LOCUS       NM_011861               4215 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus protein kinase C and casein kinase substrate in
            neurons 1 (Pacsin1), transcript variant 1, mRNA.
ACCESSION   NM_011861
VERSION     NM_011861.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4215)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4215)
  AUTHORS   Xie,C., Zhou,H., Athanasopoulos,V., Shen,Q., Zhang,Y., Meng,X.,
            Burgio,G., Arsov,T., Lungu,A.C., Zhang,P., Qin,Y., Ma,J., Wu,X.,
            Jiang,X., Ding,H., Meng,Y., Shen,N., He,Y. and Vinuesa,C.G.
  TITLE     De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role
            for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation
  JOURNAL   Arthritis Rheumatol 75 (6), 1058-1071 (2023)
   PUBMED   36622335
  REMARK    GeneRIF: De Novo PACSIN1 Gene Variant Found in Childhood Lupus and
            a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7
            Activation.
REFERENCE   3  (bases 1 to 4215)
  AUTHORS   Valente,M., Collinet,N., Vu Manh,T.P., Popoff,D., Rahmani,K.,
            Naciri,K., Bessou,G., Rua,R., Gil,L., Mionnet,C., Milpied,P.,
            Tomasello,E. and Dalod,M.
  TITLE     Novel mouse models based on intersectional genetics to identify and
            characterize plasmacytoid dendritic cells
  JOURNAL   Nat Immunol 24 (4), 714-728 (2023)
   PUBMED   36928414
REFERENCE   4  (bases 1 to 4215)
  AUTHORS   Troger,J., Seemann,E., Heintzmann,R., Kessels,M.M. and Qualmann,B.
  TITLE     Spinal Cord Synaptic Plasticity by GlyRbeta Release from Receptor
            Fields and Syndapin I-Dependent Uptake
  JOURNAL   J Neurosci 42 (35), 6706-6723 (2022)
   PUBMED   35879097
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4215)
  AUTHORS   Koch,N., Koch,D., Krueger,S., Troger,J., Sabanov,V., Ahmed,T.,
            McMillan,L.E., Wolf,D., Montag,D., Kessels,M.M., Balschun,D. and
            Qualmann,B.
  TITLE     Syndapin I Loss-of-Function in Mice Leads to Schizophrenia-Like
            Symptoms
  JOURNAL   Cereb Cortex 30 (8), 4306-4324 (2020)
   PUBMED   32147734
  REMARK    GeneRIF: Syndapin I Loss-of-Function in Mice Leads to
            Schizophrenia-Like Symptoms.
REFERENCE   6  (bases 1 to 4215)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   7  (bases 1 to 4215)
  AUTHORS   Sumoy,L., Pluvinet,R., Andreu,N., Estivill,X. and Escarceller,M.
  TITLE     PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the
            pacsin-syndapin-FAP52 gene family
  JOURNAL   Gene 262 (1-2), 199-205 (2001)
   PUBMED   11179684
REFERENCE   8  (bases 1 to 4215)
  AUTHORS   Modregger,J., Ritter,B., Witter,B., Paulsson,M. and Plomann,M.
  TITLE     All three PACSIN isoforms bind to endocytic proteins and inhibit
            endocytosis
  JOURNAL   J Cell Sci 113 Pt 24, 4511-4521 (2000)
   PUBMED   11082044
REFERENCE   9  (bases 1 to 4215)
  AUTHORS   Ritter,B., Modregger,J., Paulsson,M. and Plomann,M.
  TITLE     PACSIN 2, a novel member of the PACSIN family of cytoplasmic
            adapter proteins
  JOURNAL   FEBS Lett 454 (3), 356-362 (1999)
   PUBMED   10431838
REFERENCE   10 (bases 1 to 4215)
  AUTHORS   Plomann,M., Lange,R., Vopper,G., Cremer,H., Heinlein,U.A.,
            Scheff,S., Baldwin,S.A., Leitges,M., Cramer,M., Paulsson,M. and
            Barthels,D.
  TITLE     PACSIN, a brain protein that is upregulated upon differentiation
            into neuronal cells
  JOURNAL   Eur J Biochem 256 (1), 201-211 (1998)
   PUBMED   9746365
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK158686.1, X85124.1, AK043967.1, AC131800.4 and AI842330.1.
            
            On Nov 15, 2013 this sequence version replaced NM_011861.2.
