805.7         96551-96731         c
            401-473             AL807805.7         95704-95776         c
            474-535             AL807805.7         95033-95094         c
            536-650             AL807805.7         93631-93745         c
            651-776             AL807805.7         93413-93538         c
            777-949             AL807805.7         92350-92522         c
            950-1053            AL807805.7         92161-92264         c
            1054-1177           AL807805.7         91102-91225         c
            1178-1285           AL807805.7         90758-90865         c
            1286-1437           AL807805.7         89081-89232         c
            1438-1582           AL807805.7         83986-84130         c
            1583-1676           AL807805.7         83124-83217         c
            1677-1756           AL807805.7         82553-82632         c
            1757-1882           AL807805.7         81385-81510         c
            1883-3756           AL807805.7         77240-79113         c
FEATURES             Location/Qualifiers
     source          1..3756
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 72.62 cM"
     gene            1..3756
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /note="peptidyl arginine deiminase, type I"
                     /db_xref="GeneID:18599"
                     /db_xref="MGI:MGI:1338893"
     exon            1..219
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..2116
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /EC_number="3.5.3.15"
                     /note="peptidylarginine deiminase I; Pad type 1; PAD type
                     I; PROTEIN-ARGININE DEIMINASE TYPE I (PEPTIDYLARGININE
                     DEIMINASE I)"
                     /codon_start=1
                     /product="protein-arginine deiminase type-1"
                     /protein_id="NP_035189.1"
                     /db_xref="CCDS:CCDS18856.1"
                     /db_xref="GeneID:18599"
                     /db_xref="MGI:MGI:1338893"
                     /translation="MASPRAVQLSLRKPTHAVCVVGVETLVNVYSDVPKGAKTFGVSG
                     SSEVKIYMVYDPSRVAEPAGWAHWPLDANVDVVVVADTVSKDLYDFKVKVSYFESQEA
                     AALAHSVLYLTAVDVSLDVDTGRTGKVKKGSGDKKTWRWGPGGSGAILLVNCDRDIHG
                     SREDLHANHLKSLEDLQDMSPMVLSCGGPDELFESHKLVLKASLSDSRRLKVFCARGG
                     TSLSNYKQVLGPRHSSYEVERHSGERAIQFYVEGLAFPDASFSGLLSLSVSLVDTRPL
                     SEVSVFTDSVTFRVAPWIMTPNTQPPLELYVCSVTDIHGRNDKFLEDMSHLATKANCK
                     LVVCPRAENRNDRWIQDELEFGYIDAPHKSFPVVFDSPRNRGLRDFALKRILGPDFGY
                     VTREIEFAGASGLDSFGNLDVSPPVRVGNTDYPLGRILIGGSFPKPSGRRMARVVRDF
                     LQAQQVQSPVELYSDWLSVGHVDEFLSFVPTSDQKGFRLLLASPSACLQLFQEKKEEG
                     YGEAEQFDGLKHKAKRSINDILADKHLRRDSAHVQKCIDWNREVLKRELGLSESDIVD
                     IPQLFFLKGAYAEAFFPDMVNMVVLGKYLGIPKPFGPLINGRCCLEEKVRSLLEPLGL
                     RCVFIDDFLFYHQLLGEIHCGTNVRRKPFTFKWWNSVP"
     exon            220..400
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..473
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..535
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            536..650
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..776
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..949
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1053
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1177
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1285
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1437
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1582
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1676
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1756
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1882
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..3756
                     /gene="Padi1"
                     /gene_synonym="Pdi1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaaggcacg ctcctacccg gcagccgggt gtccccaagg agatctgggg agccggggag
       61 catctggggc ttgtggctgc tgggcaccca agctgacccg accaggagac tggaagctcg
      121 acacaggatg gcctccccga gagctgtgca gctgtctctg agaaagccga ctcacgctgt
      181 gtgcgtggta ggtgtggaga cactggtgaa cgtctatagt gatgtgccca aaggtgccaa
      241 gacctttggg gtgtctggga gctctgaggt gaagatctac atggtctacg atccctcgag
