LOCUS       NM_001358641            3672 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Mus musculus protein kinase C and casein kinase substrate in
            neurons 2 (Pacsin2), transcript variant 4, mRNA.
ACCESSION   NM_001358641 XM_006520979
VERSION     NM_001358641.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3672)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3672)
  AUTHORS   Biswas,R., Boyd,E.K., Eaton,N., Steenackers,A., Schulte,M.L.,
            Reusswig,F., Yu,H., Drew,C., Kahr,W.H.A., Shi,Q., Plomann,M.,
            Hoffmeister,K.M. and Falet,H.
  TITLE     PACSIN2 regulates platelet integrin beta1 hemostatic function
  JOURNAL   J Thromb Haemost 21 (12), 3619-3632 (2023)
   PUBMED   37678551
  REMARK    GeneRIF: PACSIN2 regulates platelet integrin beta1 hemostatic
            function.
REFERENCE   3  (bases 1 to 3672)
  AUTHORS   Dumont,V. and Lehtonen,S.
  TITLE     PACSIN proteins in vivo: Roles in development and physiology
  JOURNAL   Acta Physiol (Oxf) 234 (3), e13783 (2022)
   PUBMED   34990060
  REMARK    GeneRIF: PACSIN proteins in vivo: Roles in development and
            physiology.
            Review article
REFERENCE   4  (bases 1 to 3672)
  AUTHORS   Li,J., Fujise,K., Wint,H., Senju,Y., Suetsugu,S., Yamada,H.,
            Takei,K. and Takeda,T.
  TITLE     Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate
            formation and maturation of podosomes
  JOURNAL   Biochem Biophys Res Commun 571, 145-151 (2021)
   PUBMED   34325130
  REMARK    GeneRIF: Dynamin 2 and BAR domain protein pacsin 2 cooperatively
            regulate formation and maturation of podosomes.
REFERENCE   5  (bases 1 to 3672)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3672)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   7  (bases 1 to 3672)
  AUTHORS   Sumoy,L., Pluvinet,R., Andreu,N., Estivill,X. and Escarceller,M.
  TITLE     PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the
            pacsin-syndapin-FAP52 gene family
  JOURNAL   Gene 262 (1-2), 199-205 (2001)
   PUBMED   11179684
REFERENCE   8  (bases 1 to 3672)
  AUTHORS   Modregger,J., Ritter,B., Witter,B., Paulsson,M. and Plomann,M.
  TITLE     All three PACSIN isoforms bind to endocytic proteins and inhibit
            endocytosis
  JOURNAL   J Cell Sci 113 Pt 24, 4511-4521 (2000)
   PUBMED   11082044
REFERENCE   9  (bases 1 to 3672)
  AUTHORS   Ritter,B., Modregger,J., Paulsson,M. and Plomann,M.
  TITLE     PACSIN 2, a novel member of the PACSIN family of cytoplasmic
            adapter proteins
  JOURNAL   FEBS Lett 454 (3), 356-362 (1999)
   PUBMED   10431838
REFERENCE   10 (bases 1 to 3672)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL583889.8 and AC165945.7.