            
            Transcript Variant: This variant (1) has an alternate splice site
            in the 5' UTR, compared to variant 3. All variants encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X85124.1, SRR7652917.505662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AK158686.1         4-94
            92-916              X85124.1           1-825
            917-1652            AK043967.1         921-1656
            1653-3836           AC131800.4         131108-133291
            3837-4215           AI842330.1         1-379               c
FEATURES             Location/Qualifiers
     source          1..4215
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 14.59 cM"
     gene            1..4215
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /note="protein kinase C and casein kinase substrate in
                     neurons 1"
                     /db_xref="GeneID:23969"
                     /db_xref="MGI:MGI:1345181"
     exon            1..169
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /inference="alignment:Splign:2.1.0"
     exon            170..344
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1616
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /note="Syndapin I; syndapin-1"
                     /codon_start=1
                     /product="protein kinase C and casein kinase substrate in
                     neurons protein 1"
                     /protein_id="NP_035991.1"
                     /db_xref="CCDS:CCDS28567.1"
                     /db_xref="GeneID:23969"
                     /db_xref="MGI:MGI:1345181"
                     /translation="MSGSYDEASEEITDSFWEVGNYKRTVKRIDDGHRLCNDLMSCVQ
                     ERAKIEKAYAQQLTDWAKRWRQLIEKGPQYGSLERAWGAMMTEADKVSELHQEVKNSL
                     LNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLA
                     CKEERLAMTREMNSKTEQSVTPEQQKKLVDKVDKCRQDVQKTQEKYEKVLEDVGKTTP
                     QYMEGMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYMHVYRELEQAIRGAD
                     AQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTAKKEKQPKKAEGATLSNATGAVES
                     TSQAGDRGSVSSYDRGQTYATEWSDDESGNPFGGNEANGGANPFEDDAKGVRVRALYD
                     YDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI"
     exon            345..501
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /inference="alignment:Splign:2.1.0"
     exon            502..737
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /inference="alignment:Splign:2.1.0"
     exon            738..893
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1069
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1190
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1318
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1506
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..4198
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1700
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
     regulatory      4172..4177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /note="hexamer: GATAAA"
     polyA_site      4197
                     /gene="Pacsin1"
                     /gene_synonym="A830061D09Rik; H74; mKIAA1379; syndapin"
                     /note="major polyA site"
ORIGIN      
        1 ccttcctcct tcccgcagcc ccagagagac gcgcggcggt cgcgccagcc ttctcctcct
       61 ccttttcctc ctcctccccc gggaagccgg ccgggcttga ggctgggccg ccgccgccgc
      121 ccgctttgcc acccgccccg ctgatggtgt ccggtgctcc ggcgcccagg gacacagacc
      181 gggagcagga ccacttctct cacctccgga tctctcctgc ttccgcagcc tgtgagcagc
      241 aggcctgcta actgcagatc cacaaccgca cagctcgcta caggtgcacc atgtctggct
      301 cctacgatga ggcctcagag gagatcacag atagcttctg ggaggtgggg aactacaagc
      361 ggacggtgaa gcgcatcgac gatgggcacc gcctgtgcaa cgacctcatg agctgcgtgc
      421 aggagcgcgc caagatcgag aaggcatacg cgcagcagct caccgactgg gccaagcgct
      481 ggcgccagct catcgagaaa ggtcctcagt atggcagcct ggagcgggcg tggggcgcca
      541 tgatgacaga agcagataag gtcagcgagc tgcaccagga ggtgaagaac agcctgctga
      601 atgaggacct ggagaaagtc aagaactggc agaaggatgc ctatcacaag cagatcatgg
      661 gtggcttcaa ggagacgaaa gaggccgagg atggcttccg aaaggcccag aagccctggg
      721 ctaaaaagat gaaggagcta gaggcggcca agaaggccta tcacttggct tgtaaggagg
      781 aaaggctggc catgacccgg gagatgaaca gtaagacaga gcagtcggtc acccctgaac