      301 agtggcagag cccgcaggct gggcccactg gcccctggat gccaacgtgg acgtggtggt
      361 agtggcggac acagtcagta aggacttata tgacttcaag gtgaaggtgt catactttga
      421 gtcacaggag gctgctgccc tggcccacag tgtgctctac ctaactgctg ttgatgtgtc
      481 ccttgatgtc gacacaggcc gcacaggcaa ggtgaagaaa ggctctggtg acaagaaaac
      541 ctggcgctgg ggccctgggg gctccggggc catcctgttg gtaaactgtg acagagatat
      601 ccatgggtcc agggaagacc tgcatgctaa ccatttgaag tcgctggagg acctgcagga
      661 catgtcccca atggtgctga gttgtggtgg ccctgatgag ctttttgaga gccacaagct
      721 ggtcttgaag gcatctttgt cagattccag aagactgaag gtcttctgtg cccggggtgg
      781 gacatccctc tccaactaca aacaggtgct agggccccgt cacagctcct atgaggtgga
      841 aaggcattct ggggagaggg ccatccagtt ctacgtggaa gggctcgcct tccccgacgc
      901 cagtttctca gggctgctct ctctcagtgt cagcctggtg gacacacggc ccctctctga
      961 ggtgtcagtc ttcactgaca gcgtgacctt ccgggtggcc ccctggatca tgacccccaa
     1021 cactcagccg cccctggagc tgtatgtgtg cagcgtgaca gatatccacg gccgcaatga
     1081 caagttcctg gaggacatgt cccacctggc cacaaaggcc aactgcaaac tagtggtctg
     1141 tccccgggca gagaatcgca acgatcgctg gatccaggac gagttggagt ttggctacat
     1201 tgacgcacct cacaaatcct tccctgtggt ctttgattcc ccccgaaaca gaggcttgag
     1261 ggacttcgcc cttaagagga tcctgggtcc tgactttgga tatgtgaccc gggagatcga
     1321 gttcgcaggt gcctctggcc tggattcctt cggcaacctg gatgtgagcc caccggtgag
     1381 ggtgggcaac acagactacc ccctcggcag aatcctcatt ggtggcagct tccccaagcc
     1441 cagtgggcgg cggatggcca gagtggtgcg tgacttcctg caggcccagc aggtgcagtc
     1501 tcctgtggaa ctctactccg actggctttc cgtgggccac gtggatgagt ttctgagctt
     1561 cgtgcccacc tctgaccaaa agggcttccg cctcctcctg gccagcccca gtgcctgcct
     1621 ccagctgttc caggagaaga aggaggaggg ctacggggag gctgagcagt ttgatggcct
     1681 caagcataag gcaaaaagaa gcatcaacga catcttagct gacaagcacc tcaggaggga
     1741 tagcgcgcac gtgcagaaat gcatcgactg gaaccgcgag gtgctaaagc gggagctggg
     1801 cctctccgag agcgacatcg tggacattcc acagctcttc ttcctgaagg gagcctacgc
     1861 tgaagccttc tttcctgaca tggtcaacat ggtggttctc ggcaagtacc tgggcatccc
     1921 taagcccttc ggcccgctca tcaatggtcg ctgctgcctg gaggagaagg tgcgctccct
     1981 gctggagccg ctgggtctgc gctgcgtctt tatcgacgac tttctctttt accaccaact
     2041 gctcggagag atccactgtg gcaccaacgt gcggaggaaa ccttttacct ttaagtggtg
     2101 gaactccgtg ccctgagcct gcccgaccac cacccttgct tcccagctga tgggagtccc
     2161 agggcaaggg caagggccac gaaccagcct ccaccctcct tgggcctgaa agtgggctgg
     2221 ctactgtggt cagctgagcg ccaggaggac aacacacttc ttcgttcctg gagtcgcctg
     2281 ccctgccctg gagactatcg ccacttttcc ttctcccatt cccagctaga gccctgagag
     2341 ggtcaaggcc ggaagttgag cctgttcaag gtgtggcctc cgcagccacg ccccactttg
     2401 agctgtccca cccccaaccc tccacctctc tgaaacccga gaaaaatagc tctggaacga
     2461 aatgcccacc ttgccaggac cctggggcaa gagcaccgtg gtttcatatg actcctggat
     2521 tgcgtaagat gtaaaggaag atttggggcg tccttcttcc caaaggacct caggccatgg
     2581 ccctctggca ccgttcagtt caacggaggc aagcaagggc aggaaaactc agtccttgaa
     2641 agcgagcagg cacaaaagcc cctctaatgc tcaactccat ccagtccgac ctctgcagga
     2701 tgctcgttac ctgccggagc agcctttaat tatgagccct ggtgcttcct gttggaagat
     2761 gccgcgggcc atagggagcc cgtcgtaagt ctgcaagcgt gggtgggggt gggcaggaag
     2821 gttggaccag gaaagcagag agcttgccca tcttggggtg gggaacctgg aagcctggga
     2881 ctcgtggctg ggtgtttagg gcccctgaac ctgaaggctg ttggtccaga tgtggagggg
     2941 gtggggccca aggtattagg agagggtggg gtaggtcatt aagttacatc tggaggtgag
     3001 gcctaatttc ctctaatagt ctctaattac tcccgatcct gctgcaggca gtgggaggga
     3061 agggcccaca ctcccctagc agccagggac cctacacaac atttgtactg ccccagtaaa
     3121 ccccatggca ggcctgtgtc ccccaccccc acccccagta ggacagacag ctggcctgga
     3181 ggctaatagc accagctgag gtaacagagg catgtggagg caagcaggca ggcagaccca
     3241 gctgcagggc atggctggca gaggcctgcc atcttcctcc tgtggtccag gagccaccac
     3301 aggccactgg attctgtctt ggtattttta gtagtttctg gtgccacccc agacttgagg
     3361 cagctgctgt cacttcataa ccggcggaca ctcagttagc gaaggcttcc atgaaagtgt
     3421 taggctaggc atggcctagt aggcattggc tcttccccct tccagaaggg tctgtggaac
     3481 tggaacccca tttgtaggct ctctgcacga acagcctcct ctatgagcat ggcccggctg
     3541 cagctgagac acggagaagg agaagaagaa gataaaggag gatgagaagg gttggggcga
     3601 tgcccgacct ctgaagagga gaggagacag gcgaccatgg gagcaagtct tcagcaccac
     3661 atgatgggga ctctggagtt gccgctcagg ctgtctgggg tcctggctga ctggccaccg
     3721 tctttctcat caataaaaac atcgttgtgc attctt
//