            
            On Sep 7, 2022 this sequence version replaced NM_001358641.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849380,
                              SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AL583889.8         95055-95179
            126-258             AL583889.8         157639-157771
            259-415             AL583889.8         166981-167137
            416-651             AL583889.8         168980-169215
            652-807             AL583889.8         170968-171123
            808-983             AL583889.8         172801-172976
            984-1104            AC165945.7         124181-124301       c
            1105-1110           AC165945.7         122817-122822       c
            1111-1232           AC165945.7         120956-121077       c
            1233-1355           AC165945.7         118878-119000       c
            1356-1552           AC165945.7         118193-118389       c
            1553-3672           AC165945.7         114805-116924       c
FEATURES             Location/Qualifiers
     source          1..3672
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.4 cM"
     gene            1..3672
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /note="protein kinase C and casein kinase substrate in
                     neurons 2"
                     /db_xref="GeneID:23970"
                     /db_xref="MGI:MGI:1345153"
     exon            1..125
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            126..258
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1665
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /note="isoform 2 is encoded by transcript variant 4;
                     protein kinase C and casein kinase substrate in neurons
                     protein 2; Syndapin II; syndapin-II; syndapin-2"
                     /codon_start=1
                     /product="protein kinase C and casein kinase substrate in
                     neurons protein 2 isoform 2"
                     /protein_id="NP_001345570.1"
                     /db_xref="GeneID:23970"
                     /db_xref="MGI:MGI:1345153"
                     /translation="MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCGDLMNC
                     LHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWIAVMSEAERVSELHLEVKA
                     SLMNEDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHH
                     TACKEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKDKYEKSLKELDQT
                     TPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVASYKTIYRELEQSIKA
                     ADAVEDLRWFRANHGPGMAMNWPQFEDEEWSADLNRTLSRREKKKAVDGVTLTGINQT
                     GDQSGQNKPGSNLSVPSNPAQSTQLQSSYNPFEDEDDTGSSISEKEDIKAKNVSSYEK
                     TQTYPTDWSDDESNNPFSSTDANGDSNPFDEDTTSGTEVRVRALYDYEGQEHDELSFK
                     AGDELTKIEDEDEQGWCKGRLDSGQVGLYPANYVEAIQ"
     exon            259..415
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            416..651
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            652..807
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            808..983
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1104
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1110
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1232
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1355
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1552
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..3672
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3130..3135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /note="hexamer: AATAAA"
     polyA_site      3161
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /note="major polyA site"
     regulatory      3653..3658
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
                     /note="hexamer: AGTAAA"
     polyA_site      3672
                     /gene="Pacsin2"
                     /gene_synonym="SdpII"
ORIGIN      
        1 agaagcggct gcggcgggtc tgggcagggc cggggagctc ggttggagcg gaacgggaag
       61 gggtcggagt cgcagcccgg ccggggcggc gtgctcagtg ggacccgagg cgaacggcgg
      121 ccgaggtctg tctgcaggtt ttacacatct gacccctgaa ctggagtgtc tgctgccacc
      181 ccctcgtcct ctgcagaaat gtctgtcacc tacgatgact ctgtgggagt ggaagtgtcc