      841 agcagaagaa acttgtggac aaagtggaca aatgcagaca ggatgtgcaa aagactcagg
      901 agaagtatga gaaggtgctg gaagatgtgg gcaagaccac accacagtac atggagggca
      961 tggagcaggt gtttgagcag tgccagcagt ttgaggagaa gcggctggtc ttcctgaagg
     1021 aagtcctgct ggatatcaaa cggcatctca acctagcgga gaacagcagc tacatgcatg
     1081 tctaccgaga actggagcag gccatccggg gggccgatgc ccaggaggac ctcaggtggt
     1141 tccgcagcac cagtggcccc gggatgccca tgaactggcc gcagttcgag gagtggaacc
     1201 cagacctccc gcacaccact gccaagaagg agaaacagcc taagaaggca gagggggcca
     1261 ccctgagcaa tgccactggg gctgtagaat ccacatccca ggctggggac cgtggcagtg
     1321 ttagcagcta tgaccgaggc caaacatatg ccaccgagtg gtcagacgat gagagcggaa
     1381 accccttcgg gggcaatgag gccaatggtg gcgccaaccc cttcgaggat gatgccaagg
     1441 gagttcgtgt acgggcactc tatgactacg acggtcagga gcaggatgag ctcagcttca
     1501 aggccggaga tgagctcacc aagctcggag aggaagacga acagggttgg tgccgcgggc
     1561 ggctggacag cggacagctg ggcctctatc ctgccaacta cgttgaggct atatagctac
     1621 cttgcccacc cgactcctct cagtccttgt ccaccgcctt ccacccttcc cctccccctt
     1681 gccatagagt tccagacata ttttccgatc aagcttttat ttttttaaaa gtcaaaacag
     1741 aacaaaaaaa aaaaaaaaga agaaatacga agagacagcg tttgcagcct acctggaggc
     1801 cgggggggag ggggcttagg gtgatggcct cccccacagc gtgggcaagg atcttgggac
     1861 ttaacccaat gtcacatctg gtctatagag tccaccaaag agtctcctga gtcttgaggg
     1921 agatcttctg gatccttcta ccctgtctcg ctctcctatc ccaccacagc tgccagcagc
     1981 tgcccatgtc acctgagcct ggcttcctaa actctcctgt cccctctcct gtcccccttc
     2041 aacgccccct tctcttaaag ggcccccaat ctttagtctt ccactctgcc ctgggggtgc
     2101 ttttctcttc ccagccctgt cctagtgagg ctgggggaga aggctgcgga ggggagggga
     2161 gtgtctcttc actcccccag acatgaaggc aggtgagtgg gagggagtca tggcctccct
     2221 ggcatacagg agaggaagaa ggagaacaga ccatctgacc aggctgtgcc aacactccca
     2281 atgccaagcc cattttgagg gatgaaaacc ctagctgggc ctgtgggcag agggctcctc
     2341 ctcagagcca atgagcattt gcagagaccc tacctgtctc tttagtcctt ggcaatgggc
     2401 aaagcctctt ccttggaaag tccagggcaa agccagcaac agtagcaacc tcctctcact
     2461 ctggggagga ggcattggcc acccatcccc ctcccttcat ggtcattcag aaacgccaca
     2521 gcccctccca tccccaatca ctgtgtcagc atcagccttt gtgaagacgg tctacaaggc
     2581 tctcacctgg ccaacctagg agattcaggg gctcaggaac ctaggagatt caggggcttg
     2641 gggaacctcc accttggcac tgtaagggga agccagcagc tcaggctggt gtgaggaagg
     2701 aactctggat ggtcactgta gctttcttcc ttgacctttt agtccccaac atcccctctg
     2761 aatgctggca gcacccccac ccccacacac acactcccat ttctctaagc ccgagagtct
     2821 tgagtcttca ttaaaggatt ctgggtgtgg gaggggacac agggcccttg tggttgggaa
     2881 gcaggtggca ggctctccct tgggaggatg gggtgggaaa cgaaacaggt caaccaagac
     2941 ctcttacagt ggaaagtggt cagaggctgt ttctttggac ctttgggaac acagatttga
     3001 gaaagtctca tattcacagc tggtgtccgc taggcctctg gcctacggac accctctgcc
     3061 ttgtgaatca ggtgaccttt tgggcctcca gggaaagaac aggaccacca tccatgttct
     3121 ccgggaccct ttagctctct gctgcttctc ctgacactca ggtcatggac ccaagctttg
     3181 gggtcctgac caccgccccc ccccaccccc cttctcttga ctaggctgca gcagggcctt
     3241 ctgttgggtc agtcctccct cagggccagg agcaggaact tagcactcaa gagacagggc
     3301 tgtaagcacc cacttccctg tcactgtttg cccttggggc ttcagctgca gcccaggttg
     3361 ggccctggag ccctcagaac cggaagcagg attcaaacct ccccttctcc acagcccccc
     3421 ctgcctcccc agatggtaga catcccccag ctcttacctt caccctcatc tcagaaaggc
     3481 aagaagccgc catgtccgca ccttggggcc tgggcttccc cctctctgtg ccagcggctt
     3541 cccagcacct ggggaggggc tgtggccctg accagacccc aggcccaccc cacatagtat
     3601 actagctgcc cactctgggg caggaactgg aaaatccatc ccttttgaac aaccaccttc
     3661 aatgaccccc cccatctggg accagacttg gtcctcaagt tattcagcac ccccagtgca
     3721 ggagggtcct ccccccaccc cccgaagtcc ctggagcccg gagcagagcc ccacctgtga
     3781 ttcctggtgt tagggcacct caaaccttgg gctggaccac accccttccc gccatttcca
     3841 gacccctacc tgtactcccc agtgctcccc aggggcctct tgatgctgca cgggaccctg
     3901 cagggctcgg tcagtgatgt gttttgtccc cagttaaccg ccatccagcg acctggttcc
     3961 aggaggagct caggtcaccc ccaccaccgc cgccactgcg tctgccgccc taggctttca
     4021 gacatcatta gttccgacac ttgtgaaact ccgagacgtg ccgtggtctc agcaatgcac
     4081 ctgttttata catgattgtg taatttaaag gtatataaat acaaatatat atattatatc
     4141 tatatctatc agttgtgacc gtatggctgt cgataaaacc agaattctgt caccctggaa
     4201 aaaaaaaaaa aaaaa
//