      241 agcgacagct tctgggaggt tgggaactac aaacggactg tgaagcggat tgacgatggc
      301 caccgcctgt gtggtgacct catgaactgt ctgcatgagc gggcacgcat cgagaaggcg
      361 tatgcacagc agctcactga gtgggcccga cgctggaggc agctggtaga gaagggacca
      421 cagtatggga ccgtggagaa ggcctggata gctgtcatgt ctgaagcaga gagggtgagt
      481 gaactgcacc tggaagtgaa ggcatcactg atgaatgaag actttgagaa gatcaagaac
      541 tggcagaagg aagcctttca caagcagatg atgggaggct tcaaggagac caaagaagca
      601 gaggatggct ttcggaaggc ccagaagccc tgggccaaga agctgaaaga ggtggaagcg
      661 gcaaagaagg cgcaccacac agcgtgcaaa gaggagaagc tggccatctc ccgggaagcc
      721 aacagcaagg cagatccatc cctcaaccct gagcagctga agaaactgca agacaagata
      781 gaaaaatgca aacaggacgt tctaaagacc aaggacaagt atgagaagtc cctgaaggag
      841 cttgatcaga ccacacccca gtacatggag aacatggagc aggtgttcga gcagtgccag
      901 cagtttgaag agaagcgcct gcgcttcttc cgggaggttc tgctggaggt tcagaagcac
      961 ttggatctgt ccaatgtggc tagctataaa accatttacc gggagctgga gcagagcatc
     1021 aaagcagcag atgcggtaga ggacctgagg tggttccggg ctaaccatgg gccaggcatg
     1081 gctatgaact ggccacagtt tgaggatgaa gagtggtctg cagatctgaa tcgaactctc
     1141 agccggagag agaagaagaa ggctgttgac ggtgtcaccc taacagggat caaccagaca
     1201 ggtgaccagt ctggacagaa caagcctggc agcaacctta gtgtcccgag caaccccgcc
     1261 cagtccacgc agttacagtc cagctacaac cccttcgagg acgaggacga cacgggcagc
     1321 agcatcagtg agaaggagga cattaaggcc aaaaatgtca gcagctatga gaagactcag
     1381 acttacccca ctgactggtc tgatgatgag tctaacaacc ctttctcctc cacggatgcc
     1441 aacggggatt cgaacccatt tgatgaggac acgacctcag gaacagaagt gcgagttcgg
     1501 gccctctatg actatgaggg gcaggaacat gatgagctga gcttcaaggc tggggatgaa
     1561 ctgaccaaga tagaggatga agatgaacag ggttggtgca agggacgttt agacagcggc
     1621 caggttggcc tatacccagc caactatgtc gaggctatcc agtgacagcc catgggcagg
     1681 ctggcggaga gacggaaatg ggcagttcag gagctccgtt agccttggcc tgggcagtga
     1741 cacctctagt gcccccagca gccatgtagg catccactcc acctgcaaaa gacgatggct
     1801 ctgttgttct tggcttcctg gtgtgctttg aaggcagatg agctggtgat ttcattgggc
     1861 acttggccct tttccaagca catctgggca gatatagaca caggaagata gggtccaaca
     1921 gcgagagcca ggcccctccc cacccccacc agctctctct atcatggatc tgcaccttct
     1981 cgcccttgtc tctcctgagt catgacgggt catactgatt cttgttccac tgatgatttt
     2041 ctctgatgag gtcctatctg caaggtcaat gagcagactt acatgccatc ttctgagtaa
     2101 agagtttgag gttttaattt aaaggcaatg tacagctata cttttttata tgctcttcca
     2161 gtcagttaaa ttatggccta cactgatctg agatgttctc cacgtgagct gtcttcattt
     2221 ctctgtgcta tgtccagatg tggggttgct gcagccgggg ttctatggca agtgccagtt
     2281 gcagggctaa ccttgtgcaa cgttccccaa cacttccaca tacagaaatt attttcactc
     2341 tatccctgct tcagtttttg cagattaaca gttctattag tgatttggaa agttaacagt
     2401 aagaagacta acttttcaaa acagttgcat ctgtagatta agatgcttta cattagaccg
     2461 ttgtgtctcg atgtatatct gtatatatta tttgataatc agaaaatcta tagagttcac
     2521 ccactgttga atgagagctg gtggcttctg acagcagatc tggtcaactg cttgaagccc
     2581 atggcattga agcacaggca cggctggtta acggtgccca cccagttagg atgtggctct
     2641 ggcctctgag tggagctgct gggaagactg attctcattg gcctgggctc caagctcatg
     2701 accgagcact ggaaaagctc ctaggacttg gtagtaatcg tagacttcac agtccctgtg
     2761 tcactcactg gagagctaga gggaggggtt cgacaccctc caccacacac acacacacac
     2821 acacacacac acacacaagt tcctccagtt gcccttgtcc tcaggtgcag tgggactgtt
     2881 gtgagcccca gggatgggca caaagaggac ttttattttg ttagctcgga cagtgcagtg
     2941 gtgcacatca gcaacttgta tttcttcggt gtttggcacg agcactgtct cgctgtggct
     3001 gtgtgtcatg agaacttacc agcagaaatc cttgttccta agctacagaa tgaccaaaag
     3061 ctgtcaagtc cttaatgttt agaaactcct taaaatgtat agtattttag aacaacaaca
     3121 acaaaactca ataaacagtt gatcttgtgt gtttgacagt ccctttgcct tgcatccacc
     3181 ctcatgttca cacagctgat agacctgtct ccttgggggt gtaccagctt tgaaactggg
     3241 caagatccag ttcataggat cccttctcgg gaccatgtct cagttcctgc accagaggct
     3301 ggggacttgg ggcaccttgg gcatccctga ggagggcatc cctggtgcca ccctctctcc
     3361 cctgaccaac aaccgctcct ccccaaacct gcgtgtgttg acctttatgt gccactgttc
     3421 tgttttctca agctgatgat ctctgggtgt aatgtgatca atgcaggtcc cagctggtcc
     3481 tgctcgcaca aagaacctcc aaggatcttg cctcctattg ggatcagcta aggagataaa
     3541 gccagtgcgg tagccctgac cagtcccggt gaacggactg ctgctgctgc tgctgctgct
     3601 gctgctgctg ctgctgctgc tgctgctgct gctgctgctg ctcttcaaca ctagtaaagc
     3661 ttctctctgg cc
//
